LOCUS       NM_001271226            6528 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus chromodomain helicase DNA binding protein 5
            (Chd5), mRNA.
ACCESSION   NM_001271226 XM_001078944 XM_002726621 XM_003750090
VERSION     NM_001271226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6528)
  AUTHORS   Xie,C.R., Li,Z., Sun,H.G., Wang,F.Q., Sun,Y., Zhao,W.X., Zhang,S.,
            Zhao,W.X., Wang,X.M. and Yin,Z.Y.
  TITLE     Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma
  JOURNAL   Oncotarget 6 (38), 40940-40952 (2015)
   PUBMED   26517514
REFERENCE   2  (bases 1 to 6528)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   3  (bases 1 to 6528)
  AUTHORS   Zhuang,T., Hess,R.A., Kolla,V., Higashi,M., Raabe,T.D. and
            Brodeur,G.M.
  TITLE     CHD5 is required for spermiogenesis and chromatin condensation
  JOURNAL   Mech Dev 131, 35-46 (2014)
   PUBMED   24252660
REFERENCE   4  (bases 1 to 6528)
  AUTHORS   Egan,C.M., Nyman,U., Skotte,J., Streubel,G., Turner,S.,
            O'Connell,D.J., Rraklli,V., Dolan,M.J., Chadderton,N., Hansen,K.,
            Farrar,G.J., Helin,K., Holmberg,J. and Bracken,A.P.
  TITLE     CHD5 is required for neurogenesis and has a dual role in
            facilitating gene expression and polycomb gene repression
  JOURNAL   Dev Cell 26 (3), 223-236 (2013)
   PUBMED   23948251
REFERENCE   5  (bases 1 to 6528)
  AUTHORS   Paul,S., Kuo,A., Schalch,T., Vogel,H., Joshua-Tor,L.,
            McCombie,W.R., Gozani,O., Hammell,M. and Mills,A.A.
  TITLE     Chd5 requires PHD-mediated histone 3 binding for tumor suppression
  JOURNAL   Cell Rep 3 (1), 92-102 (2013)
   PUBMED   23318260
REFERENCE   6  (bases 1 to 6528)
  AUTHORS   Potts,R.C., Zhang,P., Wurster,A.L., Precht,P., Mughal,M.R.,
            Wood,W.H. 3rd, Zhang,Y., Becker,K.G., Mattson,M.P. and Pazin,M.J.
  TITLE     CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes,
            regulates expression of neuronal genes
  JOURNAL   PLoS One 6 (9), e24515 (2011)
   PUBMED   21931736
  REMARK    GeneRIF: CHD5 regulates expression of neuronal genes, cell cycle
            genes and remodeling genes, and is linked to regulation of genes
            implicated in aging and Alzheimer's disease.
REFERENCE   7  (bases 1 to 6528)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 6528)
  AUTHORS   Bagchi,A., Papazoglu,C., Wu,Y., Capurso,D., Brodt,M., Francis,D.,
            Bredel,M., Vogel,H. and Mills,A.A.
  TITLE     CHD5 is a tumor suppressor at human 1p36
  JOURNAL   Cell 128 (3), 459-475 (2007)
   PUBMED   17289567
REFERENCE   9  (bases 1 to 6528)
  AUTHORS   Surapureddi,S., Yu,S., Bu,H., Hashimoto,T., Yeldandi,A.V.,
            Kashireddy,P., Cherkaoui-Malki,M., Qi,C., Zhu,Y.J., Rao,M.S. and
            Reddy,J.K.
