LOCUS       NM_001107906           11580 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus chromodomain helicase DNA binding protein 7
            (Chd7), mRNA.
ACCESSION   NM_001107906 XM_001071315 XM_003749899 XM_232671
VERSION     NM_001107906.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11580)
  AUTHORS   Payne S, Burney MJ, McCue K, Popal N, Davidson SM, Anderson RH and
            Scambler PJ.
  TITLE     A critical role for the chromatin remodeller CHD7 in anterior
            mesoderm during cardiovascular development
  JOURNAL   Dev Biol 405 (1), 82-95 (2015)
   PUBMED   26102480
REFERENCE   2  (bases 1 to 11580)
  AUTHORS   Ogier JM, Carpinelli MR, Arhatari BD, Symons RC, Kile BT and Burt
            RA.
  TITLE     CHD7 deficiency in 'Looper', a new mouse model of CHARGE syndrome,
            results in ossicle malformation, otosclerosis and hearing
            impairment
  JOURNAL   PLoS One 9 (5), e97559 (2014)
   PUBMED   24840056
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11580)
  AUTHORS   Cho HJ, Song MH, Choi SY, Kim J, Lee J, Kim UK, Bok J and Choi JY.
  TITLE     Genetic analysis of the CHD7 gene in Korean patients with CHARGE
            syndrome
  JOURNAL   Gene 517 (2), 164-168 (2013)
   PUBMED   23333604
REFERENCE   4  (bases 1 to 11580)
  AUTHORS   Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin
            CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M and Chang CP.
  TITLE     Brg1 governs distinct pathways to direct multiple aspects of
            mammalian neural crest cell development
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), 1738-1743 (2013)
   PUBMED   23319608
REFERENCE   5  (bases 1 to 11580)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 11580)
  AUTHORS   Jongmans MC, Admiraal RJ, van der Donk KP, Vissers LE, Baas AF,
            Kapusta L, van Hagen JM, Donnai D, de Ravel TJ, Veltman JA, Geurts
            van Kessel A, De Vries BB, Brunner HG, Hoefsloot LH and van
            Ravenswaaij CM.
  TITLE     CHARGE syndrome: the phenotypic spectrum of mutations in the CHD7
            gene
  JOURNAL   J Med Genet 43 (4), 306-314 (2006)
   PUBMED   16155193
REFERENCE   7  (bases 1 to 11580)
  AUTHORS   Pau H, Hawker K, Fuchs H, De Angelis MH and Steel KP.
  TITLE     Characterization of a new mouse mutant, flouncer, with a balance
            defect and inner ear malformation
  JOURNAL   Otol Neurotol 25 (5), 707-713 (2004)
   PUBMED   15353999
REFERENCE   8  (bases 1 to 11580)
  AUTHORS   Vissers LE, van Ravenswaaij CM, Admiraal R, Hurst JA, de Vries BB,
            Janssen IM, van der Vliet WA, Huys EH, de Jong PJ, Hamel BC,
            Schoenmakers EF, Brunner HG, Veltman JA and van Kessel AG.
  TITLE     Mutations in a new member of the chromodomain gene family cause
            CHARGE syndrome
  JOURNAL   Nat Genet 36 (9), 955-957 (2004)
   PUBMED   15300250
REFERENCE   9  (bases 1 to 11580)
  AUTHORS   Nolan PM, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray
            IC, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T,
            Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R,
            Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C,
            Thaung C, Stevenson JA, Arkell R, Mburu P, Hardisty R, Kiernan A,
            Erven A, Steel KP, Voegeling S, Guenet JL, Nickols C, Sadri R,
            Nasse M, Isaacs A, Davies K, Browne M, Fisher EM, Martin J, Rastan
            S, Brown SD and Hunter J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
REFERENCE   10 (bases 1 to 11580)
  AUTHORS   Tellier AL, Cormier-Daire V, Abadie V, Amiel J, Sigaudy S, Bonnet
            D, de Lonlay-Debeney P, Morrisseau-Durand MP, Hubert P, Michel JL,
            Jan D, Dollfus H, Baumann C, Labrune P, Lacombe D, Philip N,
            LeMerrer M, Briard ML, Munnich A and Lyonnet S.
