LOCUS       NP_001009258             663 aa            linear   ROD 24-JUN-2024
DEFINITION  E3 ubiquitin-protein ligase CHFR [Rattus norvegicus].
ACCESSION   NP_001009258 XP_213807
VERSION     NP_001009258.1
DBSOURCE    REFSEQ: accession NM_001009258.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 663)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (residues 1 to 663)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (residues 1 to 663)
  AUTHORS   Jung,I., Sohn,D.H., Choi,J., Kim,J.M., Jeon,S., Seol,J.H. and
            Seong,R.H.
  TITLE     SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking
            CHFR mediated ubiquitination and degradation of its major
            components
  JOURNAL   Biochem Biophys Res Commun 418 (3), 512-517 (2012)
   PUBMED   22285184
REFERENCE   4  (residues 1 to 663)
  AUTHORS   Oh,Y.M., Kwon,Y.E., Kim,J.M., Bae,S.J., Lee,B.K., Yoo,S.J.,
            Chung,C.H., Deshaies,R.J. and Seol,J.H.
  TITLE     Chfr is linked to tumour metastasis through the downregulation of
            HDAC1
  JOURNAL   Nat Cell Biol 11 (3), 295-302 (2009)
   PUBMED   19182791
REFERENCE   5  (residues 1 to 663)
  AUTHORS   Ahel,I., Ahel,D., Matsusaka,T., Clark,A.J., Pines,J., Boulton,S.J.
            and West,S.C.
  TITLE     Poly(ADP-ribose)-binding zinc finger motifs in DNA
            repair/checkpoint proteins
  JOURNAL   Nature 451 (7174), 81-85 (2008)
   PUBMED   18172500
REFERENCE   6  (residues 1 to 663)
  AUTHORS   Yu,X., Minter-Dykhouse,K., Malureanu,L., Zhao,W.M., Zhang,D.,
            Merkle,C.J., Ward,I.M., Saya,H., Fang,G., van Deursen,J. and
            Chen,J.
  TITLE     Chfr is required for tumor suppression and Aurora A regulation
  JOURNAL   Nat Genet 37 (4), 401-406 (2005)
   PUBMED   15793587
REFERENCE   7  (residues 1 to 663)
  AUTHORS   Daniels,M.J., Marson,A. and Venkitaraman,A.R.
  TITLE     PML bodies control the nuclear dynamics and function of the CHFR
            mitotic checkpoint protein
  JOURNAL   Nat Struct Mol Biol 11 (11), 1114-1121 (2004)
   PUBMED   15467728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087162.1.
            
            On Jan 7, 2005 this sequence version replaced XP_213807.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087162.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..663
                     /product="E3 ubiquitin-protein ligase CHFR"
                     /EC_number="2.3.2.27"
                     /note="checkpoint with forkhead and ring finger domains,
                     E3 ubiquitin protein ligase"
                     /calculated_mol_wt=73822
     Region          15..124
                     /region_name="FHA_CHFR"
                     /note="forkhead associated (FHA) domain found in
                     checkpoint with forkhead and RING finger domains protein
                     (CHFR); cd22672"
                     /db_xref="CDD:438724"
     Site            order(15..22,40,48,50,53,55..56,60..61,72..78,80..92,
                     95..98,101..108,116..124)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:438724"
     Region          39..>252
                     /region_name="COG3456"
                     /note="Predicted component of the type VI protein
                     secretion system, contains a FHA domain [Signal
                     transduction mechanisms, Intracellular trafficking,
                     secretion, and vesicular transport]"
                     /db_xref="CDD:442679"
     Site            order(41..43,57..58,60,78..81)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438724"
     Region          299..352
                     /region_name="RING-HC_CHFR"
                     /note="RING finger, HC subclass, found in checkpoint with
                     forkhead and RING finger domains protein (CHFR); cd16503"
                     /db_xref="CDD:438166"
     Region          468..619
                     /region_name="zf-CRD"
                     /note="Cysteine rich domain with multizinc binding
                     regions; pfam17979"
                     /db_xref="CDD:465602"
     Region          631..654
                     /region_name="zf-CCHH"
                     /note="PBZ domain; pfam10283"
                     /db_xref="CDD:463043"
     CDS             1..663
                     /gene="Chfr"
                     /coded_by="NM_001009258.1:55..2046"
                     /db_xref="GeneID:288734"
                     /db_xref="RGD:1306360"
ORIGIN      
        1 mephgedeqp pprepwgrll rlgaeedepq illwkrewti grrrgcdlsf psnklvsgdh
       61 cklrvdeksg evtledtstn gtvinklrvv kkqtyplqsg diiylvyrkn epehnvayly
      121 eslngkqslt qesleanken mfhvtkessg pgqgddpqvp llspmaqtcl eepqpststs
      181 dllptastss tepeltsagq khssssgpgt isispkecss lvangelssl ssvfqdneas
      241 fsllktedte elepakkkmk gdgeldlnlq lsvadqrgia qtssedvkda svkpdkmeet
      301 ltciicqdll hdcvslqpcm htfcaacysg wmersslcpt crcpverick nhilnnlvea
      361 yllqhpdksr seedvrsmda rnkitqdmlq pkvrrsfsde egssedllel sdvdsessdi
      421 sqpyivcrqc peyrrqavqs lpcpvpesel gatqalggea pstsasltta pgytcplqgs
      481 haictccfqp mpdrraeheq dsriapqqca vclqpfchly wgctrtgcfg clapfcelnl
      541 gdkcldgvln nnnyesdilk nylttrgltw knmlteslla lqrgvfilsd yritgntvlc
      601 yccglrsfre ltyqyrqnip aselpvtvts rpdcywgrnc rtqvkahham kfnhiceqtr
      661 fkn
//
