LOCUS       NP_001258155            1948 aa            linear   ROD 01-APR-2024
DEFINITION  chromodomain-helicase-DNA-binding protein 5 [Rattus norvegicus].
ACCESSION   NP_001258155 XP_001078944 XP_002726667 XP_003750138
VERSION     NP_001258155.1
DBSOURCE    REFSEQ: accession NM_001271226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1948)
  AUTHORS   Xie,C.R., Li,Z., Sun,H.G., Wang,F.Q., Sun,Y., Zhao,W.X., Zhang,S.,
            Zhao,W.X., Wang,X.M. and Yin,Z.Y.
  TITLE     Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma
  JOURNAL   Oncotarget 6 (38), 40940-40952 (2015)
   PUBMED   26517514
REFERENCE   2  (residues 1 to 1948)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   3  (residues 1 to 1948)
  AUTHORS   Zhuang,T., Hess,R.A., Kolla,V., Higashi,M., Raabe,T.D. and
            Brodeur,G.M.
  TITLE     CHD5 is required for spermiogenesis and chromatin condensation
  JOURNAL   Mech Dev 131, 35-46 (2014)
   PUBMED   24252660
REFERENCE   4  (residues 1 to 1948)
  AUTHORS   Egan,C.M., Nyman,U., Skotte,J., Streubel,G., Turner,S.,
            O'Connell,D.J., Rraklli,V., Dolan,M.J., Chadderton,N., Hansen,K.,
            Farrar,G.J., Helin,K., Holmberg,J. and Bracken,A.P.
  TITLE     CHD5 is required for neurogenesis and has a dual role in
            facilitating gene expression and polycomb gene repression
  JOURNAL   Dev Cell 26 (3), 223-236 (2013)
   PUBMED   23948251
REFERENCE   5  (residues 1 to 1948)
  AUTHORS   Paul,S., Kuo,A., Schalch,T., Vogel,H., Joshua-Tor,L.,
            McCombie,W.R., Gozani,O., Hammell,M. and Mills,A.A.
  TITLE     Chd5 requires PHD-mediated histone 3 binding for tumor suppression
  JOURNAL   Cell Rep 3 (1), 92-102 (2013)
   PUBMED   23318260
REFERENCE   6  (residues 1 to 1948)
  AUTHORS   Potts,R.C., Zhang,P., Wurster,A.L., Precht,P., Mughal,M.R.,
            Wood,W.H. 3rd, Zhang,Y., Becker,K.G., Mattson,M.P. and Pazin,M.J.
  TITLE     CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes,
            regulates expression of neuronal genes
  JOURNAL   PLoS One 6 (9), e24515 (2011)
   PUBMED   21931736
  REMARK    GeneRIF: CHD5 regulates expression of neuronal genes, cell cycle
            genes and remodeling genes, and is linked to regulation of genes
            implicated in aging and Alzheimer's disease.
REFERENCE   7  (residues 1 to 1948)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (residues 1 to 1948)
  AUTHORS   Bagchi,A., Papazoglu,C., Wu,Y., Capurso,D., Brodt,M., Francis,D.,
            Bredel,M., Vogel,H. and Mills,A.A.
  TITLE     CHD5 is a tumor suppressor at human 1p36
  JOURNAL   Cell 128 (3), 459-475 (2007)
   PUBMED   17289567
REFERENCE   9  (residues 1 to 1948)
  AUTHORS   Surapureddi,S., Yu,S., Bu,H., Hashimoto,T., Yeldandi,A.V.,
            Kashireddy,P., Cherkaoui-Malki,M., Qi,C., Zhu,Y.J., Rao,M.S. and
            Reddy,J.K.
  TITLE     Identification of a transcriptionally active peroxisome
            proliferator-activated receptor alpha -interacting cofactor complex
            in rat liver and characterization of PRIC285 as a coactivator
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11836-11841 (2002)
   PUBMED   12189208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Sep 9, 2012 this sequence version replaced
            XP_002726667.2, XP_001078944.2, XP_003750138.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..1948
                     /product="chromodomain-helicase-DNA-binding protein 5"
                     /EC_number="3.6.4.12"
                     /note="ATP-dependent helicase CHD5"
                     /calculated_mol_wt=222148
     Region          1..136
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          144..199
                     /region_name="CHDNT"
                     /note="CHDNT (NUC034) domain; pfam08073"
                     /db_xref="CDD:462357"
     Region          228..268
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          281..336
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          341..651
                     /region_name="Histone-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          343..385
                     /region_name="PHD1_CHD_II"
                     /note="PHD finger 1 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15531"
                     /db_xref="CDD:277006"
     Site            order(343,352..356,360,380)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277006"
     Region          416..458
                     /region_name="PHD2_CHD_II"
                     /note="PHD finger 2 found in class II
                     Chromodomain-Helicase-DNA binding (CHD) proteins; cd15532"
                     /db_xref="CDD:277007"
     Site            order(416,425..429,433,453)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277007"
     Region          463..542
                     /region_name="CD1_tandem_CHD3-4_like"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18667"
