LOCUS       NM_001389277            6771 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cingulin-like 1 (Cgnl1), transcript variant 2,
            mRNA.
ACCESSION   NM_001389277 XM_006243355
VERSION     NM_001389277.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6771)
  AUTHORS   Tornavaca,O., Chia,M., Dufton,N., Almagro,L.O., Conway,D.E.,
            Randi,A.M., Schwartz,M.A., Matter,K. and Balda,M.S.
  TITLE     ZO-1 controls endothelial adherens junctions, cell-cell tension,
            angiogenesis, and barrier formation
  JOURNAL   J Cell Biol 208 (6), 821-838 (2015)
   PUBMED   25753039
REFERENCE   2  (bases 1 to 6771)
  AUTHORS   Guillemot,L., Schneider,Y., Brun,P., Castagliuolo,I., Pizzuti,D.,
            Martines,D., Jond,L., Bongiovanni,M. and Citi,S.
  TITLE     Cingulin is dispensable for epithelial barrier function and tight
            junction structure, and plays a role in the control of claudin-2
            expression and response to duodenal mucosa injury
  JOURNAL   J Cell Sci 125 (Pt 21), 5005-5014 (2012)
   PUBMED   22946046
REFERENCE   3  (bases 1 to 6771)
  AUTHORS   Elbediwy,A., Zihni,C., Terry,S.J., Clark,P., Matter,K. and
            Balda,M.S.
  TITLE     Epithelial junction formation requires confinement of Cdc42
            activity by a novel SH3BP1 complex
  JOURNAL   J Cell Biol 198 (4), 677-693 (2012)
   PUBMED   22891260
REFERENCE   4  (bases 1 to 6771)
  AUTHORS   Pulimeno,P., Paschoud,S. and Citi,S.
  TITLE     A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and
            adherens junctions of epithelial cells
  JOURNAL   J Biol Chem 286 (19), 16743-16750 (2011)
   PUBMED   21454477
  REMARK    GeneRIF: ZO-1 and PLEKHA7 are paracingulin-interacting proteins
            that are involved in its recruitment to epithelial tight and
            adherens junctions, respectively
REFERENCE   5  (bases 1 to 6771)
  AUTHORS   Ohnishi,H., Nakahara,T., Furuse,K., Sasaki,H., Tsukita,S. and
            Furuse,M.
  TITLE     JACOP, a novel plaque protein localizing at the apical junctional
            complex with sequence similarity to cingulin
  JOURNAL   J Biol Chem 279 (44), 46014-46022 (2004)
   PUBMED   15292197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 8, 2020 this sequence version replaced XM_006243355.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.787866.1,
                                           SRR26643287.20536.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000008.1  81305504-81305597   c
            95-1684             JAXUCZ010000008.1  81258982-81260571   c
            1685-1779           JAXUCZ010000008.1  81257933-81258027   c
            1780-1885           JAXUCZ010000008.1  81256273-81256378   c
            1886-1987           JAXUCZ010000008.1  81249198-81249299   c
            1988-2136           JAXUCZ010000008.1  81248229-81248377   c
            2137-2272           JAXUCZ010000008.1  81247082-81247217   c
            2273-2485           JAXUCZ010000008.1  81237912-81238124   c
            2486-2692           JAXUCZ010000008.1  81185217-81185423   c
            2693-2797           JAXUCZ010000008.1  81184446-81184550   c
            2798-2950           JAXUCZ010000008.1  81180398-81180550   c