  TITLE     CHARGE syndrome: report of 47 cases and review
  JOURNAL   Am J Med Genet 76 (5), 402-409 (1998)
   PUBMED   9556299
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000160.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107906.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001107906.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JACYVU010000160.1  9820111-9820458
            349-2162            JACYVU010000160.1  9881971-9883784
            2163-2584           JACYVU010000160.1  9918611-9919032
            2585-2726           JACYVU010000160.1  9935169-9935310
            2727-2864           JACYVU010000160.1  9938908-9939045
            2865-2930           JACYVU010000160.1  9940286-9940351
            2931-2986           JACYVU010000160.1  9946351-9946406
            2987-3101           JACYVU010000160.1  9956498-9956612
            3102-3185           JACYVU010000160.1  9959573-9959656
            3186-3323           JACYVU010000160.1  9961004-9961141
            3324-3445           JACYVU010000160.1  9961236-9961357
            3446-3689           JACYVU010000160.1  9961695-9961938
            3690-3866           JACYVU010000160.1  9962977-9963153
            3867-4010           JACYVU010000160.1  9966968-9967111
            4011-4266           JACYVU010000160.1  9968350-9968605
            4267-4477           JACYVU010000160.1  9973845-9974055
            4478-4673           JACYVU010000160.1  9974703-9974898
            4674-4841           JACYVU010000160.1  9975446-9975613
            4842-5021           JACYVU010000160.1  9975948-9976127
            5022-5132           JACYVU010000160.1  9978838-9978948
            5133-5338           JACYVU010000160.1  9979032-9979237
            5339-5538           JACYVU010000160.1  9981519-9981718
            5539-5698           JACYVU010000160.1  9981898-9982057
            5699-5788           JACYVU010000160.1  9985264-9985353
            5789-5892           JACYVU010000160.1  9985766-9985869
            5893-6022           JACYVU010000160.1  9987208-9987337
            6023-6095           JACYVU010000160.1  9987777-9987849
            6096-6153           JACYVU010000160.1  9988002-9988059
            6154-6382           JACYVU010000160.1  9988719-9988947
            6383-6591           JACYVU010000160.1  9989189-9989397
            6592-7260           JACYVU010000160.1  9989510-9990178
            7261-7421           JACYVU010000160.1  9991698-9991858
            7422-7649           JACYVU010000160.1  9993113-9993340
            7650-8093           JACYVU010000160.1  9993694-9994137
            8094-8315           JACYVU010000160.1  9997383-9997604
            8316-8456           JACYVU010000160.1  9998797-9998937
            8457-8561           JACYVU010000160.1  9999084-9999188
            8562-11580          JACYVU010000160.1  10000441-10003459
FEATURES             Location/Qualifiers
     source          1..11580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..11580
                     /gene="Chd7"
                     /note="chromodomain helicase DNA binding protein 7"
                     /db_xref="GeneID:312974"
                     /db_xref="RGD:1311921"
     exon            1..348
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            349..2162
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..9479
                     /gene="Chd7"
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 7"
                     /protein_id="NP_001101376.2"
                     /db_xref="GeneID:312974"