                     /db_xref="CDD:349314"
     Site            order(465,513,515..516,520)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349314"
     Region          547..569
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          587..640
                     /region_name="CD2_tandem_CHD3-4_like"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 3 and 4, and
                     similar proteins; cd18662"
                     /db_xref="CDD:349309"
     Site            order(607,624)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:349309"
     Region          696..>1214
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          845..848
                     /region_name="DEAH box"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1206..1250
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1296..1349
                     /region_name="DUF1087"
                     /note="CHD subfamily II, DUF1087; pfam06465"
                     /db_xref="CDD:461922"
     Region          1349..1409
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1387..1527
                     /region_name="CHDII_SANT-like"
                     /note="CHD subfamily II, SANT-like domain; pfam06461"
                     /db_xref="CDD:461920"
     Site            1388
                     /site_type="methylation"
                     /note="N5-methylglutamine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDI0; propagated from
                     UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1521..1566
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          <1530..1680
                     /region_name="LGT"
                     /note="Prolipoprotein diacylglyceryl transferase; cl00478"
                     /db_xref="CDD:469786"
     Site            1552
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A2A8L1; propagated from
                     UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1595..1692
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZD32.1)"
     Region          1727..1872
                     /region_name="CHDCT2"
                     /note="CHDCT2 (NUC038) domain; pfam08074"
                     /db_xref="CDD:462358"
     CDS             1..1948
                     /gene="Chd5"
                     /gene_synonym="CHD-5"
                     /coded_by="NM_001271226.2:23..5869"
                     /db_xref="GeneID:691589"
                     /db_xref="RGD:1582725"
ORIGIN      
        1 mrgplgteee lprlfaeeme neeemseeed gglegfedff paepvslpkk kpkklkesks
       61 kgkrkkkegs ndelseneed leeksesegs dysptkkkkk klkekkekka krkkrdedee
      121 dnedgglkep kssgqlmaew glddvdylfs eddyhtltny kafsqflrpl iakknpkipm
      181 skmmtvlgak wrefsannpf kgssaaaaaa avaaavetvt iapplaispq qvpqplpvrk
      241 aktkegkgpg vrkknkgakd skkkgrgkrv aglkfrfggi skrkkgssse edepedsdld
      301 nasihsssvr secsaalgkk nkrrrkkkri ddgdgyetdh qdycevcqqg geiilcdtcp
      361 rayhlvcldp elekapegkw scphcekegi qwepkdddee eeeggceeee ddhmefcrvc
      421 kdggellccd acpssyhlhc lnpplpeipn gewlcprctc pplkgkvqri lhwrwteppa
      481 pfmvglpgpe vepgmppprp legipereff vkwaglsywh cswvkelqle lyhtvmyrny
      541 qrkndmdepp pfdygsgded gksekrknkd plyakmeerf yrygikpewm mvhrilnhsf
      601 dkkgdvhyli kwkdlpydqc tweideidip yydnlkqtyw ghrelmlged arlpkrlvkk
      661 gkklkddkqe kppdtpivdp tvkfdkqpwy idstggtlhp yqleglnwlr fswaqgtdti
      721 lademglgkt vqtivflysl ykeghskgpy lvsaplstii nwerefemwa pdfyvvtytg
      781 dkesrsvire nefsfednai rggkkvfrmk kevqikfhvl ltsyelitid qailgsiewa
      841 clvvdeahrl knnqskffrv lnsykidykl lltgtplqnn leelfhllnf ltperfnnle
      901 gfleefadis kedqikklhd llgphmlrrl kadvfknmpa ktelivrvel sqmqkkyykf
      961 iltrnfealn skgggnqvsl lnimmdlkkc cnhpylfpva aveapmlpng sydgsslvks
     1021 sgklmllqkm lkklrdeghr vlifsqmtkm ldlledfley egykyeridg gitgglrqea
     1081 idrfnapgaq qfcfllstra gglginlata dtviiydsdw nphndiqafs rahrigqnkk
     1141 vmiyrfvtra sveeritqva krkmmlthlv vrpglgsksg smtkqelddi lkfgteelfk
     1201 ddvegmmsqg qrpttpipdv qstkggslaa gakkkhggtp pgdnkdveds svihyddaai
     1261 sklldrnqda tddtelqnmn eylssfkvaq yvvreedgve everevikqe envdpdywek
     1321 llrhhyeqqq edlarnlgkg krirkqvnyn dasqedqewq delsdnqsey sigsededed
     1381 feerpegqsg rrqsrrqlks drdkplppll arvggnievl gfnarqrkaf lnaimrwgmp
     1441 pqdafnshwl vrdlrgksek efrayvslfm rhlcepgadg aetfadgvpr eglsrqhvlt
     1501 rigvmslvrk kvqefehvng kystpdlvpe gpegkkpgev issdpntpvp aspaqlppap
     1561 lglpdkmeaq lgytdekesg tqkpkkslei qalptaldrv eaedkhqssd skdrareerm
     1621 eevekaqgsp eqplkeetlp dkepvpdkle lslshsndfr pddpkaeeke ptetqqngdr
     1681 eedeegkked kngkfkfmfn iadggftelh tlwqneeraa vssgkiyeiw hrrhdywlla
     1741 givthgyarw qdiqndprym ilnepfksev hkgnylemkn kflarrfkll eqalvieeql
     1801 rraaylnmtq dpnhpamaln arlaevecla eshqhlskes lagnkpanav lhkvlnqlee
     1861 llsdmkadvt rlpsmlsrip pvaarlqmse rsilsrltnr agdptiqqga fgssqmynns
     1921 fgpnfrgpgp ggivnynqmp lgpyvtdi
//
