LOCUS       NM_001106757            1505 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus complement factor properdin (Cfp), mRNA.
ACCESSION   NM_001106757 XM_001056015 XM_216784
VERSION     NM_001106757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Zaferani A, Vives RR, van der Pol P, Navis GJ, Daha MR, van Kooten
            C, Lortat-Jacob H, Seelen MA and van den Born J.
  TITLE     Factor h and properdin recognize different epitopes on renal
            tubular epithelial heparan sulfate
  JOURNAL   J Biol Chem 287 (37), 31471-31481 (2012)
   PUBMED   22815489
  REMARK    GeneRIF: Factor h and properdin recognize different epitopes on
            renal tubular epithelial heparan sulfate.
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Zaferani A, Vives RR, van der Pol P, Hakvoort JJ, Navis GJ, van
            Goor H, Daha MR, Lortat-Jacob H, Seelen MA and van den Born J.
  TITLE     Identification of tubular heparan sulfate as a docking platform for
            the alternative complement component properdin in proteinuric renal
            disease
  JOURNAL   J Biol Chem 286 (7), 5359-5367 (2011)
   PUBMED   21135110
  REMARK    GeneRIF: tubular HS as a novel docking platform for alternative
            pathway activation via properdin, which might play a role in
            proteinuric renal damage.
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M and Mayr M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Stover CM, Luckett JC, Echtenacher B, Dupont A, Figgitt SE, Brown
            J, Mannel DN and Schwaeble WJ.
  TITLE     Properdin plays a protective role in polymicrobial septic
            peritonitis
  JOURNAL   J Immunol 180 (5), 3313-3318 (2008)
   PUBMED   18292556
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Goundis D and Reid KB.
  TITLE     Properdin, the terminal complement components, thrombospondin and
            the circumsporozoite protein of malaria parasites contain similar
            sequence motifs
  JOURNAL   Nature 335 (6185), 82-85 (1988)
   PUBMED   3045564
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   Verroust,F., Adam,C., Kourilsky,O., Allain,J.P. and Verroust,P.
  TITLE     Circulating immune complexes and complement levels in hemophilic
            children
  JOURNAL   J Clin Lab Immunol 6 (2), 127-130 (1981)
   PUBMED   6912882
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158889.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001106757.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158889.1, FQ212442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..1505
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /note="complement factor properdin"
                     /db_xref="GeneID:299314"
                     /db_xref="RGD:1594557"
     exon            1..83
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1417
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /note="Properdin P factor, complement; properdin factor,
                     complement"
                     /codon_start=1
                     /product="properdin precursor"
                     /protein_id="NP_001100227.1"
                     /db_xref="GeneID:299314"
                     /db_xref="RGD:1594557"
                     /translation="MPVGMQAPQWLLLLLLILPTTGSDPVLCFTQYEEPSGRCKGLLG
                     RDIRVEDCCLNTAYAFQEHDGGLCQSCRSPQWSAWSSWGPCSVTCSEGSQLRHRRCVG
                     RGGQCSEKAAPGTLEWQLQACEDQLCCPEMGGWSEWGPWGPCSVTCSKGTQTRQRLCD
                     NPAPKCGGHCPGEAQQSQACDTQKICPTHGAWASWGPWSACSGSCLGGAQEPKETRSR
                     SCSAPAPSHQPPGKPCSGTAYEHRGCSGLPPCPVAGGWGPWGPSSPCPVTCGLGQTLE
                     RRTCDHPVPRHGGPFCAGDATRKHVCNTAMPCPVNGEWEAWGKWSHCSRVRMKSISCD
                     EIPGQQSRSRSCGGRKFDGQPCTGKLQDIRHCYDIHNCVLKGSWSQWSTWGLCTPPCG
                     PNPTRVRQRLCTPLLPKYSPTVSMVEGQGEKNVTFWGIPRPLCEVLQGQKLVVEEKRP
                     CLHVPSCRDPEEKKP"
     exon            84..234
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            235..410
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            411..581
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            582..773
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            774..947
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1139
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1251
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1479
                     /gene="Cfp"
                     /gene_synonym="Pfc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaaacata gtgttcacaa tgcccgttgg aatgcaagcc cctcagtggc tcctgctcct
       61 attgcttatc ctgccaacca caggctcaga ccctgtgctc tgcttcaccc agtatgagga
      121 gccctctggc aggtgcaaag gcctacttgg aagagacatc agggtggaag attgctgtct
      181 caacactgcc tatgccttcc aggaacatga tgggggcctc tgtcagtcat gcaggtcccc
      241 acaatggtca gcatggtcct catgggggcc ctgctcagtt acatgctctg aggggtccca
      301 gctgcgacac aggcgctgtg tgggtagggg tggacagtgc tctgagaagg cggctcctgg
      361 aactcttgag tggcagctac aggcctgtga ggatcagcta tgctgtccag agatgggtgg
      421 ctggtctgag tggggaccct gggggccttg ctctgtcacc tgctccaaag gaacccagac
      481 ccgtcaacga ctatgtgata atcctgctcc taagtgtgga ggccattgcc ccggagaggc
      541 ccagcaatca caggcctgtg acactcagaa gatctgcccc acacatgggg cctgggcatc
      601 ctggggcccc tggagcgcct gctcaggatc atgccttggc ggagctcaag aacctaagga
      661 gacacgaagc cgctcatgtt ctgcaccagc accttcacac caaccccctg ggaagccctg
      721 ctcaggaaca gcctatgagc atcggggctg tagtggccta ccaccttgcc cagtggctgg
      781 tggctgggga ccatggggcc cttcaagtcc ctgcccggtg acttgtggcc tgggccagac
      841 cctagaacga cggacatgtg atcaccctgt accccgtcat gggggcccct tttgtgctgg
      901 tgatgccact cggaaacacg tctgtaacac agccatgcct tgccctgtaa atggagagtg
      961 ggaggcctgg ggaaaatgga gtcactgcag ccgtgtgaga atgaagtcca tcagctgtga
     1021 tgaaatccca ggccagcagt cacgttcaag gagctgtggt ggccgcaaat ttgatgggca
     1081 gccatgtact gggaaactcc aagatattcg acactgctat gacatccata actgtgtctt
     1141 gaaaggttca tggtcacagt ggagtacctg gggtctgtgc acaccaccat gtggacccaa
     1201 ccccacccgt gtccgtcagc gactctgcac acctttgctc cccaagtact cgcctacagt
     1261 ttccatggtt gaaggtcagg gtgagaagaa tgttaccttc tgggggatcc cacggccact
     1321 gtgtgaggtg ctacaggggc agaagctggt ggtggaagag aaacggccat gtctacatgt
     1381 gccttcctgc agagatccag aagagaagaa accctaaaat cccttgcctc cattctgacc
     1441 ccctgacctt ctaaacctca ataaaccagc ctttctagaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaa
//