                     /db_xref="RGD:1311921"
                     /translation="MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPID
                     QGFPSLQPSLHHPSPNQNQTKLTHFDHYNQYEQKMHLMDQPNRMMGSAPGNGLASPHS
                     QYHTPPVPQVPHGGGSGGGQMGVYPGMQNDRHGQSFVDGGSMWGPRAVQVPDQIRAPY
                     QQQQPQPAPSGPPAQGHPQHMQQMGSYLARGDFSMQQPQQRMSQFSQGQEGLSQGSPF
                     IATSGPGGHLSHMPQQSPNIAPSLRHPVQQQFHHHPAALHGESVAHSPRFSPNPPQQG
                     AVRPQTLNFSSRSQTVPSPTVNNSGQYSPYPYRNLNQGLVNSTGMNQNLGLTNSTPMN
                     QSVPRYPNAVGFPSNSGQGLMLQQPIHSSGSLNQMNTQTMHPSQPQGTYASPPPMSPM
                     KAMSNPAGTPPPQVRPGSAGIPMDVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNIQQ
                     PRPFMGMSSTPRELTGHMRPNGCPGVGLADAQAIQERLIPGQQHPGQQPPFQQLPTCP
                     PLQPHPGLHQSSPPHPHHQPWAQLHPSPQNTPQKVPVRQHSPSEPFLEKPVPDMTQVS
                     GQNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIAAGDPSKGFGKDDFPGGVDNQELSRN
                     SLDASQEETKKRKRPKVKKDPKELKEPREKKEPKTPKAPKTPKEPKERKAKTVTPKPK
                     SSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPGPEEDEDPGVQKRRSS
                     RQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEGPVVEKIMSSR
                     LVKKQKESGEEVEVEEFYVKYKNFSYLHCQWASVEDLEKDKRIQQKIKRFKSKQGQSK
                     FLSEIEDDLFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWELRQDLD
                     QAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNW
                     YNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTEL
                     NVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPW
                     RCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFP
                     SETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQK
                     KYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKDAH
                     NADSPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRY
                     PYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWN
                     PQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGREN
                     ATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGK
                     GSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTR
                     LYSAVKEDELMEFSDLESDSEEKPCIKPRRPQDKTQGYARSECFRVEKNLLVYGWGRW
                     TDILSHGRYKRQLTEHDVETICRAILVYCLNHYRGDENIKSFIWDLITPTADGQTRAL
                     LNHSGLSAPVPRGRKGKKVKAQSMQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNK
                     VLLRVRMLYYLRQEVIGDQAEKILEGADSSEADVWIPEPFHAEVPADWWDKEADKSLL
                     IGVFKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDE
                     DPEYKPTRAPFKDEIDEFANSPPEDKEDSMEAQSTGKHSESNAELGQLYWPNTSSLTT
                     RLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRR
                     EEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCR
                     MPAKPEDEPPDLASLIEPITEERASRTLYRIELLRKIREQVLHHPQLSDRLKLCQPSL
                     DLPEWWECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKSFAQNRGASTVPSL
                     NTLAMGFGQAPPVIASAHAHEEKVMEQAEGKAEECEHSPAKERSDGKEEEEEAGGAKD
                     SRQECEAEASSVKGELKGVEGSGDPGSKSVSEKGSEEDEEEKLEDDDKSEESSQPEAG
                     AVSRGKTFDEESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMIN
                     RLDNICEAVLKGKWPINRRQMFDFQGLVPGYPPSTVDSPLQKRSFAELSMVSQASVSA
                     SEDITTSPQLSKDDALNLSVPRQRRRRRRKVEIEAERAAKRRNLMEMVAQLRESQVVS
