LOCUS       NM_001108982            2924 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cofilin 2 (Cfl2), mRNA.
ACCESSION   NM_001108982 XM_001079054 XM_345674
VERSION     NM_001108982.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Tedeschi,A., Dupraz,S., Curcio,M., Laskowski,C.J., Schaffran,B.,
            Flynn,K.C., Santos,T.E., Stern,S., Hilton,B.J., Larson,M.J.E.,
            Gurniak,C.B., Witke,W. and Bradke,F.
  TITLE     ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in
            the Adult CNS
  JOURNAL   Neuron 103 (6), 1073-1085 (2019)
   PUBMED   31400829
  REMARK    GeneRIF: Actin depolymerizing factor (ADF)/cofilin controls actin
            turnover to sustain axon regeneration after spinal cord injury
            through its actin-severing activity. This pinpoints ADF/cofilin as
            a key regulator of axon growth competence, irrespective of
            developmental stage.
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Kremneva,E., Makkonen,M.H., Skwarek-Maruszewska,A., Gateva,G.,
            Michelot,A., Dominguez,R. and Lappalainen,P.
  TITLE     Cofilin-2 controls actin filament length in muscle sarcomeres
  JOURNAL   Dev Cell 31 (2), 215-226 (2014)
   PUBMED   25373779
  REMARK    GeneRIF: cofilin-2 evolved specific biochemical and cellular
            properties that allow it to control actin dynamics in sarcomeres,
            where filament pointed ends may contain a mixture of ADP- and
            ATP/ADP-Pi-actin subunits.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Yuan,B., Wan,P., Chu,D., Nie,J., Cao,Y., Luo,W., Lu,S., Chen,J. and
            Yang,Z.
  TITLE     A cardiomyocyte-specific Wdr1 knockout demonstrates essential
            functional roles for actin disassembly during myocardial growth and
            maintenance in mice
  JOURNAL   Am J Pathol 184 (7), 1967-1980 (2014)
   PUBMED   24840128
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Gurniak,C.B., Chevessier,F., Jokwitz,M., Jonsson,F., Perlas,E.,
            Richter,H., Matern,G., Boyl,P.P., Chaponnier,C., Furst,D.,
            Schroder,R. and Witke,W.
  TITLE     Severe protein aggregate myopathy in a knockout mouse model points
            to an essential role of cofilin2 in sarcomeric actin exchange and
            muscle maintenance
  JOURNAL   Eur J Cell Biol 93 (5-6), 252-266 (2014)
   PUBMED   24598388
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Agrawal,P.B., Joshi,M., Savic,T., Chen,Z. and Beggs,A.H.
  TITLE     Normal myofibrillar development followed by progressive sarcomeric
            disruption with actin accumulations in a mouse Cfl2 knockout
            demonstrates requirement of cofilin-2 for muscle maintenance
  JOURNAL   Hum Mol Genet 21 (10), 2341-2356 (2012)
   PUBMED   22343409
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Papalouka,V., Arvanitis,D.A., Vafiadaki,E., Mavroidis,M.,
            Papadodima,S.A., Spiliopoulou,C.A., Kremastinos,D.T., Kranias,E.G.
            and Sanoudou,D.
  TITLE     Muscle LIM protein interacts with cofilin 2 and regulates F-actin
            dynamics in cardiac and skeletal muscle
  JOURNAL   Mol Cell Biol 29 (22), 6046-6058 (2009)
   PUBMED   19752190
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Won,K.J., Park,S.H., Park,T., Lee,C.K., Lee,H.M., Choi,W.S.,
            Kim,S.J., Park,P.J., Jang,H.K., Kim,S.H. and Kim,B.
  TITLE     Cofilin phosphorylation mediates proliferation in response to
            platelet-derived growth factor-BB in rat aortic smooth muscle cells
  JOURNAL   J Pharmacol Sci 108 (3), 372-379 (2008)
   PUBMED   19023180
  REMARK    GeneRIF: Cofilin phosphorylation mediates proliferation in response
            to platelet-derived growth factor-BB in rat aortic smooth muscle
            cells.
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   Agrawal,P.B., Greenleaf,R.S., Tomczak,K.K., Lehtokari,V.L.,
            Wallgren-Pettersson,C., Wallefeld,W., Laing,N.G., Darras,B.T.,
            Maciver,S.K., Dormitzer,P.R. and Beggs,A.H.
  TITLE     Nemaline myopathy with minicores caused by mutation of the CFL2
            gene encoding the skeletal muscle actin-binding protein, cofilin-2
  JOURNAL   Am J Hum Genet 80 (1), 162-167 (2007)
   PUBMED   17160903
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   Vartiainen,M.K., Mustonen,T., Mattila,P.K., Ojala,P.J.,
            Thesleff,I., Partanen,J. and Lappalainen,P.
