LOCUS       NM_031506               6287 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus CF transmembrane conductance regulator (Cftr),
            mRNA.
ACCESSION   NM_031506 XM_342645 XM_347229
VERSION     NM_031506.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6287)
  AUTHORS   Tang,X., Li,D., Zhao,T., Zhu,S., Gao,X., Zhou,R., Deng,F., Fu,W.,
            Jia,W. and Liu,G.
  TITLE     The inhibition of CFTR in the descended testis of SD rats with
            unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate
            (DEHP)
  JOURNAL   Environ Sci Pollut Res Int 29 (51), 77047-77056 (2022)
   PUBMED   35676569
  REMARK    GeneRIF: The inhibition of CFTR in the descended testis of SD rats
            with unilateral cryptorchidism induced by di-(2-ethylhexyl)
            phthalate (DEHP).
REFERENCE   2  (bases 1 to 6287)
  AUTHORS   Lu,L.Y., Pan,N., Huang,Z.H., Wang,J.S., Tang,Y.B., Sun,H.S.,
            Han,H., Yang,H.Y., Zhu,J.Z., Guan,Y.Y., Zhang,B., Li,D.Z. and
            Wang,G.L.
  TITLE     CFTR Suppresses Neointimal Formation Through Attenuating
            Proliferation and Migration of Aortic Smooth Muscle Cells
  JOURNAL   J Cardiovasc Pharmacol 79 (6), 914-924 (2022)
   PUBMED   35266910
  REMARK    GeneRIF: CFTR Suppresses Neointimal Formation Through Attenuating
            Proliferation and Migration of Aortic Smooth Muscle Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6287)
  AUTHORS   Le Ribeuz,H., To,L., Ghigna,M.R., Martin,C., Nagaraj,C., Dreano,E.,
            Rucker-Martin,C., Girerd,B., Bouligand,J., Pechoux,C., Lambert,M.,
            Boet,A., Issard,J., Mercier,O., Hoetzenecker,K., Manoury,B.,
            Becq,F., Burgel,P.R., Cottart,C.H., Olschewski,A.,
            Sermet-Gaudelus,I., Perros,F., Humbert,M., Montani,D. and
            Antigny,F.
  TITLE     Involvement of CFTR in the pathogenesis of pulmonary arterial
            hypertension
  JOURNAL   Eur Respir J 58 (5), 2000653 (2021)
   PUBMED   33926975
  REMARK    GeneRIF: Involvement of CFTR in the pathogenesis of pulmonary
            arterial hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6287)
  AUTHORS   Wang,Y., Gu,L., Yang,H.M. and Zhang,H.
  TITLE     Cystic fibrosis transmembrane conductance regulator-associated
            ligand protects dopaminergic neurons by differentially regulating
            metabotropic glutamate receptor 5 in the progression of neurotoxin
            6-hydroxydopamine-induced Parkinson's disease model
  JOURNAL   Neurotoxicology 84, 14-29 (2021)
   PUBMED   33571554
  REMARK    GeneRIF: Cystic fibrosis transmembrane conductance
            regulator-associated ligand protects dopaminergic neurons by
            differentially regulating metabotropic glutamate receptor 5 in the
            progression of neurotoxin 6-hydroxydopamine-induced Parkinson's
            disease model.
REFERENCE   5  (bases 1 to 6287)
  AUTHORS   Di Fulvio,M., Bogdani,M., Velasco,M., McMillen,T.S., Ridaura,C.,
            Kelly,L., Almutairi,M.M., Kursan,S., Sajib,A.A., Hiriart,M. and
            Aguilar-Bryan,L.
  TITLE     Heterogeneous expression of CFTR in insulin-secreting beta-cells of
            the normal human islet
  JOURNAL   PLoS One 15 (12), e0242749 (2020)
   PUBMED   33264332
  REMARK    GeneRIF: Heterogeneous expression of CFTR in insulin-secreting
            beta-cells of the normal human islet.