  TITLE     Identification of a transcriptionally active peroxisome
            proliferator-activated receptor alpha -interacting cofactor complex
            in rat liver and characterization of PRIC285 as a coactivator
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11836-11841 (2002)
   PUBMED   12189208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Oct 8, 2014 this sequence version replaced NM_001271226.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000005.1  168131112-168131212
            102-226             JAXUCZ010000005.1  168141268-168141392
            227-406             JAXUCZ010000005.1  168146660-168146839
            407-525             JAXUCZ010000005.1  168149002-168149120
            526-764             JAXUCZ010000005.1  168149473-168149711
            765-886             JAXUCZ010000005.1  168151095-168151216
            887-1010            JAXUCZ010000005.1  168152264-168152387
            1011-1177           JAXUCZ010000005.1  168153200-168153366
            1178-1399           JAXUCZ010000005.1  168153477-168153698
            1400-1606           JAXUCZ010000005.1  168155495-168155701
            1607-1818           JAXUCZ010000005.1  168155879-168156090
            1819-1950           JAXUCZ010000005.1  168158759-168158890
            1951-2059           JAXUCZ010000005.1  168158979-168159087
            2060-2251           JAXUCZ010000005.1  168160136-168160327
            2252-2452           JAXUCZ010000005.1  168160435-168160635
            2453-2590           JAXUCZ010000005.1  168161975-168162112
            2591-2712           JAXUCZ010000005.1  168162199-168162320
            2713-2886           JAXUCZ010000005.1  168163047-168163220
            2887-3028           JAXUCZ010000005.1  168163552-168163693
            3029-3160           JAXUCZ010000005.1  168164841-168164972
            3161-3278           JAXUCZ010000005.1  168165964-168166081
            3279-3403           JAXUCZ010000005.1  168166534-168166658
            3404-3635           JAXUCZ010000005.1  168167667-168167898
            3636-3746           JAXUCZ010000005.1  168168101-168168211
            3747-3919           JAXUCZ010000005.1  168168491-168168663
            3920-4094           JAXUCZ010000005.1  168169098-168169272
            4095-4187           JAXUCZ010000005.1  168169695-168169787
            4188-4276           JAXUCZ010000005.1  168169922-168170010
            4277-4410           JAXUCZ010000005.1  168170194-168170327
            4411-4555           JAXUCZ010000005.1  168170737-168170881
            4556-4715           JAXUCZ010000005.1  168171206-168171365
            4716-4795           JAXUCZ010000005.1  168171867-168171946
            4796-4928           JAXUCZ010000005.1  168172560-168172692
            4929-5006           JAXUCZ010000005.1  168173781-168173858
            5007-5144           JAXUCZ010000005.1  168174303-168174440
            5145-5253           JAXUCZ010000005.1  168174688-168174796
            5254-5386           JAXUCZ010000005.1  168175352-168175484
            5387-5582           JAXUCZ010000005.1  168175801-168175996
            5583-5746           JAXUCZ010000005.1  168176761-168176924
            5747-5861           JAXUCZ010000005.1  168177049-168177163
            5862-5915           JAXUCZ010000005.1  168177274-168177327
            5916-6528           JAXUCZ010000005.1  168178396-168179008
FEATURES             Location/Qualifiers
     source          1..6528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..6528
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /note="chromodomain helicase DNA binding protein 5"
                     /db_xref="GeneID:691589"
                     /db_xref="RGD:1582725"
     exon            1..101
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..5869
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /EC_number="3.6.4.12"
                     /note="ATP-dependent helicase CHD5"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 5"
                     /protein_id="NP_001258155.1"
                     /db_xref="GeneID:691589"
                     /db_xref="RGD:1582725"
                     /translation="MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEP
                     VSLPKKKPKKLKESKSKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPTKKKKKKL
                     KEKKEKKAKRKKRDEDEEDNEDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNY
