LOCUS       XM_039082530            6102 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus cyclic GMP-AMP synthase (Cgas),
            transcript variant X1, mRNA.
ACCESSION   XM_039082530
VERSION     XM_039082530.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039082530.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6102
                     /gene="Cgas"
                     /note="cyclic GMP-AMP synthase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 7
                     ESTs, 3 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 131
                     samples with support for all annotated introns"
                     /db_xref="GeneID:682147"
                     /db_xref="RGD:1586939"
     CDS             1625..3157
                     /gene="Cgas"
                     /codon_start=1
                     /product="cyclic GMP-AMP synthase isoform X1"
                     /protein_id="XP_038938458.1"
                     /db_xref="GeneID:682147"
                     /db_xref="RGD:1586939"
                     /translation="MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGA
                     RSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVI
                     LDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKL
                     RLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVM
                     FKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEE
                     VKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDW
                     LGTKVRTNLRREPFYLVPKNAKDGNRFQGETWRLSFSHTEKYILNNHGIGKTCCESSG
                     AKCCRKECLKLMKYLLEQLKREFQELDAFCSYHVKTAIFHMWTKDPQDSQWDPRNLST
                     CFDKFLTFFLECLRTEKLDHYFIPKFNLFSQELIDKKSKEFLSEKIEYERNNGFPIFN
                     KF"
ORIGIN      
        1 gaggcctgat ccacagagtg aattccagga caatcagggc cacacaaaga aaccctgtat
       61 cacacccccc cccataagaa tcataaatcc aattgaaact acctgtgaga atccttccca
      121 cctacatttg aagattaggc attaatccgt ccacatatgt attcagtgca gaatcttccc
      181 ttttcaagga agacattact tatagaacca gaaccataat gttcagttgt agcttaagga
      241 cagataataa agacaataga aaccgagttt ctattgtgaa agtctacaaa aacccttatg
      301 tggaaggtag tctgttgctc ttgtaccagg atcccaggat ggacctcaga tttattgctg
      361 tttgagacag gatctcactc tcttacccag gtttgtactt ctgggctcga agatgctctg
      421 cctaagcctc cagagtagct ggaaccatgg acctatgcta ccacaggtga tgctaagagt
      481 tggttaacca gaaagactca cattaaaaga attgcaatta catttacagt tacagtatgg
      541 ttgttgcagt gaactttgct cctttcaaaa tcattgttaa aatttcattc tctctggatg
      601 ctcatgcctc ttgcactgtt ttcttctttc ttctttctag ttattcttct tcctcctcct
      661 cttcctcttc tttttctgaa acagggtttc tctgtgtagc cccagctgtc ctagaactag
      721 ctctgtagac ctccaactta actgcctctg cctccgctgg gactaatggt gagtgctacc
      781 acactggcaa ggcattgcaa gtctccttta aacaagaggt ctcctgttta aagtatattt
      841 ctgcaaagga ggaagtgttt ccatccccag gcatgtctac ttgccattca aaagtgaatg
      901 ctcagaaggc aaattcccat ttggggaact caaatgcaga cattgatggg aaggaggtaa
      961 gagttgcagg ggcaacagga cggcagcaca ctgattagtg tctttttatc caggccacct
     1021 gtatcttatg gcatatggtg tgtacgcgcg cggaatctca gcacttcaaa gtaggatggc
