LOCUS       NM_001079689            2186 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus chitinase 1 (Chit1), transcript variant bChiV_5,
            mRNA.
ACCESSION   NM_001079689 XM_001061784 XM_213878
VERSION     NM_001079689.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Raafat Ibrahim,R., Shafik,N.M., El-Esawy,R.O., El-Sakaa,M.H.,
            Arakeeb,H.M., El-Sharaby,R.M., Ali,D.A., Safwat El-Deeb,O. and
            Ragab Abd El-Khalik,S.
  TITLE     The emerging role of irisin in experimentally induced arthritis: a
            recent update involving HMGB1/MCP1/Chitotriosidase I-mediated
            necroptosis
  JOURNAL   Redox Rep 27 (1), 21-31 (2022)
   PUBMED   35094663
  REMARK    GeneRIF: The emerging role of irisin in experimentally induced
            arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase
            I-mediated necroptosis.
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Verwer,P.E., ten Kate,M.T., Falcone,F.H., Morroll,S.,
            Verbrugh,H.A., Bakker-Woudenberg,I.A. and van de Sande,W.W.
  TITLE     Evidence supporting a role for mammalian chitinases in efficacy of
            caspofungin against experimental aspergillosis in immunocompromised
            rats
  JOURNAL   PLoS One 8 (10), e75848 (2013)
   PUBMED   24155872
  REMARK    GeneRIF: Invasive pulmonary aspergillosis in immunocompromised rats
            caused a dramatic increase in chitinase activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Hussain,M. and Wilson,J.B.
  TITLE     New paralogues and revised time line in the expansion of the
            vertebrate GH18 family
  JOURNAL   J Mol Evol 76 (4), 240-260 (2013)
   PUBMED   23558346
REFERENCE   4  (bases 1 to 2186)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   5  (bases 1 to 2186)
  AUTHORS   Bussink,A.P., Verhoek,M., Vreede,J., Ghauharali-van der Vlugt,K.,
            Donker-Koopman,W.E., Sprenger,R.R., Hollak,C.E., Aerts,J.M. and
            Boot,R.G.
  TITLE     Common G102S polymorphism in chitotriosidase differentially affects
            activity towards 4-methylumbelliferyl substrates
  JOURNAL   FEBS J 276 (19), 5678-5688 (2009)
   PUBMED   19725875
REFERENCE   6  (bases 1 to 2186)
  AUTHORS   Chen,X.H. and Cai,G.P.
  TITLE     Molecular cloning and characterization of rat chitotriosidase
  JOURNAL   DNA Seq 19 (2), 121-129 (2008)
   PUBMED   17852345
  REMARK    GeneRIF: Expression of cloned cDNA of chitotriosidase demonstrates
            that the encoded protein is secreted extracellularly and has
            chitinolytic activity.
REFERENCE   7  (bases 1 to 2186)
  AUTHORS   Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
            Bijl,N., Moe,C., Place,A. and Aerts,J.M.
  TITLE     Identification of a novel acidic mammalian chitinase distinct from
            chitotriosidase
  JOURNAL   J Biol Chem 276 (9), 6770-6778 (2001)
   PUBMED   11085997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Aug 3, 2012 this sequence version replaced NM_001079689.1.
            
            Transcript Variant: This variant (bChiV_5) represents the longest
            transcript. All four variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ923320.1, SRR26360181.2487680.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000013.1  48145889-48146362
            475-608             JAXUCZ010000013.1  48152190-48152323
            609-638             JAXUCZ010000013.1  48153543-48153572
            639-840             JAXUCZ010000013.1  48156469-48156670
            841-897             JAXUCZ010000013.1  48157270-48157326
            898-1063            JAXUCZ010000013.1  48158550-48158715
            1064-1188           JAXUCZ010000013.1  48158913-48159037
            1189-1312           JAXUCZ010000013.1  48159882-48160005
            1313-1498           JAXUCZ010000013.1  48160987-48161172
            1499-1606           JAXUCZ010000013.1  48163110-48163217
            1607-1733           JAXUCZ010000013.1  48164542-48164668
            1734-2186           JAXUCZ010000013.1  48165182-48165634
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2186
                     /gene="Chit1"
                     /note="chitinase 1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
     exon            1..474
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..608
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             584..1978
                     /gene="Chit1"
