LOCUS       NM_001009258            3185 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus checkpoint with forkhead and ring finger domains
            (Chfr), mRNA.
ACCESSION   NM_001009258 XM_213807
VERSION     NM_001009258.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Jung,I., Sohn,D.H., Choi,J., Kim,J.M., Jeon,S., Seol,J.H. and
            Seong,R.H.
  TITLE     SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking
            CHFR mediated ubiquitination and degradation of its major
            components
  JOURNAL   Biochem Biophys Res Commun 418 (3), 512-517 (2012)
   PUBMED   22285184
REFERENCE   4  (bases 1 to 3185)
  AUTHORS   Oh,Y.M., Kwon,Y.E., Kim,J.M., Bae,S.J., Lee,B.K., Yoo,S.J.,
            Chung,C.H., Deshaies,R.J. and Seol,J.H.
  TITLE     Chfr is linked to tumour metastasis through the downregulation of
            HDAC1
  JOURNAL   Nat Cell Biol 11 (3), 295-302 (2009)
   PUBMED   19182791
REFERENCE   5  (bases 1 to 3185)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (bases 1 to 3185)
  AUTHORS   Yu,X., Minter-Dykhouse,K., Malureanu,L., Zhao,W.M., Zhang,D.,
            Merkle,C.J., Ward,I.M., Saya,H., Fang,G., van Deursen,J. and
            Chen,J.
  TITLE     Chfr is required for tumor suppression and Aurora A regulation
  JOURNAL   Nat Genet 37 (4), 401-406 (2005)
   PUBMED   15793587
REFERENCE   7  (bases 1 to 3185)
  AUTHORS   Daniels,M.J., Marson,A. and Venkitaraman,A.R.
  TITLE     PML bodies control the nuclear dynamics and function of the CHFR
            mitotic checkpoint protein
  JOURNAL   Nat Struct Mol Biol 11 (11), 1114-1121 (2004)
   PUBMED   15467728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087162.1.
            
            On Jan 7, 2005 this sequence version replaced XM_213807.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3185
                     /gene="Chfr"
                     /note="checkpoint with forkhead and ring finger domains"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
     exon            1..43
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            44..187
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2046
                     /gene="Chfr"
                     /EC_number="2.3.2.27"
                     /note="checkpoint with forkhead and ring finger domains,
                     E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CHFR"
                     /protein_id="NP_001009258.1"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
                     /translation="MEPHGEDEQPPPREPWGRLLRLGAEEDEPQILLWKREWTIGRRR
                     GCDLSFPSNKLVSGDHCKLRVDEKSGEVTLEDTSTNGTVINKLRVVKKQTYPLQSGDI
                     IYLVYRKNEPEHNVAYLYESLNGKQSLTQESLEANKENMFHVTKESSGPGQGDDPQVP
                     LLSPMAQTCLEEPQPSTSTSDLLPTASTSSTEPELTSAGQKHSSSSGPGTISISPKEC
                     SSLVANGELSSLSSVFQDNEASFSLLKTEDTEELEPAKKKMKGDGELDLNLQLSVADQ
                     RGIAQTSSEDVKDASVKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMER
                     SSLCPTCRCPVERICKNHILNNLVEAYLLQHPDKSRSEEDVRSMDARNKITQDMLQPK
                     VRRSFSDEEGSSEDLLELSDVDSESSDISQPYIVCRQCPEYRRQAVQSLPCPVPESEL
                     GATQALGGEAPSTSASLTTAPGYTCPLQGSHAICTCCFQPMPDRRAEHEQDSRIAPQQ
                     CAVCLQPFCHLYWGCTRTGCFGCLAPFCELNLGDKCLDGVLNNNNYESDILKNYLTTR
                     GLTWKNMLTESLLALQRGVFILSDYRITGNTVLCYCCGLRSFRELTYQYRQNIPASEL
                     PVTVTSRPDCYWGRNCRTQVKAHHAMKFNHICEQTRFKN"
     exon            188..287
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            288..397
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            398..457
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            458..673
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            674..838
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            839..998
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1153
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1316
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1462
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1579
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1663
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1734
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1822
