LOCUS       NM_001033864            5820 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus CASP8 and FADD-like apoptosis regulator (Cflar),
            transcript variant 1, mRNA.
ACCESSION   NM_001033864
VERSION     NM_001033864.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5820)
  AUTHORS   Shen L, Sun Z, Zhao F, Wang W, Zhang W and Zhu H.
  TITLE     Expression of c-FLIP in a rat model of sepsis and its effects on
            endothelial apoptosis
  JOURNAL   Mol Med Rep 16 (1), 231-237 (2017)
   PUBMED   28498469
  REMARK    GeneRIF: c-FLIP expression was significantly decreased in organs of
            septic rats compared with control rats, and that c-FLIP
            overexpression protected HUVECs from LPS+CHX-induced apoptosis in
            vitro.
REFERENCE   2  (bases 1 to 5820)
  AUTHORS   Jaita G, Zarate S, Ferraris J, Gottardo MF, Eijo G, Magri ML,
            Pisera D and Seilicovich A.
  TITLE     Estradiol Upregulates c-FLIPlong Expression in Anterior Pituitary
            Cells
  JOURNAL   Horm Metab Res 48 (4), 275-279 (2016)
   PUBMED   26566102
  REMARK    GeneRIF: Estradiol increased c-FLIPlong expression in anterior
            pituitary cells but not in GH3 cells.
REFERENCE   3  (bases 1 to 5820)
  AUTHORS   Urresti J, Ruiz-Meana M, Coccia E, Arevalo JC, Castellano J,
            Fernandez-Sanz C, Galenkamp KM, Planells-Ferrer L, Moubarak RS,
            Llecha-Cano N, Reix S, Garcia-Dorado D, Barneda-Zahonero B and
            Comella JX.
  TITLE     Lifeguard Inhibits Fas Ligand-mediated Endoplasmic
            Reticulum-Calcium Release Mandatory for Apoptosis in Type II
            Apoptotic Cells
  JOURNAL   J Biol Chem 291 (3), 1221-1234 (2016)
   PUBMED   26582200
REFERENCE   4  (bases 1 to 5820)
  AUTHORS   Gao J, Wang F, Wang W, Su Z, Guo C and Cao S.
  TITLE     Emodin suppresses hyperglycemia-induced proliferation and
            fibronectin expression in mesangial cells via inhibiting cFLIP
  JOURNAL   PLoS One 9 (4), e93588 (2014)
   PUBMED   24691542
  REMARK    GeneRIF: Our results also suggest that emodin regulates cFLIP
            expression in transcriptional level.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5820)
  AUTHORS   Yin J, Liu FY, Gao YQ and Liao WG.
  TITLE     [Hypobaric hypoxia increases the expression of death receptor 5 and
            inhibits that of FLICE-like inhibitory protein in the rat testis]
  JOURNAL   Zhonghua Nan Ke Xue 19 (7), 588-592 (2013)
   PUBMED   23926673
REFERENCE   6  (bases 1 to 5820)
  AUTHORS   Wang W, Prince CZ, Mou Y and Pollman MJ.
  TITLE     Notch3 signaling in vascular smooth muscle cells induces c-FLIP
            expression via ERK/MAPK activation. Resistance to Fas
            ligand-induced apoptosis
  JOURNAL   J Biol Chem 277 (24), 21723-21729 (2002)
   PUBMED   11925448
  REMARK    GeneRIF: Notch3 signaling in vascular smooth muscle cells induces
            c-FLIP expression via ERK/MAPK activation
REFERENCE   7  (bases 1 to 5820)
  AUTHORS   Yaniv G, Shilkrut M, Lotan R, Berke G, Larisch S and Binah O.
  TITLE     Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis
            induced by activation of the Fas (CD95/Apo-1) receptor: Fas
            activation and apoptosis in hypoxic myocytes
  JOURNAL   Cardiovasc Res 54 (3), 611-623 (2002)
   PUBMED   12031707
REFERENCE   8  (bases 1 to 5820)
  AUTHORS   Imanishi T, Murry CE, Reinecke H, Hano T, Nishio I, Liles WC,
            Hofsta L, Kim K, O'Brien KD, Schwartz SM and Han DK.
  TITLE     Cellular FLIP is expressed in cardiomyocytes and down-regulated in
            TUNEL-positive grafted cardiac tissues
  JOURNAL   Cardiovasc Res 48 (1), 101-110 (2000)
   PUBMED   11033112
REFERENCE   9  (bases 1 to 5820)
  AUTHORS   Imanishi T, McBride J, Ho Q, O'Brien KD, Schwartz SM and Han DK.
