LOCUS       NM_001419921            7252 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chromodomain helicase DNA binding protein 3
            (Chd3), mRNA.
ACCESSION   NM_001419921 XM_039087621
VERSION     NM_001419921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7252)
  AUTHORS   Snijders Blok,L., Rousseau,J., Twist,J., Ehresmann,S., Takaku,M.,
            Venselaar,H., Rodan,L.H., Nowak,C.B., Douglas,J., Swoboda,K.J.,
            Steeves,M.A., Sahai,I., Stumpel,C.T.R.M., Stegmann,A.P.A.,
            Wheeler,P., Willing,M., Fiala,E., Kochhar,A., Gibson,W.T.,
            Cohen,A.S.A., Agbahovbe,R., Innes,A.M., Au,P.Y.B., Rankin,J.,
            Anderson,I.J., Skinner,S.A., Louie,R.J., Warren,H.E., Afenjar,A.,
            Keren,B., Nava,C., Buratti,J., Isapof,A., Rodriguez,D.,
            Lewandowski,R., Propst,J., van Essen,T., Choi,M., Lee,S.,
            Chae,J.H., Price,S., Schnur,R.E., Douglas,G., Wentzensen,I.M.,
            Zweier,C., Reis,A., Bialer,M.G., Moore,C., Koopmans,M.,
            Brilstra,E.H., Monroe,G.R., van Gassen,K.L.I., van Binsbergen,E.,
            Newbury-Ecob,R., Bownass,L., Bader,I., Mayr,J.A., Wortmann,S.B.,
            Jakielski,K.J., Strand,E.A., Kloth,K., Bierhals,T., Roberts,J.D.,
            Petrovich,R.M., Machida,S., Kurumizaka,H., Lelieveld,S., Pfundt,R.,
            Jansen,S., Deriziotis,P., Faivre,L., Thevenon,J., Assoum,M.,
            Shriberg,L., Kleefstra,T., Brunner,H.G., Wade,P.A., Fisher,S.E. and
            Campeau,P.M.
  CONSRTM   DDD study
  TITLE     CHD3 helicase domain mutations cause a neurodevelopmental syndrome
            with macrocephaly and impaired speech and language
  JOURNAL   Nat Commun 9 (1), 4619 (2018)
   PUBMED   30397230
  REMARK    Erratum:[Nat Commun. 2019 Feb 15;10(1):883. PMID: 30770872]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7252)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   3  (bases 1 to 7252)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   4  (bases 1 to 7252)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 7252)
  AUTHORS   Wang,L., Liu,H.L., Li,Y. and Yuan,P.
  TITLE     Proteomic analysis of pancreatic intraepithelial neoplasia and
            pancreatic carcinoma in rat models
  JOURNAL   World J Gastroenterol 17 (11), 1434-1441 (2011)
   PUBMED   21472101
REFERENCE   6  (bases 1 to 7252)
  AUTHORS   Liska,F., Gosele,C., Rivkin,E., Tres,L., Cardoso,M.C., Domaing,P.,
            Krejci,E., Snajdr,P., Lee-Kirsch,M.A., de Rooij,D.G., Kren,V.,
            Krenova,D., Kierszenbaum,A.L. and Hubner,N.
  TITLE     Rat hd mutation reveals an essential role of centrobin in spermatid
            head shaping and assembly of the head-tail coupling apparatus
  JOURNAL   Biol Reprod 81 (6), 1196-1205 (2009)
   PUBMED   19710508
  REMARK    Erratum:[Biol Reprod. 2010 Apr;82(4):804. Rooij, Dirk G de
            [corrected to de Rooij, Dirk G]]
REFERENCE   7  (bases 1 to 7252)
  AUTHORS   Sun,J.M., Chen,H.Y. and Davie,J.R.
  TITLE     Differential distribution of unmodified and phosphorylated histone
            deacetylase 2 in chromatin
  JOURNAL   J Biol Chem 282 (45), 33227-33236 (2007)
   PUBMED   17827154
REFERENCE   8  (bases 1 to 7252)
  AUTHORS   Sillibourne,J.E., Delaval,B., Redick,S., Sinha,M. and Doxsey,S.J.
