LOCUS       NM_017177               1679 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus choline kinase beta (Chkb), mRNA.
ACCESSION   NM_017177
VERSION     NM_017177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Mitsuhashi,S., Hatakeyama,H., Karahashi,M., Koumura,T., Nonaka,I.,
            Hayashi,Y.K., Noguchi,S., Sher,R.B., Nakagawa,Y., Manfredi,G.,
            Goto,Y., Cox,G.A. and Nishino,I.
  TITLE     Muscle choline kinase beta defect causes mitochondrial dysfunction
            and increased mitophagy
  JOURNAL   Hum Mol Genet 20 (19), 3841-3851 (2011)
   PUBMED   21750112
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Mitsuhashi,S., Ohkuma,A., Talim,B., Karahashi,M., Koumura,T.,
            Aoyama,C., Kurihara,M., Quinlivan,R., Sewry,C., Mitsuhashi,H.,
            Goto,K., Koksal,B., Kale,G., Ikeda,K., Taguchi,R., Noguchi,S.,
            Hayashi,Y.K., Nonaka,I., Sher,R.B., Sugimoto,H., Nakagawa,Y.,
            Cox,G.A., Topaloglu,H. and Nishino,I.
  TITLE     A congenital muscular dystrophy with mitochondrial structural
            abnormalities caused by defective de novo phosphatidylcholine
            biosynthesis
  JOURNAL   Am J Hum Genet 88 (6), 845-851 (2011)
   PUBMED   21665002
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Gallego-Ortega,D., Ramirez de Molina,A., Ramos,M.A.,
            Valdes-Mora,F., Barderas,M.G., Sarmentero-Estrada,J. and Lacal,J.C.
  TITLE     Differential role of human choline kinase alpha and beta enzymes in
            lipid metabolism: implications in cancer onset and treatment
  JOURNAL   PLoS One 4 (11), e7819 (2009)
   PUBMED   19915674
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Miyagawa,T., Honda,M., Kawashima,M., Shimada,M., Tanaka,S.,
            Honda,Y. and Tokunaga,K.
  TITLE     Polymorphism located between CPT1B and CHKB, and
            HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS
            hypersomnias (essential hypersomnia)
  JOURNAL   PLoS One 4 (4), e5394 (2009)
   PUBMED   19404393
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Miyagawa,T., Kawashima,M., Nishida,N., Ohashi,J., Kimura,R.,
            Fujimoto,A., Shimada,M., Morishita,S., Shigeta,T., Lin,L.,
            Hong,S.C., Faraco,J., Shin,Y.K., Jeong,J.H., Okazaki,Y., Tsuji,S.,
            Honda,M., Honda,Y., Mignot,E. and Tokunaga,K.
  TITLE     Variant between CPT1B and CHKB associated with susceptibility to
            narcolepsy
  JOURNAL   Nat Genet 40 (11), 1324-1328 (2008)
   PUBMED   18820697
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Sher,R.B., Aoyama,C., Huebsch,K.A., Ji,S., Kerner,J., Yang,Y.,
            Frankel,W.N., Hoppel,C.L., Wood,P.A., Vance,D.E. and Cox,G.A.
  TITLE     A rostrocaudal muscular dystrophy caused by a defect in choline
            kinase beta, the first enzyme in phosphatidylcholine biosynthesis
  JOURNAL   J Biol Chem 281 (8), 4938-4948 (2006)
   PUBMED   16371353
REFERENCE   7  (bases 1 to 1679)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 1679)
  AUTHORS   Aoyama,C., Nakashima,K., Matsui,M. and Ishidate,K.
  TITLE     Complementary DNA sequence for a 42 kDa rat kidney
            choline/ethanolamine kinase
  JOURNAL   Biochim Biophys Acta 1390 (1), 1-7 (1998)
   PUBMED   9487136
REFERENCE   9  (bases 1 to 1679)
  AUTHORS   Chen,L., Roberts,R. and Friedman,D.L.
  TITLE     Expression of brain-type creatine kinase and ubiquitous
            mitochondrial creatine kinase in the fetal rat brain: evidence for
            a nuclear energy shuttle
  JOURNAL   J Comp Neurol 363 (3), 389-401 (1995)
   PUBMED   8847407
REFERENCE   10 (bases 1 to 1679)
  AUTHORS   Ishidate,K., Nakagomi,K. and Nakazawa,Y.
