LOCUS       NM_024157               2021 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus complement factor I (Cfi), mRNA.
ACCESSION   NM_024157 XM_346633
VERSION     NM_024157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   van der Maten,E., Westra,D., van Selm,S., Langereis,J.D.,
            Bootsma,H.J., van Opzeeland,F.J., de Groot,R., Ruseva,M.M.,
            Pickering,M.C., van den Heuvel,L.P., van de Kar,N.C., de Jonge,M.I.
            and van der Flier,M.
  TITLE     Complement Factor H Serum Levels Determine Resistance to
            Pneumococcal Invasive Disease
  JOURNAL   J Infect Dis 213 (11), 1820-1827 (2016)
   PUBMED   26802141
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Patel,M., Hu,Z., Bard,J., Jamison,J., Cai,Q. and Hu,B.H.
  TITLE     Transcriptome characterization by RNA-Seq reveals the involvement
            of the complement components in noise-traumatized rat cochleae
  JOURNAL   Neuroscience 248, 1-16 (2013)
   PUBMED   23727008
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   van de Ven,J.P., Nilsson,S.C., Tan,P.L., Buitendijk,G.H.,
            Ristau,T., Mohlin,F.C., Nabuurs,S.B., Schoenmaker-Koller,F.E.,
            Smailhodzic,D., Campochiaro,P.A., Zack,D.J., Duvvari,M.R.,
            Bakker,B., Paun,C.C., Boon,C.J., Uitterlinden,A.G., Liakopoulos,S.,
            Klevering,B.J., Fauser,S., Daha,M.R., Katsanis,N., Klaver,C.C.,
            Blom,A.M., Hoyng,C.B. and den Hollander,A.I.
  TITLE     A functional variant in the CFI gene confers a high risk of
            age-related macular degeneration
  JOURNAL   Nat Genet 45 (7), 813-817 (2013)
   PUBMED   23685748
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Wu,P.B., Gu,H., Yang,X.F. and Liu,N.P.
  TITLE     [Association of single nucleotide polymorphism in complement factor
            I gene with age-related macular degeneration]
  JOURNAL   Zhonghua Yan Ke Za Zhi 49 (4), 350-356 (2013)
   PUBMED   23900096
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Fremeaux-Bacchi,V., Dragon-Durey,M.A., Blouin,J., Vigneau,C.,
            Kuypers,D., Boudailliez,B., Loirat,C., Rondeau,E. and Fridman,W.H.
  TITLE     Complement factor I: a susceptibility gene for atypical haemolytic
            uraemic syndrome
  JOURNAL   J Med Genet 41 (6), e84 (2004)
   PUBMED   15173250
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Schlaf,G., Demberg,T., Koleva,M., Jungermann,K. and Gotze,O.
  TITLE     Complement factor I is upregulated in rat hepatocytes by
            interleukin-6 but not by interferon-gamma, interleukin-1beta, or
            tumor necrosis factor-alpha
  JOURNAL   Biol Chem 382 (7), 1089-1094 (2001)
   PUBMED   11530941
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Schlaf,G., Rothermel,E., Oppermann,M., Schieferdecker,H.L.,
            Jungermann,K. and Gotze,O.
  TITLE     Rat complement factor I: molecular cloning, sequencing and
            expression in tissues and isolated cells
  JOURNAL   Immunology 98 (3), 464-474 (1999)
   PUBMED   10583609
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Patiroglu,T., Melikoglu,A. and Dusunsel,R.
  TITLE     Serum levels of C3 and factors I and B in minimal change disease
  JOURNAL   Acta Paediatr Jpn 40 (4), 333-336 (1998)
   PUBMED   9745775
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Ohkohchi,K., Torinuki,W. and Tagami,H.
