LOCUS       NM_139087               1349 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cell growth regulator with EF hand domain 1
            (Cgref1), mRNA.
ACCESSION   NM_139087
VERSION     NM_139087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Devnath,S., Kataoka,T., Miura,K., Kusuda,M., Kitamura,K.,
            Kumada,Y., Mochiduki,A., Kaneko,K., Adachi,A. and Inoue,K.
  TITLE     Cgr11 encodes a secretory protein involved in cell adhesion
  JOURNAL   Eur J Cell Biol 88 (9), 521-529 (2009)
   PUBMED   19473726
  REMARK    GeneRIF: Cgr11 encodes a secretory protein involved in cell
            adhesion
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Madden,S.L., Galella,E.A., Riley,D., Bertelsen,A.H. and
            Beaudry,G.A.
  TITLE     Induction of cell growth regulatory genes by p53
  JOURNAL   Cancer Res 56 (23), 5384-5390 (1996)
   PUBMED   8968090
  REMARK    GeneRIF: CGR11 appears to be a primary response gene expressed to
            moderate levels in functional p53 cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM040765.1, U66470.1 and BI279285.1.
            
            On May 13, 2009 this sequence version replaced NM_139087.1.
            
            Sequence Note: This RefSeq record was created from mixed strain
            transcript data because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220335.1, U66470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               FM040765.1         1-457
            458-1036            U66470.1           379-957
            1037-1349           BI279285.1         1-313               c
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1349
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /note="cell growth regulator with EF hand domain 1"
                     /db_xref="GeneID:245918"
                     /db_xref="RGD:620801"
     exon            1..121
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..984
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /note="hydrophobestin; cell growth regulatory gene 11
                     protein; cell growth regulatory with EF-hand domain"
                     /codon_start=1
                     /product="cell growth regulator with EF hand domain
                     protein 1"
                     /protein_id="NP_620787.2"
                     /db_xref="GeneID:245918"
                     /db_xref="RGD:620801"
                     /translation="MATWSGPGEGWLPAAGRGRRGAYNAHEAGAPDAHSAAAAAPVFS
                     RMSRWLMQMLMLPLLLLPLGQAAPKDGVARLDPEAQQQLTTNPFQPGPEQLRRLRDYL
                     KGLEKMEEDPEQMNREQVLLYLFALHDFDQNGQLDGLELLSMLTAALAPGAAHFPINP
                     VILVVDMVLETQDLDGDGLMTPAELINFPGEAPKRAESLPPALQEPQPAGSQPLLANS
                     PLQSETQQSLGTKEEITSQVEAKRALEPEQEAGHHIETKVDALSPEGEARGQAESEGD
                     APGPREDAERQVESKDNEGEAKDLPAETLETQNTPNVVEAHSIQLENDEI"
     exon            122..224
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            225..290
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            291..361
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            362..483
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1334
                     /gene="Cgref1"
                     /gene_synonym="Cgr11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatggcca cgtggagcgg cccgggggag ggctggctgc cggcagccgg gcgagggcgg
       61 cgcggtgcct ataacgcgca cgaagccgga gccccagacg cgcacagcgc cgccgcagca
      121 gctccggtgt tcagcaggat gtcccggtgg ctaatgcaaa tgttgatgct gcccctattg
      181 ctgctccctt tgggtcaagc tgcccccaag gatggagttg caaggctgga ccctgaggca
      241 caacagcagc tcacaaccaa ccccttccag ccaggccctg agcagctccg acgtctgcgg
      301 gattatctca agggactgga gaagatggaa gaggaccctg aacaaatgaa ccgggagcaa
      361 gtcctgctat atctctttgc tcttcacgac tttgaccaga acggacaact ggacggcctg
      421 gaactcttgt ccatgctgac agcagctctg gcccctggag ctgcacactt ccccatcaac
      481 ccggtgatcc tggtagtaga catggtgctt gagactcagg acctggatgg agacgggctc
      541 atgactcctg cagagctcat caacttccca ggagaagccc ccaagcgcgc agagtccctt
      601 cccccagctc tccaggagcc acaacctgcc ggaagtcagc cgcttttagc caacagtccg
      661 ctgcaatcag aaacccagca atccctgggg actaaagaag aaattacaag tcaggtagag
      721 gccaaaaggg ccttggagcc tgaacaggag gctggacatc acatagagac taaagtagat
      781 gctctaagcc ctgaagggga ggctaggggt caggcagagt ctgaaggaga tgccccaggt
      841 ccccgagagg atgctgagag acaggtggag agcaaggaca acgaagggga agccaaagac
      901 ctgccagcgg aaacactaga gacccaaaac actccaaatg tggttgaggc tcatagcatc
      961 caactggaaa acgacgagat atgagctaga cacacaggct catgcccctc aggatctcag
     1021 tgcagaacag aagcatgaag tgtgaataca gtgggtctgg agccacctct gacatgggta
     1081 tggtggtcca agctcgtact cccagaagca ctgagagctc caggctagcc taggccactt
     1141 agcaagtttg aagccaggct gggctacttc gtgaggccct gtcttgagga ggggaaaaga
     1201 aacgcactcc cacgtctcct ttctggcctc agtaggaagc aggactttct tcgcagctca
     1261 gggagaccac aagctgagag gcagatttca ggccccaaac aatcaataaa aaacaaaatg
     1321 gatttgtctc cataaaaaaa aaaaaaaaa
//
