LOCUS       NM_021655               1905 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus chromogranin A (Chga), mRNA.
ACCESSION   NM_021655 XM_346781
VERSION     NM_021655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Bharat,V., Siebrecht,M., Burk,K., Ahmed,S., Reissner,C.,
            Kohansal-Nodehi,M., Steubler,V., Zweckstetter,M., Ting,J.T. and
            Dean,C.
  TITLE     Capture of Dense Core Vesicles at Synapses by JNK-Dependent
            Phosphorylation of Synaptotagmin-4
  JOURNAL   Cell Rep 21 (8), 2118-2133 (2017)
   PUBMED   29166604
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Friese,R.S., Altshuler,A.E., Zhang,K., Miramontes-Gonzalez,J.P.,
            Hightower,C.M., Jirout,M.L., Salem,R.M., Gayen,J.R.,
            Mahapatra,N.R., Biswas,N., Cale,M., Vaingankar,S.M., Kim,H.S.,
            Courel,M., Taupenot,L., Ziegler,M.G., Schork,N.J., Pravenec,M.,
            Mahata,S.K., Schmid-Schonbein,G.W. and O'Connor,D.T.
  TITLE     MicroRNA-22 and promoter motif polymorphisms at the Chga locus in
            genetic hypertension: functional and therapeutic implications for
            gene expression and the pathogenesis of hypertension
  JOURNAL   Hum Mol Genet 22 (18), 3624-3640 (2013)
   PUBMED   23674521
  REMARK    GeneRIF: hypothesized that the 3'-UTR and promoter mutations lead
            to dysregulation (diminution) of Chga in brainstem cardiovascular
            control nuclei, ultimately contributing to the pathogenesis of
            hypertension in spontaneously hypertensive rats
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Pasqua,T., Corti,A., Gentile,S., Pochini,L., Bianco,M.,
            Metz-Boutigue,M.H., Cerra,M.C., Tota,B. and Angelone,T.
  TITLE     Full-length human chromogranin-A cardioactivity: myocardial,
            coronary, and stimulus-induced processing evidence in normotensive
            and hypertensive male rat hearts
  JOURNAL   Endocrinology 154 (9), 3353-3365 (2013)
   PUBMED   23751870
  REMARK    GeneRIF: Data suggest that Chga plays role in cardiocirculatory
            homeostasis and allostasis in hypertension; in hypertension,
            negative inotropic effect elicited by full-length Chga in heart may
            represent compensatory mechanism for increased blood pressure.
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Tota,B., Gentile,S., Pasqua,T., Bassino,E., Koshimizu,H.,
            Cawley,N.X., Cerra,M.C., Loh,Y.P. and Angelone,T.
  TITLE     The novel chromogranin A-derived serpinin and pyroglutaminated
            serpinin peptides are positive cardiac beta-adrenergic-like
            inotropes
  JOURNAL   FASEB J 26 (7), 2888-2898 (2012)
   PUBMED   22459152
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Koshimizu,H., Cawley,N.X., Yergy,A.L. and Loh,Y.P.
  TITLE     Role of pGlu-serpinin, a novel chromogranin A-derived peptide in
            inhibition of cell death
  JOURNAL   J Mol Neurosci 45 (2), 294-303 (2011)
   PUBMED   21537909
REFERENCE   6  (bases 1 to 1905)
  AUTHORS   Hsiao,R.J., Neumann,H.P., Parmer,R.J., Barbosa,J.A. and
            O'Connor,D.T.
  TITLE     Chromogranin A in familial pheochromocytoma: diagnostic screening
            value, prediction of tumor mass, and post-resection kinetics
            indicating two-compartment distribution
  JOURNAL   Am J Med 88 (6), 607-613 (1990)
   PUBMED   2189303
REFERENCE   7  (bases 1 to 1905)
  AUTHORS   Parmer,R.J., Koop,A.H., Handa,M.T. and O'Connor,D.T.
  TITLE     Molecular cloning of chromogranin A from rat pheochromocytoma cells
  JOURNAL   Hypertension 14 (4), 435-444 (1989)
   PUBMED   2793216
REFERENCE   8  (bases 1 to 1905)
  AUTHORS   Hutton,J.C., Nielsen,E. and Kastern,W.
  TITLE     The molecular cloning of the chromogranin A-like precursor of
            beta-granin and pancreastatin from the endocrine pancreas
  JOURNAL   FEBS Lett 236 (2), 269-274 (1988)
   PUBMED   3044825
REFERENCE   9  (bases 1 to 1905)
  AUTHORS   Iacangelo,A., Okayama,H. and Eiden,L.E.
  TITLE     Primary structure of rat chromogranin A and distribution of its
            mRNA
  JOURNAL   FEBS Lett 227 (2), 115-121 (1988)
   PUBMED   2828116
REFERENCE   10 (bases 1 to 1905)
  AUTHORS   Hutton,J.C., Hansen,F. and Peshavaria,M.
  TITLE     beta-Granins: 21 kDa co-secreted peptides of the insulin granule
            closely related to adrenal medullary chromogranin A
  JOURNAL   FEBS Lett 188 (2), 336-340 (1985)
   PUBMED   3896848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB743841.1 and BC087703.1.
