LOCUS       NM_053918                670 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus glycoprotein hormones, alpha polypeptide (Cga),
            mRNA.
ACCESSION   NM_053918
VERSION     NM_053918.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 670)
  AUTHORS   Jiang,X., Fischer,D., Chen,X., McKenna,S.D., Liu,H., Sriraman,V.,
            Yu,H.N., Goutopoulos,A., Arkinstall,S. and He,X.
  TITLE     Evidence for Follicle-stimulating Hormone Receptor as a Functional
            Trimer
  JOURNAL   J Biol Chem 289 (20), 14273-14282 (2014)
   PUBMED   24692546
REFERENCE   2  (bases 1 to 670)
  AUTHORS   Chen,H., Zhao,L., Chu,G., Kito,G., Yamauchi,N., Shigeyoshi,Y.,
            Hashimoto,S. and Hattori,M.A.
  TITLE     FSH induces the development of circadian clockwork in rat granulosa
            cells via a gap junction protein Cx43-dependent pathway
  JOURNAL   Am J Physiol Endocrinol Metab 304 (6), E566-E575 (2013)
   PUBMED   23299500
  REMARK    GeneRIF: Data suggest that FSH (Cga/FSHb) induces clock system in
            granulosa cells by up-regulation of connexin 43 expression; this
            suggests that gap junctions are implicated in circadian clock in
            peripheral oscillators besides central pacemaker.
REFERENCE   3  (bases 1 to 670)
  AUTHORS   Cao,J., Patisaul,H.B. and Petersen,S.L.
  TITLE     Aryl hydrocarbon receptor activation in lactotropes and
            gonadotropes interferes with estradiol-dependent and -independent
            preprolactin, glycoprotein alpha and luteinizing hormone beta gene
            expression
  JOURNAL   Mol Cell Endocrinol 333 (2), 151-159 (2011)
   PUBMED   21187122
  REMARK    GeneRIF: Complex interactions between Ahr and Esr alter Prl and
            luteinizing hormone (LH) synthesis by direct actions in lactotropes
            and gonadotropes.
REFERENCE   4  (bases 1 to 670)
  AUTHORS   Wang,D., Xia,X., Weiss,R.E., Refetoff,S. and Yen,P.M.
  TITLE     Distinct and histone-specific modifications mediate positive versus
            negative transcriptional regulation of TSHalpha promoter
  JOURNAL   PLoS One 5 (3), e9853 (2010)
   PUBMED   20352046
  REMARK    GeneRIF: histone-specific modifications mediate positive versus
            negative transcriptional regulation of TSHalpha promoter
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 670)
  AUTHORS   Ahtiainen,P., Rulli,S.B., Shariatmadari,R., Pelliniemi,L.J.,
            Toppari,J., Poutanen,M. and Huhtaniemi,I.T.
  TITLE     Fetal but not adult Leydig cells are susceptible to adenoma
            formation in response to persistently high hCG level: a study on
            hCG overexpressing transgenic mice
  JOURNAL   Oncogene 24 (49), 7301-7309 (2005)
   PUBMED   16007123
REFERENCE   6  (bases 1 to 670)
  AUTHORS   Berkowitz,R., Ozturk,M., Goldstein,D., Bernstein,M., Hill,L. and
            Wands,J.R.
  TITLE     Human chorionic gonadotropin and free subunits' serum levels in
            patients with partial and complete hydatidiform moles
  JOURNAL   Obstet Gynecol 74 (2), 212-216 (1989)
   PUBMED   2473429
REFERENCE   7  (bases 1 to 670)
  AUTHORS   Keene,J.L., Matzuk,M.M., Otani,T., Fauser,B.C., Galway,A.B.,
            Hsueh,A.J. and Boime,I.
  TITLE     Expression of biologically active human follitropin in Chinese
            hamster ovary cells
  JOURNAL   J Biol Chem 264 (9), 4769-4775 (1989)
   PUBMED   2494176
REFERENCE   8  (bases 1 to 670)
  AUTHORS   Burnside,J., Buckland,P.R. and Chin,W.W.