            Erratum:[PLoS One. 2023 Jul 7;18(7):e0288417. doi:
            10.1371/journal.pone.0288417.. PMID: 37418383]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6287)
  AUTHORS   Trezise,A.E., Szpirer,C. and Buchwald,M.
  TITLE     Localization of the gene encoding the cystic fibrosis transmembrane
            conductance regulator (CFTR) in the rat to chromosome 4 and
            implications for the evolution of mammalian chromosomes
  JOURNAL   Genomics 14 (4), 869-874 (1992)
   PUBMED   1282491
REFERENCE   7  (bases 1 to 6287)
  AUTHORS   Dork,T., Kalin,N., Stuhrmann,M., Schmidtke,J. and Tummler,B.
  TITLE     A termination mutation (2143delT) in the CFTR gene of German cystic
            fibrosis patients
  JOURNAL   Hum Genet 90 (3), 279-284 (1992)
   PUBMED   1283149
REFERENCE   8  (bases 1 to 6287)
  AUTHORS   Tran-Paterson,R., Davin,D., Krauss,R.D., Rado,T.A. and Miller,D.M.
  TITLE     Expression and regulation of the cystic fibrosis gene during rat
            liver regeneration
  JOURNAL   Am J Physiol 263 (1 Pt 1), C55-C60 (1992)
   PUBMED   1378998
REFERENCE   9  (bases 1 to 6287)
  AUTHORS   Shoshani,T., Augarten,A., Gazit,E., Bashan,N., Yahav,Y., Rivlin,Y.,
            Tal,A., Seret,H., Yaar,L., Kerem,E. et al.
  TITLE     Association of a nonsense mutation (W1282X), the most common
            mutation in the Ashkenazi Jewish cystic fibrosis patients in
            Israel, with presentation of severe disease
  JOURNAL   Am J Hum Genet 50 (1), 222-228 (1992)
   PUBMED   1370365
REFERENCE   10 (bases 1 to 6287)
  AUTHORS   Kalin,N., Dork,T. and Tummler,B.
  TITLE     A cystic fibrosis allele encoding missense mutations in both
            nucleotide binding folds of the cystic fibrosis transmembrane
            conductance regulator
  JOURNAL   Hum Mutat 1 (3), 204-210 (1992)
   PUBMED   1284535
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DP000027.1.
            
            On or before Apr 14, 2006 this sequence version replaced
            XM_342645.2, XM_347229.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..6287
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /note="CF transmembrane conductance regulator"
                     /db_xref="GeneID:24255"
                     /db_xref="RGD:2332"
     exon            1..190
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..4568
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /EC_number="5.6.1.6"
                     /note="cAMP-dependent chloride channel; channel
                     conductance-controlling ATPase; ATP-binding cassette
                     transporter sub-family C member 7; ATP-binding cassette
                     sub-family C member 7; cystic fibrosis transmembrane
                     conductance regulator homolog"
                     /codon_start=1
                     /product="cystic fibrosis transmembrane conductance
                     regulator"
                     /protein_id="NP_113694.1"
                     /db_xref="GeneID:24255"
                     /db_xref="RGD:2332"
                     /translation="MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSD
                     SADHLSEKLEREWDREQASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLL
                     GRIIASYDPDNTEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLI
                     YKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDL
                     LQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYC
                     WESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLR
                     KIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGL
                     VMENVTAFWEEGFQELLEKVQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKK
                     GEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIF
                     GVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDA
                     DLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSS
                     YFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAK
                     QSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHG
                     EAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLK
                     EEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRGLFA
                     VLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIY
                     VGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFS
                     KDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLH
                     TSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYL
                     ATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSI
                     DTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGG
                     EMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGE
                     IQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGL
                     KSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQ
                     VIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRA
                     LSSSEKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL"
     exon            191..301
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            302..410
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            411..626
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            627..716
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            717..880
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1006
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1253
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1346
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1529
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1721
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1816
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1903
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2612
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2741
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2779
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..3030
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3110
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3261
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3489
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3590
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3842
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3998
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4088
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4261
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4367
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..6287
                     /gene="Cftr"
                     /gene_synonym="RGD1561193"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattggaagc aaatgacatc acctcaggac tgagtaaaag ggaagagcca aaagcattga
       61 acgggtcctg gatatccaga agtcgagtcc aacctgaacc tgtccggaca cagaccttag
      121 tgcaccacgg agacatcatg cagaagtcgc ctctggagaa agccagcttt atctccaaac
      181 tcttcttcag ctggaccaca ccaattttga gaaaagggta cagacaccac ttggagctgt
      241 cagacatata ccaagcccct tcttctgatt cagctgacca cctgtctgaa aagctagaaa
      301 gagaatggga cagggaacaa gcttccaaaa agaagcccca gcttatccac gccctccggc
      361 gatgctttgt ctggagattc gtcttctacg gagtcttgtt atacctcggg gaagtcacca
