LOCUS       NP_001029036             480 aa            linear   ROD 03-APR-2024
DEFINITION  CASP8 and FADD-like apoptosis regulator isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001029036
VERSION     NP_001029036.1
DBSOURCE    REFSEQ: accession NM_001033864.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 480)
  AUTHORS   Shen,L., Sun,Z., Zhao,F., Wang,W., Zhang,W. and Zhu,H.
  TITLE     Expression of c-FLIP in a rat model of sepsis and its effects on
            endothelial apoptosis
  JOURNAL   Mol Med Rep 16 (1), 231-237 (2017)
   PUBMED   28498469
  REMARK    GeneRIF: c-FLIP expression was significantly decreased in organs of
            septic rats compared with control rats, and that c-FLIP
            overexpression protected HUVECs from LPS+CHX-induced apoptosis in
            vitro.
REFERENCE   2  (residues 1 to 480)
  AUTHORS   Jaita,G., Zarate,S., Ferraris,J., Gottardo,M.F., Eijo,G.,
            Magri,M.L., Pisera,D. and Seilicovich,A.
  TITLE     Estradiol Upregulates c-FLIPlong Expression in Anterior Pituitary
            Cells
  JOURNAL   Horm Metab Res 48 (4), 275-279 (2016)
   PUBMED   26566102
  REMARK    GeneRIF: Estradiol increased c-FLIPlong expression in anterior
            pituitary cells but not in GH3 cells.
REFERENCE   3  (residues 1 to 480)
  AUTHORS   Urresti,J., Ruiz-Meana,M., Coccia,E., Arevalo,J.C., Castellano,J.,
            Fernandez-Sanz,C., Galenkamp,K.M., Planells-Ferrer,L.,
            Moubarak,R.S., Llecha-Cano,N., Reix,S., Garcia-Dorado,D.,
            Barneda-Zahonero,B. and Comella,J.X.
  TITLE     Lifeguard Inhibits Fas Ligand-mediated Endoplasmic
            Reticulum-Calcium Release Mandatory for Apoptosis in Type II
            Apoptotic Cells
  JOURNAL   J Biol Chem 291 (3), 1221-1234 (2016)
   PUBMED   26582200
REFERENCE   4  (residues 1 to 480)
  AUTHORS   Gao,J., Wang,F., Wang,W., Su,Z., Guo,C. and Cao,S.
  TITLE     Emodin suppresses hyperglycemia-induced proliferation and
            fibronectin expression in mesangial cells via inhibiting cFLIP
  JOURNAL   PLoS One 9 (4), e93588 (2014)
   PUBMED   24691542
  REMARK    GeneRIF: Our results also suggest that emodin regulates cFLIP
            expression in transcriptional level.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 480)
  AUTHORS   Yin,J., Liu,F.Y., Gao,Y.Q. and Liao,W.G.
  TITLE     [Hypobaric hypoxia increases the expression of death receptor 5 and
            inhibits that of FLICE-like inhibitory protein in the rat testis]
  JOURNAL   Zhonghua Nan Ke Xue 19 (7), 588-592 (2013)
   PUBMED   23926673
REFERENCE   6  (residues 1 to 480)
  AUTHORS   Wang,W., Prince,C.Z., Mou,Y. and Pollman,M.J.
  TITLE     Notch3 signaling in vascular smooth muscle cells induces c-FLIP
            expression via ERK/MAPK activation. Resistance to Fas
            ligand-induced apoptosis
  JOURNAL   J Biol Chem 277 (24), 21723-21729 (2002)
   PUBMED   11925448
  REMARK    GeneRIF: Notch3 signaling in vascular smooth muscle cells induces
            c-FLIP expression via ERK/MAPK activation
REFERENCE   7  (residues 1 to 480)
  AUTHORS   Yaniv,G., Shilkrut,M., Lotan,R., Berke,G., Larisch,S. and Binah,O.