                     ENGQEKVVDLSKASREATSSTSNFSSLTSKFILPNVSTPVSDAFKTQMELLQAGLSRT
                     PTRHVLNGSLVDGEPPMKRRRGRRKNVEGLDLLFMSHKRTPLSAEDAEVTKAFEEDIE
                     TPPIRNIPSPGQLDPDTRIPVINLEDGTRLVGEEAPKNKDLVDWLKLHPMYTVDMPSY
                     VPKNADVLFSPFQKPKQKRHRCRNPNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPM
                     KDLPRWLEENPEFAVAPDWTDIVKQSGFVPESMFDRLLTGPVVRGEGASRRGRRPKSE
                     IARAAAAAAAVASTSGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATA
                     ATAGGDAKGPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDGT
                     SKAEEKGNDNEDENRDSEKSTDAVSAADSANGSVGAATAPAALPSNPLAFNPFLLSTM
                     APGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGASEEKAADKAEGGPCKDGETLEGS
                     DAEENLDKTIESSILEDEVAQGEELDSLEGGDEIENNGNDE"
     exon            2163..2584
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2726
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2864
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2930
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..2986
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3101
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3185
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3323
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3445
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3689
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3866
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..4010
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4266
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4477
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4673
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4841
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..5021
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5132
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..5338
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5339..5538
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5539..5698
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..5788
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5789..5892
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            5893..6022
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            6023..6095
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            6096..6153
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6382
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6591
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            6592..7260
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            7261..7421
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            7422..7649
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            7650..8093
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            8094..8315
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            8316..8456
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            8457..8561
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
     exon            8562..11580
                     /gene="Chd7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgctggc gtgctggggc cgcggcggcg gcggcggcgg cggcggcggc agcggtggcg
       61 gcggcggcgg cggcgcgggg gttgagccgt ggtggtgcgg acgcgctcgt gctcgggaac
      121 tatcggatta aacttgaatc gagtggaatt acacaaagga gctccgcgga ggaggcggcc
      181 cggggacccg gagaccccgc aactcgccag agccccgtcc gcgcgcggct aactccgcgt
      241 ccgtggatca gcccccggcc gcggccgccg agccaactcc ggagccgctc tgcgttttgt
