LOCUS       NM_001270846            1835 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus chitinase 1 (Chit1), transcript variant bChiV_4,
            mRNA.
ACCESSION   NM_001270846
VERSION     NM_001270846.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Raafat Ibrahim,R., Shafik,N.M., El-Esawy,R.O., El-Sakaa,M.H.,
            Arakeeb,H.M., El-Sharaby,R.M., Ali,D.A., Safwat El-Deeb,O. and
            Ragab Abd El-Khalik,S.
  TITLE     The emerging role of irisin in experimentally induced arthritis: a
            recent update involving HMGB1/MCP1/Chitotriosidase I-mediated
            necroptosis
  JOURNAL   Redox Rep 27 (1), 21-31 (2022)
   PUBMED   35094663
  REMARK    GeneRIF: The emerging role of irisin in experimentally induced
            arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase
            I-mediated necroptosis.
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Verwer,P.E., ten Kate,M.T., Falcone,F.H., Morroll,S.,
            Verbrugh,H.A., Bakker-Woudenberg,I.A. and van de Sande,W.W.
  TITLE     Evidence supporting a role for mammalian chitinases in efficacy of
            caspofungin against experimental aspergillosis in immunocompromised
            rats
  JOURNAL   PLoS One 8 (10), e75848 (2013)
   PUBMED   24155872
  REMARK    GeneRIF: Invasive pulmonary aspergillosis in immunocompromised rats
            caused a dramatic increase in chitinase activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Hussain,M. and Wilson,J.B.
  TITLE     New paralogues and revised time line in the expansion of the
            vertebrate GH18 family
  JOURNAL   J Mol Evol 76 (4), 240-260 (2013)
   PUBMED   23558346
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Bussink,A.P., Verhoek,M., Vreede,J., Ghauharali-van der Vlugt,K.,
            Donker-Koopman,W.E., Sprenger,R.R., Hollak,C.E., Aerts,J.M. and
            Boot,R.G.
  TITLE     Common G102S polymorphism in chitotriosidase differentially affects
            activity towards 4-methylumbelliferyl substrates
  JOURNAL   FEBS J 276 (19), 5678-5688 (2009)
   PUBMED   19725875
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Chen,X.H. and Cai,G.P.
  TITLE     Molecular cloning and characterization of rat chitotriosidase
  JOURNAL   DNA Seq 19 (2), 121-129 (2008)
   PUBMED   17852345
  REMARK    GeneRIF: Expression of cloned cDNA of chitotriosidase demonstrates
            that the encoded protein is secreted extracellularly and has
            chitinolytic activity.
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J Biol Chem 276 (9), 6770-6778 (2001)
   PUBMED   11085997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Transcript Variant: This variant (bChiV_4) differs in the 5' UTR
            compared to variant bChiV_5. All four variants encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ923319.1, SRR26643293.53238.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000013.1  48145889-48145910
            23-123              JAXUCZ010000013.1  48148471-48148571
            124-257             JAXUCZ010000013.1  48152190-48152323
            258-287             JAXUCZ010000013.1  48153543-48153572
            288-489             JAXUCZ010000013.1  48156469-48156670
            490-546             JAXUCZ010000013.1  48157270-48157326
            547-712             JAXUCZ010000013.1  48158550-48158715
            713-837             JAXUCZ010000013.1  48158913-48159037
            838-961             JAXUCZ010000013.1  48159882-48160005
            962-1147            JAXUCZ010000013.1  48160987-48161172
            1148-1255           JAXUCZ010000013.1  48163110-48163217
            1256-1382           JAXUCZ010000013.1  48164542-48164668
            1383-1835           JAXUCZ010000013.1  48165182-48165634
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1835
                     /gene="Chit1"
                     /note="chitinase 1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
     exon            1..22
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            23..123