            
            On Mar 9, 2007 this sequence version replaced NM_021655.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CB743841.1         57-76
            21-1905             BC087703.1         1-1885
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1905
                     /gene="Chga"
                     /note="chromogranin A"
                     /db_xref="GeneID:24258"
                     /db_xref="RGD:2338"
     exon            1..197
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1549
                     /gene="Chga"
                     /note="cgA; chromogranin A (parathyroid secretory protein
                     1)"
                     /codon_start=1
                     /product="chromogranin-A precursor"
                     /protein_id="NP_067687.2"
                     /db_xref="GeneID:24258"
                     /db_xref="RGD:2338"
                     /translation="MRSSAALALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSL
                     SKPSPMPVSPECLETLQGDERVLSILRHQNLLKELQDLALQGAKERAQQQQQQQQQQQ
                     QQQQQQQQHSSFEDELSEVFENQSPAAKHGDAASEAPSKDTVEKREDSDKGQQDAFEG
                     TTEGPRPQAFPEPKQESSMMGNSQSPGEDTANNTQSPTSLPSQEHGIPQTTEGSERGP
                     SAQQQARKAKQEEKEEEEEEKEEEEEEKEEKAIAREKAGPKEVPTAASSSHFYSGYKK
                     IQKDDDGQSESQAVNGKTGASEAVPSEGKGELEHSQQEEDGEEAMAGPPQGLFPGGKG
                     QELERKQQEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRA
                     RAYGFRDPGPQLRRGWRPSSREDSVEARGDFEEKKEEEGSANRRAEDQELESLSAIEA
                     ELEKVAHQLQALRRG"
     exon            198..244
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            245..338
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            339..407
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            408..548
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            549..998
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1465
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1883
                     /gene="Chga"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgctgct accgccacca ccatcaccgc cactgccacc accaccgcta ccgcagtgct
       61 cccactggtg cagagctcca gtggtcacag acccacttcc gccatcctcc tgcagcagct
      121 cgccctctct ttccgcaccg tccggctcgc tatgcgctcc tccgcggctt tggcgcttct
      181 gctgtgcgcc gggcaagtct ttgcccttcc tgtgaacagc cctatgacaa aaggggacac
      241 taaggtgatg aagtgtgtcc tggaggtcat ctccgactcg ctgtccaaac ccagccccat
      301 gcctgtcagc cctgagtgtc tggagaccct ccaaggagat gagagggtcc tctccatcct
      361 tcgacaccag aatttgctga aggaacttca agacctggcg cttcaaggtg ccaaggagcg
      421 ggcccagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc aacaacaaca
      481 acacagcagc tttgaggatg aactctcgga agtatttgag aaccagagcc ctgcagccaa
      541 gcatggagac gcagcatcag aagccccctc caaggacact gtagagaaga gagaggattc
      601 tgacaagggg caacaggatg cctttgaggg aaccacagaa ggacccagac ctcaggcctt
      661 tccagagccc aagcaggagt cctctatgat gggaaacagt caatctccag gggaggacac
      721 agccaacaat acccaatcac caaccagcct ccccagccag gagcatggga ttccacagac
      781 cacagaaggc agtgagagag gtcccagtgc ccagcagcaa gccagaaaag ccaagcaaga
      841 ggagaaagag gaagaggagg aggagaaaga ggaagaggag gaggagaaag aggagaaggc
      901 gatcgccaga gagaaggctg ggcctaaaga agtccccacg gcagcatcca gttctcactt
      961 ctattcaggc tacaagaaga tccagaaaga tgatgatggt cagtcggagt ctcaggcagt
     1021 gaatggaaag acaggggctt ctgaagctgt gccatctgaa gggaaggggg agctggagca
     1081 ctctcagcag gaggaagatg gggaagaggc catggcaggg cccccccaag gtctcttccc
     1141 aggtgggaag ggccaggagc tggaacgtaa gcagcaggag gaggaagagg aagaggagcg
     1201 tctgtccaga gaatgggagg acaagcgatg gagcaggatg gaccagctgg ccaaggagct
     1261 gacagcagag aagcggctgg agggggaaga tgaccctgac cggtccatga agctctcctt
     1321 ccgggcccgg gcctatggct tcagggaccc tgggcctcag ctacgccggg gctggaggcc
     1381 atcttccaga gaagacagtg tggaggcccg aggcgacttt gaggaaaaga aggaagagga
     1441 gggcagcgcc aaccgcagag cagaggacca ggagctagag agcctgtcag ccatcgaggc
     1501 agagctggag aaggtggccc accagctgca ggctttgcga cggggatgag gcactggctg
     1561 gtggggtccg gccatggctt caaggcccaa ctgctgctca agtagggagg cttccagcct
     1621 cagagcccag gttacccctt gccccttccc ttctcttgct ctcagcccct gccctggaca
     1681 cttctgcagg gcagccctga aagtcaacac agattctttc tcggaacaca ggcagctttc
     1741 tagaagtttc tcttccacct tctaatccat ggggcacaac tgcagtagtt ctgatctttg
     1801 ggcgaaagcc gagaactcct gactattaag atattccaga taaaatttat tgaaggaaga
     1861 ataaacctgc tttgggctct tcaaaaaaaa aaaaaaaaaa aaaaa
//