      301 tccccacggc gcgcggcggc ggactaaccc gagcgaacga gcgagccgga cctatatcca
      361 gacttcgccc ggcactgcag ggtccaagag aattaaagaa atttagaatg acatgaagaa
      421 gattagttaa ggattatagg ttttgaggac aagcacccag agaagtgaag cacagacaag
      481 ctcccaagct gtgttcgggg aagtcggcgt gttagaagaa gatggcggat ccaggaatga
      541 tgagtctttt tggcgaggat gggaatattt tcagcgaagg ccttgaaggc ctcggggaat
      601 gtggctatcc tgaaaaccca gtgaatccca tgggtcagca gatgcccata gaccaaggtt
      661 ttccctcctt acagccgtcc ctccatcatc cttcccctaa ccagaatcaa accaagctga
      721 cccacttcga tcactataac cagtacgaac aaaagatgca tctgatggat cagcctaacc
      781 gaatgatggg cagcgccccc gggaacggat tggcgtctcc gcactcccag tatcacaccc
      841 ctcccgtccc ccaggtgcca cacggaggag gcagcggtgg cggtcagatg ggagtctatc
      901 ccggcatgca gaacgacagg cacgggcaat cttttgtgga tggtggctcc atgtggggcc
      961 cccgggctgt tcaggtacca gaccagatac gagcccccta ccagcaacag cagccacagc
     1021 cagctccgtc ggggccacca gcgcagggcc acccccagca catgcagcag atgggcagct
     1081 atctggcgcg tggggatttc tctatgcagc agcctcagca gaggatgagc cagttttccc
     1141 aaggtcagga gggcctcagt cagggaagcc ctttcatcgc cacctcagga ccgggcggcc
     1201 acttgtcgca catgccccag cagagcccca acatagcccc ttccctgcgc cacccagtgc
     1261 aacagcagtt ccaccatcac cccgctgctc tccacggaga atccgttgcc cacagtccca
     1321 gattctcccc caatcctcct caacaagggg ctgtcaggcc gcaaaccctt aactttagtt
     1381 ctcggagcca gacagtcccc tcccctaccg taaacaactc agggcagtat tctccgtatc
     1441 cttacagaaa cctaaatcag ggattagtta acagtacagg gatgaatcaa aatttaggcc
     1501 ttacaaacag tactccaatg aaccagtccg taccaaggta ccccaatgct gtaggattcc
     1561 cgtcaaacag tggtcagggg ctaatgctcc agcagcccat ccactccagt ggctcactta
     1621 accaaatgaa cacacaaact atgcaccctt cgcagcctca gggaacttac gcctctccac
     1681 ctcccatgtc acccatgaaa gcaatgagta atccagcagg cacacctcct ccacaagtca
     1741 gacccggaag tgctgggata ccaatggacg ttggcagtta tccaaatatg ccccaccctc
     1801 agccatctca ccagcccccc ggtgccatgg gaatcggaca gaggaacatg ggccccagaa
     1861 acattcagca gccacggccg ttcatgggca tgtcctcgac acccagggag ctgaccggac
     1921 acatgagacc aaatggctgc cccggtgtcg gcctcgcgga tgcgcaagcc atccaggaac
     1981 gactgatacc cggccagcaa caccctggtc agcagccacc ctttcagcag ttgccaacct
     2041 gtcctccgtt acagccccac ccaggcctgc accagtcttc acctccacac ccccatcacc
     2101 agccttgggc acaactccac ccgtcacccc agaatacccc gcagaaagtg cctgtgcgtc
     2161 agcattctcc atcggagccc tttctagaga agccagtgcc ggatatgact caggtcagcg
     2221 gacagaacgc tcagctagtg aagagcgacg attacctgcc gtcaatagag cagcagccac
     2281 agcagaaaaa gaagaaaaag aaaaacaacc acatcgctgc aggggatccc agtaaaggtt
     2341 ttggtaaaga tgacttccct ggtggggttg ataaccaaga actgagcagg aactcactgg
     2401 atgcgtccca ggaagaaaca aagaaaagga aaaggccgaa ggtcaaaaaa gatccgaagg
     2461 aattgaagga gccgagggag aagaaagagc ccaagacccc aaaagccccg aagaccccca
     2521 aagagccaaa ggaaaggaaa gcaaaaactg tcacgccaaa acccaaatcc agcaaaaaat
     2581 caagtaataa gaaaccggat tcagaagcaa gtgctttgaa gaaaaaggtc aacaaaggaa
     2641 aaacagaagg ttctgaaaat tcagacttgg acaaaacacc cccaccatcc cctggccctg
     2701 aagaagacga agacccaggg gtccagaaga ggcggtccag caggcaggtg aaaaggaagc
     2761 gctacactga agatttggag ttcaagattt ctgatgagga ggcagatgac gcagatgctg
     2821 ctgggagaga ctccccatcc aacacctcac agtcagagca gcaggaatct gttgatgcag
     2881 aaggcccagt ggtggagaag attatgagca gtcgcttagt gaaaaagcag aaggaatctg
     2941 gcgaggaagt agaagttgag gaattttatg tgaaatacaa aaacttctcc tatcttcatt
     3001 gtcaatgggc atcagtagaa gatctggaaa aagacaagag gattcagcaa aagataaaac
     3061 ggtttaaatc aaaacagggc cagagcaaat tcctttcaga gattgaggat gatcttttca