      421 aggctgtcca gcctgtcttg ctaggaagaa tcatagcatc ctatgatcca gacaacacgg
      481 aggagcgttc cattgccatt tacctaggca taggcttatg cctcctcttc attgtcagga
      541 cactgcttct gcacccagct atttttggcc ttcatcacat tggaatgcag atgagaatag
      601 ccatgtttag cttgatttat aagaagactt taaagttgtc aagccgtgtt cttgataaaa
      661 taagtattgg acaacttatt agtcttcttt ccaacaacct gaacaaattt gatgaaggac
      721 ttgccttggc acattttata tggattgctc ctttacaagt ggttcttctg atggggcttc
      781 tctgggactt gttacagttc tcagccttct gtggccttgg tttactgata gtcttggtta
      841 tttttcaagc tatcttaggg aagatgatgg tgaagtacag agataaaaga gctgcaaaga
      901 tcaatgaaag acttgtgatc acatcagaag ttattgacaa tatctattct gttaaggcat
      961 attgttggga atcagcgatg gagaagataa ttgaaagctt gagagaggag gaactgaaaa
     1021 tgacccggag gtcagcctat atgaggttct tcactagctc tgccttcttc ttttcagggt
     1081 tttttgtagt ctttttatct gtgcttccct acacagtcat caatggaatc gtcctccgaa
     1141 aaatattcac aaccatttca ttctgcattg tcctgcgtat gtcagtcaca cggcaattcc
     1201 ccactgctgt acagatatgg tatgattctt tgggaatgat aagaaaaata caggatttcc
     1261 tacagactca agaatataaa gtgctggagt ataacttaat gttcacaggc ctagtcatgg
     1321 agaatgtaac agcattttgg gaggagggat ttcaggaatt actggagaaa gtacaactaa
     1381 acaatgatga cagaaaaact tccaatggtg agaaccacct cagttttagt catctctgtc
     1441 tagtgggaaa tcctgtgttg aaaaacatca atttgaatat aaagaaagga gagatgttgg
     1501 ctattactgg atctactgga gcaggaaaga catcactcct gatgctgata ctgggagaac
     1561 tggaagcgtc agagggaatt attaagcaca gtggaagagt ttcattctcc tctcaaattt
     1621 cttggattat gccgggtact atcaaagaaa atatcatctt tggtgtttcc tatgatgagt
     1681 acagatataa gagtgttgtc aaagcttgcc aactacagga ggacatcacc aagtttgcag
     1741 aacaagacaa cacagttctt ggagaaggtg gagtcacact cagtggaggt caacgtgcaa
     1801 gaatttcttt agcaagagca gtatataaag atgctgattt gtacctgtta gattccccct
     1861 tcggatatct agatgtttta actgaagaac aaatatttga aagttgtgtc tgtaaattga
     1921 tggccagcaa aactaggatt ctggtcacat ctaaaatgga gcagttaaag aaagctgaca
     1981 agatactcat tttgcatgag ggcagcagct atttttatgg gacgttttct gaactacaaa
     2041 gtctacgtcc agacttcagt tccaaactca tggggtatga tacttttgac cagtttactg
     2101 aggaaagaag gagttcaatt ctaactgaga ccttacgcag gttctcagtg gacgatgcct
     2161 ctaccacctg gaacaaagcc aaacagtcat ttagacagac tggagagttt ggagaaaaaa
     2221 ggaagaactc tattctaagt tcattcagct ctgtgaagaa aatttccatt gtgcaaaaga
     2281 ctccattgtc catagaagga gaatctgatg acctccaaga aaggagactg tccctggttc
     2341 cagactctga acatggagag gccgctctgc ctcgcagcaa catgatcacc gccgggccca
     2401 cgtttccagg cagaagaaga cagtctgttt tggatcttat gacattcaca cccagctcag
     2461 tctccagcag tctccagagg accagagctt ctattcgaaa aatatcctta gcccctcgga
     2521 taagcttaaa ggaagaggat atatattcaa ggcgattatc gcaagatagc acactgaaca
     2581 tcaccgaaga aattaatgaa gaagatttaa aggagtgttt ttttgatgat atggtaaaga
     2641 tccccacggt gacaacatgg aacacatacc ttcgatattt cacgctccac agaggcttat
     2701 ttgcagtgct gatttggtgc gtgctggttt ttctggttga ggtggctgct tctttatttg
     2761 tgttgtggtt gcttaaaaac aaccccgtta atggtggaaa caatggcact aaaattgcca
     2821 atacctccta tgttgtggtc atcaccagtt ccagcttcta ttacattttt tacatttacg
     2881 tgggagtggc tgacactttg cttgctctga gcctcttcag aggtttgccc ctggtgcata
     2941 cgttaatcac agcatcaaaa attttgcaca ggaaaatgtt acattctatt cttcatgccc
     3001 ctatgtcaac cttcaacaag ctgaaagcag gtgggattct taacagattc tccaaagata
     3061 tagcaatttt ggatgacttt ctgcctctta ccatatttga cttcatccag ttgctgttca
     3121 ttgtggtcgg agcaataata gttgtctcgg ctttacaacc ctacatcttc ctagcaacgg
     3181 tgccagggct agcagtcttc attttactga gggcatactt ccttcatacc tcccaacagc
     3241 tcaaacaact ggaatctgaa ggcaggagtc caattttcac gcaccttgtt acaagcttaa
     3301 aaggactgtg gacacttcga gccttccgac gccagactta ctttgaaacc ctattccaca
