LOCUS       NP_001257775             464 aa            linear   ROD 03-APR-2024
DEFINITION  chitotriosidase-1 precursor [Rattus norvegicus].
ACCESSION   NP_001257775
VERSION     NP_001257775.1
DBSOURCE    REFSEQ: accession NM_001270846.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Raafat Ibrahim,R., Shafik,N.M., El-Esawy,R.O., El-Sakaa,M.H.,
            Arakeeb,H.M., El-Sharaby,R.M., Ali,D.A., Safwat El-Deeb,O. and
            Ragab Abd El-Khalik,S.
  TITLE     The emerging role of irisin in experimentally induced arthritis: a
            recent update involving HMGB1/MCP1/Chitotriosidase I-mediated
            necroptosis
  JOURNAL   Redox Rep 27 (1), 21-31 (2022)
   PUBMED   35094663
  REMARK    GeneRIF: The emerging role of irisin in experimentally induced
            arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase
            I-mediated necroptosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Verwer,P.E., ten Kate,M.T., Falcone,F.H., Morroll,S.,
            Verbrugh,H.A., Bakker-Woudenberg,I.A. and van de Sande,W.W.
  TITLE     Evidence supporting a role for mammalian chitinases in efficacy of
            caspofungin against experimental aspergillosis in immunocompromised
            rats
  JOURNAL   PLoS One 8 (10), e75848 (2013)
   PUBMED   24155872
  REMARK    GeneRIF: Invasive pulmonary aspergillosis in immunocompromised rats
            caused a dramatic increase in chitinase activity.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Hussain,M. and Wilson,J.B.
  TITLE     New paralogues and revised time line in the expansion of the
            vertebrate GH18 family
  JOURNAL   J Mol Evol 76 (4), 240-260 (2013)
   PUBMED   23558346
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Bussink,A.P., Verhoek,M., Vreede,J., Ghauharali-van der Vlugt,K.,
            Donker-Koopman,W.E., Sprenger,R.R., Hollak,C.E., Aerts,J.M. and
            Boot,R.G.
  TITLE     Common G102S polymorphism in chitotriosidase differentially affects
            activity towards 4-methylumbelliferyl substrates
  JOURNAL   FEBS J 276 (19), 5678-5688 (2009)
   PUBMED   19725875
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Chen,X.H. and Cai,G.P.
  TITLE     Molecular cloning and characterization of rat chitotriosidase
  JOURNAL   DNA Seq 19 (2), 121-129 (2008)
   PUBMED   17852345
  REMARK    GeneRIF: Expression of cloned cDNA of chitotriosidase demonstrates
            that the encoded protein is secreted extracellularly and has
            chitinolytic activity.
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J Biol Chem 276 (9), 6770-6778 (2001)
   PUBMED   11085997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Transcript Variant: This variant (bChiV_4) differs in the 5' UTR
            compared to variant bChiV_5. All four variants encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ923319.1, SRR26643293.53238.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..464
                     /product="chitotriosidase-1 precursor"
                     /EC_number="3.2.1.14"
                     /note="chitotriosidase-1; chitinase 1 (chitotriosidase)"
                     /calculated_mol_wt=48610
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2191
     Region          24..383
                     /region_name="GH18_chitolectin_chitotriosidase"
                     /note="This conserved domain family includes a large
                     number of catalytically inactive chitinase-like lectins
                     (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1,
                     oviductin, and AMCase (acidic mammalian chitinase), as
                     well as catalytically active...; cd02872"
                     /db_xref="CDD:119351"
     Site            order(27,31,99..100,138,140..141,186..187,210,212..213,
                     218,267,269,297,356)
                     /site_type="active"
                     /db_xref="CDD:119351"
     Region          416..463
                     /region_name="ChtBD2"
                     /note="Chitin-binding domain type 2; smart00494"
                     /db_xref="CDD:214696"
     CDS             1..464
                     /gene="Chit1"
                     /coded_by="NM_001270846.1:233..1627"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
ORIGIN      
        1 mvqslalagv ttllmiqwgs aaklfcyftn waqyrsgaar flprdvdpnl cthviyafag
       61 lnnhqvstve pndelfyqel nslkkrnpkl ktllavggws fgtqkftdmv atastrqtfv
      121 nsalsflrth gfdgldldwe ypgsrgspav dkerftaliq dlakafqeea rasgksrlll
      181 taavptgrgh vdagyevdki vqsldfinlm aydfhsswdk ttghnsplyk rqgetgkdae
      241 knvdaavtlw lqkgtpaskl mlgmpaygrs ftlasssdsg vgapatgpga pgpytkekgi
      301 lvyfevcswk gkqriedqkv pyvsqgnqwv gfddresfra kaayvkqkgl ggamvwildg
      361 ddfkgsfcne gqyplirtlh qelslssgpp rspeqevpgp hqpsepeqgp spglddfcqg
      421 kadglypnpt ekssfyscgg grlfqhscpp glvfidsckc ctwg
//
