LOCUS       NM_001044227            1142 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus complement factor H-related 1 (Cfhr1), mRNA.
ACCESSION   NM_001044227
VERSION     NM_001044227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1142)
  AUTHORS   Irmscher,S., Brix,S.R., Zipfel,S.L.H., Halder,L.D., Mutluturk,S.,
            Wulf,S., Girdauskas,E., Reichenspurner,H., Stahl,R.A.K.,
            Jungnickel,B., Wiech,T., Zipfel,P.F. and Skerka,C.
  TITLE     Serum FHR1 binding to necrotic-type cells activates monocytic
            inflammasome and marks necrotic sites in vasculopathies
  JOURNAL   Nat Commun 10 (1), 2961 (2019)
   PUBMED   31273197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1142)
  AUTHORS   Fratelli,M., Bolis,M., Kurosaki,M., Dori,M., Guarnaccia,V.,
            Spinelli,O., Alberti,M., Valoti,E., Pileggi,S., Noris,M.,
            Remuzzi,G., Rambaldi,A., Terao,M. and Garattini,E.
  TITLE     Association of CFHR1 homozygous deletion with acute myelogenous
            leukemia in the European population
  JOURNAL   Leuk Lymphoma 57 (5), 1234-1237 (2016)
   PUBMED   26317246
REFERENCE   3  (bases 1 to 1142)
  AUTHORS   Tortajada,A., Yebenes,H., Abarrategui-Garrido,C., Anter,J.,
            Garcia-Fernandez,J.M., Martinez-Barricarte,R., Alba-Dominguez,M.,
            Malik,T.H., Bedoya,R., Cabrera Perez,R., Lopez Trascasa,M.,
            Pickering,M.C., Harris,C.L., Sanchez-Corral,P., Llorca,O. and
            Rodriguez de Cordoba,S.
  TITLE     C3 glomerulopathy-associated CFHR1 mutation alters FHR
            oligomerization and complement regulation
  JOURNAL   J Clin Invest 123 (6), 2434-2446 (2013)
   PUBMED   23728178
REFERENCE   4  (bases 1 to 1142)
  AUTHORS   Goicoechea de Jorge,E., Caesar,J.J., Malik,T.H., Patel,M.,
            Colledge,M., Johnson,S., Hakobyan,S., Morgan,B.P., Harris,C.L.,
            Pickering,M.C. and Lea,S.M.
  TITLE     Dimerization of complement factor H-related proteins modulates
            complement activation in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (12), 4685-4690 (2013)
   PUBMED   23487775
REFERENCE   5  (bases 1 to 1142)
  AUTHORS   Hofer,J., Janecke,A.R., Zimmerhackl,L.B., Riedl,M., Rosales,A.,
            Giner,T., Cortina,G., Haindl,C.J., Petzelberger,B., Pawlik,M.,
            Jeller,V., Vester,U., Gadner,B., van Husen,M., Moritz,M.L.,
            Wurzner,R. and Jungraithmayr,T.
  CONSRTM   German-Austrian HUS Study Group
  TITLE     Complement factor H-related protein 1 deficiency and factor H
            antibodies in pediatric patients with atypical hemolytic uremic
            syndrome
  JOURNAL   Clin J Am Soc Nephrol 8 (3), 407-415 (2013)
   PUBMED   23243267
REFERENCE   6  (bases 1 to 1142)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   7  (bases 1 to 1142)
  AUTHORS   Cumova,J., Jedlickova,L., Potesil,D., Sedo,O., Stejskal,K.,
            Potacova,A., Zdrahal,Z. and Hajek,R.
  TITLE     [Comparative plasma proteomic analysis of patients with multiple
            myeloma treated with bortezomib-based regimens]
  JOURNAL   Klin Onkol 25 (1), 17-25 (2012)
   PUBMED   22348216
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001044227.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088173.1, FQ218705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000013.1  53961171-53961282   c
            113-307             JAXUCZ010000013.1  53958438-53958632   c
            308-484             JAXUCZ010000013.1  53957347-53957523   c
            485-667             JAXUCZ010000013.1  53949201-53949383   c
            668-1142            JAXUCZ010000013.1  53946298-53946772   c
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1142
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /note="complement factor H-related 1"
                     /db_xref="GeneID:289057"
                     /db_xref="RGD:1310510"
     exon            1..112
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..864
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /note="complement factor H-related protein 1; complement
                     component factor h-like 1"
                     /codon_start=1
                     /product="complement factor H-related protein 1 precursor"
                     /protein_id="NP_001037692.1"
                     /db_xref="GeneID:289057"
                     /db_xref="RGD:1310510"
                     /translation="MGFCRLLFLVNVLLTSWFSSAKGEGIHCDFPKIRHGIVYDEKKY
                     EPFSPVPGGKILYYSCEYNFASPSSSFWNPIICTEAGWSPVPKCLRICFFPSVENGHS
                     TSSGQTHKEGDIVQIVCNQGYSLQNNQSTITCGEEGWSIPPKCISPNSAGKCGPPPSI
                     DNGDITSLSLPEYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDPPTCLHACVIPEDI
                     LEKHNIVLRWRENGRIYSQSGENIEFMCKPGYRKLRGSPPFRSKCIDGHINYPTCL"
     exon            113..307
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..484
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..667
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1142
                     /gene="Cfhr1"
                     /gene_synonym="Cfhl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggagcac cacggctgga gtgtccacgg cttcagaaga tggggttctg tcgcctgttg
       61 ttcttagtca atgtcctcct aacctcatgg ttctcttctg ccaaagggga agggatccat
      121 tgtgattttc caaaaataag acatggaata gtgtatgatg aaaagaaata tgagccattt
      181 tcaccagttc ctggtgggaa gattttatac tactcctgtg aatataattt tgcgtctcct
      241 tcaagttcct tctggaatcc cataatttgc acagaagcag gatggtcacc agttccaaag
      301 tgtctaagga tctgcttctt tccttctgtg gaaaacggtc attctacatc ttcaggtcaa
      361 acacacaaag aaggtgatat tgtacaaatt gtttgcaatc aaggctacag ccttcagaat
      421 aatcagagca ccatcacctg tggtgaagag ggctggtcca ttccgccaaa atgcatttcc
      481 cccaattcag cagggaaatg tgggcctcct ccatctattg acaatggaga catcacctcc
      541 ttgtcattac cagaatatgc accattatca tcagttgaat atcagtgcca gaactacttt
      601 ttacttaagg gaaataagat aataacatgc agaaatggaa agtggtctga cccaccaacc
      661 tgcttacatg catgtgtaat accagaagat attctggaaa aacataacat agttctgaga
      721 tggagagaaa atggaaggat ttattcccaa tcaggggaga atattgaatt catgtgtaaa
      781 cctggatata gaaaattaag aggatcacct ccatttcgtt caaaatgcat tgatggtcac
      841 atcaattatc ccacttgtct gtaaaatcac aatagattta ttagtaaacc ttatggatga
      901 acctttgttt agaaatacac atgcttatta ctaattcaat ttcaatttac atttgaaata
      961 ttgtttagct catttcttct aataagcata taaacttttt tgttatatgg tgattaatct
     1021 tagcgactgt tgccacaatg caagaagact gaattcaaag cttctaatcc aaaatatgat
     1081 atgtctaagg acaaactatg tccaagcaaa aaaaaataaa tgtaagttct ttctgttcag
     1141 aa
//
