LOCUS       NM_001107523            6092 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus chromodomain helicase DNA binding protein 2
            (Chd2), mRNA.
ACCESSION   NM_001107523 XM_001058641 XM_218790
VERSION     NM_001107523.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6092)
  AUTHORS   Harada,A., Okada,S., Konno,D., Odawara,J., Yoshimi,T.,
            Yoshimura,S., Kumamaru,H., Saiwai,H., Tsubota,T., Kurumizaka,H.,
            Akashi,K., Tachibana,T., Imbalzano,A.N. and Ohkawa,Y.
  TITLE     Chd2 interacts with H3.3 to determine myogenic cell fate
  JOURNAL   EMBO J 31 (13), 2994-3007 (2012)
   PUBMED   22569126
REFERENCE   2  (bases 1 to 6092)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 6092)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 6092)
  AUTHORS   Nagarajan,P., Onami,T.M., Rajagopalan,S., Kania,S., Donnell,R. and
            Venkatachalam,S.
  TITLE     Role of chromodomain helicase DNA-binding protein 2 in DNA damage
            response signaling and tumorigenesis
  JOURNAL   Oncogene 28 (8), 1053-1062 (2009)
   PUBMED   19137022
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058641.1, XM_218790.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6092
                     /gene="Chd2"
                     /note="chromodomain helicase DNA binding protein 2"
                     /db_xref="GeneID:308738"
                     /db_xref="RGD:1310056"
     exon            1..502
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..635
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..6078
                     /gene="Chd2"
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 2"
                     /protein_id="NP_001100993.1"
                     /db_xref="GeneID:308738"
                     /db_xref="RGD:1310056"
                     /translation="MMRNKDKSQEEDSSLHSNASSHSASEEASASDSGSQSESEQGSD
                     PGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKKERIADVKKMWEE
                     YPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQDPSEDDQ
                     EQGSSAESEAEQKKVKARRPIPRRTVPKPQVKKQPKIQRGKRKKQESSDDDDDDDEAP
                     KRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSRLGKKGV
                     DLNPFAATGASTTVYAVEANGDPSGDFDTEREEGEIQYLIKWKGWSYIHSTWESEESL
                     QQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDVEYFNCQQELASELNKQYQIVERVIA
                     VKTSKSALGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQSCIDS
                     FHSRNNSKTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCK
                     SNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTSWQREFEIWAPEV
                     NVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVD
                     EAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFE
                     EDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVEMSALQKQYYKWIL
                     TRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIRAPEDSERETGQEVLQSLIRSSG
                     KLILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQA
                     LDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQK
                     KQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTVLENNSGRSNSNPFNK
                     EELTAILKFGAEDLFKEIEGEESEPQEMDIDEILRLAETRENEVSTSATDELLSQFKV
                     ANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKAQ
                     TNDSDSDTESKRQAQRSSASESETDDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRF
                     IKAYKKFGLPLERLECIARDAELVDKSVADLKRLGELVHNSCVSAMQEYEEQLKENAS
