LOCUS       NP_001100993            1834 aa            linear   ROD 24-JUN-2024
DEFINITION  chromodomain-helicase-DNA-binding protein 2 [Rattus norvegicus].
ACCESSION   NP_001100993 XP_001058641 XP_218790
VERSION     NP_001100993.1
DBSOURCE    REFSEQ: accession NM_001107523.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1834)
  AUTHORS   Harada,A., Okada,S., Konno,D., Odawara,J., Yoshimi,T.,
            Yoshimura,S., Kumamaru,H., Saiwai,H., Tsubota,T., Kurumizaka,H.,
            Akashi,K., Tachibana,T., Imbalzano,A.N. and Ohkawa,Y.
  TITLE     Chd2 interacts with H3.3 to determine myogenic cell fate
  JOURNAL   EMBO J 31 (13), 2994-3007 (2012)
   PUBMED   22569126
REFERENCE   2  (residues 1 to 1834)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (residues 1 to 1834)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (residues 1 to 1834)
  AUTHORS   Nagarajan,P., Onami,T.M., Rajagopalan,S., Kania,S., Donnell,R. and
            Venkatachalam,S.
  TITLE     Role of chromodomain helicase DNA-binding protein 2 in DNA damage
            response signaling and tumorigenesis
  JOURNAL   Oncogene 28 (8), 1053-1062 (2009)
   PUBMED   19137022
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001058641.1, XP_218790.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     Protein         1..1834
                     /product="chromodomain-helicase-DNA-binding protein 2"
                     /EC_number="3.6.4.12"
                     /calculated_mol_wt=211546
     Region          259..350
                     /region_name="CD1_tandem_CHD1-2_like"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; cd18666"
                     /db_xref="CDD:349313"
     Site            order(261,318,320..321,325)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349313"
     Region          383..454
                     /region_name="CD2_tandem_CHD1-2_like"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 1 and 2, and
                     similar proteins; cd18661"
                     /db_xref="CDD:349308"
     Site            order(419,436)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349308"
     Region          471..707
                     /region_name="DEXHc_CHD2"
                     /note="DEAH-box helicase domain of the chromodomain
                     helicase DNA binding protein 2; cd18054"
                     /db_xref="CDD:350812"
     Region          475..>1028
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Site            order(518..524,558,624..625)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350812"
     Region          1137..1225
                     /region_name="CDH1_2_SANT_HL1"
                     /note="CDH1/2 SANT-Helical linker 1; pfam18375"
                     /db_xref="CDD:465731"
     Region          1478..1560
                     /region_name="DUF4208"
                     /note="Domain of unknown function (DUF4208); pfam13907"
                     /db_xref="CDD:464035"
     CDS             1..1834
                     /gene="Chd2"
                     /coded_by="NM_001107523.1:574..6078"
                     /db_xref="GeneID:308738"
                     /db_xref="RGD:1310056"
ORIGIN      
        1 mmrnkdksqe edsslhsnas shsaseeasa sdsgsqsese qgsdpgsghg sesnsssess
       61 esqseseses agsksqpvlp eakekpaskk eriadvkkmw eeypdvygvr rsnrsrqeps
      121 rfnikeeass gsesgspkrr gqrqlkkqek wkqdpseddq eqgssaesea eqkkvkarrp
      181 iprrtvpkpq vkkqpkiqrg krkkqessdd dddddeapkr qtrrraaknv sykedddfet
      241 dsddliemtg egvdeqqdns etiekvldsr lgkkgvdlnp faatgasttv yaveangdps
      301 gdfdtereeg eiqylikwkg wsyihstwes eeslqqqkvk glkklenfkk kedeikqwlg
      361 kvspedveyf ncqqelasel nkqyqiverv iavktsksal gqtdfpahsr kpapsnepey
      421 lckwmglpys ecswedeali gkkfqscids fhsrnnskti ptreckalkq rprfvalkkq
      481 paylggenle lrdyqlegln wlahswcksn svilademgl gktiqtisfl sylfhqhqly
      541 gpflivvpls tltswqrefe iwapevnvvv yigdlmsrnt ireyewihsq tkrlkfnali
      601 ttyeillkdk tvlgsinwaf lgvdeahrlk nddsllyktl idfksnhrll itgtplqnsl
      661 kelwsllhfi mpekfefwed feedhgkgre ngyqslhkvl epfllrrvkk dvekslpakv
      721 eqilrvemsa lqkqyykwil trnykalakg trgstsgfln ivmelkkccn hcyliraped
      781 seretgqevl qslirssgkl illdklltrl rergnrvlif sqmvrmldil aeyltikhyp
      841 fqrldgsikg eirkqaldhf nadgsedfcf llstragglg inlasadtvv ifdsdwnpqn
      901 dlqaqarahr igqkkqvniy rlvtkgtvee eiierakkkm vldhlviqrm dttgrtvlen
      961 nsgrsnsnpf nkeeltailk fgaedlfkei egeesepqem dideilrlae trenevstsa
     1021 tdellsqfkv anfatmedee eleerphkdw deiipeeqrk kveeeerqke leeiymlpri
     1081 rsstkkaqtn dsdsdteskr qaqrssases etddsdddkk pkrrgrprsv rkdlvegftd
     1141 aeirrfikay kkfglplerl eciardaelv dksvadlkrl gelvhnscvs amqeyeeqlk
     1201 enasegkgpg krrgptikis gvqvnvksii qheeefemlh ksipvdpeek kkycltcrvk
     1261 aahfdvewgv eddsrlllgi yehgygnwel iktdpelklt dkilpvetdk kpqgkqlqtr
     1321 vdyllkllrk glekkgtvts geeaklkkrk prvkkenkap rlkdehglel ssprhsdnps
     1381 eegevkddgl eksptkkkqk kkenkenkek pvssrkdreg dkekkkskdk kekvkggdak
     1441 ssskskrsqg pvhitagsep vpigededdd ldqetfsick ermrpvkkal kqldkpdkgl
     1501 nvqeqlehtr scllkigdri aeclrayseq ehiklwrrnl wifvskftef darklhklyk
     1561 mahkkrsqee eeqkkkddtl ggkkpfrpea sgssrdslis qshashnlhp qkphlpashg
     1621 pqmhghprdt yshpnkrhfs nadrgdwqre rkfnygggnn apwggdrhhq yeqhwykdhh
     1681 ygdrrhmdah rsgsyrpnnm srkrpyeqyn sdrdhrghrd yydrhhhdsk rrrsddfrpq
     1741 nyhqqdfrrm sdhrptmgyh gqgpsdhyrs fhtdklgeyk qpmptlhtal sdprsppaqk
     1801 sphdskspld hrsplersle qknnpdynwn vrkt
//