                     KAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVET
                     VTIAPPLAISPQQVPQPLPVRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFR
                     FGGISKRKKGSSSEEDEPEDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGD
                     GYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQW
                     EPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPN
                     GEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFMVGLPGPEVEPGMPPPRPLEGIPERE
                     FFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKR
                     KNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDVHYLIKWKDLPYDQCTWEI
                     DEIDIPYYDNLKQTYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTV
                     KFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSL
                     YKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDN
                     AIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSK
                     FFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQ
                     IKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSK
                     GGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPMLPNGSYDGSSLVKSSGKLMLLQKM
                     LKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPG
                     AQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRF
                     VTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVE
                     GMMSQGQRPTTPIPDVQSTKGGSLAAGAKKKHGGTPPGDNKDVEDSSVIHYDDAAISK
                     LLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEK
                     LLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDED
                     EDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMR
                     WGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLS
                     RQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGPEGKKPGEVISSDPNTPVPAS
                     PAQLPPAPLGLPDKMEAQLGYTDEKESGTQKPKKSLEIQALPTALDRVEAEDKHQSSD
                     SKDRAREERMEEVEKAQGSPEQPLKEETLPDKEPVPDKLELSLSHSNDFRPDDPKAEE
                     KEPTETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKI
                     YEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEVHKGNYLEMKNKFLA
                     RRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLA
                     GNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNR
                     AGDPTIQQGAFGSSQMYNNSFGPNFRGPGPGGIVNYNQMPLGPYVTDI"
     exon            102..226
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            227..406
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            407..525
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            526..764
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            765..886
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1010
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1177
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1399
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1606
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1818
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1950
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2059
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2251
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2452
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2590
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2712
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2886
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3028
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3160
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3278
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3403
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3635
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3746
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3919
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4094
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4187
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4276
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4410
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4555
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4715
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..4795
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4928