                     EGKGPGKRRGPTIKISGVQVNVKSIIQHEEEFEMLHKSIPVDPEEKKKYCLTCRVKAA
                     HFDVEWGVEDDSRLLLGIYEHGYGNWELIKTDPELKLTDKILPVETDKKPQGKQLQTR
                     VDYLLKLLRKGLEKKGTVTSGEEAKLKKRKPRVKKENKAPRLKDEHGLELSSPRHSDN
                     PSEEGEVKDDGLEKSPTKKKQKKKENKENKEKPVSSRKDREGDKEKKKSKDKKEKVKG
                     GDAKSSSKSKRSQGPVHITAGSEPVPIGEDEDDDLDQETFSICKERMRPVKKALKQLD
                     KPDKGLNVQEQLEHTRSCLLKIGDRIAECLRAYSEQEHIKLWRRNLWIFVSKFTEFDA
                     RKLHKLYKMAHKKRSQEEEEQKKKDDTLGGKKPFRPEASGSSRDSLISQSHASHNLHP
                     QKPHLPASHGPQMHGHPRDTYSHPNKRHFSNADRGDWQRERKFNYGGGNNAPWGGDRH
                     HQYEQHWYKDHHYGDRRHMDAHRSGSYRPNNMSRKRPYEQYNSDRDHRGHRDYYDRHH
                     HDSKRRRSDDFRPQNYHQQDFRRMSDHRPTMGYHGQGPSDHYRSFHTDKLGEYKQPMP
                     TLHTALSDPRSPPAQKSPHDSKSPLDHRSPLERSLEQKNNPDYNWNVRKT"
     exon            636..867
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..954
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1016
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1124
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1265
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1399
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1646
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1747
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1792
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1971
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2096
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2313
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2403
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2594
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2783
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2946
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3099
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3171
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3321
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3470
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3567
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3660
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3831
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4007
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4049
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4189
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4328
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4479
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4480..4602
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..4731
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..4872
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5007
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5186
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5286
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5287..5500
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5501..5744
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
     exon            5745..6092
                     /gene="Chd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagctggg aaggaggctc tagatggcgg ctgtgcctta gagagagcgc gctttgctcc
       61 ctgcttcggt tcactttacg caactttccc taactttcgg gcagcctcag ggggcccccg
      121 cagccccctg cctctcctag tgacttactg gggtcgatcc gaaccttttt ttgggagaaa
      181 agctgctttt agaagctttc ttttcgtgcc ttgttggaag aagctgccgt attgagagcc
      241 caggtcgttg ttttttccag cttagaagcc atggcgcacc tccatttttg tgcgctctcc
      301 taatgaggtt tttttttccc cttccggacc tgttttagta ttaattattg ctttattttt
      361 tgacaagtca acatatttga ggattatttc atttactttt tggcttttaa cggaggattt