  TITLE     Increased plasma concentrations of complement modulating proteins
            (C1 inhibitor, C4-binding protein, factor H and factor I) in
            psoriasis
  JOURNAL   Tohoku J Exp Med 154 (4), 315-321 (1988)
   PUBMED   2973157
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Y18965.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y18965.1, BC089798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2021
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /note="complement factor I"
                     /db_xref="GeneID:79126"
                     /db_xref="RGD:620429"
     CDS             1..1815
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /EC_number="3.4.21.45"
                     /note="C3B/C4B inactivator"
                     /codon_start=1
                     /product="complement factor I precursor"
                     /protein_id="NP_077071.1"
                     /db_xref="GeneID:79126"
                     /db_xref="RGD:620429"
                     /translation="MKLALLILLLLNPHLSSSKNTPASGQPQEDLVEQKCLLKNYTHH
                     SCDKVFCQPWQKCIEGTCACKLPYQCPKAGTPVCATNGRGYPTYCHLKSFECLHPEIK
                     FSNNGTCTAEEKFNVSLIYGSTDTEGIVQVKLVDQDEKMFICKNSWSTVEANVACFDL
                     GFPLGVRDIQGRFNIPVNHKINSTECLHVRCQGVETSLAECTFTKKSSKAPHGLAGVV
                     CYTQDADFPTSQSFQCVNGKRIPQEKACDGVNDCGDQSDELCCKGCRGQAFLCKSGVC
                     IPNQRKCNGEVDCITGEDESGCEEDKKNKIHKGLARSDQGGETEIETEETEMLTPDMD
                     TERKRIKSLLPKLSCGVKRNTHIRRKRVVGGKPAEMGDYPWQVAIKDGDRITCGGIYI
                     GGCWILTAAHCVRPSRYRNYQVWTSLLDWLKPNSQLAVQGVSRVVVHEKYNGATYQND
                     IALVEMKKHPGKKECELINSVPACVPWSPYLFQPNDRCIISGWGREKDNQKVYSLRWG
                     EVDLIGNCSRFYPGRYYEKEMQCAGTSDGSIDACKGDSGGPLVCKDVNNVTYVWGIVS
                     WGENCGKPEFPGVYTRVASYFDWISYYVGRPLVSQYNV"
     exon            1..57
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            58..337
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            338..491
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            492..673
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            674..787
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            788..898
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            899..925
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            926..946
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1006
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1110
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1214
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1492
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1597
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2010
                     /gene="Cfi"
                     /gene_synonym="FI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagctcg ctctgcttat tctgctactc ttgaatcctc acttgagttc ttccaagaac
       61 acaccagcct caggtcagcc tcaggaggat ctggtagagc agaaatgctt actgaaaaac
      121 tacacgcatc actcctgtga caaagtcttc tgccagccat ggcagaaatg tatcgaggga
      181 acctgtgcct gcaaactccc ttaccagtgc ccaaaggccg ggaccccggt gtgcgccact
      241 aatggaagag gctacccgac atactgtcac ctgaagagtt tcgaatgtct tcacccggag
      301 ataaagttct cgaataatgg aacatgcaca gctgaagaaa agtttaatgt ttccttaatt
      361 tatggaagca cagatacaga gggaattgtt caagttaaac tcgtggacca agatgagaaa
      421 atgttcatat gtaaaaatag ctggagcacc gtggaagcca acgtggcctg cttcgacctc
      481 ggatttccac tgggtgttcg tgacatacaa ggaaggttta atatacctgt aaatcacaaa
      541 ataaactcca ccgaatgcct gcatgtgcgt tgccagggag tagagaccag tttggcagag
      601 tgtaccttta ccaagaagag ttcgaaggct ccccatggct tggcaggtgt agtgtgctac
      661 acacaggatg cagatttccc aacaagtcag tccttccagt gtgtgaatgg gaagcgcatt
      721 cctcaggaga aagcctgtga tggtgtcaac gactgtggag atcaaagtga tgagctgtgt
      781 tgcaaaggtt gccgaggcca agccttcctt tgcaagtcgg gagtttgcat cccaaaccaa
      841 cgtaagtgta acggtgaggt ggactgcatc accggcgagg acgagagtgg ctgtgaagaa
      901 gacaaaaaga ataaaattca taaaggcctt gcacggtcag accaaggagg agaaactgaa
      961 attgagactg aagaaacaga aatgttgact cctgatatgg acacagaaag aaaacggata
     1021 aagtccttat tacctaaact atcctgtgga gtcaaaagaa atactcacat tcgcaggaaa
     1081 agagtggtcg gagggaagcc agccgagatg ggagattacc catggcaggt ggcgattaag
     1141 gatggagata gaataacctg tgggggcatt tatatcggtg gctgttggat tctgacagct
     1201 gcacactgtg tcagacccag tagatatcgc aactaccaag tatggacgtc tttattagac
     1261 tggctaaagc ctaactctca gttggcagtt cagggagtga gcagagttgt cgttcatgaa
     1321 aagtataacg gagccaccta ccagaatgac atagctttgg ttgaaatgaa aaaacacccg
     1381 ggcaagaaag aatgtgagct catcaattct gtccctgcct gtgtcccatg gtctccatat
     1441 ctattccaac cgaatgacag atgcatcatt tctggatggg gtcgagaaaa agataaccaa
     1501 aaagtctact cactcaggtg gggcgaagtc gacctaatag gcaactgctc gaggttttac
     1561 ccgggtcgct actatgaaaa agagatgcag tgtgcgggta ccagtgatgg gtccattgat
     1621 gcctgcaaag gagactctgg aggccccttg gtctgcaagg atgtcaacaa tgtcacttat
     1681 gtttggggca ttgtgagctg gggagaaaac tgtgggaaac cagagttccc aggtgtttac
     1741 accagagtgg ccagctattt tgattggatt agctactacg tgggaagacc ccttgtttct
     1801 caatacaatg tctgaagcta cgacctcctt ctttctgcac ttcttctttc cagggttata
     1861 ctttaattga aatgaaactg tataattagt tctcctcgat gctggcaaga agcaagtctt
     1921 actggctagt tcctaaagtt tcttcaaagt ttatgccatt ttagaattct gtcatataat
     1981 ccccaataaa tattccagtt aagcacacaa aaaaaaaaaa a
//