     1081 ttccactgtt gccgcccaag aaactcacat aagcacttta aagttcttta agatcccgtg
     1141 tcctttttag aaagatgagt tgaaatacta attccaagca gtcaatctaa cctgtaaagg
     1201 ctcagtgaat ttctatttct cattaacaag gacggcaaat tttcacttga agtttacatt
     1261 aaaacacgtt ttttatggac tacaaatgta ctagagacag tagtgtactg aaatacttgg
     1321 tggtaggtcg gcaaatttgg ccgtctaaac ctctgctagt gttttccgcg tctttgcggt
     1381 aaaggagggg gcgggtggtt tcccagtcag tggctcagct gatctccact ggtgaaaaag
     1441 ttcgcatctc ttggaccgcc tcttcctggc gctgaatcct gcgcctgctg gtggcgctta
     1501 cagacaggct acgttcccgc cacattttta agtttcgttt ccagcggtca ctgagagttc
     1561 cccttcccgc ggcctttctc cgaagtcgat tatactttct ggcagcgaag gaagaacggc
     1621 agatatggaa gatccgcgta gaaggacgac ggcgccgcgc gctaagaagc cgtctgcgaa
     1681 gcgcgccccg acgcggccca gcggaacccg ggccaccgtg tcccacgcgg gaagctgcgg
     1741 cccgcaaaga ggggcgcgat cgcgacgggt ggagcgtgac ggggacacca cggagaagcc
     1801 acacacccca gcgccccgag tgcgtcccag aagggccgct gagcgcaccg aggatgcaca
     1861 gcccttggcc acggacgcgg ctggagcctc cgagaggccc gcggtccggg agccccagcg
     1921 gcaagtcatc ctcgatcctg agccgcccgc tgtgccggag ccccaggcgc ccgaggatcc
     1981 cgaggcgccg actgtcgcaa ggggacctgt ccgcagaagg ggcgcacgct ccatccggca
     2041 gcccagagcg tcgcaagggt ccaggaagga gccagacaag ctaaagaagg tgctggacaa
     2101 attgagattg aaacgcaaag aaatctcggc ggcggccgag acggtgaata aagtcgtgga
     2161 tcaactgctg cgcagaatgc agagacggga gtccgagttc aaaggcgtgg agcagctgaa
     2221 caccggcagc tattatgaac atgtgaagat ttctgctcct aatgaatttg atgttatgtt
     2281 taaactggaa gtccccagaa tcgagctaga agaatattac gaaactggtg ctttctatcg
     2341 tgtgaagttc aagagaattc cacgaggaaa tcctctgagt cattttttag aaggggaagt
     2401 attatcagct accaaggtgc tgtcaaagtt tagggaactc attaaagaag aagtgaaaga
     2461 gatcaaagat acagatgtca ccgtggagga ggaaaaacca ggaagccctg ctgtaaccct
     2521 tctcatcagg aaccctgaag aaatatctgt ggatataatc ctggctttgg aatcgaaagg
     2581 cagctggcct attagtacca aaggaggact acctattcaa gactggctcg gcacaaaagt
     2641 gaggaccaat ctaagacgag agccgtttta tcttgtaccc aagaatgcaa aagatggaaa
     2701 tcgttttcaa ggagagacat ggcgcctctc cttctctcac actgaaaaat acattttgaa
     2761 taatcatggg ataggaaaaa catgttgtga atcttctgga gcaaaatgtt gcaggaaaga
     2821 atgtttaaaa ttaatgaaat accttttgga acagttgaaa agagagtttc aagagctaga
     2881 tgcattctgt tcttaccacg tgaaaactgc catctttcat atgtggacca aggacccaca
     2941 ggacagtcag tgggacccca ggaacctaag cacctgcttt gataagtttt tgacattctt
     3001 cctggagtgc ctcaggacag agaaactgga ccactatttt attccaaagt ttaatctgtt
     3061 ttctcaagag ctaattgaca aaaaaagtaa agaatttctg tcagagaaaa tcgaatatga
     3121 aagaaacaat ggatttccaa ttttcaacaa gttttgaaac tatgtatttg tgtatacatt
     3181 atactgtgtt ttgtgggtgt ttaggtcaga ggttgatgcc agatgtcttc ttcagtctta
     3241 ttcacttttg ggtgtggggt ggaaagagtg gtgatttcaa gacatcattt ctctgtgtag
     3301 tcctggctgt cttgtaactc cctctgtaga ccaggctggt cttaaacaaa gagatctgcc
     3361 tgcctctgcc actggaatgc tgcgattaaa ggcgagtgcc gcgctagttg gcacacttca
     3421 cttttttgag agagggtcag cctctgagct catggaggtg tccgggctga tcagccaagt
     3481 gagctcctgg gatccacctg tctctgcttc cccaaccctg gggcgataga tgaacatgac
     3541 ctacacagct ttcacatggt tgctagagat ctgaactcaa gtaagacctc atgcttgcac