      421 tgcgttttta aaaatcattt tggatctgat atttttctac tactagatag gactcttgct
      481 ttggacatac tacatggatc agtaaatacc tgggcacagg acttcaaagc aaatacagat
      541 tccccctccc ccttaatatt taagaattaa aagatgatga gaaataagga caaaagccaa
      601 gaggaggaca gttcgctaca cagcaatgca tcgagtcatt cagcctctga agaagcttcg
      661 gcttcagact ctggcagtca gtctgaaagt gagcagggca gcgatcccgg aagtggacat
      721 ggcagcgagt ccaatagcag ttcggaatct tctgagagcc aatcagagtc tgagagtgaa
      781 tcagcaggtt ccaaatccca gccagtcctt ccagaagcca aagagaagcc tgcctctaag
      841 aaggaacgga tagctgatgt gaagaagatg tgggaagaat atcctgatgt ttatggggtt
      901 aggaggtcaa atcggagcag acaagaacca tcacgattta atattaagga agaggcaagt
      961 agcgggtctg agagtgggag tccgaaaaga agaggccaga ggcagctgaa aaaacaagaa
     1021 aaatggaagc aggacccctc agaagacgat caggaacagg gaagcagtgc agagagtgag
     1081 gcagagcaaa agaaagtaaa agctagaaga cccatcccta gaagaacagt gcccaaacct
     1141 caagttaaaa agcaacctaa gattcagcgt ggaaagagga aaaaacaaga gtcttcagat
     1201 gatgatgacg acgatgatga agctcccaaa aggcagactc gacgaagagc tgctaaaaat
     1261 gtgagttaca aagaagatga tgactttgag actgattcag atgatctcat tgaaatgact
     1321 ggagaaggag ttgatgaaca gcaagataat agtgaaacta ttgaaaaggt cttagattca
     1381 agactgggaa agaaaggagt tgacttgaat ccttttgcag ccactggagc gtctaccact
     1441 gtgtatgctg ttgaagctaa tggagatcct agcggtgact ttgacacgga gagggaagaa
     1501 ggtgaaatcc aataccttat caagtggaag ggctggtcgt atattcacag cacgtgggag
     1561 agtgaagaat ccttacaaca acagaaagta aagggcctaa aaaaactgga gaatttcaag
     1621 aagaaagagg acgagattaa gcaatggtta gggaaagttt ctcctgaaga tgttgaatat
     1681 ttcaattgcc aacaggagct ggcatcagag ttgaataaac agtatcagat agtagaaaga
     1741 gtaatagctg tgaagacaag taaatctgca ctgggccaaa cagattttcc agctcacagt
     1801 cggaagccag caccttcaaa tgagcctgaa tatctgtgca agtggatggg actgccctac
     1861 tcagagtgca gctgggaaga tgaagccttg attggaaaga aattccagag ttgtatcgac
     1921 agcttccaca gtcgaaacaa ctctaaaacc attcccacaa gagaatgcaa ggcactaaag
     1981 caaagaccac ggtttgtagc tttgaagaag caaccagcat acttaggagg agagaatctg
     2041 gagctccgag actatcagct ggagggtctc aactggcttg ctcactcctg gtgcaaaagt
     2101 aacagcgtaa tccttgctga tgaaatgggc ctaggaaaga ccatccagac catatcgttt
     2161 ctctcctacc tgttccatca gcaccagctc tacgggccct ttctcatagt tgtcccctta
     2221 tccaccctta cctcatggca gagagagttt gagatctggg caccggaggt taacgtcgtg
     2281 gtttacatag gtgacctgat gagcaggaac acgataaggg aatatgagtg gattcattct
     2341 caaaccaaaa ggttgaagtt caatgcactt ataacaacat atgagatcct attaaaagat
     2401 aagacggtgc tgggaagtat taactgggcc ttcctgggag tagatgaagc ccatcggttg
     2461 aagaatgatg actctttgtt gtataaaact ctgattgatt tcaagtccaa ccataggcta
     2521 ctgatcacgg gcacccctct tcagaattcc ctcaaggaac tttggtcctt gctgcacttt
     2581 attatgccgg agaagtttga gttctgggaa gattttgaag aagaccatgg aaaggggaga
     2641 gagaatggct accagagtct tcataaggta ctagagcctt ttcttcttcg aagagtcaaa
     2701 aaagatgtgg agaaatccct tcctgccaaa gtggaacaga ttctcagggt ggagatgtca
     2761 gcccttcaga aacagtatta taaatggatc ctgaccagga attacaaggc tcttgccaaa
     2821 ggaacgagag gcagcacgtc cggcttcctt aatattgtga tggagctgaa gaagtgctgc
     2881 aaccactgct acctgatcag agctcccgag gacagcgaaa gggagacggg ccaggaggtc
     2941 cttcagtctc taattaggag cagtgggaag ctgattctgt tagacaaact gttgacaaga
     3001 ctccgagaaa ggggaaacag agtccttatc ttctctcaga tggtgaggat gttggatatc
     3061 ctggctgagt acctgactat caaacattat cctttccagc gcctggatgg ttctatcaag
     3121 ggagaaatcc gaaaacaggc attggatcac ttcaatgcag atgggtctga ggacttctgc
     3181 ttcctgctct ccacacgggc tggcggcctg ggaatcaact tggcttcagc ggacacagtt