     3361 aagctctgaa tttgcacact gccaactggt ttatgtatct ggcaaccttg cgctggttcc
     3421 agatgagaat agacatgatt ttcgtcctct tcttcattgt tgttaccttc atctccattt
     3481 taacaacagg tgaaggagaa ggaacgactg gtattattct aactttagct atgaatatta
     3541 tgagtacttt gcaatgggct gtgaactcaa gcattgatac agatagcttg atgcgatctg
     3601 tgagcagagt ctttaagttt attgatatac aaacagaaga aagtatatgt accaagataa
     3661 tgaaagaact acatagtgaa gactcaccta atgctttagt cattaagaat gaacatgtga
     3721 agaaatgtga tacctggccc tctggaggtg aaatggttgt caaagacctt actgtgaaat
     3781 atgtggatga tgggaatgcc atattagaga acatttcttt ttcaataagt cctggccaga
     3841 gggtggggct cttaggaaga actggctcag gaaaaagtac tttgctgtca gcctttttac
     3901 gaatgttgaa cattaaaggc gaaatacaga tcgatggtgt ctcctggaac tcaatgacct
     3961 tacaagaatg gagaaaagct tttggagtga taacacagaa agtatttatc ttttctggaa
     4021 cattcagaca aaacttggat cccaatggaa aatggagaga tgaagaaata tggaaagttg
     4081 cagatcaggt tggcctcaag tctgtgatag agcagtttcc tggacagctc aactttaccc
     4141 ttgtggatgg gggttatgtg ctaagccatg gtcacaagca gttgatgtgc ttggcccgat
     4201 ctgttctcag taaggccaag atcatactgc ttgatgagcc tagtgccaat ctagacccca
     4261 taacatacca agtgattcga cgagttctaa gacaagcctt cgctggttgc acagtagtcc
     4321 tctgtgaaca caggatagaa gcaatgttgg actgtcagcg atttttggtc atagagcagg
     4381 gcaatgtctg gcagtatgaa tccctccagg cacttctgag cgagaagagt gtcttccagc
     4441 gagcccttag ctcctcagaa aagatgaagc tcttccacgg ccggcactcc agcaagcaga
     4501 agcctcggac acagatcact gctgtgaaag aggagacgga ggaagaagtg caagagaccc
     4561 ggctctagtg ctgggtgctg gagaagcaac tcgaaaaccc atgcaaaatg aaaagggcag
     4621 gcagtcccca tgcttctaac ccagtgctgg ggacacaggc acaggtggct actaggggct
     4681 ctgtggaaag tgatcctagc ccacaaagag agttccaggc cgggcacctg aaagacaata
     4741 cctgtggata tcctctcgct tccttatgca agttcaaaca cacacacaca cacacacaca
     4801 cacacacaca cacacacaca cacacacacg cacacgcaca ctaatgggca tacacacaga
     4861 aaagcaaaga ccgaaagaag gaaagaatca gtgcaagtga ctgcgaagca atcatgcatg
     4921 gagtctgctc atggacttgg aggagctgag ccccactacc tatgcccgtg aaagcagggt
     4981 gaagtccaag gcttgctttt taagagactg ttttggaaga gaaatcaaaa ccattcatct
     5041 gggtatgggt aaactgactt tctagcagtg gtcaaattgt ttgaaagggg atggtgacca
     5101 ctgagtattg caagttttct gaaaacattt gccctctaga ggtagctgta aagatagcta
     5161 taaatggcaa ccaggagagc tgttcagctt atcattcaat gcagctgatt aatttgtgtt
     5221 attgaagaac tgaaatcata gtgcttagat acagggtaag taaagagaac taaaacaggg
     5281 ctcacatagc tcatagccca actttctttg taatattttg gcacacagct gtattgcctt
     5341 ctatacattg tttgtcacat tccaagtaag tgttagaata ctatacaaat actgagaggt
     5401 attgaaagtt gcctcacttt acatctggtg accctgtaac ctatcagggt taagaatatc
     5461 cagatcttgg aaattaagat taagaccatc tagccttact accatacagc taaacattct
     5521 tagctgacct aggaaaagaa ctgttacagt cccatgacgg ggccaggata atcaccttga
     5581 tatggaaagt gacacactta tgttcccaga aagcgacaga tctttaagag ttctgaagtg
     5641 aagggaggtt gtgttagtgc aaactagtgc agcacagcac caggtgcagg agttagcatg
     5701 tagaaggcca tgggcgctca tggaaatgtg cagtggtgtg ttcatgtgct ctcagctagc
     5761 tgtgtgtact tcatactgtc tccacagagt tgtggagaca ctctgaaaaa gatttaatca
     5821 tgaattagtt ttatatgctt tattttataa tttgtgatgc aaatgaaatt ttctctgaga
     5881 aatatttatt ttagtagtaa tgtttcaaac tcatatataa caatgctgta ttttagaatg
     5941 attatataat gacttacact tgtataaaat aatttttata tttgaagtgt tgaattttca
     6001 tagcactagc tattttagaa cagggagtga ggaagacaag gatgataagg accattcaca
     6061 acgatgtgaa gcacggagac tgatgtagac ctcggaccca tctgtgtggt tctcagtcaa
     6121 cacatactcc cttttaatgc agctttgaag aagatgatac caaaagttaa gatggtcccc
     6181 ttctgggaac atcagcttct gaactgcaaa ctaagcctta gatgaatgta ttgtatttat
     6241 tactgtaata gaatatcatg tgtcaataaa attcttttat ttgtgtg
//