  TITLE     The three mouse actin-depolymerizing factor/cofilins evolved to
            fulfill cell-type-specific requirements for actin dynamics
  JOURNAL   Mol Biol Cell 13 (1), 183-194 (2002)
   PUBMED   11809832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 19, 2011 this sequence version replaced NM_001108982.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1364789.1, FQ228820.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840117
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000006.1  78094752-78094888   c
            138-445             JAXUCZ010000006.1  78093522-78093829   c
            446-522             JAXUCZ010000006.1  78093330-78093406   c
            523-2924            JAXUCZ010000006.1  78090843-78093244   c
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2924
                     /gene="Cfl2"
                     /note="cofilin 2"
                     /db_xref="GeneID:366624"
                     /db_xref="RGD:1306982"
     exon            1..137
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..635
                     /gene="Cfl2"
                     /note="cofilin 2, muscle"
                     /codon_start=1
                     /product="cofilin-2"
                     /protein_id="NP_001102452.2"
                     /db_xref="GeneID:366624"
                     /db_xref="RGD:1306982"
                     /translation="MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDK
                     RQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFI
                     FWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGSVVVS
                     LEGKPL"
     exon            138..445
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     exon            446..522
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..2924
                     /gene="Cfl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcccgg ctgcagctcc cggcgtcccc tgcactctct gctgcccgcc gccggcccct
       61 ccttcttctc attccagtgc caccgagccg gagccgtagc cgccgctgcc gcagcaacct
      121 cagccgcggg cactatggca tctggagtta cagtgaatga tgaagtcatc aaagttttta
      181 atgatatgaa agtaagaaaa tcttctaccc aggaggagat caaaaaaaga aagaaagcag
      241 ttctcttctg tttaagcgat gacaaaagac aaataattgt agaggaagca aagcagatct
      301 tggtgggtga cattggtgat actgtagagg acccctacac atcttttgtg aagttgctac
      361 ctctgaatga ttgccgatat gctttgtacg atgccacata cgaaacaaaa gagtctaaga
      421 aagaagacct agtatttata ttctgggctc ctgaaagtgc accgttaaaa agcaagatga
      481 tttatgctag ctctaaagat gccattaaaa agaaatttac aggtattaaa catgagtggc
      541 aagtaaatgg cttggacgat attaaggacc gctcgacact gggagagaaa ctgggaggca
      601 gtgttgtagt ttccctggaa ggaaagccac tgtaaaataa tagccaagtg ccatttgatc
      661 ttaaggggct tacatttatt tctccagctc agtccactgg aattgtatta ggttttgttt
      721 tttgtttatt ccctttccac tggtcccgtt caacacaatg aatgagtgaa tataagaagc
      781 ctgtcagtga tcgccattag actgtttcat atggttactt tctgtagatc ccaaggaatg
      841 ccttcccgtc ctattttagc caaaacaact ggttccatgc cttccttgcg tgagcactac
      901 aacggattgt cagcgtgaat agcttagagt actacagagg gtgagctaat tgaatgcctt
      961 gaaagtattc tccactggtc atatgggaaa cttgtttcag tattatttat agtcgagctg
     1021 cacttgatca cagttctctg cggcactgga gcagtcacac acctcacccg ccttggctcg
     1081 cctattgtga catggcagca caggtttaac actattggtt aaaagcactt ttattttgta
     1141 atgcgtttag tcccttataa agaatgccaa ttaagtttca ttacctgtcc tcaatttatc
     1201 ctagtatctc agtgttcatt tttcttacct gcatattttc ttcaaaggaa tagctgtgtt
     1261 gatgtctttg gattcccaat gagtgtacac tactgtataa ttataggagt tttatgttta
     1321 ccatatgagt cttgaaacac tacagatatt ttgaatatca gtcatgatgg caatttctgt
     1381 ataaaagagc cttaaatgga acattgtttt gagatcaaac tccctgccct cataaaagtg
     1441 gccacgttgc aataaaaatt gtggcagatt acagaatgtt gccttgtttt ccttggaaat
     1501 tttgcaaatt attatgtgaa agtttagggt aaatggtgac taagctctgc actggtattt
     1561 ggaatttttt tcctttaatc tttggtttaa aatatcttaa aatcacttat atacaatcat
     1621 taaaagagtg gtacttttac aaatgtttat gttacaatat ggagatcaaa atttttctgc
     1681 actttggcat actccactta atttgttctc tagataaatt aggagattaa ttcagagtta
     1741 agttataaat aattgagtcg gatgaatagg atgttttatt acttggtcat aatgaaaata
     1801 atttgtaaaa tgtcattcaa aggtttaatg atgattgtga tatttaggaa agtctgtttc
     1861 agccacaatt ccttaatatc ttttccaaat tgaattggag gagaaaatag tatagcagtc
     1921 ttaaacatta gtaatgggat ttggctgtgg tcccgagcgt tctccttcct tatagagaac
     1981 ttgatctgct cagtgtgcgc tctttgctat tagccagagc tatttatggc aaacacatgc
     2041 ttttgtatct tgtcatagtc atccacagat ggcaaaactg gacttgattc taccggtatg
     2101 caaggcagga gtgctagtga gcagtcgttt gtggctctgg actccattgc cgtagcctgt
     2161 ggagtgcttt tatcagaata taggaaatga aatgtccttt ttaaaaatat gtggaagtaa
     2221 tttgggtgta attaattttt ttctaacttt ttgaaagttt tttttcttca gatgagaaca
     2281 ttaacatagt ggttaaatgt ctaggcttcc atttaaaact acacaactga acgtgggatc
     2341 tttttagcac taagcaattt tatttcagcc tttcagctgt cgctgtgagt tgttccagac
     2401 ctttctgtgg ctttttggta aggctgctaa taagcaaagc atgagaatgg tgtatgctaa
     2461 accatatgtt taaactgatc tttgcaccaa aggacttttt caccaagtta ttttgttatt
     2521 cttccaaata ttaagagatt tttaaaaagt aaaggagtga cctttttttt ttatagctga
     2581 tttctcaatt tctttatatg cttttttaga ataatttcaa agattaagtg ctgctttaaa
     2641 ctattatact ttgagtttta gattggccaa atacattaat gtagttaaat tcatctttaa
     2701 agtacacata tgtgcctaga gccaaaaaaa ataatgattt aatttatgat cttatgttga
     2761 gactaatttg acatcttatt ttacagtcat ttacagtgaa acaatgttcc aggtagcttt
     2821 aaaagctata cggtgctaat tagtaaaata ttaagggcaa tattttactg ctagcttgca
     2881 aaattttaag tgttttaaaa ataaaataca tgaaaatatt taaa
//