  TITLE     Chromatin remodeling proteins interact with pericentrin to regulate
            centrosome integrity
  JOURNAL   Mol Biol Cell 18 (9), 3667-3680 (2007)
   PUBMED   17626165
REFERENCE   9  (bases 1 to 7252)
  AUTHORS   Kim,J., Sif,S., Jones,B., Jackson,A., Koipally,J., Heller,E.,
            Winandy,S., Viel,A., Sawyer,A., Ikeda,T., Kingston,R. and
            Georgopoulos,K.
  TITLE     Ikaros DNA-binding proteins direct formation of chromatin
            remodeling complexes in lymphocytes
  JOURNAL   Immunity 10 (3), 345-355 (1999)
   PUBMED   10204490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 21, 2023 this sequence version replaced XM_039087621.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.24606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000010.1  54588535-54588810   c
            277-389             JAXUCZ010000010.1  54584078-54584190   c
            390-560             JAXUCZ010000010.1  54583353-54583523   c
            561-685             JAXUCZ010000010.1  54582805-54582929   c
            686-972             JAXUCZ010000010.1  54581048-54581334   c
            973-1103            JAXUCZ010000010.1  54580704-54580834   c
            1104-1254           JAXUCZ010000010.1  54580392-54580542   c
            1255-1448           JAXUCZ010000010.1  54580042-54580235   c
            1449-1679           JAXUCZ010000010.1  54579539-54579769   c
            1680-1883           JAXUCZ010000010.1  54579169-54579372   c
            1884-2095           JAXUCZ010000010.1  54578811-54579022   c
            2096-2227           JAXUCZ010000010.1  54578127-54578258   c
            2228-2327           JAXUCZ010000010.1  54577327-54577426   c
            2328-2519           JAXUCZ010000010.1  54576774-54576965   c
            2520-2720           JAXUCZ010000010.1  54576441-54576641   c
            2721-2858           JAXUCZ010000010.1  54575993-54576130   c
            2859-2980           JAXUCZ010000010.1  54575590-54575711   c
            2981-3154           JAXUCZ010000010.1  54575269-54575442   c
            3155-3296           JAXUCZ010000010.1  54574865-54575006   c
            3297-3428           JAXUCZ010000010.1  54574577-54574708   c
            3429-3546           JAXUCZ010000010.1  54573611-54573728   c
            3547-3671           JAXUCZ010000010.1  54573300-54573424   c
            3672-3903           JAXUCZ010000010.1  54572893-54573124   c
            3904-4070           JAXUCZ010000010.1  54572445-54572611   c
            4071-4248           JAXUCZ010000010.1  54571822-54571999   c
            4249-4314           JAXUCZ010000010.1  54571378-54571443   c
            4315-4400           JAXUCZ010000010.1  54570327-54570412   c
            4401-4534           JAXUCZ010000010.1  54570030-54570163   c
            4535-4679           JAXUCZ010000010.1  54569341-54569485   c
            4680-4842           JAXUCZ010000010.1  54569010-54569172   c
            4843-4964           JAXUCZ010000010.1  54568391-54568512   c
            4965-5100           JAXUCZ010000010.1  54568144-54568279   c
            5101-5202           JAXUCZ010000010.1  54567934-54568035   c
            5203-5331           JAXUCZ010000010.1  54567612-54567740   c
            5332-5440           JAXUCZ010000010.1  54566924-54567032   c
            5441-5573           JAXUCZ010000010.1  54566191-54566323   c
            5574-5769           JAXUCZ010000010.1  54565748-54565943   c
            5770-5933           JAXUCZ010000010.1  54564629-54564792   c
            5934-6060           JAXUCZ010000010.1  54564301-54564427   c
            6061-7252           JAXUCZ010000010.1  54562437-54563628   c
FEATURES             Location/Qualifiers
     source          1..7252
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..7252
