LOCUS       NM_001025415            1341 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus cholesterol 25-hydroxylase (Ch25h), mRNA.
ACCESSION   NM_001025415 XM_220063
VERSION     NM_001025415.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Fan,D., Geng,Q., Wang,B., Wang,X., Xia,Y., Yang,L., Zhang,Q.,
            Deng,T., Xu,Y., Zhao,H., Liu,B., Lu,C., Gu,X. and Xiao,C.
  TITLE     Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H
  JOURNAL   Clin Immunol 261, 109929 (2024)
   PUBMED   38331303
  REMARK    GeneRIF: Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H.
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Yi,T., Wang,X., Kelly,L.M., An,J., Xu,Y., Sailer,A.W.,
            Gustafsson,J.A., Russell,D.W. and Cyster,J.G.
  TITLE     Oxysterol gradient generation by lymphoid stromal cells guides
            activated B cell movement during humoral responses
  JOURNAL   Immunity 37 (3), 535-548 (2012)
   PUBMED   22999953
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Lukyanenko,Y., Chen,J.J. and Hutson,J.C.
  TITLE     Testosterone regulates 25-hydroxycholesterol production in
            testicular macrophages
  JOURNAL   Biol Reprod 67 (5), 1435-1438 (2002)
   PUBMED   12390873
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Chen,J.J., Lukyanenko,Y. and Hutson,J.C.
  TITLE     25-hydroxycholesterol is produced by testicular macrophages during
            the early postnatal period and influences differentiation of Leydig
            cells in vitro
  JOURNAL   Biol Reprod 66 (5), 1336-1341 (2002)
   PUBMED   11967195
REFERENCE   5  (bases 1 to 1341)
  AUTHORS   Lukyanenko,Y.O., Chen,J.J. and Hutson,J.C.
  TITLE     Production of 25-hydroxycholesterol by testicular macrophages and
            its effects on Leydig cells
  JOURNAL   Biol Reprod 64 (3), 790-796 (2001)
   PUBMED   11207193
REFERENCE   6  (bases 1 to 1341)
  AUTHORS   Lund,E.G., Kerr,T.A., Sakai,J., Li,W.P. and Russell,D.W.
  TITLE     cDNA cloning of mouse and human cholesterol 25-hydroxylases,
            polytopic membrane proteins that synthesize a potent oxysterol
            regulator of lipid metabolism
  JOURNAL   J Biol Chem 273 (51), 34316-34327 (1998)
   PUBMED   9852097
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097964.1.
            
            On Jul 15, 2005 this sequence version replaced XM_220063.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC097964.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..1341
                     /gene="Ch25h"
                     /note="cholesterol 25-hydroxylase"
                     /db_xref="GeneID:309527"
                     /db_xref="RGD:1310575"
     exon            1..1319
                     /gene="Ch25h"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..902
                     /gene="Ch25h"
                     /EC_number="1.14.99.38"
                     /note="cholesterol 25-monooxygenase"
                     /codon_start=1
                     /product="cholesterol 25-hydroxylase"
                     /protein_id="NP_001020586.1"
                     /db_xref="GeneID:309527"
                     /db_xref="RGD:1310575"
                     /translation="MACHNVSELQDLGCSNQLLLQPLWDSIRTGEASARSPFFPVIFS
                     IFTYLGFCLPFVVLDVLCPWVPILRRYKIHPDFSPSVRQLLPCLGLTLYQHLVFVFPV
                     TLMHWARSPALLPREAPELSQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVH
                     HQNSSSFALATQYMSVWELLSLTFFDVLNVAMLQCHPLTILVFHVVNIWLSVEDHSGY
                     DFPWSTHRLVPFGWYGGVAHHDLHHSQFNCNFAPYFTHWDKMLGTLRCAPHSKRLCAG
                     SESCLDSGEQCTVHLNQKKKQT"
ORIGIN      
        1 tcagcatggc ctgccacaac gtttcggagc tccaagacct tggttgttcc aaccagctgc
       61 tcctgcagcc tctctgggac agcataagga cgggagaggc gtccgcgcgc tcacccttct
      121 tcccagtcat cttttctatc ttcacttacc tgggcttctg cctaccgttc gtggtgctag
      181 atgtcctctg tccctgggtg cccatcttga gacgctacaa gatccacccg gacttctcgc
      241 cgtccgtaag gcagcttctg ccctgcctgg ggctgacact ctaccagcac ctggtgttcg
      301 tgttcccagt gacgctgatg cactgggcgc gcagccccgc gctgctgccg cgggaggccc
      361 ccgagctctc ccagctcctg agtcacgtcc tgatctgcct gctgctcttc gacaccgaga
      421 tcttcgcgtg gcatctgctg caccataagg tgccctggct gtaccgcacc ttccacaagg
      481 tgcatcacca gaactcgtcc tccttcgcgt tggctaccca atacatgagc gtctgggagc
      541 tgctttctct gaccttcttc gatgtgctga acgtcgcgat gcttcagtgt cacccactca
      601 ccatcctcgt ctttcacgtg gttaacatct ggctgtcggt ggaggaccac tcaggttacg
      661 actttccgtg gtccactcac agacttgtgc cgtttggctg gtacgggggc gtggctcacc
      721 acgacctgca tcactctcag tttaactgca actttgctcc gtacttcaca cactgggaca
      781 aaatgctggg gaccctgcgt tgcgcacccc actcgaagcg cctgtgtgcc ggcagtgaga
      841 gctgcttgga ctccggagag caatgtactg tacacttgaa ccagaagaag aaacagactt
      901 gagttatttt ttcagaagtt agtacatttt taagtgatga acactgctat aaaatctaat
      961 gtgtttctgc agcccgacaa agtaatttat ataatgttta tatatgaatt taattgtggt
     1021 cttgatgtca aattccaact cgtcccagtg tccttgactt caggacacaa gttagacatt
     1081 ctctagaatg gtttgtttgt agaaccaaga ctttcctatg tatgaaactg cactggaaca
     1141 gggctaatca cgcatgttga tggaagacct gatgtctgac tctttaaaat aatcaaattt
     1201 gttcctgctg ggcagtgatc aagattatag tatatttttt ctatttttga gcaaaatgat
     1261 atatttatat tgaaagaatt tttattcgta ttttaaaaat aaaaagaaca tgaactaaaa
     1321 aaaaaaaaaa aaaaaaaaaa a
//