     3121 atccagatta tgtggaagtt gaccggataa tggactttgc acggagcaca gatgaccggg
     3181 gcgagcccgt gactcactat ctggtaaagt ggtgctcact cccttatgaa gacagcacat
     3241 gggagctgag gcaggaccta gatcaagcaa agatcgaaga gttcgaaaag ctcatgtcca
     3301 gggagccgga gaccgagcgc gtggagcgac ctcctgctga tgactggaag aaatcggaga
     3361 gttccaggga gtacaaaaac aataacaaac tcagggaata ccagttggag ggagtaaact
     3421 ggctactttt caattggtac aacatgcgaa actgcatttt agcagatgaa atgggtttgg
     3481 gaaaaaccat ccagtccatt acatttctct atgagatata tttgaaagga atccatggcc
     3541 cttttttagt cattgccccg ttgtccacga tccccaactg ggaaagggaa ttccgaacct
     3601 ggacggagtt gaacgtggtt gtgtatcacg ggagccaagc tagtcgtcgg accattcagt
     3661 tgtatgaaat gtacttcaaa gatccccagg gtcgagtgat aaaggggtcc tataagttcc
     3721 acgccatcat cactacgttc gagatgattc tgaccgactg tcccgagctg cgcaatatcc
     3781 cctggcgctg cgtggtcatc gatgaagcac acaggctgaa gaacaggaac tgcaagcttc
     3841 tggagggact gaagatgatg gacttggaac acaaagtgct gctgaccggg accccgctgc
     3901 agaacactgt ggaggagctc tttagcctgc ttcatttcct ggagccaagt cgcttccctt
     3961 cagaaacaac cttcatgcag gaatttggcg atctgaaaac agaagagcag gtgcaaaaac
     4021 tacaggctat tctaaagccg atgatgttga gacgcctgaa agaggatgta gaaaagaact
     4081 tggcccccaa agaagagacc attattgaag ttgagctaac aaacattcag aagaagtatt
     4141 accgagccat ccttgagaag aattttacat ttctttccaa aggtggtgga caagctaacg
     4201 tacctaacct tttaaacact atgatggaac tcagaaagtg ctgcaatcat ccttacctaa
     4261 tcaatggtgc tgaagagaaa attctggaag agttcaaaga cgcgcacaac gcagattctc
     4321 cagatttcca gctccaggca atgatccagg cggccggcaa gctggttctg attgacaagc
     4381 tgctgccaaa gctgaaggct ggtggccaca gggtgctcat cttttcccag atggtgcgct
     4441 gcctggacat cctggaagac tatctcatcc agagacggta cccgtacgaa agaattgatg
     4501 gccgagtcag aggcaacctc cgccaggcag ctattgacag attctccaaa cctgattctg
     4561 ataggtttgt tttcctcctg tgcacacggg caggagggct aggcattaat cttaccgctg
     4621 ctgacacctg catcatcttc gactcagact ggaatcccca gaatgacctc caggctcaag
     4681 ctagatgcca cagaataggg cagagcaaat ccgtgaaaat ctacaggctg atcaccagga
     4741 actcctatga aagggagatg tttgacaagg ctagcctgaa gctgggtctg gataaagccg
     4801 tgttgcagtc aatgagtgga agagaaaatg ccaccaatgg ggtacaacag ctgtccaaga
     4861 aggaaataga agacctccta cgaaaggggg cttatggtgc acttatggat gaagaagatg
     4921 aagggtctaa gttttgtgaa gaagatattg accagattct ccttcgtcga acccacacta
     4981 ttaccattga gtccgaagga aaaggttcca cattcgcgaa ggccagtttt gttgcatctg
     5041 gaaataggac ggacatttct ttggatgacc caaatttctg gcagaagtgg gctaagaagg
     5101 ctgaattgga catcgatgcc ttaaacggga ggaacaacct ggttatcgac accccgagag
     5161 tgaggaagca gacccggctc tacagcgcgg tgaaggagga tgagctcatg gagttctccg
     5221 acctggaaag tgactctgaa gagaagcctt gcataaagcc tcggcggccc caggataaga
     5281 ctcagggcta tgcccggagc gagtgcttca gggtggagaa gaatctgctg gtgtatggct
     5341 ggggccgctg gacagatatc ctgtcccacg gacgctacaa acgtcagctc acggagcacg
     5401 atgtagaaac catctgcaga gccatcctgg tgtactgtct gaatcactac cgaggggacg
     5461 agaacatcaa gagctttatc tgggacctga tcactcccac ggccgatggc cagactcgag
     5521 ccctgctcaa tcattccggt ctgtcggccc ccgtgccaag gggccggaag gggaagaagg
     5581 tgaaggccca gagtatgcag cccgtggtac aggatgccga ttggctggcg agctgcaacc
     5641 cagatgccct gttccaggag gacagctaca agaagcacct gaagcaccac tgcaacaagg
     5701 tcctgctgcg tgtccgcatg ctgtactacc taagacaaga agtgatagga gaccaggcag
     5761 agaagatcct cgagggcgct gactcaagtg aggccgacgt gtggattcct gagccatttc
     5821 atgcggaagt tcctgcagac tggtgggata aggaagcaga taaatccctc ttaattggag
     5881 tgtttaaaca tggctatgag aagtacaatt ccatgagagc tgaccccgca ctctgcttcc
