LOCUS       NM_012526               2564 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus chromogranin B (Chgb), mRNA.
ACCESSION   NM_012526
VERSION     NM_012526.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Bearrows,S.C., Bauchle,C.J., Becker,M., Haldeman,J.M.,
            Swaminathan,S. and Stephens,S.B.
  TITLE     Chromogranin B regulates early-stage insulin granule trafficking
            from the Golgi in pancreatic islet beta-cells
  JOURNAL   J Cell Sci 132 (13) (2019)
   PUBMED   31182646
  REMARK    GeneRIF: CgB is necessary for efficient trafficking of secretory
            proteins into the budding granule, which impacts the availability
            of insulin-containing secretory granules for exocytic release.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Papanikolaou,N.A., Tillinger,A., Liu,X., Papavassiliou,A.G. and
            Sabban,E.L.
  TITLE     A systems approach identifies co-signaling molecules of early
            growth response 1 transcription factor in immobilization stress
  JOURNAL   BMC Syst Biol 8, 100 (2014)
   PUBMED   25217033
  REMARK    GeneRIF: Possible involvement of Stat3 and Prlh1/Chgb up-regulation
            in the transition from short to repeated stress activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Zhang,K., Biswas,N., Gayen,J.R., Miramontes-Gonzalez,J.P.,
            Hightower,C.M., Mustapic,M., Mahata,M., Huang,C.T., Hook,V.Y.,
            Mahata,S.K., Vaingankar,S. and O'Connor,D.T.
  TITLE     Chromogranin B: intra- and extra-cellular mechanisms to regulate
            catecholamine storage and release, in catecholaminergic cells and
            organisms
  JOURNAL   J Neurochem 129 (1), 48-59 (2014)
   PUBMED   24266713
  REMARK    GeneRIF: When released extra-cellulary, CHGB proteolytic fragments
            exert a feedback effect to inhibit catecholamine secretion.
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   Giordano,T., Brigatti,C., Podini,P., Bonifacio,E., Meldolesi,J. and
            Malosio,M.L.
  TITLE     Beta cell chromogranin B is partially segregated in distinct
            granules and can be released separately from insulin in response to
            stimulation
  JOURNAL   Diabetologia 51 (6), 997-1007 (2008)
   PUBMED   18437352
  REMARK    GeneRIF: Stimulation with a secretagogue mixture induced parallel
            release of insulin and chromogranin B from pancreatic beta cells.
REFERENCE   5  (bases 1 to 2564)
  AUTHORS   Heidrich,F.M., Zhang,K., Estrada,M., Huang,Y., Giordano,F.J. and
            Ehrlich,B.E.
  TITLE     Chromogranin B regulates calcium signaling, nuclear factor kappaB
            activity, and brain natriuretic peptide production in
            cardiomyocytes
  JOURNAL   Circ Res 102 (10), 1230-1238 (2008)
   PUBMED   18420944
  REMARK    GeneRIF: CGB is a novel regulator of cardiomyocyte
            InsP(3)/Ca(2+)-dependent signaling, nuclear factor kappaB activity,
            and brain natriuretic peptide production
REFERENCE   6  (bases 1 to 2564)
  AUTHORS   Huh,Y.H., Jeon,S.H. and Yoo,S.H.
  TITLE     Chromogranin B-induced secretory granule biogenesis: comparison
            with the similar role of chromogranin A
  JOURNAL   J Biol Chem 278 (42), 40581-40589 (2003)
   PUBMED   12902350
  REMARK    GeneRIF: Chromogranin B has a role in secretory granule biogenesis
REFERENCE   7  (bases 1 to 2564)
  AUTHORS   Yoo,S.H., You,S.H., Kang,M.K., Huh,Y.H., Lee,C.S. and Shim,C.S.
  TITLE     Localization of the secretory granule marker protein chromogranin B
            in the nucleus. Potential role in transcription control
  JOURNAL   J Biol Chem 277 (18), 16011-16021 (2002)
   PUBMED   11854265
  REMARK    GeneRIF: CGB was localized in the nucleus; transcription control
            role of CGB in the nucleus
REFERENCE   8  (bases 1 to 2564)
  AUTHORS   Wang,Z., Vandenberghe,I., Depreitere,J., Devreese,B., Clerens,S.,
            Nouwen,E.J., Van Beeumen,J. and De Potter,W.