                     /gene="Chd3"
                     /note="chromodomain helicase DNA binding protein 3"
                     /db_xref="GeneID:303241"
                     /db_xref="RGD:1311923"
     exon            1..276
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..6188
                     /gene="Chd3"
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 3"
                     /protein_id="NP_001406850.1"
                     /db_xref="GeneID:303241"
                     /db_xref="RGD:1311923"
                     /translation="MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEVEAADEDDEE
                     EDEEGVLGRGPGHDRGRDRHSPPSCHLFPPPPPPPPPLPPPPPPDKDDIRLLPSALGV
                     KKRKRGPKKQKENKPGKPRKRKKLDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRR
                     KHREKREKKTKRRKRGEGDGGHKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYK
                     AFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVA
                     EQVSAAVSSATPIAPSGPPPALPPPPAPEIQPPPIRRAKTKEGKGPGHKRRGKSARAP
                     DGRKKLRGKKMAPLKIKLGLLGGRRRKAGSCVFQGDEGPEPEAEESDLDSGSVHSASG
                     RPDGPVRAKKLKRGRPGRKKKKVLGCPTVTGEEEVDGYETDHQDYCEVCQQGGEIILC
                     DTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEEDYEEEGEEGEKEEED
                     DHMEYCRVCKDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCPRCTCPVLKGRVQK
                     ILHWRWGEPPVAVPAPQQADGDPDAPPPRVLQGRSEREFFVKWVGLSYWHCSWAKELQ
                     LEIFHLVMYRNYQRKNDMDEPPPLDYGSGEDDGKSDKRKVKDPHYAEMEEKYYRFGIK
                     PEWMTVHRIINHSMDKKGNYHYLVKWKDLPYDQSTWEEDEMNIPEYDDHKQSYWRHRE
                     LIMGEDPAQPRKYKKKKKEIQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEG
                     LNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWE
                     REFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLL
                     TSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQN
                     NLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKN
                     MPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVSLLNIMMDLKKCCNHPY
                     LFPVAAMESPKLPSGAYEGGALIKSSGKLLLLQKMLRKLKEQGHRVLIFSQMTKMLDL
                     LEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATAD
                     TVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHL
                     VVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAIARLLD
                     RNQDATDDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEKLLR
                     HHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEGR
                     RQSKRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQW
                     LVRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGLSRQQVLTRIGVMSL
                     VKKKVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASTTNSPCTSKP
                     ATPAPSEKGDGVRTLLEKDDTENPEEKPEKSSKVGEKMETEIDSPSPAPSLGERLEHR
                     KILLEDDAPGVPGEIEPEPGYRGDREKSASEPTPGERGEEKPLDGQEHRERTEGETGD
                     LGKREDVKADRELRLGPPRDEPRPNGRREEKVEKPRFMFNIADGGFTELHTLWQNEER
                     AAISSGKLNEIWHRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFL
                     EMKNKFLARRFKLLEQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQ
                     HLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERS
                     ILSRLASKGTEPHPTPAFPPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFIT
                     ATTNGPPVLVKKEKEMVGALVSDGLGLDRKEPRAGEVICIDD"
     exon            277..389
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            390..560
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..685
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..972
