LOCUS       NM_001077642             846 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus complement factor D (Cfd), mRNA.
ACCESSION   NM_001077642 XM_001077068 XM_343169
VERSION     NM_001077642.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 846)
  AUTHORS   Ueda,Y., Mohammed,I., Song,D., Gullipalli,D., Zhou,L., Sato,S.,
            Wang,Y., Gupta,S., Cheng,Z., Wang,H., Bao,J., Mao,Y., Brass,L.,
            Zheng,X.L., Miwa,T., Palmer,M., Dunaief,J. and Song,W.C.
  TITLE     Murine systemic thrombophilia and hemolytic uremic syndrome from a
            factor H point mutation
  JOURNAL   Blood 129 (9), 1184-1196 (2017)
   PUBMED   28057640
REFERENCE   2  (bases 1 to 846)
  AUTHORS   Williams,J.A., Stampoulis,D., Gunter,C.E., Greenwood,J., Adamson,P.
            and Moss,S.E.
  TITLE     Regulation of C3 Activation by the Alternative Complement Pathway
            in the Mouse Retina
  JOURNAL   PLoS One 11 (8), e0161898 (2016)
   PUBMED   27564415
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 846)
  AUTHORS   Bubenek,S., Nastase,A., Niculescu,A.M., Baila,S., Herlea,V.,
            Lazar,V., Paslaru,L., Botezatu,A., Tomescu,D., Popescu,I. and
            Dima,S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   4  (bases 1 to 846)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 846)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 846)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
REFERENCE   7  (bases 1 to 846)
  AUTHORS   Zhu,L., Wigle,D., Hinek,A., Kobayashi,J., Ye,C., Zuker,M., Dodo,H.,
            Keeley,F.W. and Rabinovitch,M.
  TITLE     The endogenous vascular elastase that governs development and
            progression of monocrotaline-induced pulmonary hypertension in rats
            is a novel enzyme related to the serine proteinase adipsin
  JOURNAL   J Clin Invest 94 (3), 1163-1171 (1994)
   PUBMED   8083356
REFERENCE   8  (bases 1 to 846)
  AUTHORS   Miner,J.L., Byatt,J.C., Baile,C.A. and Krivi,G.G.
  TITLE     Adipsin expression and growth in rats as influenced by insulin and
            somatotropin
  JOURNAL   Physiol Behav 54 (2), 207-212 (1993)
   PUBMED   8372111
REFERENCE   9  (bases 1 to 846)
  AUTHORS   Baker,B.C., Campbell,C.J., Grinham,C.J. and Turcatti,G.
  TITLE     Purification and partial characterization of rat factor D
  JOURNAL   Biochem J 279 (Pt 3) (Pt 3), 775-779 (1991)
   PUBMED   1953671
REFERENCE   10 (bases 1 to 846)
  AUTHORS   Johnson,P.R., Spiegelman,B., Rosen,B., Turkenkopf,I., Ree,H. and
            Greenwood,M.R.
  TITLE     Reduced adipsin mRNA and circulating adipsin protein are modulated
            by adrenal steroids in obese Zucker rats
  JOURNAL   Am J Physiol 259 (1 Pt 2), R184-R188 (1990)
   PUBMED   2197880
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S73894.1.
            
            On or before Nov 10, 2006 this sequence version replaced
            XM_343169.2, XM_001077068.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M92059.1, FM041271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680417
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..846
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /note="complement factor D"
                     /db_xref="GeneID:54249"
                     /db_xref="RGD:2498"
     CDS             1..792
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /EC_number="3.4.21.46"
                     /note="adipsin; endogenous vascular elastase; properdin
                     factor D; C3 convertase activator; D component of
                     complement (adipsin)"
                     /codon_start=1
                     /product="complement factor D precursor"
                     /protein_id="NP_001071110.1"
                     /db_xref="GeneID:54249"
                     /db_xref="RGD:2498"
                     /translation="MHSSVYLVALVVLEAAVCVAQPRGRILGGQEAMAHARPYMASVQ
                     VNGTHVCGGTLVDEQWVLSAAHCMDGVTKDEVVQVLLGAHSLSSPEPYKHLYDVQSVV
                     LHPGSRPDSVEDDLMLFKLSHNASLGPHVRPLPLQREDREVKPGTLCDVAGWGVVTHA
                     GRRPDVLQQLTVSIMDRNTCNLRTYHDGAITKNMMCAESNRRDTCRGDSGGPLVCGDA
                     VEAVVTWGSRVCGNRRKPGVFTRVATYVPWIENVLSGNVSVNVTA"
     exon            1..55
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /inference="alignment:Splign:2.1.0"
     exon            56..212
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /inference="alignment:Splign:2.1.0"
     exon            213..360
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /inference="alignment:Splign:2.1.0"
     exon            361..618
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /inference="alignment:Splign:2.1.0"
     exon            619..836
                     /gene="Cfd"
                     /gene_synonym="Adn; Df; EVE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcacagct ccgtgtacct cgtggctctg gtggtcctgg aggcggctgt atgtgttgcg
       61 cagccccgag gtcggattct gggtggccag gaggccatgg cccatgctcg gccctacatg
      121 gcttcagtgc aagtgaatgg cacgcacgtg tgcggtggca ccctggtgga tgagcagtgg
      181 gtgctgagcg ccgcgcactg catggatgga gtgaccaagg atgaggttgt gcaggtgctc
      241 ctgggtgccc actccctgtc cagtcctgaa ccctacaagc atttgtatga tgtgcaaagt
      301 gtagtgcttc acccgggcag ccggcctgac agcgttgagg acgacctcat gctctttaag
      361 ctctcccaca atgcctcact gggtccccat gtgagacccc tgcccttgca acgcgaggac
      421 cgggaggtga aacccggcac gctctgcgat gtggccggtt ggggcgtggt cactcatgcg
      481 ggacgcaggc ccgatgtcct gcagcaactg acagtgtcaa tcatggaccg gaacacctgc
      541 aatctgcgca cgtaccatga tggggcaatc accaagaaca tgatgtgtgc agagagcaac
      601 cgcagggaca cttgcagggg cgactccggc ggtcctctgg tgtgcgggga tgcggtcgaa
      661 gctgtggtta cgtggggatc tcgagtctgt ggcaaccgga gaaagccagg tgtctttacc
      721 cgcgtggcaa cctacgtgcc gtggattgaa aacgttctga gtggtaacgt gagtgttaac
      781 gtgacggcct gaggggacac cggagaccgt gactcacaat aaatgcatgc atctaaaaaa
      841 aaaaaa
//
