LOCUS       NP_058763                650 aa            linear   ROD 03-APR-2024
DEFINITION  rab proteins geranylgeranyltransferase component A 1 [Rattus
            norvegicus].
ACCESSION   NP_058763
VERSION     NP_058763.1
DBSOURCE    REFSEQ: accession NM_017067.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 650)
  AUTHORS   Guo,Z., Wu,Y.W., Das,D., Delon,C., Cramer,J., Yu,S., Thuns,S.,
            Lupilova,N., Waldmann,H., Brunsveld,L., Goody,R.S., Alexandrov,K.
            and Blankenfeldt,W.
  TITLE     Structures of RabGGTase-substrate/product complexes provide
            insights into the evolution of protein prenylation
  JOURNAL   EMBO J 27 (18), 2444-2456 (2008)
   PUBMED   18756270
  REMARK    GeneRIF: RabGGTase has evolved from a GGTase-I-like molecule that
            'learned' to interact with a recycling factor (GDI) that, in turn,
            eventually gave rise to REP1.
REFERENCE   2  (residues 1 to 650)
  AUTHORS   Shi,W., van den Hurk,J.A., Alamo-Bethencourt,V., Mayer,W.,
            Winkens,H.J., Ropers,H.H., Cremers,F.P. and Fundele,R.
  TITLE     Choroideremia gene product affects trophoblast development and
            vascularization in mouse extra-embryonic tissues
  JOURNAL   Dev Biol 272 (1), 53-65 (2004)
   PUBMED   15242790
REFERENCE   3  (residues 1 to 650)
  AUTHORS   Rak,A., Pylypenko,O., Niculae,A., Pyatkov,K., Goody,R.S. and
            Alexandrov,K.
  TITLE     Structure of the Rab7:REP-1 complex: insights into the mechanism of
            Rab prenylation and choroideremia disease
  JOURNAL   Cell 117 (6), 749-760 (2004)
   PUBMED   15186776
REFERENCE   4  (residues 1 to 650)
  AUTHORS   Pylypenko,O., Rak,A., Reents,R., Niculae,A., Sidorovitch,V.,
            Cioaca,M.D., Bessolitsyna,E., Thoma,N.H., Waldmann,H.,
            Schlichting,I., Goody,R.S. and Alexandrov,K.
  TITLE     Structure of Rab escort protein-1 in complex with Rab
            geranylgeranyltransferase
  JOURNAL   Mol Cell 11 (2), 483-494 (2003)
   PUBMED   12620235
REFERENCE   5  (residues 1 to 650)
  AUTHORS   Tolmachova,T., Ramalho,J.S., Anant,J.S., Schultz,R.A., Huxley,C.M.
            and Seabra,M.C.
  TITLE     Cloning, mapping and characterization of the human RAB27A gene
  JOURNAL   Gene 239 (1), 109-116 (1999)
   PUBMED   10571040
REFERENCE   6  (residues 1 to 650)
  AUTHORS   Alexandrov,K., Horiuchi,H., Steele-Mortimer,O., Seabra,M.C. and
            Zerial,M.
  TITLE     Rab escort protein-1 is a multifunctional protein that accompanies
            newly prenylated rab proteins to their target membranes
  JOURNAL   EMBO J 13 (22), 5262-5273 (1994)
   PUBMED   7957092
REFERENCE   7  (residues 1 to 650)
  AUTHORS   Andres,D.A., Seabra,M.C., Brown,M.S., Armstrong,S.A., Smeland,T.E.,
            Cremers,F.P. and Goldstein,J.L.
  TITLE     cDNA cloning of component A of Rab geranylgeranyl transferase and
            demonstration of its role as a Rab escort protein
  JOURNAL   Cell 73 (6), 1091-1099 (1993)
   PUBMED   8513495
REFERENCE   8  (residues 1 to 650)
  AUTHORS   Seabra,M.C., Brown,M.S., Slaughter,C.A., Sudhof,T.C. and
            Goldstein,J.L.
  TITLE     Purification of component A of Rab geranylgeranyl transferase:
            possible identity with the choroideremia gene product
  JOURNAL   Cell 70 (6), 1049-1057 (1992)
   PUBMED   1525821
REFERENCE   9  (residues 1 to 650)
  AUTHORS   Zderkiewicz,E.
  TITLE     [Autoregulation of cerebral blood flow]
  JOURNAL   Pol Tyg Lek 33 (29), 1157-1159 (1978)
   PUBMED   704419
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L13722.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NP_058763.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq31"
     Protein         1..650
                     /product="rab proteins geranylgeranyltransferase component
                     A 1"
                     /function="escort protein"
                     /note="REP-1; rab escort protein 1; choroideraemia protein
                     homolog; choroidermia; choroideremia (Rab escort protein
                     1); choroideremia protein homolog; CHM, Rab escort protein
                     1"
                     /calculated_mol_wt=72350
     Region          6..530
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Region          156..208
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P37727.1)"
     Region          603..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P37727.1)"
     CDS             1..650
                     /gene="Chm"
                     /coded_by="NM_017067.1:6..1958"
                     /db_xref="GeneID:24942"
                     /db_xref="RGD:2340"
ORIGIN      
        1 madnlpsdfd vivigtglpe siiaaacsrs gqrvlhvdsr syyggnwasf sfsgllswlk
       61 eyqenndvvt ensmwqeqil eneeaiplss kdktiqhvev fcyasqdlhk dveeagalqk
      121 nhasvtsaqs aeaaeaaets clptavepls mgsceipaeq sqcpgpessp evndaeatgk
      181 kensdaksst eepsenvpkv qdntetpkkn ritysqiike grrfnidlvs qllysrglli
      241 dlliksnvsr yaefknitri lafregtveq vpcsradvfn skqltmvekr mlmkfltfcv
      301 eyeehpdeyr ayegttfsey lktqkltpnl qyfvlhsiam tsettsctvd glkatkkflq
      361 clgrygntpf lfplygqgel pqcfcrmcav fggiyclrhs vqclvvdkes rkckavidqf
      421 gqriiskhfi iedsylsent csrvqyrqis ravlitdgsv lktdadqqvs ilavpaeepg
      481 sfgvrvielc sstmtcmkgt ylvhltcmss ktaredlerv vqklftpyte ieaeneqvek
      541 prllwalyfn mrdssdisrd cyndlpsnvy vcsgpdsglg ndnavkqaet lfqqicpned
      601 fcpappnped ivldgdssqq evpessvtpe tnsetpkest vlgnpeepse
//