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1103
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1254
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1448
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1679
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1883
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2095
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2227
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2327
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2519
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2720
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2858
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2980
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3154
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3296
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3428
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3546
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3671
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3903
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4070
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4248
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4314
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4400
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4401..4534
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4535..4679
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4680..4842
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4843..4964
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4965..5100
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5101..5202
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5203..5331
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5440
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5441..5573
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5574..5769
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5770..5933
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5934..6060
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
     exon            6061..7252
                     /gene="Chd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccacag gatggcttcc cctctgaggg acgaggagga ggaggaggag gagatggtgg
       61 tgtcggagga ggaagaagag gaggaagaag agggcgacga ggaggaggag gaggtggagg
      121 cggccgacga ggacgatgag gaggaggacg aagagggagt actcgggcgc gggccgggcc
      181 acgaccgggg ccgcgaccgc cacagccccc ccagctgcca cctcttcccg ccgccgccgc
      241 cgccgccgcc gccgctgccg ccgcccccgc cgccagataa ggatgatatc cggctgctgc
      301 cttcagcatt gggtgtgaag aagcgaaaac ggggtcccaa gaagcagaag gaaaacaagc
      361 caggcaaacc ccggaaacga aagaagcttg acagtgaaga ggagtttggc tcagagcgag
      421 atgagtaccg ggagaagtca gagagtggag gcagcgagta tggaactgga ccaggtcgga
      481 agcgaaggag gaagcaccgg gaaaagagag agaagaaaac aaaacggagg aaaaggggag
      541 aaggggatgg gggacacaag caggtggagc agaagtcatc cgccaccttg cttctgacct
      601 ggggcttgga ggatgtggaa cacgtgttct ctgaggagga ctatcacaca cttactaatt
      661 acaaagcctt cagtcagttc atgaggccct taattgctaa gaagaatcct aagatcccga
      721 tgtcgaagat gatgaccatc ctgggggcca agtggagaga gttcagcgcc aataacccct
      781 tcaaagggtc agcagctgct gtggcggcag cggcagcggc agcagcagca gctgtagctg
      841 agcaggtgtc agctgctgtc tcctcagcca cccccatagc accatctgga cccccccctg
      901 cccttccacc accccctgct cctgaaatcc agcccccacc catcagaaga gccaaaacca
      961 aagagggcaa aggtccaggc cacaagaggc ggggtaagag cgcccgagcc cccgatgggc
     1021 gcaagaagct tcgaggaaag aagatggcac cactcaaaat caagctaggg ctgctggggg
     1081 gcaggaggag gaaggcgggc tcgtgtgttt ttcagggtga tgagggccct gaaccagagg
     1141 ctgaggagtc agacctggac agtggtagtg ttcatagtgc ctcaggccgg cctgatggtc
     1201 ctgtccgtgc caagaaactg aagcgaggcc ggccaggaag gaagaagaag aaggtcctgg