     3601 aacaagtact attgtgactg agccatcttc ctgccctggg attgtctttt gaaatggaat
     3661 tgggttaaag tgacttaagt ccattgtggt ggtgtatgtt tgcagtttcg gtacttggga
     3721 agttttcttt ttctttttct tttttaacat ggacagtttt tgttatatga aaacatccaa
     3781 agcacaaaca cacatgcccc actctcaggg agcgtaagaa tcctagattc tccttttctc
     3841 tcaagcattt atatcctagt tacaaaaatg gagctgtaaa ggatgtataa agacatgagg
     3901 atcttcttgc ttgttctgta cagcgtctga agtaatcttg tacaagcatc tggagtaatc
     3961 ttgacaagaa gaagcaaaat cttcctaatt aaagaacaga gtgtctgcca cctgcccaca
     4021 agcagttcct gtttgcctga catgtctata ggagcatggg cacaggaaat gttgagacag
     4081 acacgggcca ggctattgct tctcattccc agaaggcaca catccccaca ccatttacta
     4141 gttattcctg acctctatag gcgaatccct tcgattctac ctactttgag gtattaaatg
     4201 cgtaagaaaa ggactagtta tgtccaagta acatgcaata aaaatatttt tagggctgga
     4261 gagatggctc agaggttaag agaacgggct gctcttccag aggttctgag ttcaatttcc
     4321 aacaaacaca tgggggctca caatcatctg taatgggatc tgatgctccc ttctggtgtg
     4381 tcagactaaa taaatcttaa agaaaaaaaa taaaagaaag aaagaaagaa aatattttta
     4441 aaccaacatg gttaagtgtt aaggttttta gaaatcgaaa aaatttattc acatgatttt
     4501 aaactagtca aagctatttc ttttgtagta gttttcttag tttgggtttt acggctatga
     4561 agagatacca tgaccaaggc aactcttata agggtcaaca tttaattggg gctggcttac
     4621 aggttcagag gttcagtcca ttatcactat ggcaggaagc atggcagtgt ccaggaaggc
     4681 atagtactgg agaaggagct gaacattcta tatcttcatc caaaggaagc taggagcaga
     4741 ctcacccaca tggctagcag gagggtctca aaagcccgcc tccacagtga cacacttcct
     4801 ccaatgaggc cacatctact ccaacaaggc tatacctcct aatagtgcca ctccctgagc
     4861 caagcatatt caaaccacca cagatgtgga agcagaaaaa ataatccagt gtgatccttg
     4921 acaatatttt tagttcacgg atagcctggg gtacacgaaa cctgcttaaa acaaagcaca
     4981 aaggggctaa agaaggggtt cagtggttaa cagcagccat tgctctttta ggacctatgt
     5041 cggctcccag cacctagtgg cagacacaac tgtaactcca gttccaggga atctagtttg
     5101 accacacaca cacacacaca cacacacaca caattttttt ttcggagctg gggaccgaac
     5161 ccaggacctt gcgcttgcta ggcacaattt tttttaagag cacaaaaaga aaagaaaatg
     5221 aaatggatct gatcccataa taggataatt gtgctggcac ttacttataa tcctggtact
     5281 tgagaagccg agataggagg caaggccagc cttggctaca gaataagatc ttgtttcaaa
     5341 aacaaaacaa aacaaaacaa caacaacaaa aaccaaacca ccaaaagcca acagcagtcc
     5401 ccataagtca ccataagtcg tttgagtttg gcctgggttt gctcatctgt cctgactcaa
     5461 aaggtacatt ttctttttct tttttcctct ttaggatggt cagaacctag gaggcctttt
     5521 tgggtatgct gtacttcctt cctttctcat gaaattcccc ccaacccctg acacatacac
     5581 catatggctg tctgtccatc aaatggctgg tgttcttttt tgaatacaaa ataaccccca
     5641 aaaatgtgac tataataatc cagatgttgt gagagactgt atcagaagtg gtggattcag
     5701 actttgttca aacacaagag atgcgtaggg aagccctgcc cactctctgt cctagggtag
     5761 aaaggaagac cacgttctcc ataggctcta cctcaggtac tttatcatgt gtgcataagc
     5821 acgtaattta tttttattta ttttcattct gtgtgtgttt ttacaaatgc aatggtacct
     5881 agcgcggaga gacgggcgtg ggacagggga tgactctgca tctaagcgcg ttctccaggg
     5941 acagctggtg agcttccact ctttccagta ctttgttgca tgtattgttg caggagcctg
     6001 cttcagcgtt ctgtagttgt tccctgtgta acaaatcatg tctaccatgt gtgttgtcct
     6061 cccttttctt agtatctttc aataaatagg atttaaacat gt
//