     3241 gtcatctttg actctgactg gaacccccag aacgacctgc aggcacaagc ccgagcacat
     3301 agaatcggtc agaagaagca ggtgaatatt taccgcctgg ttacgaaggg gactgtggaa
     3361 gaggaaatca tagaaagggc caaaaagaag atggtgttgg accatctggt gattcagcgc
     3421 atggatacta ctggcaggac agttcttgaa aacaactcag ggagatccaa ctcaaatcct
     3481 tttaataaag aagagctgac agctattttg aaatttggag cagaggatct cttcaaagaa
     3541 attgaaggag aggagtcaga gcctcaggaa atggatatag atgaaatttt gcgtttagct
     3601 gaaaccagag agaatgaagt gtcaactagt gcgacagatg agctgctatc acagtttaag
     3661 gttgccaact ttgcaacaat ggaagatgaa gaggagctag aagagcgtcc tcacaaggac
     3721 tgggatgaaa tcattcccga agagcagagg aaaaaagtgg aggaggaaga gcggcagaag
     3781 gagctggaag aaatttatat gctgcctcgg attcgcagtt ctactaaaaa ggctcagacc
     3841 aatgacagtg attctgacac tgagtctaag aggcaggccc agaggtcttc agcttctgag
     3901 agtgagacgg atgactctga cgatgataag aagccaaagc gcagagggcg cccccggagt
     3961 gtgcgcaaag acctcgtgga aggcttcacg gatgccgaga tcagaaggtt tatcaaggct
     4021 tataagaagt ttggtctccc tcttgaaagg ctagagtgca tagcacgtga tgctgagcta
     4081 gttgataagt ccgtggcaga cctgaaacgc ctaggggagc tggttcataa tagctgtgtg
     4141 tcagcaatgc aggagtatga ggaacagctg aaagaaaatg ccagcgaagg aaaaggacca
     4201 ggcaagagaa gaggcccgac aatcaagatc tctggggttc aggttaatgt gaagtccatt
     4261 atccaacatg aagaagagtt tgagatgctg cataaatcta tccctgtgga ccctgaggaa
     4321 aaaaaaaaat actgcttaac ctgccgagtc aaagcagcac attttgacgt cgagtggggc
     4381 gtggaggatg attctcgtct gttgcttgga atctatgaac atggctatgg aaattgggag
     4441 ctaattaaga cagaccctga gctaaagcta actgataaaa ttctaccagt ggagacagat
     4501 aagaagcctc agggaaagca gctgcagacc cgagtggact acttgctgaa actgctcagg
     4561 aagggtctgg agaagaaggg caccgtgacc agcggggaag aggccaaatt aaagaagcgg
     4621 aagcctcgag taaagaagga gaacaaagca cccaggctga aggatgagca tgggctggag
     4681 ctttcgtctc ctcgacactc tgacaacccc tctgaggaag gggaagtgaa ggatgatggt
     4741 ttagaaaaaa gtccaacgaa aaaaaagcag aagaagaaag agaacaaaga gaacaaagag
     4801 aaaccagtga gttctcggaa ggacagagaa ggagacaaag aaaagaagaa gtccaaggac
     4861 aagaaagaaa aggttaaagg tggtgatgcc aagtcttcaa gtaaatcaaa gcgatctcag
     4921 ggtcctgtcc acattacagc aggaagtgag cctgttccca ttggggagga tgaagatgat
     4981 gatctggacc aggaaacctt cagcatttgt aaggagagga tgaggcctgt gaagaaggca
     5041 ctgaaacagt tggacaaacc cgacaaggga ctcaatgtgc aagaacagct ggaacacacc
     5101 aggagctgcc tgctgaagat tggagaccgc atagctgagt gccttagagc ttattcagag
     5161 caggagcaca tcaaattgtg gaggaggaac ctatggattt ttgtttccaa gtttacagaa
     5221 tttgatgcac ggaaactaca taagttatat aagatggctc ataagaaaag atctcaagaa
     5281 gaggaggaac aaaagaagaa agatgatacg cttggtggta agaaaccatt tcgaccagag
     5341 gcctcgggct ccagccggga ctctctgata tctcagtccc atgcctcaca caaccttcat
     5401 cctcagaagc ctcatttgcc tgcctcccat ggcccacaga tgcatggaca tccaagagat
     5461 acctacagtc accccaacaa gagacacttt agtaatgcag atcgaggaga ctggcagagg
     5521 gaaagaaagt tcaactatgg cggcggtaat aatgccccct gggggggcga ccggcaccat
     5581 cagtatgagc agcactggta taaggaccac cactatggtg accggagaca tatggatgcc
     5641 caccgttctg gaagctaccg acccaacaac atgtccagaa agagaccata tgagcagtac
     5701 aacagtgacc gagaccaccg gggacacaga gactattatg acaggcacca tcatgactcc
     5761 aagcggagga ggtcagatga ctttaggccc cagaattacc accagcagga tttccgacga
     5821 atgtctgacc acagacccac catgggttac catggccagg gaccctcaga ccattaccgc
     5881 tctttccaca cagacaaatt gggggaatac aaacaaccca tgcctacatt gcacaccgcg
     5941 ctctcagacc ctcgctcccc ccctgcccag aaatctcccc atgattctaa gtcacccttg
     6001 gatcacaggt ctcctttgga gagatcacta gaacagaaaa acaacccaga ttataactgg
     6061 aatgttcgga agacataaag gacagctccg ga
//