     1261 gctgtcctac agtgaccggg gaggaggaag ttgatggcta tgagacggat caccaggatt
     1321 actgtgaggt gtgccagcag ggcggggaaa ttattctgtg tgacacctgc ccccgtgcct
     1381 accacctcgt ctgccttgac cctgagcttg atcgagctcc tgagggcaaa tggagctgcc
     1441 cccactgtga gaaggaaggg gtacagtggg aggccaagga agaagaggaa gactatgagg
     1501 aggaagggga ggaaggagag aaggaggaag aggatgacca catggagtac tgccgagtgt
     1561 gcaaggacgg cggggagctc ctgtgctgtg acgcctgcat ctcttcctac cacatccact
     1621 gtctgaaccc cccactgccc gacatcccca atggtgaatg gctgtgccct cgatgcacgt
     1681 gtcctgtgct aaagggccgt gttcagaaga tcttgcactg gcgatggggg gagccacctg
     1741 tggcagtgcc ggccccgcag caggcagacg gggatccaga cgccccaccc cctcgtgttc
     1801 ttcaaggcag atcagagagg gagttctttg tcaagtgggt gggactgtcc tactggcatt
     1861 gctcctgggc caaggagctt cagctggaaa tcttccactt ggtaatgtac cgaaactatc
     1921 aacggaaaaa tgacatggac gagcccccac cgctggacta tggatctggt gaggacgatg
     1981 ggaagagtga taagcggaag gtgaaggacc cgcactacgc agagatggag gagaagtact
     2041 accgtttcgg catcaagcca gagtggatga ctgtgcaccg cattattaac catagtatgg
     2101 ataaaaaggg gaattaccac tatcttgtga aatggaagga cctgccttac gaccagtcta
     2161 catgggagga ggatgagatg aacatccctg agtatgacga ccataagcag agctactgga
     2221 ggcaccgtga gctaattatg ggcgaggacc ctgcacagcc tcgaaagtac aagaagaaga
     2281 agaaggagat acagggcgat gggcctccca gttcccctac taatgatcct acagtgaaat
     2341 atgagactca gccacggttt atcacagcca caggaggcac gctgcacatg tatcagctgg
     2401 aagggctgaa ctggctgcgc ttctcatggg cccaaggcac tgacacaatt ctggctgatg
     2461 agatggggct gggcaagacc atccaaacca ttgtctttct ctactcactc tataaggagg
     2521 gccacacaaa aggtcccttc ctggtaagtg ctccactctc taccatcatc aactgggaac
     2581 gggagttcca gatgtgggca cccaagttct atgtggtcac atacacgggt gacaaggata
     2641 gccgggccat tattcgagaa aacgagttct cctttgagga taatgccata aaaggcggga
     2701 agaaagcttt taagatgaag agagaggcac aggtgaagtt ccatgttctc ctgacatcat
     2761 acgagctgat caccattgat caggcagctc taggctccat tcgctgggcc tgtcttgtgg
     2821 tggatgaagc tcatcgactc aagaacaatc agtccaagtt tttcagggtc ctcaatggct
     2881 acaagataga tcataagttg ttgttgacgg ggactccact gcagaataac ttggaggagc
     2941 tcttccacct tctcaacttc ctcactccag agaggtttaa caacctggag ggctttctgg
     3001 aggagtttgc tgacatatcc aaagaggacc agattaagaa actgcatgat ttactgggac
     3061 cacacatgct tcggagactc aaggcagatg tctttaagaa catgccagcc aagacagagc
     3121 tcattgttcg agtggagcta agccccatgc agaagaaata ctacaagtac atcctaactc
     3181 gaaattttga ggccttgaac tctcgaggtg gtgggaacca agtgtccctg cttaacatca
     3241 tgatggacct taagaagtgc tgtaaccacc cgtacctctt ccccgtggct gctatggagt
     3301 ctcccaaact ccccagtggg gcttatgagg gtggggcact tattaagtcg tcagggaagc
     3361 tgctgctgct acagaagatg ctgcggaagc tgaaggagca aggacacaga gtgctcatct
     3421 tctcccagat gaccaaaatg ttagaccttc tggaagactt cctagactac gaagggtaca
     3481 agtatgagcg cattgatggt ggcatcacgg gcgcccttag gcaggaggcc atcgatcgct
     3541 ttaatgctcc tggagcccaa caattctgct tcctcctgtc cacccgggct ggtggactgg
     3601 gcatcaacct ggccactgct gacactgtca tcattttcga ttctgattgg aacccccata
     3661 atgacatcca ggccttcagc agagcccatc ggattggcca ggccaacaaa gtgatgattt
     3721 accggtttgt gacccgagcc tcggtagaag agcgaatcac acaggtggct aagagaaaga
     3781 tgatgctgac acacctggtc gtgcggccag gcctgggctc caaggctggt tccatgtcca
     3841 agcaggagtt ggatgacatc ctcaaatttg gcaccgagga gctattcaaa gatgaaaatg
     3901 agggagagaa taaggaggag gatagcagtg tgatccacta tgacaatgaa gccattgctc
     3961 gactgctaga ccgaaaccag gatgcgaccg atgacacaga cgtgcagaac atgaacgaat
     4021 acctcagctc cttcaaggtg gcacaatatg ttgtgcggga ggaagacaag attgaggaga
     4081 tcgagcgaga gatcatcaag caggaggaga atgtggaccc tgactactgg gagaagctac
     4141 tgcgacacca ctatgagcag cagcaggaag acctcgcccg gaacctaggc aaggggaagc
     4201 gagtccgaaa gcaggtcaac tacaatgacg ctgcccagga ggaccaagat aaccagtcag