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            4929..5006
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5007..5144
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5145..5253
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5254..5386
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5582
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5583..5746
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5747..5861
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5862..5915
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
     exon            5916..6528
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccctcccc cccgcgccgg gcatgcgggg cccgctgggc accgaggagg agctgccgcg
       61 gctgttcgcg gaggagatgg agaacgagga ggagatgtca gaagaagaag acggtggcct
      121 tgaaggcttt gaggacttct ttcctgcaga gcccgtgagc cttcccaaga agaagccgaa
      181 gaagctgaag gagagcaagt ccaaagggaa gaggaagaag aaagagggga gcaatgatga
      241 gctgtcagaa aatgaggagg atctggagga gaagtcagag agcgaaggta gcgactacag
      301 ccccaccaag aagaagaaga agaaactgaa ggagaaaaag gagaagaagg ctaagcggaa
      361 aaagagggat gaggatgaag aggataatga ggacggaggc ttgaaggagc ccaagtcctc
      421 gggacagctc atggccgaat gggggcttga cgatgtggat tacctatttt ctgaggatga
      481 ctaccacacg ctgaccaact acaaggcctt cagccagttc ctccggcctc ttattgctaa
      541 gaagaacccg aagatcccca tgtccaaaat gatgactgtc ctgggggcca agtggcgaga
      601 attcagcgcc aacaacccat tcaagggcag ctcggcggcg gcagctgcgg cggccgtggc
      661 tgcggccgtg gagacggtga ccatcgctcc tccactggcc atcagtcccc agcaagtgcc
      721 ccagcctctg cccgtacgca aggccaagac caaagagggc aaggggcccg gagtgaggaa
      781 gaagaacaaa ggcgccaaag attccaagaa aaagggcagg ggcaagagag tggcagggct
      841 caagttccgc ttcggaggga tcagcaagag gaagaagggt tcctcgagcg aggaggatga
      901 accggaggac tcagatttgg acaatgccag catccacagc tcttctgtgc gttctgagtg
      961 ctctgcagct ctgggcaaga agaataagag gaggcgcaag aagaagagga ttgatgatgg
     1021 tgacggctat gagacagacc accaggacta ctgcgaggtg tgccagcagg gaggggagat
     1081 cattctctgt gatacctgcc cgagggcgta ccacctggtc tgcctggacc cggagctgga
     1141 gaaggctcca gagggcaagt ggagctgccc acactgtgag aaggagggga tccagtggga
     1201 gccgaaggat gatgatgagg aagaggagga gggcggttgc gaggaggagg aggatgacca
     1261 catggagttc tgccgcgtgt gcaaggacgg tggcgagctt ctgtgctgtg atgcttgtcc
     1321 ctcctcctac cacttgcact gcctcaaccc gccgctgccg gagatcccga acggtgaatg
     1381 gctctgcccg cgctgtacat gtcccccact gaagggcaag gttcagcgga tcctacactg
     1441 gaggtggacg gaacccccgg ctccctttat ggtggggctg ccaggaccag aggtggagcc
     1501 cggtatgccc ccgcccaggc ctctggaggg catacctgag agagagttct ttgtcaagtg
     1561 ggctggtctc tcctactggc actgctcctg ggtgaaggag ctacagttgg agctgtacca
     1621 caccgtgatg tatcgcaact accaaagaaa gaatgacatg gacgaaccac cacccttcga
     1681 ttacggctct ggtgatgagg acggtaagag cgagaaacgg aagaacaagg accctctcta
     1741 cgccaagatg gaggaacgct tctaccgcta cggcatcaag cccgagtgga tgatggtcca
     1801 ccgcatcctg aaccacagct ttgacaagaa gggggatgta cattacctga tcaagtggaa
     1861 ggacctgccc tacgaccagt gcacctggga gattgacgag attgacatcc cctactatga
     1921 caacctgaag cagacctact ggggccacag ggaactgatg ctgggagagg acgctaggct
     1981 gcccaagagg ctggtcaaga agggcaagaa gctgaaggat gataaacaag agaagccacc
     2041 cgatacaccc atcgtggacc ccacagtcaa gttcgacaag cagccgtggt acatcgactc
     2101 cacaggaggc acgctgcacc cttaccagct ggagggcctc aactggttac gcttctcctg
     2161 ggcccagggc accgacacta tcctggctga tgagatgggt ttggggaaga cagtacagac
     2221 cattgtgttt ctctattctc tgtacaagga gggccactcc aaggggcctt acctggtcag
     2281 cgcgcccctg tccaccatca tcaactggga acgggagttt gagatgtggg ctcctgactt
     2341 ttacgtggtc acctacacgg gggacaagga gagccgctct gtgatccgtg agaacgagtt
     2401 ttcttttgag gacaacgcga ttcgaggcgg gaagaaagta ttccgcatga agaaggaggt
     2461 gcagatcaaa ttccacgtgt tgcttacctc ctatgagctc atcaccattg accaagccat
     2521 cctgggctcc atcgagtggg cctgcctcgt ggtggatgag gcccatcggc tcaagaacaa
     2581 ccagtccaag ttctttaggg tcttgaatag ctacaagatc gactacaagc tgctgctgac
     2641 ggggaccccc ctccagaaca acctggagga gctgttccac ctcctcaact tcctgactcc
     2701 agagaggttc aacaatctgg aaggcttctt ggaggagttt gccgacatct ccaaggaaga
     2761 tcagatcaag aagctgcatg acctgctggg gccacacatg cttcggcggc tcaaggccga
     2821 cgtgttcaag aacatgccgg ccaagacgga gctgattgtc cgcgtggagc tgagccagat
     2881 gcagaagaag tactacaagt tcatcctgac gcggaacttc gaggcgctca actccaaggg
     2941 gggtggcaac caggtgtctc tgctcaacat catgatggat ctgaagaagt gctgcaacca