                     /EC_number="3.2.1.14"
                     /note="chitotriosidase-1; chitinase 1 (chitotriosidase)"
                     /codon_start=1
                     /product="chitotriosidase-1 precursor"
                     /protein_id="NP_001073157.1"
                     /db_xref="GeneID:289032"
                     /db_xref="RGD:1305646"
                     /translation="MVQSLALAGVTTLLMIQWGSAAKLFCYFTNWAQYRSGAARFLPR
                     DVDPNLCTHVIYAFAGLNNHQVSTVEPNDELFYQELNSLKKRNPKLKTLLAVGGWSFG
                     TQKFTDMVATASTRQTFVNSALSFLRTHGFDGLDLDWEYPGSRGSPAVDKERFTALIQ
                     DLAKAFQEEARASGKSRLLLTAAVPTGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSW
                     DKTTGHNSPLYKRQGETGKDAEKNVDAAVTLWLQKGTPASKLMLGMPAYGRSFTLASS
                     SDSGVGAPATGPGAPGPYTKEKGILVYFEVCSWKGKQRIEDQKVPYVSQGNQWVGFDD
                     RESFRAKAAYVKQKGLGGAMVWILDGDDFKGSFCNEGQYPLIRTLHQELSLSSGPPRS
                     PEQEVPGPHQPSEPEQGPSPGLDDFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPP
                     GLVFIDSCKCCTWG"
     exon            609..638
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..840
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..897
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1063
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1188
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1312
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1498
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1606
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1733
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..2186
                     /gene="Chit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaccact gaggtggcca tggtaagaag ctgtatcagg cagggtctga ttaaagtgtc
       61 tcaaaggaca ccctggctgc tccggaagtg ccagcagagg gcagagagga aggagggaac
      121 tcagagaaga ggctctgttg gtgtgcaggg taccagctga caccatcgtg gaggtggagg
      181 agataggcca gctagtaaca cctggccatt gagggtggag aaaagaggga gtttctatgt
      241 gtgatagttg gcatatagtt ggcccaggga gtggcactat taaaagatgt gactctgttg
      301 gagtgggtgt gtcactgtgc atgtgggttt taagaccctc atcttggctg cctgggagta
      361 ttctgttagt agccttcaga tgaagatgta gaactctcag ctcctcctgc accatgcctg
      421 cctggatgct gccatgttcc caccctgttg ataatggact gaacctctga acctgtatcc
      481 atttcaacat ttctggctgt gtggcagcag gccagcctga ggagagcaga gcaggacctg
      541 tggagccgct cctcacagag ctctatctgc tggaggcagg gtcatggtgc agtccctggc
      601 cttggcaggt gtgacgactc tgctgatgat ccagtggggc tctgctgcaa aactgttctg
      661 ctacttcacc aactgggccc agtaccggtc cggggcagct cgattcctac ctagggatgt
      721 ggatcccaac ctgtgtaccc atgtcatcta tgcctttgct ggactgaaca accaccaggt
      781 cagcactgta gagcccaatg acgagctttt ctaccaagag ctgaacagcc taaagaagag
      841 gaaccccaag ctcaagaccc tgttagccgt cgggggctgg agctttggta cccagaagtt
      901 cacagacatg gtggccacag ccagcacccg gcagaccttt gtcaactcag ctctctcgtt
      961 cctgcgcact catggttttg acggccttga ccttgactgg gaatacccag gaagccgagg
     1021 gagcccagca gtagacaaag agagattcac agcgctgata caggatttgg ccaaagcctt
     1081 ccaggaggaa gcccgggcct cagggaaaag tcgcctcctt ctgactgcag ctgtaccaac
     1141 tggtcgaggc catgtggatg ctggttatga ggtggacaag attgttcaga gtttggattt
     1201 catcaacctt atggcctacg acttccacag ctcctgggac aagaccacag ggcacaacag
     1261 ccccctctac aaaaggcaag gagagactgg gaaagatgct gaaaaaaatg tggatgctgc
     1321 tgtgacgctc tggctgcaga aggggacccc tgccagcaaa ctgatgcttg gcatgcccgc
     1381 ctacggacgc tccttcacct tggcctcctc atcagacagt ggagttgggg ctccagccac
     1441 aggacctggg gccccaggcc cctatactaa ggaaaagggg atactggttt actttgaggt
     1501 ctgctcctgg aagggaaaac agagaatcga ggaccagaag gtgccctatg tctcccaggg
     1561 caaccaatgg gtgggatttg atgacaggga aagcttcaga gccaaggctg cctatgtgaa
     1621 acagaaggga ctgggagggg ccatggtctg gattctggat ggggatgact tcaaaggttc
     1681 cttctgcaac gagggccagt accctctcat ccggacacta caccaggagc tgagcctttc
     1741 atccgggcct ccaagaagcc cagaacagga agtacctggg ccacaccagc cttctgagcc
     1801 cgagcagggc cccagcccag ggctagatga cttctgccaa ggcaaagctg atgggctcta
     1861 ccccaaccct acagaaaagt ccagtttcta cagctgtgga ggggggcgac tgttccagca
     1921 cagctgcccc ccaggcctgg tgtttatcga ctcttgcaaa tgctgtacct ggggttgagt
     1981 ccctggagtc ccatcagact ccagtctgag gccaggcttg ggacgccccg ccccctgcca
     2041 gtagcttgct tctgctttcc ctggggggct gcaggaggcc tctctgttct ttccctgact
     2101 cggcctctgc tcagcttttt ggcttccttt ttgtctcttc taggctcccg ctttacctga
     2161 aaaaataaac ttatttttca cccccg
//