  TITLE     Complete purification of choline kinase from rat kidney and
            preparation of rabbit antibody against rat kidney choline kinase
  JOURNAL   J Biol Chem 259 (23), 14706-14710 (1984)
   PUBMED   6094572
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB006607.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006607.1, BC060515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1679
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /note="choline kinase beta"
                     /db_xref="GeneID:29367"
                     /db_xref="RGD:61826"
     exon            1..502
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1463
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /EC_number="2.7.1.32"
                     /EC_number="2.7.1.82"
                     /note="CKEKB; choline/ethanolamine kinase beta; EK; CKB"
                     /codon_start=1
                     /product="choline/ethanolamine kinase"
                     /protein_id="NP_058873.1"
                     /db_xref="GeneID:29367"
                     /db_xref="RGD:61826"
                     /translation="MAADGTGVVGGGAVGGPLSKDGLLDAKCPEPIPNRRRSSSLSRD
                     AQRRAYQWCREYLGGAWRRARPEELSVCPVSGGLSNLLFRCSLPNHVPSMGGEPREVL
                     LRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYLPSRPLKTQELRD
                     PVLSGAIATKMARFHGMEMPFTKEPRWLFGTMERYLKQIQDLPSTSLPQMNLVEMYSL
                     KDEMNHLRTLLDATPSPVVFCHNDIQEGNILLLSEPDSDDNLMLVDFEYSSYNYRGFD
                     IGNHFCEWVYDYTYEEWPFYKARPADYPTREQQLLFIRHYLAEVQKGEVLSEEEQKKQ
                     EEDLLIEISRYALASHFFWGLWSTLQASMSTIEFGYLEYAQSRFQFYFQQKGQLTSFL
                     SP"
     exon            503..611
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            612..725
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            726..859
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            860..955
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1014
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1096
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1205
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1309
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1391
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1679
                     /gene="Chkb"
                     /gene_synonym="Chetk; Chkl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgatagg cgtgtcgggc gggaccagag cgcgccccac tcagcgaaag ctgccgtccc
       61 tctttgcctt gagcgccgca gccctgagaa tcgcatctgg cttggaaaca gtcctaagac
      121 tggagtctcg aagaaagccg gagacagtcg cgaagaacgg aggacgccca gagactcttc
      181 ggcttcccgg aagtggaacc gagcataccc ggaaggagct aatcccacct gaagattgct
      241 gagcacccgc aggcgttaag cctaacggag tccacgtcat ggcggcggat gggacaggtg
      301 tagtcggagg aggggctgtc ggcggccccc tgtccaagga cggtttgctg gatgctaagt
      361 gcccagaacc aatccccaat cggcggcgct cttcctcgct gtcccgtgac gcgcagcgcc
      421 gagcctatca gtggtgccgg gagtacctgg gcggagcctg gcgcagagcg cggccggagg
      481 agctgagcgt ttgccccgtg agcggaggcc tcagcaacct gctcttccga tgctcgctac
      541 cgaaccacgt gcccagtatg ggcggggagc cccgggaggt gctgctacgg ctgtacgggg
      601 ctatcttgca gggtgtagac tccttggtat tagaaagcgt gatgttcgcc attcttgcag
      661 agagatctct agggccccaa ctttatggag tgtttccaga gggccgcttg gaacagtacc
      721 tcccaagccg gccattgaaa actcaagagc tccgggaccc agtgttgtca ggagccattg
      781 caacaaagat ggcccgtttc catggtatgg agatgccctt caccaaggag ccccgctggt
      841 tgtttgggac catggagcgg tacctaaagc agatccagga cctgccgtcc actagccttc
      901 cccagatgaa cctggtggag atgtacagcc tcaaggatga gatgaatcac ctcaggacgt
      961 tgctagacgc tacaccgtcc ccagtggtct tctgccacaa tgacatccag gaaggaaaca
     1021 tcttactgct ctcagagcca gacagtgatg acaacctcat gttggttgat ttcgagtaca
     1081 gtagttacaa ctacaggggc tttgacattg ggaatcattt ctgtgagtgg gtttacgatt
     1141 acacttacga ggagtggcct ttctacaaag caagacctgc agactacccc actagagaac
     1201 agcagctcct tttcatccgt cattatctgg cggaggttca gaaaggtgag gtcctctccg
     1261 aagaggagca gaagaaacag gaagaagatt tgctgataga gatcagccgg tatgccctgg
     1321 cctctcattt cttctggggc ctatggtcca ccctccaggc ttccatgtcc actatagagt
     1381 ttggctactt ggaatacgcc caatctcggt tccagttcta cttccagcag aaggggcagc
     1441 tgaccagctt cctatcacct tgaggatcca acccccacct cagatttctc ctggagcctc
     1501 cggggcaggc cctcggaggg aggggcaaag agcagaagcc cccagagctt gggctgtgcc
     1561 tctaagtgag actgtcgttg aagtagctga cctccgtact cctttcttag tacttgccca
     1621 aggggggcat ctgacagccc ctggggctgt gcacctaaat aaatgaactt cacaaatac
//
