LOCUS       NM_130409               4250 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus complement factor H (Cfh), mRNA.
ACCESSION   NM_130409 XM_213893 XM_346447
VERSION     NM_130409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4250)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   2  (bases 1 to 4250)
  AUTHORS   Sivapathasuntharam,C., Hayes,M.J., Shinhmar,H., Kam,J.H.,
            Sivaprasad,S. and Jeffery,G.
  TITLE     Complement factor H regulates retinal development and its absence
            may establish a footprint for age related macular degeneration
  JOURNAL   Sci Rep 9 (1), 1082 (2019)
   PUBMED   30705315
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4250)
  AUTHORS   Li,T.R., Jia,Y.J., Ma,C., Qiu,W.Y., Wang,Q., Shao,X.Q. and Lv,R.J.
  TITLE     The role of the microRNA-146a/complement factor
            H/interleukin-1beta-mediated inflammatory loop circuit in the
            perpetuate inflammation of chronic temporal lobe epilepsy
  JOURNAL   Dis Model Mech 11 (3) (2018)
   PUBMED   29590637
  REMARK    GeneRIF: enhancive miR-146a could upregulate the expression of
            IL-1beta and downregulate the expression of CFH, whereas reductive
            miR-146a could downregulate the expression of IL-1beta and
            upregulate the expression of CFH, in hippocampi of chronic temporal
            lobe epilepsy rat models.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4250)
  AUTHORS   Kane,S.J., Farley,T.K., Gordon,E.O., Estep,J., Bender,H.R.,
            Moreno,J.A., Bartz,J., Telling,G.C., Pickering,M.C. and Zabel,M.D.
  TITLE     Complement Regulatory Protein Factor H Is a Soluble Prion Receptor
            That Potentiates Peripheral Prion Pathogenesis
  JOURNAL   J Immunol 199 (11), 3821-3827 (2017)
   PUBMED   29070671
REFERENCE   5  (bases 1 to 4250)
  AUTHORS   Calippe,B., Augustin,S., Beguier,F., Charles-Messance,H.,
            Poupel,L., Conart,J.B., Hu,S.J., Lavalette,S., Fauvet,A., Rayes,J.,
            Levy,O., Raoul,W., Fitting,C., Denefle,T., Pickering,M.C.,
            Harris,C., Jorieux,S., Sullivan,P.M., Sahel,J.A., Karoyan,P.,
            Sapieha,P., Guillonneau,X., Gautier,E.L. and Sennlaub,F.
  TITLE     Complement Factor H Inhibits CD47-Mediated Resolution of
            Inflammation
  JOURNAL   Immunity 46 (2), 261-272 (2017)
   PUBMED   28228282
REFERENCE   6  (bases 1 to 4250)
  AUTHORS   Demberg,T., Pollok-Kopp,B., Gerke,D., Gotze,O. and Schlaf,G.
  TITLE     Rat complement factor H: molecular cloning, sequencing and
            quantification with a newly established ELISA
  JOURNAL   Scand J Immunol 56 (2), 149-160 (2002)
   PUBMED   12121434
  REMARK    GeneRIF: molecular cloning, sequencing and quantification with a
            newly established ELISA
REFERENCE   7  (bases 1 to 4250)
  AUTHORS   Schlaf,G., Beisel,N., Pollok-Kopp,B., Schieferdecker,H., Demberg,T.
            and Gotze,O.
  TITLE     Constitutive expression and regulation of rat complement factor H
            in primary cultures of hepatocytes, Kupffer cells, and two hepatoma
            cell lines
  JOURNAL   Lab Invest 82 (2), 183-192 (2002)
   PUBMED   11850531
  REMARK    GeneRIF: expression and regulation in cultured heptocytes, Kupffer
            cells, and hepatoma cell lines
REFERENCE   8  (bases 1 to 4250)
  AUTHORS   Ying,L., Katz,Y., Schlesinger,M., Carmi,R., Shalev,H., Haider,N.,
            Beck,G., Sheffield,V.C. and Landau,D.
  TITLE     Complement factor H gene mutation associated with autosomal
            recessive atypical hemolytic uremic syndrome
  JOURNAL   Am J Hum Genet 65 (6), 1538-1546 (1999)
   PUBMED   10577907
REFERENCE   9  (bases 1 to 4250)
  AUTHORS   Ohali,M., Shalev,H., Schlesinger,M., Katz,Y., Kachko,L., Carmi,R.,
            Sofer,S. and Landau,D.