            2951-3121           JAXUCZ010000008.1  81179379-81179549   c
            3122-3283           JAXUCZ010000008.1  81175558-81175719   c
            3284-3373           JAXUCZ010000008.1  81171846-81171935   c
            3374-3457           JAXUCZ010000008.1  81160317-81160400   c
            3458-3582           JAXUCZ010000008.1  81159430-81159554   c
            3583-3691           JAXUCZ010000008.1  81158470-81158578   c
            3692-3855           JAXUCZ010000008.1  81158117-81158280   c
            3856-6771           JAXUCZ010000008.1  81154169-81157084   c
FEATURES             Location/Qualifiers
     source          1..6771
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..6771
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /note="cingulin-like 1"
                     /db_xref="GeneID:315795"
                     /db_xref="RGD:1304623"
     exon            1..94
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            95..1684
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3988
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /codon_start=1
                     /product="cingulin-like protein 1"
                     /protein_id="NP_001376206.1"
                     /db_xref="GeneID:315795"
                     /db_xref="RGD:1304623"
                     /translation="MELYFGEYQHVQQEYGVHLRLASDGTPKPRNSQPSKAGSYGVSI
                     RVQGIDGHPYIVLNNTERCLAGIPFPENRPFPSPMINNLSLHPSNGTVLKENTPEELQ
                     LPENPYLQASPVSGQKQFSFHEGRNGVLERKDGPTKLPHVLNFQRHPELLQPYDPEKN
                     EVNSKKHHPPESPWLRNATEEGTNCKMSRNCFPKPCGSQPNSPTPEDLAKTNMTAIRL
                     CSSVVIEDPQKQTSVCVNVQRCAKEGVGEETLSPRRKSPTAPSPQAYSETKKSRPDVL
                     PFRRQDSAGPILDGARSRRSSSSSTTPTSATSLYKFLLDDQECAIHADSVNRHENRRY
                     IPFLPGTGRDIDTCSIPGVDQLIEKFDQKPGQRRGRSGRRNRINADDRKRSRSVDSAF
                     PFGLQGNTEYLTEFSRNLGKSSEHLLRPSQVFLQRSVAQEHRGKHSPISTLAKLQGAH
                     PKPPLQNKDGKVLNKGSQESIGAGAPSLPAQNKKEEEIKIATATLMLQNRAVAATSDS
                     GAKKISVKTFPSDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLREGGTDNEDATK
                     RKVNLVFEKIQTLKSRATGSAQGNNQAPNSSSEGNDLLDQKNKLILEVSELQQQLQLE
                     MKNHQNIKEERERMREDLEELRVRHQSQVEETATLQRRLEESEEELRKNLEELFQVKI
                     EREQHQTEIRDLQDQLSEMHDELDSTKRSEDQEKGALIEELLQAKQDLQDLLIAKEEQ
                     EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLA
                     SRSHSSEQTQAEADLREKALKEENEKLQGRIVELERRAAQLQRQMEDVKGDEAQAKET
                     LRKCESEVQQLEEALVCARNEEKEAACARTAVERELEQAQRELSQISQEQKELLEKLQ
                     EEVEQKEQLRKLKNEMESERWHLDKTIEKLQKEMADIAEASRTSSLELQKQLDEYKEK
                     NRRELAEMQTQLKEKSLEVEKARLAASKMQDELRLKEEELRDYQRAEEEALTKRQLLE
                     QSLKDLEYQLEAKSHLKDDRSRLVKQMEDKVSQLEIELEEERTNADLLSERITWSREQ
                     MEQMRSELLQEKAAKQDLECDKISLERQNKDLKSRITHLEGSYRSSKEGLVVQMEARI
                     AELEDRLENEERDRANLQLNNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKR
                     QVEEAEEEIDRLESSKKKLQRELEEQIGVNEQLQGQLNSMKKGLRLKTLSSKVLDDSD
                     DDDLSSDAGSLYEAPLSYPFPKDSTITSQI"
     exon            1685..1779
