LOCUS       NM_198731               3409 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus choline dehydrogenase (Chdh), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_198731 XM_224605
VERSION     NM_198731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Slow,S. and Garrow,T.A.
  TITLE     Liver choline dehydrogenase and kidney betaine-homocysteine
            methyltransferase expression are not affected by methionine or
            choline intake in growing rats
  JOURNAL   J Nutr 136 (9), 2279-2283 (2006)
   PUBMED   16920841
  REMARK    GeneRIF: kidney betaine-homocysteine methyltransferase (BHMT) and
            liver Choline dehydrogenase (CHDH) expression were refractory to
            dietary choline and methionine
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Huang,S. and Lin,Q.
  TITLE     Functional expression and processing of rat choline dehydrogenase
            precursor
  JOURNAL   Biochem Biophys Res Commun 309 (2), 344-350 (2003)
   PUBMED   12951056
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198731.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085787.1, SRR26360181.1258696.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               JAXUCZ010000016.1  5200801-5201000
            201-969             JAXUCZ010000016.1  5225121-5225889
            970-1121            JAXUCZ010000016.1  5226770-5226921
            1122-1251           JAXUCZ010000016.1  5227595-5227724
            1252-1386           JAXUCZ010000016.1  5228669-5228803
            1387-1529           JAXUCZ010000016.1  5229110-5229252
            1530-1632           JAXUCZ010000016.1  5229650-5229752
            1633-3409           JAXUCZ010000016.1  5230291-5232067
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3409
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /note="choline dehydrogenase"
                     /db_xref="GeneID:290551"
                     /db_xref="RGD:735166"
     exon            1..200
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            201..969
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2051
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /EC_number="1.1.99.1"
                     /codon_start=1
                     /product="choline dehydrogenase, mitochondrial"
                     /protein_id="NP_942026.1"
                     /db_xref="GeneID:290551"
                     /db_xref="RGD:735166"
                     /translation="MWQVLRSWSKRCLSPRGALAWAAQGQPRPPCSCAVASAASGGKD
                     EYTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIHMPAALVAN
                     LCDDKYNWYYHTEAQPGLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWHRQGA
                     EGWDYAHCLPYFRKAQKHELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAGYPF
                     TEDMNGFQQEGFGWMDMTIHQGKRWSTASAYLRPALSRPNLRAEVQTLVSRVLFEGTR
                     AVGVEYIKDGQSHKAYVSREVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPG
                     VGQNLQDHLEIYIQHACTQPITLHSAQKPLRKVCIGLEWLWRFTGDGATAHLETGGFI
                     RSRPGVPHPDIQFHFLPSQVIDHGRKPTQQEAYQVHVGTMRATSVGWLKLRSTNPQDH
                     PMINPNYLSTETDVEDFRQCVKLTREIFAQEAFAPFRGKELQPGSHVQSDKEIDAFVR
                     AKADSAYHPSCTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTI
                     MIAEKAADVIKGCPALGDENVPVYKPQTLDTQR"
     exon            970..1121
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1251
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1386
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1529
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1632
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..3409
                     /gene="Chdh"
                     /gene_synonym="CDH; CHD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgtgtcga gccccgcgca caggtgtgtg ccgcaggtca ggcgcctgga gccagacaga
       61 gcagccccat ccgggccgag gagagcacgc gacactccgg gtccgccagt taaagcgcag
      121 cgggcgagga tcggcggcca ccgccttgtc ggtgctcctg attccaatcc ttctgcggcc