  TITLE     Hypocomplementemic autosomal recessive hemolytic uremic syndrome
            with decreased factor H
  JOURNAL   Pediatr Nephrol 12 (8), 619-624 (1998)
   PUBMED   9811382
REFERENCE   10 (bases 1 to 4250)
  AUTHORS   Ohkohchi,K., Torinuki,W. and Tagami,H.
  TITLE     Increased plasma concentrations of complement modulating proteins
            (C1 inhibitor, C4-binding protein, factor H and factor I) in
            psoriasis
  JOURNAL   Tohoku J Exp Med 154 (4), 315-321 (1988)
   PUBMED   2973157
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB816813.1,
            AJ320522.1, BC083174.1, CK359694.1 and CF110979.1.
            
            On Oct 19, 2005 this sequence version replaced NM_130409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ320522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CB816813.1         1-26
            27-942              AJ320522.1         1-916
            943-1385            BC083174.1         952-1394
            1386-2132           AJ320522.1         1360-2106
            2133-2798           CK359694.1         14-679
            2799-4001           CF110979.1         155-1357
            4002-4250           BC083174.1         2373-2621
FEATURES             Location/Qualifiers
     source          1..4250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..4250
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /note="complement factor H"
                     /db_xref="GeneID:155012"
                     /db_xref="RGD:620428"
     exon            1..107
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3757
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /EC_number="4.2.1.2"
                     /note="complement component factor H; platelet complement
                     factor H; complement inhibitory factor H; adrenomedullin
                     binding protein-1"
                     /codon_start=1
                     /product="complement factor H precursor"
                     /protein_id="NP_569093.2"
                     /db_xref="GeneID:155012"
                     /db_xref="RGD:620428"
                     /translation="MRLSARIIWLILWTVCVAEDCKGPPPRENSEILSGSWSEQLYSE
                     GTQATYKCRPGYRTLGTIVKVCKNGEWVPSNPSRICRKRPCGHPGDTPFGSFRLAVGS
                     EFEFGAKVVYTCDEGYQLLGEIDYRECDADGWTNDIPICEVVKCLPVTELENGRIVSG
                     AAEPDQEYYFGQVVRFECNSGFKIEGQKEMHCSENGLWSNEKPQCVEISCLPPRVENG
                     DGIYLKPVYKENERFQYKCKQGFVYKERGDAVCTGSGWNPQPSCEEMTCLTPYIPNGI
                     YTPHRIKHRIDDEIRYECKNGFYPATRSPVSKCTITGWIPAPRCSLKPCDFPQFKHGR
                     LYYEESRRPYFPVPIGKEYSYYCDNGFTTPSQSYWDYLRCTVNGWEPEVPCLRQCIFH
                     YVEYGESLYWQRRYIEGQSAKVQCHSGYSLPNGQDTILCTENGWSPPPKCVRIKTCSV
                     SDIEIENGFFSESDYTYALNRKTRYRCKQGYVTNTGEISGIITCLQDGWSPRPSCIKS
                     CDMPVFENAMTKNNNTWFKLNDKLDYECHIGYENEYKHTKGSITCTYDGWSSTPSCYE
                     RECSIPLLHQDLVVFPREVKYKVGDSLSFSCRSGHRVGADLVQCYHFGWSPNFPTCEG
                     QVKSCDQPLEIPNGEIKGTKKVEYSHGDVVEYDCKPRFLLKGPNKIQCVDGKWTTLPI
                     CVEYERTCGDLPALEHGSVQLSVPPYHHGDSVEFTCAETFTMIGHAVVFCISGRWTEL
                     PQCVATDQLEKCKAPKSTGIDAIHPNKNEFNHNFSVSYRCRQKQEYEHSICINGRWDP
                     EPNCTRNEKRFCPPPPQIPNAQVIETTVKYLDGEKVSVLCQDGYLTQGPEEMVCKHGR
                     WQSLPRCTEKIPCSQPPKIEHGSIKSPRSSEERDLIESSSYEHGTTFSYVCDDGFRIS
                     EENRVTCNMGKWSSLPRCVGIPCGPPPSIPLGIVSHELESYQYGEEVTYNCSEGFGID
                     GPAFIKCVGGQWSEPPKCIKTDCDNLPTFEIAKPTEKKKKSYRSGEQVTFRCPPPYRM