     5941 tggaacgagt cggtatgcct gatgccaagg ccatcgctgc cgagcaaaga gggacagaca
     6001 tgctagcaga tggtggtgac ggtggggaat ttgatagaga agatgaagat ccggaataca
     6061 aaccaacgag agcgccattc aaagatgaaa tagacgaatt tgcaaattct cccccagagg
     6121 acaaggaaga ctccatggag gcccagagca caggcaagca cagtgagagc aatgctgagt
     6181 taggtcaact ttactggccg aacacgtcaa gcctgactac gcgtctgcgc cggctcatta
     6241 ctgcctatca gcgcagctat aaaaggcaac aaatgaggca ggaggcccta atgaagacgg
     6301 accggcgcag acggaggcct cgggaggaag tgagagcgct ggaggcggaa agggaagcta
     6361 ttatatctga gaaaaggcaa aagtggacaa ggagagagga agctgacttt taccgtgtgg
     6421 tatccacctt tggggttatt tttgacccag tgaagcagca gtttgattgg aaccaattcc
     6481 gagcctttgc cagactagac aaaaagtccg atgagagtct ggagaagtat ttcagctgct
     6541 tcgtggccat gtgcaggcgg gtatgtcgga tgcctgccaa gcccgaggac gagccaccag
     6601 acctcgcctc ccttatcgaa cccatcacag aggagcgtgc atccaggacg ctgtaccgca
     6661 ttgaactgct tcgcaaaatc cgagagcagg tccttcatca cccacaactg agcgacaggc
     6721 tgaagctctg ccagcccagc ctagacctgc cggagtggtg ggagtgcgga cggcatgaca
     6781 gggacctgct ggtgggtgct gctaagcacg gggtcagccg gacagactac cacattctca
     6841 atgaccctga gttgtccttc ttagatgcac acaaaagctt tgctcagaac cgtggggcca
     6901 gtaccgtccc ttctttgaat actctggcca tgggctttgg ccaggctcct ccagtcattg
     6961 cctctgctca tgctcatgaa gaaaaggtaa tggaacaggc cgaaggcaag gcagaggagt
     7021 gcgaacactc accggccaaa gagaggtcgg atgggaaaga ggaggaagaa gaagctggtg
     7081 gggccaagga cagcaggcag gagtgtgagg ccgaggccag ctctgtgaag ggcgaactca
     7141 aaggggtgga gggcagtgga gaccctgggt ccaagtctgt ctcagagaaa ggctcagaag
     7201 aggatgagga agaaaagctg gaggacgacg ataagtcgga ggagtcatcg cagccagaag
     7261 caggagctgt ctcgagaggg aagactttcg atgaagaaag taatgcttct atgagcactg
     7321 ctagagatga aacccgagat ggattctaca tggaggacgg agatccttcg gtggctcagc
     7381 tccttcacga aaggacattt gccttctcct tttggcccaa ggacagagta atgataaacc
     7441 gattagacaa catctgtgaa gctgtactga aaggcaaatg gccaataaac cggcgccaga
     7501 tgtttgattt ccagggcctc gtccctggtt acccaccctc caccgtggac agtcccctgc
     7561 agaagaggag ctttgccgag ctctccatgg tcagccaggc cagtgtcagc gcaagtgagg
     7621 acatcaccac atctcctcag ctgtccaagg atgacgccct caacctgtct gtccctcgcc
     7681 agcggcggcg gagaaggagg aaagttgaaa tcgaggctga aagagccgcc aagaggcgta
     7741 atcttatgga gatggtggcc cagcttcgag agtctcaggt ggtctcagaa aatggacaag
     7801 agaaagtcgt ggacttatca aaggcctcga gagaggcaac aagttctacc tcaaattttt
     7861 catctcttac ttcaaagttt atcttgccta atgtctccac accagtgtct gatgccttta
     7921 agactcaaat ggagctgctc caagcaggcc tttcgcgcac acccacgagg cacgtgctca
     7981 acggctccct ggtggacgga gagcccccca tgaagaggag gcgaggcagg aggaaaaacg
     8041 tggagggcct cgacctactt ttcatgagcc acaaacggac gccattaagt gcagaggatg
     8101 ctgaggtgac caaagctttt gaagaagata tagagactcc accaataaga aacattcctt
     8161 ctcccggaca gctggacccc gacacccgga tccctgtgat aaaccttgaa gacgggacta
     8221 ggctggtggg agaagaggct cctaaaaaca aggacttggt tgattggctg aagctgcacc
     8281 ctatgtacac cgtcgacatg ccaagttatg taccaaagaa tgcagacgtg ctcttttccc
     8341 cgtttcagaa accgaaacag aaacggcata gatgtcggaa tcctaataaa ttggacataa
     8401 acaccttgac aggggaagaa agagttcctg tggttaacaa acgaaatggg aagaagatgg
     8461 gcggagccat ggcccctccg atgaaggacc tgcccaggtg gctggaggag aaccctgagt
     8521 ttgcagtcgc tccagactgg accgatatcg tcaagcaatc tggttttgtt cccgagtcaa
     8581 tgtttgaccg gctcctcact ggacctgtgg tgcggggaga aggagccagc aggagaggac
     8641 ggaggcccaa gagcgagatc gcccgagcag ctgcagcggc tgctgctgtc gcctctactt
     8701 cagggatcaa ccctctattg gtgaacagcc tgtttgctgg gatggacctg acgagccttc