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1930
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2003
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..3152
                     /gene="Chfr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgactgt gctgccggtt ccgggatccg cgcagggagg gggatgtgag tcctatggag
       61 ccacacgggg aagacgagca gccgccaccg cgggagccct gggggaggct tcttcgccta
      121 ggcgcagagg aggacgaacc ccagatcctt ctttggaaac gcgagtggac catcggaagg
      181 aggagaggct gtgacctctc ttttcccagc aataaactgg tctctggaga tcactgtaaa
      241 cttagagtgg atgaaaaatc tggtgaggtg acactggaag acaccagcac caatggaaca
      301 gtaatcaaca aactgcgagt tgttaagaag cagacttacc ctttacagag tggggatatc
      361 atctatttgg tgtacaggaa gaacgagcca gagcacaatg tggcatacct ctatgaatct
      421 ttaaatggca aacagagctt aactcaagaa tcccttgaag ccaataaaga aaatatgttc
      481 catgtgacca aagaatcctc aggtccaggg cagggtgatg acccccaggt tccactcttg
      541 tcacccatgg ctcagacatg cttagaggaa ccacagccat caacatcgac atcagacctc
      601 cttcccacgg cctctacctc ttctacggag ccagagctga cctctgcagg gcaaaagcat
      661 tcctctagct ctggacctgg gactataagc atctccccaa aagaatgtag ttcacttgtt
      721 gcaaatggtg aactctctag cctttcttca gttttccaag acaacgaagc atccttttct
      781 ttgttgaaaa ccgaagacac tgaggaattg gagcctgcca aaaaaaagat gaaaggagat
      841 ggggagcttg acttgaacct ccagttatca gttgcagacc agcgtggaat tgcccaaacc
      901 tcaagtgagg atgtcaaaga tgcctctgtg aaaccagaca agatggagga gacactaacc
      961 tgtatcatct gtcaagacct tctgcatgac tgtgtgagtt tgcagccttg tatgcacaca
     1021 ttttgtgcgg cttgctactc tggttggatg gagcgttcat ctctgtgccc tacctgccga
     1081 tgtccagtgg agcggatttg caaaaaccac atcctgaaca accttgtgga agcatacctt
     1141 ctccagcacc cagataagag tcgcagtgaa gaagatgtga gaagtatgga tgcaaggaat
     1201 aaaatcactc aagatatgct gcaacccaaa gtcaggaggt ctttctctga tgaagagggg
     1261 agttcagagg acctgctaga gctgtctgat gttgatagtg aatcctcaga catcagtcag
     1321 ccatacattg tatgcagaca gtgtcctgaa tacagaaggc aagcagtgca gtctcttcct
     1381 tgcccagtcc cagagagtga gctgggagcc acacaggccc ttggtgggga agcaccttca
     1441 acatctgcca gcttgacaac agccccgggt tatacatgcc ctcttcaggg aagccatgcc
     1501 atatgcacct gctgcttcca gcctatgccg gaccggagag ctgagcatga gcaggattcc
     1561 cgcatcgccc ctcaacagtg tgcagtgtgc ctgcagccct tctgccacct gtactggggc
     1621 tgcacgcgaa ctggctgctt tggctgcttg gccccattct gtgagctcaa cctgggggac
     1681 aagtgtttgg atggagtgct gaacaataac aattatgagt cggatatcct gaagaattac
     1741 ctgacaacca ggggtctgac atggaaaaat atgttgacag agagtctcct ggctctacag
     1801 cggggtgtat ttatactgtc tgattacaga atcactggaa acaccgtgct gtgttactgc
     1861 tgtggtctgc gtagcttccg agagctgacc tatcagtatc gtcagaacat tcctgcttca
     1921 gagttgccag tgaccgtaac atcccgtcct gattgctact ggggccgcaa ctgtcgcact
     1981 caggtgaagg ctcaccatgc aatgaaattc aatcacatct gtgagcaaac aaggttcaag
     2041 aactaaatat tggaggagac acatgaaaca gttacagagc acaggaggca atgatactat
     2101 ggtttttttt tttaaatacc atgtacattt ttacggtttt ccctaagcag cactgaggtt
     2161 tctggtcaga ctctctggtg tggcgagctt tatcttcagt cacacacaca cacacacaca
     2221 cacacactct acatgcccca ctaacctggg aggcctactg gccacactgg ccttctagtc
     2281 agtgtgagag gatgagcaga ctgagatccc ccctcccact agacagctct cccttcctgt
     2341 gtggtggggc agtgacagtg caggtttgca ggtttgcagg tttgtacttc tgtgtctttt
     2401 ctaccttgta ccttgactac agttaaatgg gaaagtttgt gggaaaagct gtcagatatg
     2461 ttagaaacat tctccggaag gaaaggaagc atacgtttac agcctccagg gatgtatagg
     2521 atattcttct gtctgaaaag acacagcctt ttgtatattt tttattttaa taagtttggt
     2581 ggtgcttatc ttctaataag atttaaatat taaaaactgt agcacaaata ctataattta
     2641 taatttacaa attgactaaa attaggaata gcctgacatt tggaagaatg agcatatgtt
     2701 tttgtttatt taaaaactta tcaaatgtcc aaaactgcta atcctgggga ggatgtcttg
     2761 agtatccagg tccttgacac agggctggcc aatgcctctt gtccagcagg ccaagccctt
     2821 agccctccag tccctgagag caactccctg ctgaagctcc agatggctcc agactgacag
     2881 ggccttgctt ctccagccct gatctggtac attattaggt ttgccatgtc atctggaata
     2941 atacttgaaa ttttgttctt agtttttttt aaacttttta tcttttattg aaatcacctg
     3001 ttatatttgt ttgcaaactg gtaacttttt gcttctcagg aatacaattt tcaactgttg
     3061 tcttgctctt gatatagact gagaggcagt actctgtgtt tgtgggagat ggttctcttt
     3121 ttttaattct aataaatgag ctgtgtttgt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3181 aaaaa
//