  TITLE     Identification and characterization of novel chromogranin B-derived
            peptides from porcine chromaffin granules by liquid
            chromatography/electrospray tandem MS
  JOURNAL   Eur J Biochem 268 (2), 235-242 (2001)
   PUBMED   11168356
REFERENCE   9  (bases 1 to 2564)
  AUTHORS   Nielsen,E., Welinder,B.S. and Madsen,O.D.
  TITLE     Chromogranin-B, a putative precursor of eight novel rat glucagonoma
            peptides through processing at mono-, di-, or tribasic residues
  JOURNAL   Endocrinology 129 (6), 3147-3156 (1991)
   PUBMED   1954895
REFERENCE   10 (bases 1 to 2564)
  AUTHORS   Forss-Petter,S., Danielson,P., Battenberg,E., Bloom,F. and
            Sutcliffe,J.G.
  TITLE     Nucleotide sequence and cellular distribution of rat chromogranin B
            (secretogranin I) mRNA in the neuroendocrine system
  JOURNAL   J Mol Neurosci 1 (2), 63-75 (1989)
   PUBMED   2641278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB705583.1 and BC128743.1.
            
            On Jul 24, 2012 this sequence version replaced NM_012526.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128743.1, AF019974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               CB705583.1         1-181
            182-2564            BC128743.1         1-2383
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2564
                     /gene="Chgb"
                     /note="chromogranin B"
                     /db_xref="GeneID:24259"
                     /db_xref="RGD:2339"
     exon            1..312
                     /gene="Chgb"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2291
                     /gene="Chgb"
                     /note="secretogranin-1; cgB; sgI; secretogranin-I;
                     glucagonoma peptide; Chromogranin B, parathyroid secretory
                     protein; chromogranin B (secretogranin 1)"
                     /codon_start=1
                     /product="secretogranin-1 precursor"
                     /protein_id="NP_036658.2"
                     /db_xref="GeneID:24259"
                     /db_xref="RGD:2339"
                     /translation="MQRAMLLGLLGAAALAAVISAPVDNRDHNEEMVTRCIIEVLSNA
                     LSKSSAPTITPECRQVLRKSGKEVKGEEKGENENSKFEVRLLRDPSDASVGRWASSRE
                     ETGAPVEDSPGQAKVDNEEWTGGGGHSREAVDDQESLHPSNQQVSKEAKIRHSEERGG
                     KEEEEEEGKIYPKGEHRGDAGEEKKHTEESGEKHNAFSNKRSEASAKKKEESVARAEA
                     HFVELEKTHSREQSSQESGEETRRQEKPQELPDQDQSEEESEEGEEGEEGATSEVTKR
                     RPRHHHWRSQSNKPSYEGRRPLSEERKHAAGESKDANVATANLGEKRGHHLAHYRASE
                     EEPDYGEELRSYPGFQAPQGLQYQGRGSEEVRAPSPRSEESQEKEYKRNHPDSELEST
                     ANRHSEETEEERSYEGAKGRQHRGRGREPGAYPALDSRQEKRLLDEGHDPVHESPVDT
                     AKRYPQSKWQEQEKNYLNYDEEGDQGRWWQQEEQLEPEESREEVSFPDRQYAPYPTTE
                     KRKRLGALFNPYFDPLQWKNSDFEKKGNPDDSFLDDDGEDGNGVTMTEKNFFPEYNYD
                     WWEKRPFSEDVNWGYEKRSFARAPHLDLKRQYDDGVAELDQLLHYRKKAAEFPDFYDS
                     EEQMGPHQEAEDEKDRADQRVLTEEEKKELENLAAMDLELQKIAEKFSQRG"
     exon            313..359
                     /gene="Chgb"
                     /inference="alignment:Splign:2.1.0"
     exon            360..453
                     /gene="Chgb"
                     /inference="alignment:Splign:2.1.0"
     exon            454..2213
