LOCUS       NM_001007008             640 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain
            containing 10 (Chchd10), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001007008 XM_342118
VERSION     NM_001007008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 640)
  AUTHORS   Genin,E.C., Bannwarth,S., Lespinasse,F., Ortega-Vila,B.,
            Fragaki,K., Itoh,K., Villa,E., Lacas-Gervais,S., Jokela,M.,
            Auranen,M., Ylikallio,E., Mauri-Crouzet,A., Tyynismaa,H.,
            Vihola,A., Auge,G., Cochaud,C., Sesaki,H., Ricci,J.E., Udd,B.,
            Vives-Bauza,C. and Paquis-Flucklinger,V.
  TITLE     Loss of MICOS complex integrity and mitochondrial damage, but not
            TDP-43 mitochondrial localisation, are likely associated with
            severity of CHCHD10-related diseases
  JOURNAL   Neurobiol Dis 119, 159-171 (2018)
   PUBMED   30092269
REFERENCE   2  (bases 1 to 640)
  AUTHORS   Woo,J.A., Liu,T., Trotter,C., Fang,C.C., De Narvaez,E.,
            LePochat,P., Maslar,D., Bukhari,A., Zhao,X., Deonarine,A.,
            Westerheide,S.D. and Kang,D.E.
  TITLE     Loss of function CHCHD10 mutations in cytoplasmic TDP-43
            accumulation and synaptic integrity
  JOURNAL   Nat Commun 8, 15558 (2017)
   PUBMED   28585542
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 640)
  AUTHORS   Genin,E.C., Plutino,M., Bannwarth,S., Villa,E.,
            Cisneros-Barroso,E., Roy,M., Ortega-Vila,B., Fragaki,K.,
            Lespinasse,F., Pinero-Martos,E., Auge,G., Moore,D., Burte,F.,
            Lacas-Gervais,S., Kageyama,Y., Itoh,K., Yu-Wai-Man,P., Sesaki,H.,
            Ricci,J.E., Vives-Bauza,C. and Paquis-Flucklinger,V.
  TITLE     CHCHD10 mutations promote loss of mitochondrial cristae junctions
            with impaired mitochondrial genome maintenance and inhibition of
            apoptosis
  JOURNAL   EMBO Mol Med 8 (1), 58-72 (2016)
   PUBMED   26666268
REFERENCE   4  (bases 1 to 640)
  AUTHORS   Bannwarth,S., Ait-El-Mkadem,S., Chaussenot,A., Genin,E.C.,
            Lacas-Gervais,S., Fragaki,K., Berg-Alonso,L., Kageyama,Y.,
            Serre,V., Moore,D.G., Verschueren,A., Rouzier,C., Le Ber,I.,
            Auge,G., Cochaud,C., Lespinasse,F., N'Guyen,K., de Septenville,A.,
            Brice,A., Yu-Wai-Man,P., Sesaki,H., Pouget,J. and
            Paquis-Flucklinger,V.
  TITLE     A mitochondrial origin for frontotemporal dementia and amyotrophic
            lateral sclerosis through CHCHD10 involvement
  JOURNAL   Brain 137 (Pt 8), 2329-2345 (2014)
   PUBMED   24934289
REFERENCE   5  (bases 1 to 640)
  AUTHORS   Martherus,R.S., Sluiter,W., Timmer,E.D., VanHerle,S.J., Smeets,H.J.
            and Ayoubi,T.A.
  TITLE     Functional annotation of heart enriched mitochondrial genes GBAS
            and CHCHD10 through guilt by association
  JOURNAL   Biochem Biophys Res Commun 402 (2), 203-208 (2010)
   PUBMED   20888800
REFERENCE   6  (bases 1 to 640)
  AUTHORS   Kocher,O., Yesilaltay,A., Cirovic,C., Pal,R., Rigotti,A. and
            Krieger,M.
  TITLE     Targeted disruption of the PDZK1 gene in mice causes
            tissue-specific depletion of the high density lipoprotein receptor
            scavenger receptor class B type I and altered lipoprotein
            metabolism
  JOURNAL   J Biol Chem 278 (52), 52820-52825 (2003)
   PUBMED   14551195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082751.1.
            
            On Nov 22, 2004 this sequence version replaced XM_342118.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082751.1, FQ216195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155312, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..640
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 10"
                     /db_xref="GeneID:361824"
                     /db_xref="RGD:1359417"
     exon            1..99
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..475
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /note="Nur77 downstream gene 2"
                     /codon_start=1
                     /product="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 10, mitochondrial"
                     /protein_id="NP_001007009.1"
                     /db_xref="GeneID:361824"
                     /db_xref="RGD:1359417"
                     /translation="MPRGSRSAAARPASRPAHPPAHPPPSAPAPAPATSGQPGLMAQM
                     ASTAAGVAVGSAVGHVMGSALTSAFSGGSSEPAQPAVQQAPARPASHPLQMGPCAYEI
                     KQFLDCSTTQSDLTLCEGFSEALKQCKYNHGLSSLP"
     exon            100..307
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..455
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..619
                     /gene="Chchd10"
                     /gene_synonym="Ndg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcgtctg ccacggtcca cgcttcttac tcatctccat cttgatccca ccgctgtcat
       61 gccacgagga agccgcagtg cggctgccag gccggccagc cgcccagccc atcctcctgc
      121 gcacccacca ccctcagccc ccgcccccgc acctgccacc tcgggacagc cgggtcttat
      181 ggctcagatg gcatccaccg ccgcgggcgt agctgtgggc tcagctgtag ggcatgtcat
      241 gggtagcgcc ctgaccagtg ccttcagtgg gggaagctca gagcctgccc agcctgcggt
      301 ccagcaggcc cctgcccgtc ctgcctctca ccccctgcag atggggccct gcgcctatga
      361 gatcaagcag ttcctggact gctccaccac tcagagcgac ctaaccctgt gtgagggctt
      421 cagtgaggcc ctcaaacagt gcaaatacaa tcacggtctg agctccctac cctgaagagg
      481 ctgtgggctt gctcgtagcc taacccctca ccgacagttt gatggcgaag agacggtcct
      541 tgtgcgtaag gaaggacagt tctcaccccg cagaataaca ggagacagaa atgttcaatt
      601 aaaaagagtt tactttagaa aaaaaaaaaa aaaaaaaaaa
//
