LOCUS       NM_001270847            1734 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus chitinase 1 (Chit1), transcript variant bChiV_3,
            mRNA.
ACCESSION   NM_001270847
VERSION     NM_001270847.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Raafat Ibrahim,R., Shafik,N.M., El-Esawy,R.O., El-Sakaa,M.H.,
            Arakeeb,H.M., El-Sharaby,R.M., Ali,D.A., Safwat El-Deeb,O. and
            Ragab Abd El-Khalik,S.
  TITLE     The emerging role of irisin in experimentally induced arthritis: a
            recent update involving HMGB1/MCP1/Chitotriosidase I-mediated
            necroptosis
  JOURNAL   Redox Rep 27 (1), 21-31 (2022)
   PUBMED   35094663
  REMARK    GeneRIF: The emerging role of irisin in experimentally induced
            arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase
            I-mediated necroptosis.
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Verwer,P.E., ten Kate,M.T., Falcone,F.H., Morroll,S.,
            Verbrugh,H.A., Bakker-Woudenberg,I.A. and van de Sande,W.W.
  TITLE     Evidence supporting a role for mammalian chitinases in efficacy of
            caspofungin against experimental aspergillosis in immunocompromised
            rats
  JOURNAL   PLoS One 8 (10), e75848 (2013)
   PUBMED   24155872
  REMARK    GeneRIF: Invasive pulmonary aspergillosis in immunocompromised rats
            caused a dramatic increase in chitinase activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Hussain,M. and Wilson,J.B.
  TITLE     New paralogues and revised time line in the expansion of the
            vertebrate GH18 family
  JOURNAL   J Mol Evol 76 (4), 240-260 (2013)
   PUBMED   23558346
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Bussink,A.P., Verhoek,M., Vreede,J., Ghauharali-van der Vlugt,K.,
            Donker-Koopman,W.E., Sprenger,R.R., Hollak,C.E., Aerts,J.M. and
            Boot,R.G.
  TITLE     Common G102S polymorphism in chitotriosidase differentially affects
            activity towards 4-methylumbelliferyl substrates
  JOURNAL   FEBS J 276 (19), 5678-5688 (2009)
   PUBMED   19725875
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Chen,X.H. and Cai,G.P.
  TITLE     Molecular cloning and characterization of rat chitotriosidase
  JOURNAL   DNA Seq 19 (2), 121-129 (2008)
   PUBMED   17852345
  REMARK    GeneRIF: Expression of cloned cDNA of chitotriosidase demonstrates
            that the encoded protein is secreted extracellularly and has
            chitinolytic activity.
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J Biol Chem 276 (9), 6770-6778 (2001)
   PUBMED   11085997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Transcript Variant: This variant (bChiV_3) differs in the 5' UTR
            compared to variant bChiV_5. All four variants encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ923318.1, SRR26643293.53239.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000013.1  48145889-48145910
            23-156              JAXUCZ010000013.1  48152190-48152323
            157-186             JAXUCZ010000013.1  48153543-48153572
            187-388             JAXUCZ010000013.1  48156469-48156670
            389-445             JAXUCZ010000013.1  48157270-48157326
            446-611             JAXUCZ010000013.1  48158550-48158715
            612-736             JAXUCZ010000013.1  48158913-48159037
            737-860             JAXUCZ010000013.1  48159882-48160005
            861-1046            JAXUCZ010000013.1  48160987-48161172
            1047-1154           JAXUCZ010000013.1  48163110-48163217
            1155-1281           JAXUCZ010000013.1  48164542-48164668
            1282-1734           JAXUCZ010000013.1  48165182-48165634
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1734
                     /gene="Chit1"
                     /note="chitinase 1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
     exon            1..22
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            23..156
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1526
                     /gene="Chit1"
                     /EC_number="3.2.1.14"
                     /note="chitotriosidase-1; chitinase 1 (chitotriosidase)"
                     /codon_start=1
                     /product="chitotriosidase-1 precursor"
                     /protein_id="NP_001257776.1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
                     /translation="MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPR
                     DVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFG
                     TQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQ
                     DLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSW
                     DKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASS
                     SDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDD
                     RESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRS
                     PEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPP
                     GLVFIDSCKCCTWG"
     exon            157..186
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..388
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..445
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..611
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..736
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..860
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1046
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1154
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1281
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1734
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaccact gaggtggcca tggtatccat ttcaacattt ctggctgtgt ggcagcaggc
       61 cagcctgagg agagcagagc aggacctgtg gagccgctcc tcacagagct ctatctgctg
      121 gaggcagggt catggtgcag tccctggcct tggcaggtgt gacgactctg ctgatgatcc
      181 agtggggctc tgctgcaaaa ctgttctgct acttcaccaa ctgggcccag taccggtccg
      241 gggcagctcg attcctacct agggatgtgg atcccaacct gtgtacccat gtcatctatg
      301 cctttgctgg actgaacaac caccaggtca gcactgtaga gcccaatgac gagcttttct
      361 accaagagct gaacagccta aagaagagga accccaagct caagaccctg ttagccgtcg
      421 ggggctggag ctttggtacc cagaagttca cagacatggt ggccacagcc agcacccggc
      481 agacctttgt caactcagct ctctcgttcc tgcgcactca tggttttgac ggccttgacc
      541 ttgactggga atacccagga agccgaggga gcccagcagt agacaaagag agattcacag
      601 cgctgataca ggatttggcc aaagccttcc aggaggaagc ccgggcctca gggaaaagtc
      661 gcctccttct gactgcagct gtaccaactg gtcgaggcca tgtggatgct ggttatgagg
      721 tggacaagat tgttcagagt ttggatttca tcaaccttat ggcctacgac ttccacagct
      781 cctgggacaa gaccacaggg cacaacagcc ccctctacaa aaggcaagga gagactggga
      841 aagatgctga aaaaaatgtg gatgctgctg tgacgctctg gctgcagaag gggacccctg
      901 ccagcaaact gatgcttggc atgcccgcct acggacgctc cttcaccttg gcctcctcat
      961 cagacagtgg agttggggct ccagccacag gacctggggc cccaggcccc tatactaagg
     1021 aaaaggggat actggtttac tttgaggtct gctcctggaa gggaaaacag agaatcgagg
     1081 accagaaggt gccctatgtc tcccagggca accaatgggt gggatttgat gacagggaaa
     1141 gcttcagagc caaggctgcc tatgtgaaac agaagggact gggaggggcc atggtctgga
     1201 ttctggatgg ggatgacttc aaaggttcct tctgcaacga gggccagtac cctctcatcc
     1261 ggacactaca ccaggagctg agcctttcat ccgggcctcc aagaagccca gaacaggaag
     1321 tacctgggcc acaccagcct tctgagcccg agcagggccc cagcccaggg ctagatgact
     1381 tctgccaagg caaagctgat gggctctacc ccaaccctac agaaaagtcc agtttctaca
     1441 gctgtggagg ggggcgactg ttccagcaca gctgcccccc aggcctggtg tttatcgact
     1501 cttgcaaatg ctgtacctgg ggttgagtcc ctggagtccc atcagactcc agtctgaggc
     1561 caggcttggg acgccccgcc ccctgccagt agcttgcttc tgctttccct ggggggctgc
     1621 aggaggcctc tctgttcttt ccctgactcg gcctctgctc agctttttgg cttccttttt
     1681 gtctcttcta ggctcccgct ttacctgaaa aaataaactt atttttcacc cccg
//
