LOCUS       NM_001173437            1569 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus ChaC glutathione-specific
            gamma-glutamylcyclotransferase 1 (Chac1), mRNA.
ACCESSION   NM_001173437 XM_001080834 XM_342497
VERSION     NM_001173437.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1569)
  AUTHORS   Li,H., Ma,J., Fang,Q., Li,H., Shen,H., Li,X., Xue,Q., Zhu,J. and
            Chen,G.
  TITLE     Botch protects neurons from ischemic insult by antagonizing
            Notch-mediated neuroinflammation
  JOURNAL   Exp Neurol 321, 113028 (2019)
   PUBMED   31377404
  REMARK    GeneRIF: we found that Botch exerts neuroprotective effects via
            antagonizing the maturation of Notch1-induced neuronal injury and
            neuroinflammation after cerebral ischemia-reperfusion (I/R) injury
REFERENCE   2  (bases 1 to 1569)
  AUTHORS   Chi,Z., Zhang,J., Tokunaga,A., Harraz,M.M., Byrne,S.T., Dolinko,A.,
            Xu,J., Blackshaw,S., Gaiano,N., Dawson,T.M. and Dawson,V.L.
  TITLE     Botch promotes neurogenesis by antagonizing Notch
  JOURNAL   Dev Cell 22 (4), 707-720 (2012)
   PUBMED   22445366
REFERENCE   3  (bases 1 to 1569)
  AUTHORS   Dai,C., Liang,D., Li,H., Sasaki,M., Dawson,T.M. and Dawson,V.L.
  TITLE     Functional identification of neuroprotective molecules
  JOURNAL   PLoS One 5 (11), e15008 (2010)
   PUBMED   21124846
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1569)
  AUTHORS   Mungrue,I.N., Pagnon,J., Kohannim,O., Gargalovic,P.S. and
            Lusis,A.J.
  TITLE     CHAC1/MGC4504 is a novel proapoptotic component of the unfolded
            protein response, downstream of the ATF4-ATF3-CHOP cascade
  JOURNAL   J Immunol 182 (1), 466-476 (2009)
   PUBMED   19109178
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF688602.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001080834.2, XM_342497.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF688602.1, CB545266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Crl:CD(SD)"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1569
                     /gene="Chac1"
                     /gene_synonym="RGD1307153"
                     /note="ChaC glutathione-specific
                     gamma-glutamylcyclotransferase 1"
                     /db_xref="GeneID:362196"
                     /db_xref="RGD:1307153"
     exon            1..417
                     /gene="Chac1"
                     /gene_synonym="RGD1307153"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..855
                     /gene="Chac1"
                     /gene_synonym="RGD1307153"
                     /EC_number="4.3.2.7"
                     /note="neuroprotective protein 7; ChaC, cation transport
                     regulator-like 1; cation transport regulator homolog 1;
                     cation transport regulator-like protein 1; botch; blocks
                     Notch protein; ChaC, cation transport regulator homolog 1;
                     gamma-GCG 1"
                     /codon_start=1
                     /product="glutathione-specific
                     gamma-glutamylcyclotransferase 1"
                     /protein_id="NP_001166908.1"
                     /db_xref="GeneID:362196"
                     /db_xref="RGD:1307153"
                     /translation="MKQESAAQSTPPPSLSPAPSAQPSWEDGDPQALWIFGYGSLVWK
                     PDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVRGE
                     QVSEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEV
                     IATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGSLLPCSYLSEQP
                     LALI"
     exon            418..453
                     /gene="Chac1"
                     /gene_synonym="RGD1307153"
                     /inference="alignment:Splign:2.1.0"
     exon            454..1569
                     /gene="Chac1"
                     /gene_synonym="RGD1307153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggacagc tggaggcagt cagagggcct tcctggccgg agggtttaaa gagcgcctct
       61 ggagggacca ctcagctgga acgaccgatc ggtgccaggc caggtgtacg cgtccgtcgg
      121 tccttccgtg cccgtgccgg agaccagccc cggaggccgc ccgggcccgt ccctgcgccc
      181 ggcaccatga agcaggagtc cgcagcccag agcaccccgc ctccttcact gtcccctgca
      241 ccatccgcgc agccttcctg ggaggatggc gacccccaag ccctgtggat tttcgggtac
      301 ggctccctag tgtggaagcc tgactttgcc tacagcgaca gccgtgtggg cttcgtacgt
      361 ggctatagcc gacggttctg gcagggagac accttccaca ggggcagcga taagatgcct
      421 ggccgagtgg tgaccctcct tgaagatcat gagggctgca cttggggtgt ggcataccag
      481 gttcgagggg agcaggtgag cgaggcactg aagtacctga acgtgagaga agctgtgctt
      541 ggtggctacg acactaagga agtcaccttt tatcctcaag acacccctga ccaacccctc
      601 acagcactgg cctatgtggc caccccacag aaccctggct acctgggccc tgctcccgaa
      661 gaggtcattg ccacacagat ccttgcttgc cgaggcttct ctggccacaa ccttgaatac
      721 ttgttgcgtt tggcagactt catgcagctc tgtgggcctc aggcacaaga tgagcacctg
      781 gaagccatcg tggatgccgt aggaagcttg ctgccctgct cttacctctc tgagcagcct
      841 ctggcactga tctgaggagc ctagctcctg caaggagtgt ccggtggata ctggtggaca
      901 tcagcatgca gtacttgaga tagacttgat ggacctagag aaagctgaga aggcatggcg
      961 ggtggccagg ggactttgtg tcttataccc ctgcctgctt actagcctcc aactcttcct
     1021 tcattgaccc tgacttatta cttgaaactt tatttattgc accatgttgg tgtggtgggc
     1081 agggcaggtg ggggacctgc cctggatgtg ggccctgctg tgcggtggct ctgccctagt
     1141 cctctggtac caaccagaat ccccccaccc ccattgctgc tgctaatccc acactaccca
     1201 ggcccccaca gccccaggga gcctccaaga gccttgatcc tctgtccacc cagagtaccc
     1261 caaccctggt aacatcacct gcccatgttc ctggcctttt ggatgaggga gagcagagaa
     1321 ggaggcgaag tagctcttca aggaccaagg tccagcatcc ctcgtcattg accgagtcca
     1381 gggcagagct ggatcctatg cacagacaca gcatccccat gttttcattt ccttatccct
     1441 ctgtctgtct gcttgtttgt ctggatcact tcctatagac ccattgatct gttcctggga
     1501 aatgtcacta caggtccttg tctgttctcc gttgacccac actgtcatcc ataaactatc
     1561 tttaattac
//