     8761 agaatctcca gaacctccag tccctccagc tggcagggct catgggcttc cctccaggac
     8821 tggccactgc tgccaccgcc ggaggcgatg cgaagggccc cgccgcagtg ctgcccctga
     8881 tgctgccggg gatggcgggc ctgcccaacg tgttcggcct gggcgggctg ctgaacaacc
     8941 ccctctcagc tgctactgga aacaccacta ctgcttcgag tcaaggagag ccagaggacg
     9001 gcacttcaaa agcggaagag aaaggaaacg acaatgaaga cgagaaccga gactctgaga
     9061 aaagcacaga cgccgtttcg gctgctgact ctgcgaacgg atctgttggt gctgctactg
     9121 ccccggctgc attgccctcc aacccgctgg ccttcaaccc tttcctcctg tccaccatgg
     9181 ccccaggcct cttctaccca tccatgtttc tacctccagg actgggggga ttgacactgc
     9241 ctggcttccc agcactggcg ggactccaaa acgccgtggg cgccagcgaa gagaaggctg
     9301 ctgacaaggc cgagggaggc ccctgtaaag acggagagac cctggaaggc agcgacgccg
     9361 aggagaacct ggacaagact atagagtcct ccatcttgga agacgaggtt gcacagggtg
     9421 aagagctgga ctccctcgaa ggcggggacg agatagaaaa caacggaaat gacgaatagc
     9481 agcagcagtt ccactgaaag tgttgaaaac tgttgacagg tggtagtcct actgtttaca
     9541 ctcacagtta atgttcatac ctagttttat aagctgttct gtaacatagt gtagcaaaaa
     9601 ggaaaaaaaa aaggaaaaaa aaaagaaagg aaaaaagtcc aagtcatgtt atgcaggtgc
     9661 gtccggaggt atcttggtca ttaagtattc tgcagtgcat tatttattat gcctaggaag
     9721 gatgaaattt gagaggtgat catgtctctt taaggaaact tacataatgc tctgctcttt
     9781 tctcctttgg gtaccactgg tattataata aaaaacaatt tgtaaccgag cggcacgagc
     9841 ggaaggaagt gctgctcaga ggaagtatga agttatatat ttaatttttt aattttaatt
     9901 tcttttttgc tgtgaaggtc aagatgaaat tcaccgtaca tatcataacc ttgctcgttc
     9961 gcctcccttt cctgacttta tgggggttcc cacctttttc gcatacacac atccacacac
    10021 tctgacaatc tccacgttag tgtgaacgcc tcccgccccg aggcgcagca ataataaggc
    10081 agctgttgaa tgtgaagggt ccctttggaa aactaacctt ctgggagggt tctcgccaga
    10141 caactgcagt tccattggct tgtggtcttg tgatgcactg gtataaacaa aaataaagag
    10201 aagagtaaat agaagactga gagaagtgag aatcaggtac cttttttttt tttttttttt
    10261 tttaaattaa aggactttgt tactttagcc acaaagctaa aacagcatta cctcagctct
    10321 aaactagcct tgaagtttac agacaggact ttgtaaatgt ttttctttgt tgtgatgtcc
    10381 ttttattttt ctctctctct gaaaactgct atcatgtaag ataaaatgta catttctgcc
    10441 aactgtagta atgatgcttt taataaaagt gacccatgat acgcagagat gtagttatag
    10501 aatgcagtgt ataggggaac cggtgttcac tttttttttt tttttttttt tttttttcgc
    10561 aatagctgca gatacagcgt tctggctttc gtgctttgct cactctgtcc cctcgtgcta
    10621 gattagctgt tagtgacccg cactagccat cttcaagacc agatggggag ggaaaccttg
    10681 aattaccacc ttcatgtaat tccacgccag atatctcagc agacacacac atacacagac
    10741 ctcttactgc tcccctgaaa gggcatctga gagaaggaat cccgaaaatg tgtgcagcct
    10801 gtgataatgg ggcacaccgt agacaaaagg gcaggagaaa aacgaggctt taataagcac
    10861 actatctagg tcatttatcc ttggataatg ggagaaaagc acgatgtcgt agtgtcagca
    10921 agggacacaa aggcattgtg gtatcctgcc gcccagagct tgatgtcagc agccagtgtg
    10981 tggagagacc cacacggaac taaaatggac ccacttttgt gtgtgtgtgt gtgtgtgtgt
    11041 gtgtgttgtg tgtacacgta cccacgcatg cacattcacc cagtctcaag agctactaga
    11101 ttattatacc cttcgttttt tgcgataaga tttaaattat aagacctatt ttccctgtca
    11161 tccgagcaaa ccctattcta tctaaacaag aagtgaatgc ataaggatag aactgagcgt
    11221 gtcttttacc ctcctactcc ccctctacac gccagtgcac acacaggtta tcctttacat
    11281 ggggtaggtc agtctatcta aattcctttt gggcgtcgag attccagctg acttgtgtat
    11341 ccaagatgaa aatatgcccg tatgtctgga agaggaagag cagcttgacg ctaccagagt
    11401 ggctgaatct tgaaagttaa ccagcctgtg ctcggtaagc aagtgccttg gaatgccttc
    11461 tgaaatggcg tcctttgact gtgggagcga aactagatct gcacaaagca gagaccttaa
    11521 atgttttcct gaaagacttc agtagggaga cctcgtctaa taaaatgcat tatgaaaggg
//