                     DGSDIVTCVNTKWIGQPVCKDNSCVNPPHVPNATILTRHKTKYPSGDKVRYDCNKPFE
                     LFGEVEVMCQNGIWTEPPKCKDSTGKCGPPPPIDNGDITSLSLPVYAPLSSVEYQCQN
                     YYLLKGNKIVTCRNGKWSQPPTCLHACVIPEDIMEKHNIVLRWRENAKIYSQSGENIE
                     FMCKPGYRKFRGSPPFRTKCIEGHINYPTCV"
     exon            108..293
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            294..399
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            400..476
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            477..668
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            669..839
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1013
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1208
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1385
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1568
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1745
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1919
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2102
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2282
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2459
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2642
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2849
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3023
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3200
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3377
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3560
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..4250
                     /gene="Cfh"
                     /gene_synonym="AMBP-1; AMBP1; Fh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcacata cttctcttcg agtcaactgc tcccagatag atccaagaca tgagactgtc
       61 agcaagaatt atttggctta tattatggac tgtttgtgta gcagaagatt gtaaaggtcc
      121 tcctccaaga gaaaattcag aaattctctc aggttcgtgg tctgaacaac tatattcaga
      181 aggcactcag gcaacctaca aatgccgccc tggataccga acacttggta ctattgtaaa
      241 agtatgcaag aatggagaat gggtaccttc taacccatca aggatatgtc ggaaaaggcc
      301 atgtgggcat cccggagaca caccctttgg gtcctttagg ctggcagttg gatctgaatt
      361 tgaatttggt gcaaaggttg tttatacatg tgatgaaggg taccaactct taggtgaaat
      421 tgattaccgt gaatgtgatg cagatgggtg gaccaatgat attccaatat gtgaagttgt
      481 gaagtgcttg ccagtgacag aactggagaa tggaagaatt gtgagtggtg cagccgaacc
      541 agaccaggaa tattattttg gacaggtggt acgctttgaa tgcaactccg gcttcaagat
      601 tgaaggacag aaagaaatgc actgctcaga aaatggcctc tggagcaatg aaaagccaca
      661 gtgtgtggaa atttcttgcc tgccaccacg agttgaaaat ggagatggta tatatctgaa
      721 accagtttac aaggagaatg aaagattcca atataaatgt aagcaaggtt ttgtgtacaa
      781 agaaagaggg gatgctgtct gcacgggttc tggatggaat cctcagcctt cctgtgaaga
      841 aatgacatgt ttgactccat atattccaaa tggtatctac acacctcaca ggattaaaca
      901 cagaattgat gatgaaatca gatatgaatg taaaaatggc ttctatcctg caacccgatc
      961 acctgtttca aagtgtacaa ttactggctg gatccctgct ccaagatgta gcttgaaacc
     1021 ttgtgatttt ccacaattca aacatggacg tctgtattat gaagaaagcc ggagacccta
     1081 cttcccagta cctataggaa aggagtacag ctattactgt gacaacgggt ttacaacgcc
     1141 ttcacagtca tactgggact accttcgttg cacagtaaat gggtgggagc ctgaagttcc
     1201 atgcctcagg caatgtattt tccattatgt ggaatatgga gaatctttat actggcaaag
     1261 aagatatata gagggtcagt ctgcaaaagt ccagtgtcac agtggctata gtcttccaaa
     1321 tggtcaagat acaatattat gtacagaaaa tggctggtcc cctcctccca aatgcgtccg
     1381 tatcaagact tgttcagtat cagatataga aattgaaaat gggttttttt ctgaatctga