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1885
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1987
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2136
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2272
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2485
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2692
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2797
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2950
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3121
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3283
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3373
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3457
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3582
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3691
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3855
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..6771
                     /gene="Cgnl1"
                     /gene_synonym="RGD1304623"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctggtg cggcctcctg gcgacgcggc gtccgctgct ctcccgcccg gctctgcggg
       61 ctgctgcggg agtggaaccc cggaggcgga ggcgctggga cagtgaacca tggagctgta
      121 ttttggtgaa tatcaacacg tgcagcagga atacggtgtc cacctgagac ttgccagtga
      181 tggcactcca aagccaagga attcccagcc ctcaaaggca ggctcctatg gtgtcagtat
      241 cagagtccag ggaattgatg gccaccctta catagtcctg aataacactg aacggtgtct
      301 agcaggcata cctttcccag aaaacaggcc gtttccatct ccgatgataa ataacttgtc
      361 cctacatcca agcaatggaa ccgtgttgaa ggagaacacg ccagaggaac tgcaacttcc
      421 agaaaaccca tacctgcaag ccagcccggt aagcggccag aagcagttct ccttccacga
      481 gggcaggaat ggagttctag aacgcaaaga cgggcccaca aaactacccc acgtgctcaa
      541 cttccagagg caccccgagc ttctgcagcc ctacgaccca gaaaagaatg aggtgaactc
      601 aaagaagcat cacccaccgg agagtccctg gctgagaaac gcgacagagg aagggaccaa
      661 ctgtaagatg tcccggaact gctttcccaa accctgcggt tcccagccca acagccctac
      721 tccagaagac ttagccaaga ccaacatgac agctatccgt ctctgcagct ccgtggtcat
      781 agaagacccc caaaagcaga cctcggtgtg tgtgaatgtt cagaggtgtg ccaaggaagg
      841 ggtgggagag gagacccttt cccctcgacg gaaatcccca acagccccca gcccacaggc
      901 ctactccgaa accaagaaaa gcaggccaga tgtactaccc tttagacgac aagattctgc
      961 aggacccatc ctggatggag ctcggtcacg aaggtcctct tcgtcatcca cgactcccac
     1021 ttcagccact tccttgtaca aatttttact tgatgatcag gaatgtgcca tccacgctga
     1081 cagtgtcaac cgccatgaaa accgaaggta tattcccttc ttgccaggaa ctgggcggga
     1141 catcgacacc tgctcaattc ctggtgtgga ccagttaatt gaaaagtttg accaaaagcc
     1201 tggccagaga agaggaaggt ctgggaggag aaacaggatc aatgcagacg acaggaaaag
     1261 atcccgaagt gtagatagtg cctttccatt tggtctccag ggaaatacag aatacctcac
     1321 agagttcagc aggaatctgg gcaaatctag tgaacacctc cttcggccat cccaggtctt
     1381 cctgcagagg tcagtggccc aggagcaccg tgggaagcac agtcccatca gcacccttgc
     1441 aaaactgcaa ggtgcccacc ccaagcctcc cctgcagaac aaagacggga aagttctgaa
     1501 caaaggaagt caggaaagca taggggcagg tgccccctcc cttccagcac agaataaaaa
     1561 agaggaagaa atcaaaatag ccaccgccac gttgatgtta cagaaccggg ctgtggctgc
     1621 cacatctgat tctggtgcca agaaaatttc agtgaagaca tttccttccg actcgagtac
