LOCUS       NM_017147               1105 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cofilin 1 (Cfl1), mRNA.
ACCESSION   NM_017147
VERSION     NM_017147.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1105)
  AUTHORS   Vogl,A.M., Phu,L., Becerra,R., Giusti,S.A., Verschueren,E.,
            Hinkle,T.B., Bordenave,M.D., Adrian,M., Heidersbach,A.,
            Yankilevich,P., Stefani,F.D., Wurst,W., Hoogenraad,C.C.,
            Kirkpatrick,D.S., Refojo,D. and Sheng,M.
  TITLE     Global site-specific neddylation profiling reveals that NEDDylated
            cofilin regulates actin dynamics
  JOURNAL   Nat Struct Mol Biol 27 (2), 210-220 (2020)
   PUBMED   32015554
  REMARK    GeneRIF: Global inhibition of neddylation in developing neurons
            leads to cytoskeletal defects, altered actin dynamics and neurite
            growth impairments, whereas site-specific neddylation of cofilin 1
            at K112 regulates neurite outgrowth, suggesting that cofilin 1
            neddylation contributes to the regulation of neuronal actin
            organization.
            Erratum:[Nat Struct Mol Biol. 2020 Apr;27(4):400. doi:
            10.1038/s41594-020-0395-7.. PMID: 32103165]
REFERENCE   2  (bases 1 to 1105)
  AUTHORS   Shu,L., Chen,B., Chen,B., Xu,H., Wang,G., Huang,Y., Zhao,Y.,
            Gong,H., Jiang,M., Chen,L., Liu,X. and Wang,Y.
  TITLE     Brain ischemic insult induces cofilin rod formation leading to
            synaptic dysfunction in neurons
  JOURNAL   J Cereb Blood Flow Metab 39 (11), 2181-2195 (2019)
   PUBMED   29932353
  REMARK    GeneRIF: identified cofilin rod, a pathological rod-like
            aggregation, formed in neurons of in vivo ischemic stroke animal
            model and induced neuronal impairment.
REFERENCE   3  (bases 1 to 1105)
  AUTHORS   Tedeschi,A., Dupraz,S., Curcio,M., Laskowski,C.J., Schaffran,B.,
            Flynn,K.C., Santos,T.E., Stern,S., Hilton,B.J., Larson,M.J.E.,
            Gurniak,C.B., Witke,W. and Bradke,F.
  TITLE     ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in
            the Adult CNS
  JOURNAL   Neuron 103 (6), 1073-1085 (2019)
   PUBMED   31400829
  REMARK    GeneRIF: Actin depolymerizing factor (ADF)/cofilin controls actin
            turnover to sustain axon regeneration after spinal cord injury
            through its actin-severing activity. This pinpoints ADF/cofilin as
            a key regulator of axon growth competence, irrespective of
            developmental stage.
REFERENCE   4  (bases 1 to 1105)
  AUTHORS   Rogg,M., Yasuda-Yamahara,M., Abed,A., Dinse,P., Helmstadter,M.,
            Conzelmann,A.C., Frimmel,J., Sellung,D., Biniossek,M.L., Kretz,O.,
            Grahammer,F., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     The WD40-domain containing protein CORO2B is specifically enriched
            in glomerular podocytes and regulates the ventral actin
            cytoskeleton
  JOURNAL   Sci Rep 7 (1), 15910 (2017)
   PUBMED   29162887
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1105)
  AUTHORS   Yu,L., Ye,J., Liu,Q., Feng,J., Gu,X., Sun,Q. and Lu,G.
  TITLE     c-Maf inducing protein inhibits cofilin-1 activity and alters
            podocyte cytoskeleton organization
  JOURNAL   Mol Med Rep 16 (4), 4955-4963 (2017)
   PUBMED   28791377
  REMARK    GeneRIF: CMIP inhibits cofilin1 activity and alters podocyte
            cytoskeleton organization at least through RhoA signaling in
            PAinduced podocyte injury
REFERENCE   6  (bases 1 to 1105)
  AUTHORS   Yeoh,S., Pope,B., Mannherz,H.G. and Weeds,A.
  TITLE     Determining the differences in actin binding by human ADF and
            cofilin
  JOURNAL   J Mol Biol 315 (4), 911-925 (2002)
   PUBMED   11812157
REFERENCE   7  (bases 1 to 1105)
  AUTHORS   Vartiainen,M.K., Mustonen,T., Mattila,P.K., Ojala,P.J.,
            Thesleff,I., Partanen,J. and Lappalainen,P.