     3001 cccgtacctc ttccccgtgg ctgccgtgga agcccccatg ttgcccaacg gctcctatga
     3061 cggcagctcc ctggtcaagt cttcagggaa gctgatgcta cttcagaaga tgctgaagaa
     3121 gctgcgggat gaggggcacc gagtgctcat cttctcccag atgaccaaga tgttggacct
     3181 gttggaggac ttcctggagt atgagggcta caagtatgag cggatcgacg ggggtatcac
     3241 tgggggcctc cggcaagaag ccatcgacag attcaatgct cctggggccc aacagttctg
     3301 cttcctgctc tcaacacgtg ccggtggcct gggcatcaat ctggccacgg ccgacacagt
     3361 catcatttac gactcggact ggaaccccca caatgacatc caggccttca gccgtgctca
     3421 ccgcatcggg cagaacaaga aggtcatgat ctaccgcttc gtgacacggg cctcggtgga
     3481 ggaacgcatc actcaggtgg ccaagcgcaa gatgatgctc acgcacctgg tggtgcgacc
     3541 cggcctgggc tccaagtcgg gctccatgac caagcaggag ctggacgata tccttaagtt
     3601 cgggacagag gagctcttca aggatgacgt ggagggtatg atgtcccagg gccagaggcc
     3661 gaccacgccc atccctgatg tacagtccac caagggcgga tctctggctg ccggtgcaaa
     3721 gaaaaagcac ggcggcaccc cgccaggcga caacaaagat gtagaagaca gcagtgtgat
     3781 ccactacgac gacgcagcca tatcaaagct gctggaccgg aaccaggacg ccacggatga
     3841 cactgagctg cagaacatga acgagtacct gagctccttc aaagtggccc agtacgtggt
     3901 ccgtgaggaa gatggcgtgg aggaggtgga gagggaggtg atcaagcagg aggagaatgt
     3961 ggatcctgac tactgggaga agcttttgcg ccatcactac gagcagcagc aggaggactt
     4021 ggcccgcaac ctgggcaaag gcaagcgcat ccgtaagcag gtcaactaca acgacgcctc
     4081 ccaggaggac caggagtggc aggatgagct ctcggacaac cagtcggaat attccatcgg
     4141 ctctgaggac gaggacgagg acttcgagga gaggccagaa gggcagagcg gacgtcgaca
     4201 atccaggagg cagctgaaga gtgacaggga caagcccctg ccgcctcttc tggcccgagt
     4261 tgggggcaac attgaggttc tgggcttcaa tgccagacag aggaaggcat ttttgaatgc
     4321 catcatgcgt tggggcatgc cacctcagga tgccttcaac tcccactggc tggtgcgcga
     4381 ccttcgtggg aagagtgaga aggaatttag agcctatgta tcactcttca tgcgccacct
     4441 gtgtgagccc ggcgcagacg gcgcggagac ctttgcagac ggcgtgcccc gggagggcct
     4501 gtccaggcag cacgtactca cgcgcattgg ggtcatgtcg ctggttagga agaaggtgca
     4561 ggagtttgaa catgtcaacg gcaagtacag caccccagac ctggtccccg aggggcccga
     4621 gggcaagaag ccaggcgagg tcatctcctc ggaccccaac acacccgtgc ctgccagccc
     4681 tgcacagctc ccaccggctc cgctgggcct gccagacaaa atggaagccc agctgggcta
     4741 cacggacgag aaggagtcag gcacacagaa gccaaagaag tccctggaaa tccaggccct
     4801 gccaactgcc ctggacagag tagaggctga agacaaacat cagagctcag acagcaagga
     4861 cagagctcgg gaggagagga tggaggaggt ggagaaggct cagggctctc cggagcagcc
     4921 actgaaagag gaaacactac cggacaagga acctgtccca gacaagctgg agctaagcct
     4981 gagtcacagc aacgatttca ggccagatga ccccaaggcc gaggagaagg agcccacaga
     5041 gacccagcaa aacggcgaca gagaggaaga cgaggagggc aagaaagaag acaagaacgg
     5101 gaaattcaag ttcatgttca acattgcaga tggtggtttc acagagctgc acacgctgtg
     5161 gcagaatgag gaacgggcag ctgtgtcctc ggggaaaatc tacgaaatct ggcaccgtcg
     5221 ccatgactac tggctgctgg caggcattgt gacgcatggc tatgcccgct ggcaggacat
     5281 tcagaatgac ccgaggtaca tgatcctaaa tgagcctttc aagtctgagg ttcataaggg
     5341 taactacctg gagatgaaga ataagttctt ggcccgtcgg ttcaagctgc tggagcaggc
     5401 gctggtgatc gaggagcagc tccggagggc agcgtacctc aacatgaccc aggatcccaa
     5461 ccacccagcc atggcgctca atgctcgcct ggcagaggtg gagtgccttg ccgagagcca
     5521 ccagcaccta tccaaggagt cccttgccgg gaacaagccc gccaacgctg tcctgcacaa
     5581 ggtcctgaac cagctggaag agctgctgag tgatatgaaa gcagatgtga cacgcttgcc
     5641 ctccatgtta tcacgcatcc ccccggtggc cgcccgtctg cagatgtcgg aacgcagcat
     5701 cctgagtcgc ctgaccaacc gcgccggtga ccctaccatc cagcagggcg ctttcggctc
     5761 ctctcagatg tacaacaaca gctttgggcc caacttccgg ggccccggac cgggagggat
     5821 tgtcaactac aaccagatgc ccctggggcc ctatgtgact gacatctagc catcctcgtg
     5881 acttccccct gtttcagcgt tcctttccag ctgagccaag ccacctgccc cacgggagag
     5941 aaaagctaca gcctttttag gagttggtgc cgtgtcgggg tacaaaaggg aaaacaagca
     6001 attctatcac acggaggaca ggcccaggct ggctgtgcaa gagtccagaa gtgccacctc
     6061 atcgtagctg aagtgttctt ccacacagca tcccatcgga cagccacgcc cggcaaggtc
     6121 ccagcaccat ttccagagtg acttacttag aggagattcc atttacctgt attttttttt
     6181 ttttttttgc actttcctac tgaagatgag aacatgtttg tcttgataaa aagttggatg
     6241 acgtgtggaa gattcagatt cacgacgctc ctgtctgtca ccggctccag acctcaaggg
     6301 gaagctcagc tctttggagg cccttggtgc tgctgctcta tggactcact gcggggctgg
     6361 ggagaaatgc agcatccagt gttctggaaa cccttagtat gtcccccccc cagccccttg
     6421 actgcacccg tgtgactacc cttccgctcc agccccctgc ctgcctgctt gggaccctag
     6481 tgctagcggg ggaggggatc aggtctggag agtggctgct gacgtcga
//