     1681 tcaggccacg ccagatctct taaagggcca gcaggagctc acacaacaaa ccaacgagga
     1741 gaccgccaag cagatccttt acaattacct cagagaagga ggcacagata acgaggatgc
     1801 caccaaaagg aaggtgaacc tggtctttga gaaaatccag actttgaagt ccagagcaac
     1861 agggagtgcc caaggaaaca atcaagctcc gaattcttcc tctgaaggca acgatctatt
     1921 ggatcagaag aacaaattga tcctagaagt gtctgaacta cagcagcaac tgcagttgga
     1981 gatgaagaac catcagaaca tcaaggagga gagagaaagg atgagagagg atttagaaga
     2041 gctgcgagtc cggcaccaga gccaagtgga ggagacggcc accctgcaga gacggctgga
     2101 ggaaagtgaa gaagagctga ggaagaactt ggaagagctg ttccaagtga agatagagcg
     2161 agaacagcac cagactgaga tcagagacct gcaggaccag ctgtcagaaa tgcacgacga
     2221 actcgacagc accaagcgat ccgaggacca ggagaaggga gccctgatcg aggagctcct
     2281 gcaggccaag caggaccttc aagacctgct cattgccaaa gaggaacagg aagatctctt
     2341 gaggaagcgg gagagggagc tgactgcctt gaagggtgcc ttgaaggagg aggtttccag
     2401 ccatgaccag gagatggaca agctgaaaga acagtacgac gctgagctgc aggccctcag
     2461 ggagagtgtg gaggaagcca ccaagaatgt tgaggtcctg gccagcagga gccactcctc
     2521 agagcagacc caagcagagg ctgacctgcg tgagaaagcc ctgaaggagg agaatgagaa
     2581 gctgcaggga aggatagtgg agctggagcg cagggcggcc cagctgcaga ggcagatgga
     2641 ggatgtgaag ggtgacgagg cccaagcaaa ggagacactc cggaagtgtg agagtgaagt
     2701 acagcagctt gaggaagccc ttgtgtgtgc cagaaacgaa gaaaaggaag ccgcatgtgc
     2761 cagaacggct gtggagaggg agctggagca agctcagaga gagctgagcc agatctccca
     2821 agagcagaag gaactcctag agaaactcca ggaggaggtg gagcagaagg agcagctgag
     2881 gaagctgaag aacgagatgg agagtgagcg atggcacctg gacaagacca tcgagaagct
     2941 gcagaaggag atggccgaca ttgctgaggc gtcccgcact tcctctttgg agctgcaaaa
     3001 gcagctggat gagtataagg agaagaatcg ccgggagctt gcggaaatgc agacacagct
     3061 gaaggagaaa agcctggagg tggaaaaggc cagactggca gcctcaaaga tgcaggatga
     3121 gttgcgcctc aaggaggaag agttgcggga ctaccaacga gctgaggagg aagcgctcac
     3181 gaaacggcag cttctggagc agtcactgaa ggatctggag taccagctgg aggccaagag
     3241 tcacctcaag gatgaccgaa gccgactggt caagcagatg gaggacaagg tgtcccaatt
     3301 ggagattgag ttggaagaag aaagaacgaa cgctgacttg ctgtctgaga ggatcacttg
     3361 gagcagggaa cagatggagc agatgaggag tgagttactt caagagaaag ctgccaagca
     3421 agacttagag tgtgacaaga tttccctaga gagacagaac aaagacttaa agagccggat
     3481 tacccacctg gaaggttcct acaggtccag taaggagggc ctggtggtgc aaatggaggc
     3541 caggattgca gagctggagg accggctgga gaacgaagag agggaccggg ccaacctgca
     3601 gctcaacaac cgaaggctgg agcggaaggt gaaggagttg gtgatgcagg tggatgatga
     3661 gcatctgtca ctgactgacc agaaggacca gctgagcttg cgcctgaaag ccatgaagcg
     3721 ccaggtggag gaggctgaag aggagatcga cagactggaa agttctaaga agaagctgca
     3781 gagggagctg gaggagcaga taggagtgaa cgagcagctg caggggcagc tcaactctat
     3841 gaagaagggc ttaaggctta agacactgtc tagtaaagta ctggatgact cagacgatga
     3901 tgacctcagc agtgatgcgg gaagcctcta tgaagcccca ctgagctatc cctttcccaa
     3961 agacagcact atcaccagcc agatctgatc tgcttccggg cccgttcatc ctgacaggac
     4021 tccgcagcca tctcgacagt aggagggctt gggaatggag tcagacccac agttcccacc
     4081 tcacattctt cccggggcct ctacgtggtt gagtgacctt ggatcttaga tagggagcta
     4141 ttgaaatttc agatgaccta actgggatat tgggggtaag acaaagccct gttgtgccct
     4201 gctgtctgcc atcactcctt ctcctgcccc tgttccaatg ccggctgtaa tactataggg
