LOCUS       NM_001013431            1367 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain
            containing 4 (Chchd4), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001013431 XM_232200
VERSION     NM_001013431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Wang,Y., Zeng,Z., Zeng,Z., Chu,G. and Shan,X.
  TITLE     Elevated CHCHD4 orchestrates mitochondrial oxidative
            phosphorylation to disturb hypoxic pulmonary hypertension
  JOURNAL   J Transl Med 21 (1), 464 (2023)
   PUBMED   37438854
  REMARK    GeneRIF: Elevated CHCHD4 orchestrates mitochondrial oxidative
            phosphorylation to disturb hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Petrungaro,C., Zimmermann,K.M., Kuttner,V., Fischer,M., Dengjel,J.,
            Bogeski,I. and Riemer,J.
  TITLE     The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer
            from MCU Regulates Mitochondrial Ca(2+) Uptake
  JOURNAL   Cell Metab 22 (4), 721-733 (2015)
   PUBMED   26387864
REFERENCE   3  (bases 1 to 1367)
  AUTHORS   Mordas,A. and Tokatlidis,K.
  TITLE     The MIA pathway: a key regulator of mitochondrial oxidative protein
            folding and biogenesis
  JOURNAL   Acc Chem Res 48 (8), 2191-2199 (2015)
   PUBMED   26214018
REFERENCE   4  (bases 1 to 1367)
  AUTHORS   Hangen,E., Feraud,O., Lachkar,S., Mou,H., Doti,N., Fimia,G.M.,
            Lam,N.V., Zhu,C., Godin,I., Muller,K., Chatzi,A., Nuebel,E.,
            Ciccosanti,F., Flamant,S., Benit,P., Perfettini,J.L., Sauvat,A.,
            Bennaceur-Griscelli,A., Ser-Le Roux,K., Gonin,P., Tokatlidis,K.,
            Rustin,P., Piacentini,M., Ruvo,M., Blomgren,K., Kroemer,G. and
            Modjtahedi,N.
  TITLE     Interaction between AIF and CHCHD4 Regulates Respiratory Chain
            Biogenesis
  JOURNAL   Mol Cell 58 (6), 1001-1014 (2015)
   PUBMED   26004228
REFERENCE   5  (bases 1 to 1367)
  AUTHORS   Zhuang,J., Wang,P.Y., Huang,X., Chen,X., Kang,J.G. and Hwang,P.M.
  TITLE     Mitochondrial disulfide relay mediates translocation of p53 and
            partitions its subcellular activity
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17356-17361 (2013)
   PUBMED   24101517
REFERENCE   6  (bases 1 to 1367)
  AUTHORS   Fischer,M., Horn,S., Belkacemi,A., Kojer,K., Petrungaro,C.,
            Habich,M., Ali,M., Kuttner,V., Bien,M., Kauff,F., Dengjel,J.,
            Herrmann,J.M. and Riemer,J.
  TITLE     Protein import and oxidative folding in the mitochondrial
            intermembrane space of intact mammalian cells
  JOURNAL   Mol Biol Cell 24 (14), 2160-2170 (2013)
   PUBMED   23676665
REFERENCE   7  (bases 1 to 1367)
  AUTHORS   Banci,L., Bertini,I., Cefaro,C., Cenacchi,L., Ciofi-Baffoni,S.,
            Felli,I.C., Gallo,A., Gonnelli,L., Luchinat,E., Sideris,D. and
            Tokatlidis,K.
  TITLE     Molecular chaperone function of Mia40 triggers consecutive induced
            folding steps of the substrate in mitochondrial protein import
  JOURNAL   Proc Natl Acad Sci U S A 107 (47), 20190-20195 (2010)
   PUBMED   21059946
REFERENCE   8  (bases 1 to 1367)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   9  (bases 1 to 1367)
  AUTHORS   Banci,L., Bertini,I., Cefaro,C., Ciofi-Baffoni,S., Gallo,A.,
            Martinelli,M., Sideris,D.P., Katrakili,N. and Tokatlidis,K.