  TITLE     The three mouse actin-depolymerizing factor/cofilins evolved to
            fulfill cell-type-specific requirements for actin dynamics
  JOURNAL   Mol Biol Cell 13 (1), 183-194 (2002)
   PUBMED   11809832
REFERENCE   8  (bases 1 to 1105)
  AUTHORS   Lee,K., Jung,J., Kim,M. and Guidotti,G.
  TITLE     Interaction of the alpha subunit of Na,K-ATPase with cofilin
  JOURNAL   Biochem J 353 (Pt 2), 377-385 (2001)
   PUBMED   11139403
REFERENCE   9  (bases 1 to 1105)
  AUTHORS   Kanamori,T., Suzuki,M. and Titani,K.
  TITLE     Complete amino acid sequences and phosphorylation sites, determined
            by Edman degradation and mass spectrometry, of rat parotid destrin-
            and cofilin-like proteins
  JOURNAL   Arch Oral Biol 43 (12), 955-967 (1998)
   PUBMED   9877327
REFERENCE   10 (bases 1 to 1105)
  AUTHORS   Moriyama,K., Iida,K. and Yahara,I.
  TITLE     Phosphorylation of Ser-3 of cofilin regulates its essential
            function on actin
  JOURNAL   Genes Cells 1 (1), 73-86 (1996)
   PUBMED   9078368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017147.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059143.1, FQ230091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000001.1  212227124-212227203
            81-388              JAXUCZ010000001.1  212229073-212229380
            389-465             JAXUCZ010000001.1  212229745-212229821
            466-1105            JAXUCZ010000001.1  212230017-212230656
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1105
                     /gene="Cfl1"
                     /note="cofilin 1"
                     /db_xref="GeneID:29271"
                     /db_xref="RGD:69285"
     exon            1..80
                     /gene="Cfl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..578
                     /gene="Cfl1"
                     /note="cofilin 1, non-muscle"
                     /codon_start=1
                     /product="cofilin-1"
                     /protein_id="NP_058843.1"
                     /db_xref="GeneID:29271"
                     /db_xref="RGD:69285"
                     /translation="MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDK
                     KNIILEEGKEILVGDVGQTVDDPYTTFVKMLPDKDCRYALYDATYETKESKKEDLVFI
                     FWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVIS
                     LEGKPL"
     exon            81..388
                     /gene="Cfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..465
                     /gene="Cfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..1105
                     /gene="Cfl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcggatc ccggcagcag ctgcggcggc tctgttcttc tgtagctctt ttctgtctcc
       61 ctttcgtttc cggaaacatg gcctctggtg tggctgtctc tgatggagtc atcaaggtgt
      121 tcaatgacat gaaagttcgc aagtcttcaa cgccagaaga agtgaagaaa cgcaagaagg
      181 cagtgctctt ttgcctgagt gaggacaaga agaacatcat cctggaggag ggcaaggaga
      241 ttctggtagg agatgtgggg cagactgtgg acgaccccta caccactttt gtcaagatgc
      301 tgccagacaa ggactgccgc tatgctctct atgacgcaac ctatgagacc aaggagagca
      361 agaaggagga cctggtattc attttctggg cccccgagag tgcacccctt aagagcaaaa
      421 tgatctatgc cagctccaag gatgccatca agaagaaact gacaggaatc aagcacgaat
      481 tacaagctaa ctgctacgag gaggtcaagg accgctgcac cctggcagag aaactaggtg
      541 gcagcgccgt catttccctg gagggcaagc ctttgtgagc cacctccagc cccctgcctg
      601 gagcatctag cagccccaga cctgctcttg ggtgttgcag gctgcccttt tcctgccaga
      661 ccggaggggc tgggggggtt ccagcagggg gagggttttc ccttcacccc agttgccaaa
      721 catccctccc accccctgga ccgtcctttt ccctccatcc ctgacggttc tggccttccc
      781 aaactgcttt tgatcttctg attcctcttg ggttgaagca gaccaagtcc cgtcctaggc
      841 acccagtttg gggggagcct gtattttttt ttttaacgac acccctactc ctcatctgtc
      901 ccatcccatg ctgccaactt ctaaccacaa tagtgactct gtgcttgtct gtttagttct
      961 gtgtgtaaat gaactgtgga aatgaccctc cctgcaccag ctggttgccc tcccctttcc
     1021 cttgatcttg gccactcatg gaagcaggac cagtaaggga ccttcaattt aaaaaaaaaa
     1081 aaacacaata aaaaggctaa ttaac
//