     4261 aatactcagt ggggtccgag gaggaggatg aagacttcga tgagcgtcct gaagggcgtc
     4321 gacagtcaaa gaggcagctt cgaaatgaga aggacaagcc gctgcctcca ttgctggctc
     4381 gagtcggggg caacattgaa gtattgggat tcaatacccg gcagcggaag gctttcctta
     4441 atgctgtgat gcgctggggg atgccgccac aagatgcttt caccacacag tggctagtga
     4501 gagacctgag gggcaaaacg gagaaggagt tcaaggccta tgtgtctttg ttcatgcgcc
     4561 atctgtgcga gcctggggca gatggctctg aaacctttgc ggatggggtc cctcgggagg
     4621 ggctgagtcg ccagcaggtg ttgacccgca ttggagtcat gtctctcgtc aagaagaagg
     4681 tgcaagagtt tgagcatatc aatggacgct ggtcaatgcc agagctgatg cctgacccca
     4741 gtgctgactc caaacgctct tccagagcct cctctccaac caaaacgtct cccaccactc
     4801 ctgaggcttc tacaaccaac agtccttgca cctctaaacc tgctactccg gctccaagtg
     4861 agaagggaga tggtgtaagg acactgctgg agaaggatga cactgagaac ccggaagaga
     4921 agccagagaa gagcagcaaa gtgggagaaa agatggagac agagattgat tctcccagcc
     4981 ctgccccatc acttggagaa cggctagaac ataggaagat tctgttagag gatgatgcac
     5041 caggggtacc tggagagata gagcctgaac ctgggtaccg aggagacagg gaaaagtctg
     5101 cctcagagcc aacgccagga gaaagggggg aggagaagcc attggatgga caggaacaca
     5161 gggagaggac agagggggag acaggggatt tgggcaagag agaagatgta aaagcagatc
     5221 gggagcttcg acttgggcct cctcgggatg agccacggcc caatgggcgc cgtgaggaga
     5281 aggtggagaa gccaagattc atgttcaaca ttgctgatgg tggtttcaca gagctgcaca
     5341 cactgtggca gaatgaggaa agagcagcta tttcctcggg gaaactcaat gagatctggc
     5401 accggagaca tgactactgg cttctagctg gcattgtcct ccatggctat gcccggtggc
     5461 aagacatcca gaacgatgct cagtttgcca ttattaatga accatttaaa acggaagcca
     5521 ataaggggaa cttcctggag atgaaaaata aattcctggc ccggaggttc aagctcctgg
     5581 agcaggcgct ggtgatcgag gagcagctgc ggcgggcggc ctacctgaac ctgtcacagg
     5641 agccggcgca ccccgccatg gccctccacg cccgctttgc cgaggccgag tgcctagccg
     5701 agagccacca gcacctctcc aaggagtcgc tggcagggaa caagccagcc aacgctgtcc
     5761 tgcacaaggt tctgaaccag ctggaggagt tgctgagcga catgaaggca gatgtgaccc
     5821 gcctgccagc cacgctgtcc cgaatacccc ccatcgcagc ccgccttcag atgtccgagc
     5881 gcagcatcct cagccgactg gccagcaagg gcacggagcc tcaccccaca ccggcctttc
     5941 ccccgggtcc ttacgccaca cctccggggt acggggcagc cttcagcgcc gcacccgtag
     6001 gggccctggc cgccgcaggc gccaattaca gccagatgcc agcagggtcc ttcatcacag
     6061 ccaccaccaa cggccctcca gtgctggtga agaaagagaa ggaaatggtg ggggcgttgg
     6121 tgtcagacgg gctggggctg gatcggaagg agccccgagc aggggaggtg atttgtatag
     6181 acgactgact ggatcccagg cctgcccttc acctaggccc cgaccccgga gccgacccac
     6241 atctcaggcc ttggggcctg ctgccaaccc tccaccttcc ccaccccttg ggccaccact
     6301 gggctaggag cccttttgcc cctctataat gcctcccttc aagaaggacc cctatctctc
     6361 tccgcctcca cacacctttc ccaccaaact tgaagactgt gctggtgtga agaggtctgg
     6421 gtgggagatg gttagcaggg tcttccaagt acccggatgc cccaccacca aatatacagc
     6481 ttcccaacaa atgagtatcc gggaggaagg aggtggggcc tcccaggcct ttcctgcagc
     6541 atcacctcca cctcctgcca aagtggggga ttagccttgc tgccctttag gaacttttgt
     6601 gagatcttca gagaggaggg gaacctcatt acaaagatga aaatagcagg aggaggagga
     6661 gggcggggct gcatggcact ttccctccct ctcccaaagg gtgggtaaaa gctacaagga
     6721 agggagcgga ttgctgctcc tggctcagtt acctcctgtg tgccagcatc ctgcagtagg
     6781 aactgttctt ctccccaggg accaaggacc acccccacag taatggttgg gtgatactcc
     6841 ctcaagccaa agaggagctc cccaacctgt tctaggtgac ctagaaaggg tgggagagaa
     6901 tacagagggc cagatatggg gcagaccccc actctggggc tcaggtttct gggggactaa
     6961 atcctccctc ctcaaggcct gaatacagac taaatttgag taggtcaggc caggggccca
     7021 gtcaggagcc tgccttgcct tgggaccaga gcaacccagt ggataacagg ctagggagat
     7081 tcgggcacat tccccctcta aggaggggcc agggagtggc agtttgcatg gggaaccccc
     7141 atatcctcct tgctgcccct ttcccagtct ctttgctccc gctcctggtc tgtcccaatc
     7201 ccttcttctg tatcaggtta ttggttgtac atataaatta tactttcctt tc
//