  TITLE     MIA40 is an oxidoreductase that catalyzes oxidative protein folding
            in mitochondria
  JOURNAL   Nat Struct Mol Biol 16 (2), 198-206 (2009)
   PUBMED   19182799
REFERENCE   10 (bases 1 to 1367)
  AUTHORS   Hofmann,S., Rothbauer,U., Muhlenbein,N., Baiker,K., Hell,K. and
            Bauer,M.F.
  TITLE     Functional and mutational characterization of human MIA40 acting
            during import into the mitochondrial intermembrane space
  JOURNAL   J Mol Biol 353 (3), 517-528 (2005)
   PUBMED   16185709
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091407.1.
            
            On Apr 20, 2005 this sequence version replaced XM_232200.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091407.1, FQ229282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1367
                     /gene="Chchd4"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 4"
                     /db_xref="GeneID:312559"
                     /db_xref="RGD:1310746"
     exon            1..196
                     /gene="Chchd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..594
                     /gene="Chchd4"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 4"
                     /codon_start=1
                     /product="mitochondrial intermembrane space import and
                     assembly protein 40"
                     /protein_id="NP_001013449.1"
                     /db_xref="GeneID:312559"
                     /db_xref="RGD:1310746"
                     /translation="MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLIL
                     PNGDINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEDIKGSDCIDQFRAMQECMQKYP
                     DLYPQDEEEEEEAKPVEPVEETADTKASAAKEQGASS"
     exon            197..295
                     /gene="Chchd4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..1343
                     /gene="Chchd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttaggacg agcggaggca ggcgcgcggc gggcaggcct ggagggggcg ggtccgtgtg
       61 ggcctcagtg ccacccgcca ggcctgagaa gaggcgaggg aggtcacaac gagaaggtgt
      121 agccgctgta gccgcgcctg ctccctctgc gagctgggaa cgttgagaac aaccatgtcc
      181 tactgccggc aggaagggaa ggatcggatc atatttgtga ccaaagaaga ccatgaaact
      241 cctagcagtg ctgagctggt ggctgatgac cccaatgatc cctatgaaga gcacgggttg
      301 atactgccta atggagacat taactggaat tgcccatgtc ttgggggaat ggccagcggc
      361 ccctgtgggg agcagttcaa gtctgccttt tcctgcttcc actacagcac agaggatatc
      421 aagggatcag actgtataga ccagttccgg gccatgcagg aatgcatgca gaaataccca
      481 gacctctatc cccaagacga ggaggaggaa gaggaggcaa agccagtgga accagtggag
      541 gaaacggctg acactaaggc ctctgcagcc aaagagcagg gggcaagctc ctgaaggcct
      601 caggccctgg ctgccactca ccatgggact ttctatacaa tgccttttgg tcacctctgt
      661 gaaagttctt tccctctgtg cactgtaata tacaaaataa cttattttaa taatcagggg
      721 tcttggctac ttgccgtata cactgaagaa aagggggtgt gtgcacctgt gtcctgcata
      781 aacctgtcct taaacgttag gccactcctg gatgtactct gtgattgccc tggattttgc
      841 cactttgaaa taatgtgctg aggcttctca gcaaccaaaa gttgttactc aggaaagttt
      901 accgtgagaa agctgattta ttctggtcca tggtatgtat tccttttggt agatttttca
      961 cctcttggga aaattaagta agtagatgcc aaaactctta agagtaggtc catccctact
     1021 ggaagaggct ggtggtcagg tactggagct ggaggatgag gctgctgcct cgttcctgac
     1081 agctatgttt ctgtgtttgc agtccaggct ccagggccta cagctgcagg gtgggattgg
     1141 actctgtgac tcccagtccc tcctaagtga aaggagaggc tggctttgca gtttattgtt
     1201 ttcctgttct gagagccctg gtttggggcc catgttcact cagttgtgat attgaggtgg
     1261 ggacctagct gcttccagag cagaagccaa cagaggaatg tctgaatgaa gtactcaatt
     1321 aaagagaaac aatttctatc tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