  TITLE     Expression of cellular FLICE-inhibitory protein in human coronary
            arteries and in a rat vascular injury model
  JOURNAL   Am J Pathol 156 (1), 125-137 (2000)
   PUBMED   10623660
REFERENCE   10 (bases 1 to 5820)
  AUTHORS   Shu HB, Halpin DR and Goeddel DV.
  TITLE     Casper is a FADD- and caspase-related inducer of apoptosis
  JOURNAL   Immunity 6 (6), 751-763 (1997)
   PUBMED   9208847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000214.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001033864.5.
            
            On Feb 10, 2021 this sequence version replaced NM_001033864.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132294,
                              SAMD00132296 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JACYVU010000214.1  16180267-16180384
            119-208             JACYVU010000214.1  16182415-16182504
            209-635             JACYVU010000214.1  16198738-16199164
            636-741             JACYVU010000214.1  16201403-16201508
            742-877             JACYVU010000214.1  16203144-16203279
            878-960             JACYVU010000214.1  16204446-16204528
            961-1015            JACYVU010000214.1  16207783-16207837
            1016-1065           JACYVU010000214.1  16213083-16213132
            1066-1147           JACYVU010000214.1  16213840-16213921
            1148-1643           JACYVU010000214.1  16225511-16226006
            1644-5820           JACYVU010000214.1  16226888-16231064
FEATURES             Location/Qualifiers
     source          1..5820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..5820
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /note="CASP8 and FADD-like apoptosis regulator"
                     /db_xref="GeneID:117279"
                     /db_xref="RGD:620847"
     exon            1..118
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            119..208
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            209..635
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1782
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="CASP8 and FADD-like apoptosis regulator isoform
                     1"
                     /protein_id="NP_001029036.1"
                     /db_xref="GeneID:117279"
                     /db_xref="RGD:620847"
                     /translation="MALSTVSAEVIHQVEESLDEDEKEMMLFLCRDVTENLAPPNVRD
                     LLDCLSERGQLSFAALAELLYRVRRFDLLKRILKTDKAAVEDHLCRSPHLVSDYRVLL
                     MEIGENLNQSDVSSLIFLTKDYTGRGKVAKDKSFLDLVIELEKLNLIGSDQLNLLEKC
                     LKSIHRIDLKTKIQKYTQSSQEARSNMNALQASLPKLSIKEHLYNSRLQNGRSKEPRF
                     VEHHGIQRKPVKTSIQESGIFLPPHIHEESYRMQSKPLGICLIIDCIGNDTEYLRETF
                     TSLGYRVQPFLFPSSHEITQIVRRFSNMTQHQDYDSFVCVLVSRGGSQSMMGVDQVYS
                     GFSLENVKDMFKGDMCPSLRGKPKLFFIQNYEALEDNSLEVDGPAIKNVNSRHLHPRH
                     CTTHPDADIFWSLCTADVSRLEQPSSSLSVYLQKLSQLLEQGRKRSLVDLHVELMDKV
                     YAWNSNVPSKEKYYLSLQHTLRKKLILSHT"
     exon            636..741
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            742..877
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            878..960
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1015
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1065
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1147
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1643
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..5820
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgcgcct gctgccacgt ctgctttcgg tttctaggcg tctccatttt gtggacccca