     1441 ttatacatat gctctaaata gaaaaacacg gtatagatgt aaacagggat atgtaacaaa
     1501 taccggagaa atatcaggaa taattacttg tcttcaagat ggatggtcac ctcgaccctc
     1561 atgcattaag tcttgtgata tgcctgtatt tgagaatgct atgactaaga ataataacac
     1621 atggtttaaa ctcaatgaca aattagacta tgaatgtcac attggatatg aaaatgaata
     1681 taaacatacc aaaggctcta taacatgtac ttatgatgga tggtctagta caccctcctg
     1741 ttatgaaaga gaatgcagca ttcccctgtt acaccaagac ttagttgttt ttcccagaga
     1801 agtaaaatac aaagttggag attcgttgag tttctcttgc cgttcaggac acagagttgg
     1861 agcagattta gtgcaatgct accactttgg atggtcccct aatttcccaa cgtgtgaagg
     1921 ccaagtaaaa tcatgtgacc aacctcttga aatcccgaat ggggaaataa agggaacaaa
     1981 aaaagttgaa tacagccatg gtgacgtggt ggaatatgat tgcaaaccta gatttctact
     2041 gaagggaccc aataaaatcc agtgtgttga cgggaagtgg acaaccttgc cgatatgcgt
     2101 tgagtatgag agaacatgtg gagaccttcc tgcacttgag catggctctg tccagttatc
     2161 tgtccctccc taccaccacg gagattcagt ggagttcact tgtgcagaaa ccttcacaat
     2221 gattgggcat gcagtagttt tctgcattag tggaaggtgg accgagcttc ctcaatgtgt
     2281 tgcaacagat caactggaga agtgtaaagc cccgaagtca actggcatag atgcaattca
     2341 tccaaataag aatgaattta atcataactt tagtgtgagt tacagatgta gacaaaagca
     2401 ggagtatgaa cattcaatct gcatcaatgg aagatgggat cctgaaccaa actgtacaag
     2461 aaatgagaaa agattctgcc ctcctccccc acagattcca aatgcccaag tgattgaaac
     2521 cacagtgaaa tacttggatg gagagaaagt atctgttctt tgccaagatg gttacctaac
     2581 tcagggccca gaagaaatgg tgtgtaaaca tggaaggtgg cagtcgttac cacgctgcac
     2641 ggaaaaaatt ccatgttccc agccccctaa aattgaacat ggatctatta agtcgcccag
     2701 gtcctcagaa gagagagatt taattgagtc cagcagttat gaacacggaa ctacattcag
     2761 ctatgtctgt gatgatggat tcaggatatc tgaagaaaat agggtaacct gcaacatggg
     2821 aaaatggagc tctctgcctc gttgtgttgg aataccttgt ggacccccac cttcaattcc
     2881 tcttggtatt gtttctcatg aactagaaag ttaccaatat ggagaggagg ttacatacaa
     2941 ttgttctgaa ggctttggaa ttgatggacc agcatttatt aaatgtgtag gaggacagtg
     3001 gtctgaacca cccaaatgca taaaaactga ttgtgacaac ttgcccacat ttgaaattgc
     3061 caaaccgaca gaaaagaaaa aaaaatcata caggtcagga gaacaagtga cattcagatg
     3121 tccacctccg tatcgaatgg atggctctga cattgtcaca tgtgttaata cgaagtggat
     3181 tggacagccg gtatgcaaag ataattcctg tgtgaatcca ccacatgtgc caaatgctac
     3241 tatactaaca aggcacaaga ctaaatatcc atctggtgac aaagtacgtt atgactgtaa
     3301 taaacctttt gaattatttg gggaagtgga agtgatgtgc caaaacggga tttggacaga
     3361 accaccgaaa tgcaaagatt caacagggaa atgtgggcct cctccaccta ttgacaatgg
     3421 agacatcacc tccttgtcat taccagtata tgcaccatta tcatcagttg aatatcaatg
     3481 ccagaactat tatctactta agggaaataa gatagtaaca tgtagaaatg gaaagtggtc
     3541 tcagccacca acctgcttac atgcatgtgt gataccagaa gatattatgg aaaaacataa
     3601 tatagttctc agatggaggg aaaatgcaaa gatttattcc caatcagggg agaatattga
     3661 attcatgtgt aaacctggat atagaaaatt cagaggatca cctccgtttc gtacaaagtg
     3721 cattgagggt cacatcaatt atcccacttg tgtataaaat cgctatacaa ttattagtaa
     3781 accttatgga tgaacctttg tttagaaatg cacatgtata ttactaatac agtttgaatt
     3841 tacatttgaa atattgttta gctcatttct tctaataagt atataaactt tttttatatg
     3901 gtggttaatc agtaacttta cagactgttg ccacaaagca agaacattgc attcaaaact
     3961 cctaatccaa aatatgatat gtccaaggac aaactatgtc taagcaagaa aataaatgtt
     4021 agttcttcaa tgtctgtttt tattcaggac ttttcagatt ttcttggata ccttttgttg
     4081 ttaggttctg attcacagtg agtggaagac acactgactc tgacttcaaa ttagtattac
     4141 ttgccaatac ataacaacca aactatcata atatcacaaa tgtatacagc taattactgt
     4201 gtcctacctt tgtatcaata aagaaatcta agaaagttct tgcttatgaa
//