                     /gene="Chgb"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2540
                     /gene="Chgb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtcccca catccctgcc tgtgcctgct gggaccctgc gcaaggccac gcgcactggc
       61 tgaggtaccg cccgctggcg ccgcctcggg gctgctccgt gacgtcaggg ctgagcgagg
      121 ggcgcccccg cccgccgctc gcccccgggc tctgcacccc gcctgccctt cataagagcc
      181 aggcctgcgc ccaccgcgcc acagctgctc tgcggagccc gcacccgccg agctcctcct
      241 acatgcagct ggcgagcggc accatgcagc gggccatgct cctcggcctc ctgggcgcag
      301 cagctctggc tgctgtcatc tcagctccag tggataacag ggatcacaat gaagaaatgg
      361 tgactcgctg cattattgaa gtcctctcaa atgccctatc caagtccagt gctccaacca
      421 tcacccctga gtgccggcaa gtcctgagga agagtggaaa agaggtcaaa ggtgaagaga
      481 aaggtgaaaa tgagaactcg aagtttgaag tacggttgct aagagaccca tctgatgcct
      541 cagtaggccg ctgggcctcc agtagggagg aaacaggggc tccagtagaa gactctccag
      601 gtcaggcgaa ggtagacaat gaggagtgga caggaggagg aggacacagt cgagaggcag
      661 tagatgacca ggagagcctc catccctcca accaacaagt gtccaaagaa gcaaagatac
      721 gccattcgga ggagaggggc ggaaaagagg aggaggagga agaaggcaag atttatccaa
      781 agggagagca taggggagat gctggtgagg agaagaaaca cactgaagaa tctggagaga
      841 aacacaacgc cttctccaac aaaagaagcg aagcttcagc taagaaaaaa gaggagtcag
      901 tggccagagc agaggcacac ttcgtggagc tggagaagac acacagcagg gagcagagca
      961 gccaggagag tggagaggag acgaggaggc aggagaaacc acaggagctt cccgaccagg
     1021 accagagcga ggaagaatcc gaggaaggcg aggaaggcga ggaaggcgca acctcagaag
     1081 taaccaaacg caggcccagg caccaccact ggagaagcca gtccaacaag ccctcttacg
     1141 aagggcgtcg tcctctgtct gaggaaagga aacatgctgc tggggagtcc aaggatgcaa
     1201 atgtggccac agccaattta ggggaaaaaa ggggccacca cctagctcac taccgggctt
     1261 cagaggaaga acctgactat ggggaagaat tgagaagcta tccgggcttc caggctcccc
     1321 agggactgca gtaccagggc agaggaagtg aagaggtcag agccccaagc cctcggagtg
     1381 aggagagcca ggaaaaggag tacaagagaa accaccccga ctctgaactg gaaagcacag
     1441 caaacagaca cagtgaagaa actgaggaag agaggagcta cgagggggca aagggacgac
     1501 aacacagagg cagggggcgg gagccaggag cttatcctgc tcttgacagc agacaagaaa
     1561 aaaggctcct ggatgaaggg catgaccctg ttcatgaaag cccagtagat acggcaaaaa
     1621 ggtatccaca aagcaaatgg caggaacagg agaaaaacta cctcaactat gacgaggaag
     1681 gggaccaagg aagatggtgg cagcaggaag agcagctaga accggaagaa agcagggagg
     1741 aagtgagctt tccagacaga caatacgcgc cctaccccac cactgaaaag aggaagaggc
     1801 taggggcgct gttcaacccg tactttgacc ctctccagtg gaagaatagc gactttgaga
     1861 aaaaaggcaa cccagatgac agtttccttg atgatgacgg cgaagacgga aatggggtga
     1921 caatgactga gaagaatttc ttcccagagt acaactatga ctggtgggag aaaaggccct
     1981 tctcggagga tgtgaattgg ggatatgaga agagaagctt tgccagggcc cctcacttgg
     2041 acttgaaaag gcaatacgac gatggagtgg ctgaactgga ccagctcctt cactacagga
     2101 agaaggcagc cgaatttccc gacttctacg attcagagga gcagatgggg cctcaccagg
     2161 aggcagaaga tgaaaaggac agggctgacc agagagttct gaccgaggaa gagaaaaagg
     2221 aactggagaa cttggcggcc atggatctgg aactgcagaa aatagcggaa aagttcagcc
     2281 agcggggctg acagtcggag agacgagcca ttcgctgaaa gacagcattg attcacccaa
     2341 aggcagaaag cagaatttac tatttattaa atgtttgatg cagttggaaa tatcactaat
     2401 ctttgccaga atgctaatgc tatgcgacta gcgtgacttg tagcatattc ttcctgcaaa
     2461 atagatgttc cacatgtctg tgacaatgac cgtgttactg tctttgaaac acaaacaata
     2521 aaagatttac ctgaaacaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