       61 aggcacgcag tgaagtctga gacctgagcc tctcaagaag ccacttaggg ccggaccgtg
      121 tctcgttcga tccagttttc tggaggtctc ctggcgaaaa caagtgacaa agccactgtt
      181 gagtgagatg ggccagcgac cgcccggtag tgtctctatt gcaagaactc tgaaagagat
      241 gaagagagcc cttagcaatg atgctgactt ctcgtggttc ccggagccct gctgaacgga
      301 tggaggctgg cccagagcct gacttctgcg gttctgaaca tggccctgag cactgtgtct
      361 gctgaggtca ttcaccaggt ggaggagtct cttgatgagg atgagaagga gatgatgctc
      421 ttcttgtgta gagatgtgac tgagaacctg gctccaccca acgtcaggga cctcctggat
      481 tgtttaagtg agagaggcca gctctccttc gctgccttag ctgagctgct gtacagggtg
      541 cggcggtttg acctgctcaa gaggattttg aagacagata aagcagcggt ggaggaccat
      601 ctgtgcagaa gccctcacct tgtttccgat tatagggtgc tgctgatgga gattggggag
      661 aatttgaatc aatctgatgt atcctcctta attttcctta caaaggatta cacaggccga
      721 ggcaaggtag ccaaggacaa gagtttcttg gacctggtga ttgaactgga gaaactgaat
      781 ttgattggtt ccgatcagtt gaatttatta gaaaaatgcc tgaagagcat ccacagaata
      841 gacttgaaga caaaaatcca gaagtacacg cagtccagcc aagaagcaag atcaaatatg
      901 aatgctctcc aggcttctct cccaaaattg agtatcaagg aacatttata taactcaagg
      961 ctccagaatg ggcgaagcaa agagccaaga tttgtggaac accatggcat tcagagaaaa
     1021 ccggtgaaga catccattca ggaatcagga atttttctgc ctccgcacat acatgaagag
     1081 agctacagga tgcagagcaa gcctctaggg atctgcttga tcatcgactg tattggcaat
     1141 gacacagaat atcttcgaga gaccttcact tccttgggct atcgcgtcca gcctttcttg
     1201 tttcccagtt cacatgaaat aacccagatt gttcgccgat tctccaatat gacccaacat
     1261 caagactatg acagctttgt atgtgtcctg gtgagccgag gaggctccca aagcatgatg
     1321 ggcgtagatc aggtttactc aggattctcc ttggagaatg tcaaggacat gttcaagggg
     1381 gacatgtgcc cttctctcag aggaaaaccc aagctctttt ttattcaaaa ctatgaggcg
     1441 ttggaagata acagcctgga agtagatggg ccagcaataa aaaatgtgaa ctctaggcac
     1501 ctgcatccca gacactgcac aactcacccg gacgctgata tcttctggag cctgtgcaca
     1561 gcagacgtat cccggttgga gcagccctcc agctcgctct ctgtgtacct gcagaaactc
     1621 tcccagctgc tggagcaggg caggaagcgc tcactcgtgg atctccatgt tgaactcatg
     1681 gacaaagtgt atgcctggaa cagtaatgtt ccttccaagg agaaatacta cctcagtctg
     1741 cagcacactc tgaggaagaa actcatcctg tctcacacat gaaaacccaa agccttcgga
     1801 gttctcggtg tagcatccaa ggtggcctgg agctggcaag cctcctgatt gcctgggagc
     1861 aatccaaaga atcaggtgct gcccttgaag gttccggctg cttctagttc tggtgtgagt
     1921 cctgctttcc agttcccctg tgcacaagca gaatccatac actgctgctg ccatgagcgt
     1981 ctcactccag ccaccatgcc tttaccactc tgacgaactg aatcctccaa cactgtgagg
     2041 cacagcaaac ttccccctta ccttccttag tcagatgttt cgccacagtg tggagagcag
     2101 acttaaacct actggttttg gagatttata tcaaactata ttaagttatt gtatgtgata
     2161 gtgtatggct ccagatttga acagtggcac tgactgtaat ttgagactta cctaagttca
     2221 tcaggtaact gggtaaattg tctctatggc tgaaatgtgc atatctaatc atttagtaag
     2281 ttattagctc attaagttat tataagtacc cattgcctta gcaatgctgt atcattgctc
     2341 ctggactttc acatttgcct cctatttctg taacttagct ccacatccat attctttctc
     2401 cacagaaaca aattccatca tgtatgttta acattcatag tataatgctt tgtaacacac
     2461 atagatagaa aaatagttac ccatgagcac gggagagctg gccctgactc tcgccagcta
     2521 tgtgatggtt gggtgaagta gaactggctc tgccccttga aggttgtagc gcttaggaga
     2581 gtagctcgct ccttgcctgg gcagcacagt agagccagcc ccaagagcac aacagtgagt
     2641 gggagagctc gccctggctg gctcgggaac aggagaacag gtgagctgac caactcagat
     2701 accatccaga gctttgagtt ggcctaccct ggccagcatc cgcgtcatct gctggagcat
     2761 gtgaaggggc aggtcctgca gaagcaaagc ttcatgacac agggcaacaa taggctatct
     2821 gagaggagtc ccggggaggg ccagtactga gtgcagcaga agccagaggc ctccaccagg
     2881 ccagtgattc actgtaatga acattcgtaa ggaaagctgt gcggactcat gggtgtgctg