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..257
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1627
                     /gene="Chit1"
                     /EC_number="3.2.1.14"
                     /note="chitotriosidase-1; chitinase 1 (chitotriosidase)"
                     /codon_start=1
                     /product="chitotriosidase-1 precursor"
                     /protein_id="NP_001257775.1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
                     /translation="MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPR
                     DVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFG
                     TQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQ
                     DLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSW
                     DKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASS
                     SDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDD
                     RESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRS
                     PEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPP
                     GLVFIDSCKCCTWG"
     exon            258..287
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..489
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..546
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..712
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..837
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..961
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1147
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1255
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1382
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1835
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaccact gaggtggcca tggaaagcag agtcacaggg caccatgcgc tcctcaacca
       61 acttctgaag gaccttcaag ggagcttatc tcagaggtga cagatccctg atgacctcag
      121 agggtatcca tttcaacatt tctggctgtg tggcagcagg ccagcctgag gagagcagag
      181 caggacctgt ggagccgctc ctcacagagc tctatctgct ggaggcaggg tcatggtgca
      241 gtccctggcc ttggcaggtg tgacgactct gctgatgatc cagtggggct ctgctgcaaa
      301 actgttctgc tacttcacca actgggccca gtaccggtcc ggggcagctc gattcctacc
      361 tagggatgtg gatcccaacc tgtgtaccca tgtcatctat gcctttgctg gactgaacaa
      421 ccaccaggtc agcactgtag agcccaatga cgagcttttc taccaagagc tgaacagcct
      481 aaagaagagg aaccccaagc tcaagaccct gttagccgtc gggggctgga gctttggtac
      541 ccagaagttc acagacatgg tggccacagc cagcacccgg cagacctttg tcaactcagc
      601 tctctcgttc ctgcgcactc atggttttga cggccttgac cttgactggg aatacccagg
      661 aagccgaggg agcccagcag tagacaaaga gagattcaca gcgctgatac aggatttggc
      721 caaagccttc caggaggaag cccgggcctc agggaaaagt cgcctccttc tgactgcagc
      781 tgtaccaact ggtcgaggcc atgtggatgc tggttatgag gtggacaaga ttgttcagag
      841 tttggatttc atcaacctta tggcctacga cttccacagc tcctgggaca agaccacagg
      901 gcacaacagc cccctctaca aaaggcaagg agagactggg aaagatgctg aaaaaaatgt
      961 ggatgctgct gtgacgctct ggctgcagaa ggggacccct gccagcaaac tgatgcttgg
     1021 catgcccgcc tacggacgct ccttcacctt ggcctcctca tcagacagtg gagttggggc
     1081 tccagccaca ggacctgggg ccccaggccc ctatactaag gaaaagggga tactggttta
     1141 ctttgaggtc tgctcctgga agggaaaaca gagaatcgag gaccagaagg tgccctatgt
     1201 ctcccagggc aaccaatggg tgggatttga tgacagggaa agcttcagag ccaaggctgc
     1261 ctatgtgaaa cagaagggac tgggaggggc catggtctgg attctggatg gggatgactt
     1321 caaaggttcc ttctgcaacg agggccagta ccctctcatc cggacactac accaggagct
     1381 gagcctttca tccgggcctc caagaagccc agaacaggaa gtacctgggc cacaccagcc
     1441 ttctgagccc gagcagggcc ccagcccagg gctagatgac ttctgccaag gcaaagctga
     1501 tgggctctac cccaacccta cagaaaagtc cagtttctac agctgtggag gggggcgact
     1561 gttccagcac agctgccccc caggcctggt gtttatcgac tcttgcaaat gctgtacctg
     1621 gggttgagtc cctggagtcc catcagactc cagtctgagg ccaggcttgg gacgccccgc
     1681 cccctgccag tagcttgctt ctgctttccc tggggggctg caggaggcct ctctgttctt
     1741 tccctgactc ggcctctgct cagctttttg gcttcctttt tgtctcttct aggctcccgc
     1801 tttacctgaa aaaataaact tatttttcac ccccg
//