  TITLE     Isolation and characterization of the gene encoding the
            alpha-subunit of the rat pituitary glycoprotein hormones
  JOURNAL   Gene 70 (1), 67-74 (1988)
   PUBMED   2467841
REFERENCE   9  (bases 1 to 670)
  AUTHORS   Godine,J.E., Chin,W.W. and Habener,J.F.
  TITLE     alpha Subunit of rat pituitary glycoprotein hormones. Primary
            structure of the precursor determined from the nucleotide sequence
            of cloned cDNAs
  JOURNAL   J Biol Chem 257 (14), 8368-8371 (1982)
   PUBMED   6177696
REFERENCE   10 (bases 1 to 670)
  AUTHORS   Shindelman,J.E., Ortmeyer,A.E., Wada,H.G., Stockdale,F. and
            Sussman,H.H.
  TITLE     Distribution and characterization of alpha hCG in the serum and
            tumor cytosol of patients with breast cancer
  JOURNAL   Int J Cancer 25 (5), 599-604 (1980)
   PUBMED   6768680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 10, 2022 this sequence version replaced NM_053918.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB567274.1, CB566815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000005.1  54283340-54283412
            74-187              JAXUCZ010000005.1  54292673-54292786
            188-372             JAXUCZ010000005.1  54293757-54293941
            373-670             JAXUCZ010000005.1  54295167-54295464
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..670
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /note="glycoprotein hormones, alpha polypeptide"
                     /db_xref="GeneID:116700"
                     /db_xref="RGD:620436"
     exon            1..73
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..187
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..450
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /note="glycoprotein hormones alpha chain; FSH-alpha;
                     LSH-alpha; TSH-alpha; lutropin alpha chain; follitropin
                     alpha chain; thyrotropin alpha chain; luteinizing hormone
                     alpha chain; thyroid-stimulating hormone alpha chain;
                     follicle-stimulating hormone alpha chain; anterior
                     pituitary glycoprotein hormones common subunit alpha;
                     glycoprotein hormones, alpha subunit; pituitary hormone
                     alpha subunit; glycoprotein hormone alpha subunit"
                     /codon_start=1
                     /product="glycoprotein hormones alpha chain precursor"
                     /protein_id="NP_446370.3"
                     /db_xref="GeneID:116700"
                     /db_xref="RGD:620436"
                     /translation="MDCYRRYAAVILVMLSMVLHILHSLPDGDLIIQGCPECKLKENK
                     YFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKSFTKATVMGNA
                     RVENHTDCHCSTCYYHKS"
     exon            188..372
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..670
                     /gene="Cga"
                     /gene_synonym="Gpa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaatcgg agaccaagtt cccctcagat cgacaatcaa ctgcccagaa cacatccttc
       61 caaagatcca gagtttgcag gagagctatg gattgctaca gaagatatgc ggctgtcatt
      121 ctggtcatgc tgtccatggt cctgcatatt cttcattctc ttcctgatgg agaccttatt
      181 attcagggtt gtccagaatg taaactaaag gaaaacaaat acttctccaa gctgggtgcc
      241 cccatctatc agtgtatggg ctgttgcttc tccagggcat acccgactcc cgcaaggtcc
      301 aagaagacaa tgttggttcc aaagaatatt acctcggagg ccacgtgctg tgtggccaaa
      361 tcatttacta aggccacagt gatgggaaac gccagagtgg agaaccacac ggactgccac
      421 tgtagcactt gttactacca caagtcgtag cttccatgtg tgccaagggc tgcgctgacg
      481 actgctgacc cgtgcgatgg cactgagtgt cgccacctcc tccttaccag acttctgaca
      541 cgcttcagtc atacactgct gctttcctgt cacatccctt atacttcagt accatcgaca
      601 gtctcttctc attaggggaa aatgtgtatc taccatggtc ccatcagaaa taaagccttt
      661 tcaatcatca
//