     2941 tgggactcac ggtgacacac gggggctttt atgcacagag atgttttcat ttttatttgt
     3001 attttttgtt ttctttggca gggacagatt gctagagcag agagtgggta tggagggctg
     3061 gagagaagaa tgggattggg gtgcatgatg aagaattcac aaagaatcaa aaggggttgg
     3121 ggatttagct cagtggtaga gcgcttgcct agcaacctca aggccctggg ttcagtcccc
     3181 agctccgaaa agaagaaaaa aaaaaaaaaa aaaaagaaag aaaaaaaaaa agaaaggtgc
     3241 atcacaaaga atcaaaaacc taaaaagaaa ggaaaagtga atagttgcat agtgaaacag
     3301 attaacttta tttataattt catagctagc tttttttaaa taacaggagc agttagaact
     3361 tatttattta ttaaatactt ttggcataag atttcaatat tcatagaaaa atcctgtcat
     3421 accagtacta ggataggcca aaggaccaca tgctctgagc cagtctaggt gtgtaaacac
     3481 aaaggtgtgt gtgtgtttgt gtgagagagg accgagaaat tctatcacat ccaatacaat
     3541 ataattttgt tagctgctat aaaacatggt taatttactt ctgtgtactt tcgagtaacc
     3601 aaataatata gtctttatct gtatttaaga atagtagtca agccccaccc cctgaggttt
     3661 ggggatctgt tccaaagagg aggcagaaag accgtaagag tcagaggttg tggatgactc
     3721 caaggagcag cagcatccag acacaacagg acccatgcac agtggacgca cagagactca
     3781 aaccagagtc ccagcactga gaaaggggtt aggaagttgt ggcccatgag cacatgggaa
     3841 ccaggaatgt tcaacactca ggtctgcctc ttcgagggga gagacatatg acctgcttct
     3901 gcccagaagg caggaacaat gtgagtcata gctggtggtg tccacactat ctgtatggcc
     3961 aggccatgcc gcctccctca gactcatgtt tatctctgtc agtcggcagt ctgtcttccc
     4021 tgccaccgtc atggggacca cttttaccct gagcctgctt cctcagttaa tccagggaac
     4081 ctgtctgtgg ggaagatgtt gcttgtactc tacgagagtc tccatatggc catctcttag
     4141 gctttgtaca cacaggactg attaatcacc accagaaact attctgacat tgtgctgtgc
     4201 ttaagtatgc ctaaaataaa ccacccggtg tcagactcca aaagtttgaa caaaaactgt
     4261 ccactgagtc ttgttgagtc ggacgtcctt cctgcctttc ttggaccaac accctgtggt
     4321 tgaggtgttt gcagagaccc ccacagagag ggacttcgac taagaaggct ggtgcaatag
     4381 agctgctgag aaagggaaag cagttttctc cggcagagtc ttgctgggca cgtccactgt
     4441 gcgccagggt aggcctcacg cccaggagga gttggctaac ataaaatgga ctctgtatgt
     4501 gtgtcttttt attgattttc tttttttctt ttttcttttt tggtttgttt gtttgctttg
     4561 cttatcaact ttttgctttt ctgagggaga gaacatgaag ttgcatgagt gtggtggggt
     4621 agtgcaggag gatctgggga aagcaggaag ggagaaaaga gcatctcaca ggattgtttc
     4681 aaggatgaag tgtgaggctc tttacagcca tttttgagct gtgctcctaa ttaattacat
     4741 cattacttgt atcattagac cacattataa agggctgttt tggagggact gaatcaaact
     4801 ttgaaaaaag tcggtaggat tgggtaggtt gtgagagaga ggtgtaagct aaggaaagga
     4861 gcagccggga ggtgtacagt gtgctttaga aaccttgact tttagctgga acggatgtgc
     4921 acagtgatgg gggataagcg gggaggtgga tgtggtcctg aagtggagag ctctgacagc
     4981 cccacttctt tttttttttt tttaacattt gtaaaaacaa ttttaatgaa gttatcttac
     5041 aaaaaggaga taccaccctg accagacatc aaatgctaac acatgggtat accccagctt
     5101 catacatgtg ttacttactt ttgagctgtt gaccagtagg gttccataaa cttccaggta
     5161 ttacaggctg tttccaatac tcttggttga tctctataac ttaatggtaa gcctctattg
     5221 ctaatattac cacatatttg agtcatatag catgtctcat cagtacttgc tagacagccc
     5281 cacttcttta gctagttgta aatacctctg taaggtgttt ctcctgactt taacagtgat
     5341 cttctttgtt ccttttgtac acagaattat ggttttgttt ttcactgact gtgttttgtt
     5401 aaaatatttt agacatatta aaagataatt atgtacaaaa gacaatacct ggtttgaata
     5461 agaaactcat atgaatattc aatatagttc tttaagcact gatcttatat atatttatta
     5521 attaacatgt gctggcattt aaacactggt accaggtgtg ctgcttgaga ggtgtggctt
     5581 cgctagagga agtgtgtccc tgcgggcagg ctttgaggtt tcaaagactt aatgccattc
     5641 tgtttgcttt ttctgcttca cctttgctct tcaagatatg agctctcctt tcctttggct
     5701 tccatgcatt tgctgcacca tcacagacaa tgagtttctg gtaccatgag tgtgtaaact
     5761 gtctcctaca ccgtagttgt gatgttttat cacagcaata aaaacaaact agtacagcga
//