      181 caggtgcgga ggtgtcttgg gacgagagat ttcccactcg tgtccgtgga gagaggaacc
      241 cggctggaag catgtggcag gtccttagaa gctggagcaa aagatgtctg agcccacgtg
      301 gagccctggc ttgggctgcg cagggccagc cacgtccccc ctgcagctgc gctgttgcta
      361 gcgccgcctc tgggggcaag gatgagtaca ccttcatcgt ggtgggcgca ggctctgctg
      421 gctgcgtgct ggccaatcgg ctcactgagg acccgaatca tcgggtactg ctactggagg
      481 cggggcccaa ggacttgttg atggggagca agcggcttca gtggaagatc cacatgccag
      541 ctgcccttgt ggccaacttg tgcgacgaca aatacaactg gtactatcac actgaggctc
      601 agcccggcct agatggccgg gtactgtact ggccacgagg ccgggtctgg gggggttcct
      661 cctccctcaa tgccatggtc tacatccgag gtcatgcgga ggactataac cgctggcacc
      721 gccaaggtgc tgagggctgg gactatgcac actgcctgcc ctacttccgc aaggcacaga
      781 aacatgagct aggtgccaat atgtaccgtg gtggggatgg cccactgcat gtgtctcggg
      841 gcaaaaccaa ccacccactc caccaggcct tcctgcaggc agcacgtcag gctggctacc
      901 ccttcactga agacatgaat ggcttccaac aggagggctt cggctggatg gacatgacca
      961 tccaccaagg gaagcgctgg agcacggcca gtgcctactt gcgcccagcg ctgagccgcc
     1021 ccaacctcag ggccgaggtc cagacacttg taagcagagt gctgtttgag ggcacgcgag
     1081 cagtgggcgt ggagtacatc aaggacggcc agagccacaa ggcttacgtc agcagggagg
     1141 tgatcctgag cgggggcgcc atcaactctc cacagctgct catgctctct ggtgttggga
     1201 atgcagatga cctcaagaaa ctgggcatcc ctgtggtgtg ccatctgccc ggagttggtc
     1261 agaacctgca ggaccacctg gagatctaca ttcagcatgc ttgcacacag cccatcaccc
     1321 tccactctgc ccagaagcct ctgcggaagg tctgcatcgg cctggagtgg ctctggaggt
     1381 tcacaggaga tggagccaca gcccatctag agaccggagg gttcatccgc agccggcctg
     1441 gggtccccca tccggacatc cagttccact tcctgccatc acaagtgatt gaccatgggc
     1501 ggaaacctac ccagcaggag gcctaccagg tacatgtggg aaccatgagg gccacaagtg
     1561 tgggctggct gaaactgaga agcaccaacc ctcaggacca cccaatgatc aatcccaact
     1621 acctgtcaac agaaaccgat gtcgaggact tccgtcagtg tgtgaagctg acacgggaaa
     1681 tttttgcaca ggaagccttc gctccctttc ggggcaaaga gctgcagccg ggaagccatg
     1741 tccagtcaga caaagagata gatgcctttg tgcgggcaaa agcagacagt gcataccatc
     1801 cctcctgtac ctgtaagatg ggccagccct ctgaccccac tgctgtggtt gatcagcaaa
     1861 ccagggtcat cggggtagaa aacctcagag tcattgatgc ctccatcatg cccagtgtgg
     1921 tcagtggcaa cctgaacgct cccacgatca tgattgcaga gaaagcagct gacgttatta
     1981 agggatgccc tgcactcggg gacgagaatg ttcctgtcta caagccccag actctggaca
     2041 cccagcgtta agacaaacaa acactgcctg aggacaacag aggaactcct gtcaagccaa
     2101 gagatccaac cagtacagtc ctgccccaga tagttctgaa actgtagaaa cttgggaccc
     2161 agatacctct attcttggct cagactttca tgttatctga gcaaatgaga tcatggtagc
     2221 ttgtgaggca agtccctttc cccagtgtct ctctgagggc cctccacaaa aaagctagca
     2281 agcacactgg ggccttcttg ccctcctggc gtgagcagtt agggatggta actcttgcca
     2341 ctgttttttt cttttctcct ccagccatct ccggctcaga gctttgcttc cataagtggg
     2401 atgcttcctt tccctggtct cccacctgag gtcaccctgc aaaggcaggg tggttgaact
     2461 ggactgggct ctccaaggaa gctttaactg aagccaagag ccaggcagca gctcagccag
     2521 ggctggttac ctgagctcat gtccctgact agagggaagg gcagccagct ggaggacatc
     2581 ttctccccct cttcactcct ctcctgccct gatttaaatc tgaagtgtga ggtgcatgga
     2641 ggagggctca ggtgactgca taactcatgc ccacctctct ggttcttgtt cttatgaaac
     2701 cgtccagagg agaggcttgc aggatgttgt tcaagaagag gccatttggg ccttactgcc
     2761 aacgatttca ttgtttaacc cttaccacaa aagtgcagga acgtagggcc agtcccacct
     2821 gctagtccct acctcatgcc aaggacatga gcctacgaga gcatttcatg gtggcccagg
     2881 aagtggacca ggcaccacag ctacttctgc agaccgtttc ttagtctcta gacatggcaa
     2941 cagacagcat agcaccgagg ctgacgggaa acagcagagg actttggagt gaaagataaa
     3001 ccagccagtg tttgggtctt gggtcaggag agcggatagc ggcagcgttg acaagagtgc
     3061 cttgatctgg aacgttcgat gtgatcggta acttactttt gagccaagat gcctcatcct
     3121 gactgtcctt ataagagaat gaagaccaaa tgcattttta gaccaatttt tctgaagatg
     3181 tccaaagcca ccatctgtag tggggaagaa aaagatcatt gtgtagaaat cacattgctg
     3241 agcgaagagt ggaggggaat agcaggattt taggctctcc tatcccagga ttgactggta
     3301 tgtgctgcct cctggacgtt tgagtccaga tagctgcacc tgagacagac cctctgaagg
     3361 gtttttttaa aaaaaaaaaa agtacaaacc atcactttta ctttgaaaa
//