     4261 acgtgtaggg atgaaatgat gaacagactg cacacatttt aaaccagaac ttctcaagca
     4321 ctgctcttct actttagaat gctccagagt ctttggagtg tgatgtcttt gtaaagttca
     4381 cacatggatc ttgattaact tttaaaatat gaagctacca gatctcaaga attaaaaagc
     4441 gggaggcaaa ggagggagag tgaaggctac tctggaaacc agaggggttc agactggaaa
     4501 agtagcactg ggaatcaatc catggattgt atgggaaaac agttcattga tggttgggga
     4561 aggacactta gggctgagtg tgaggccttg gtttcttatt ttactgagga ggcttattgt
     4621 atctgaacca tgtgaagagc tgtttccact ccccatttcc ttcaagcaag tagaatgggg
     4681 agacagatga gattttcaac aagtgctgtg cttctcaaag gtcaagaacc ctattgttgt
     4741 atctccttgg cccttttcct ccatggcaga cctccaagtg aagcttgctc aggcctggaa
     4801 ttggaggact aggaggggcc ttgagatgag gcttctgggc ttagatatga ggacgaggag
     4861 ggaggcatcc aggaagttca aggaataagt gggagtaggg ctgaagtaag aaggaataca
     4921 gagatgttct tgaaagctgg aggatgtgca agaaggacag agggttgggg gttgagctgg
     4981 agcttgggat gatgggaaaa agaattgggg gtgcttgcca tctgaaggtc ttttttggac
     5041 cttcttcagg tgtcaggaag gggagaggtc caagggcaag cacagaatgc caaggtggct
     5101 ttgggaggat gctgggcatc cctgtctatc tcctggccta cctgtgtctc ctcattacca
     5161 tgacagtcgc ctataaaaga accttgtgag ttgcctatgt gtgtaaggca gagaagacag
     5221 gacactgaag cagggtcccc gggcttcctg atgtggggac tcctggggac caggttacca
     5281 aaaggtctgg tcccctacag gtcagagatc accacctaga tttaaagaga agagatttga
     5341 aggatgagca tttgctacca gagaaccaag ccctatcaca catcacgaga gccagtctcc
     5401 cgcgacatag ctgggcacag cccttgcccg tttcctcact gggtatggag agatttctgc
     5461 tttcagccat tcttccattt aaccaatatg tattatcatc catcaagatg tgtcaggcac
     5521 agatgttggc actggacaca cagtgaataa aagtgaaaat gtctgtgggc tggagctgga
     5581 gttcagctgt gcctagcatg taggaagccc tgtgtttaaa tccccaactc cctaaaccgg
     5641 gtgtggtgca gcatgctgtc atcccaacac tcaggaagtg gcgacaggag gatccagagt
     5701 tcaaggtcag ccttggatac atatgcagtt ccagaccaac ctgggatata ggagacccca
     5761 tctcaaaaaa acaaaccaac cctgccctcc agtaaccgtc caggagagtg tggtggtgca
     5821 ggctgagccg ctctataccc agcctctgag aactttgtcc tctcggcaac ttgatagcct
     5881 gcggttggtt ggctagttcc ccagaactca caggaattct ttgacttcta gaatcttatg
     5941 tcgtcatctg atacttgcag taagcctaga aatgccttgg ccactcgtcc cagagattca
     6001 ggtgacaaaa tcaagacccg gaggaaaggg gtgtttgttt tggggtttga caaaatcagc
     6061 cagctcctat tctagttctt tctggtagcc atggggctag ctacatgaag gaaaacagct
     6121 cctgaaaggg agaacagagg tcaccactgg aaacacttgt agagttccct gccgccgcct
     6181 ccccccacca aagcaggcta ggcagggtga gaacatgtct cctgtgccgt aatggaatgg
     6241 gagcagtcgg ggcttgtgcg gtgtgtgtgg tacagccagc ggcacaacac tggactgagg
     6301 tttagagaga ggtttgtaaa tcccagactc atctcttccc tgtgatcatg acaggtgcat
     6361 cctgggacaa ggtggggatt agggctccag gtctttcttg gctcaaacct gtgagcatgc
     6421 cttggttttc ttatatatac atgatgtttt tattcccctg tttattgctt taagaactaa
     6481 tcctgcttga gtattttctt tcgctagctt aaaaatatct tgtgtgaaaa catacatgtt
     6541 gccagctgca aagctcagaa gacaatcact gtatgccttt tagaaatttg tttttcctgc
     6601 tccagagtgt cattccacca ggacagttgg tgtactcggg caggtctttc agtagggatt
     6661 ggtcgctatg cgttgtcatg gggaagagac actttatcac agctacctcc atggaagtga
     6721 cttcatggat aaagcaagat ttcctttcaa taaactgtcg gctgacagga a
//