  TITLE     Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis
            induced by activation of the Fas (CD95/Apo-1) receptor: Fas
            activation and apoptosis in hypoxic myocytes
  JOURNAL   Cardiovasc Res 54 (3), 611-623 (2002)
   PUBMED   12031707
REFERENCE   8  (residues 1 to 480)
  AUTHORS   Imanishi,T., Murry,C.E., Reinecke,H., Hano,T., Nishio,I.,
            Liles,W.C., Hofsta,L., Kim,K., O'Brien,K.D., Schwartz,S.M. and
            Han,D.K.
  TITLE     Cellular FLIP is expressed in cardiomyocytes and down-regulated in
            TUNEL-positive grafted cardiac tissues
  JOURNAL   Cardiovasc Res 48 (1), 101-110 (2000)
   PUBMED   11033112
REFERENCE   9  (residues 1 to 480)
  AUTHORS   Imanishi,T., McBride,J., Ho,Q., O'Brien,K.D., Schwartz,S.M. and
            Han,D.K.
  TITLE     Expression of cellular FLICE-inhibitory protein in human coronary
            arteries and in a rat vascular injury model
  JOURNAL   Am J Pathol 156 (1), 125-137 (2000)
   PUBMED   10623660
REFERENCE   10 (residues 1 to 480)
  AUTHORS   Shu,H.B., Halpin,D.R. and Goeddel,D.V.
  TITLE     Casper is a FADD- and caspase-related inducer of apoptosis
  JOURNAL   Immunity 6 (6), 751-763 (1997)
   PUBMED   9208847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.31765.1,
                                           SRR26643429.33875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     Protein         1..480
                     /product="CASP8 and FADD-like apoptosis regulator isoform
                     1"
                     /calculated_mol_wt=54928
     Region          6..85
                     /region_name="DED_c-FLIP_r1"
                     /note="Death Effector Domain, repeat 1, of cellular
                     FLICE-Inhibitory Protein; cd08337"
                     /db_xref="CDD:260044"
     Site            order(20..21,25,28..29,31..32,62,66)
                     /site_type="other"
                     /note="DED1/DED2 interface [polypeptide binding]"
                     /db_xref="CDD:260044"
     Region          96..176
                     /region_name="DED_c-FLIP_r2"
                     /note="Death Effector Domain, repeat 2, of cellular
                     FLICE-Inhibitory Protein; cd08340"
                     /db_xref="CDD:260046"
     Site            order(96,99..100,102..103,107,135,137,141)
                     /site_type="other"
                     /note="DED1/DED2 interface [polypeptide binding]"
                     /db_xref="CDD:260046"
     Region          249..479
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; Cysteine-dependent aspartate-directed
                     proteases that mediate programmed cell death (apoptosis).
                     Caspases are synthesized as inactive zymogens and
                     activated by proteolysis of the peptide...; cl00042"
                     /db_xref="CDD:444667"
     Site            order(320,365)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(321,363,412..417,421..422)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(370,397..398,405,408,411,434,441,447,462,467..468,
                     470,473..474)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(371,396)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..480
                     /gene="Cflar"
                     /gene_synonym="Flip"
                     /coded_by="NM_001033864.5:340..1782"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:117279"
                     /db_xref="RGD:620847"
ORIGIN      
        1 malstvsaev ihqveeslde dekemmlflc rdvtenlapp nvrdlldcls ergqlsfaal
       61 aellyrvrrf dllkrilktd kaavedhlcr sphlvsdyrv llmeigenln qsdvsslifl
      121 tkdytgrgkv akdksfldlv ieleklnlig sdqlnllekc lksihridlk tkiqkytqss
      181 qearsnmnal qaslpklsik ehlynsrlqn grskeprfve hhgiqrkpvk tsiqesgifl
      241 pphiheesyr mqskplgicl iidcigndte ylretftslg yrvqpflfps sheitqivrr
      301 fsnmtqhqdy dsfvcvlvsr ggsqsmmgvd qvysgfslen vkdmfkgdmc pslrgkpklf
      361 fiqnyealed nslevdgpai knvnsrhlhp rhctthpdad ifwslctadv srleqpsssl
      421 svylqklsql leqgrkrslv dlhvelmdkv yawnsnvpsk ekyylslqht lrkklilsht
//
