LOCUS       NM_001109304            1009 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cripto, FRL-1, cryptic family 1 (Cfc1), mRNA.
ACCESSION   NM_001109304 XM_001055310 XM_576538
VERSION     NM_001109304.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1009)
  AUTHORS   Arganaraz,M.E., Zampini,R., Apichela,S.A., Barraza,D.E., Angiono,G.
            and Lombardo,D.
  TITLE     Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in
            vivo
  JOURNAL   Mol Reprod Dev 86 (11), 1652-1662 (2019)
   PUBMED   31418961
REFERENCE   2  (bases 1 to 1009)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   3  (bases 1 to 1009)
  AUTHORS   Cao,R., Long,F., Wang,L., Xu,Y., Guo,Y., Li,F., Chen,S., Sun,K. and
            Xu,R.
  TITLE     Duplication and deletion of CFC1 associated with heterotaxy
            syndrome
  JOURNAL   DNA Cell Biol 34 (2), 101-106 (2015)
   PUBMED   25423076
REFERENCE   4  (bases 1 to 1009)
  AUTHORS   Sheng,W., Qian,Y., Zhang,P., Wu,Y., Wang,H., Ma,X., Chen,L., Ma,D.
            and Huang,G.
  TITLE     Association of promoter methylation statuses of congenital heart
            defect candidate genes with Tetralogy of Fallot
  JOURNAL   J Transl Med 12, 31 (2014)
   PUBMED   24479926
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1009)
  AUTHORS   Liu,Y., Asakura,M., Inoue,H., Nakamura,T., Sano,M., Niu,Z.,
            Chen,M., Schwartz,R.J. and Schneider,M.D.
  TITLE     Sox17 is essential for the specification of cardiac mesoderm in
            embryonic stem cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (10), 3859-3864 (2007)
   PUBMED   17360443
REFERENCE   6  (bases 1 to 1009)
  AUTHORS   Yan,Y.T., Liu,J.J., Luo,Y., E,C., Haltiwanger,R.S., Abate-Shen,C.
            and Shen,M.M.
  TITLE     Dual roles of Cripto as a ligand and coreceptor in the nodal
            signaling pathway
  JOURNAL   Mol Cell Biol 22 (13), 4439-4449 (2002)
   PUBMED   12052855
REFERENCE   7  (bases 1 to 1009)
  AUTHORS   Kimura,C., Shen,M.M., Takeda,N., Aizawa,S. and Matsuo,I.
  TITLE     Complementary functions of Otx2 and Cripto in initial patterning of
            mouse epiblast
  JOURNAL   Dev Biol 235 (1), 12-32 (2001)
   PUBMED   11412024
REFERENCE   8  (bases 1 to 1009)
  AUTHORS   Bamford,R.N., Roessler,E., Burdine,R.D., Saplakoglu,U., dela
            Cruz,J., Splitt,M., Goodship,J.A., Towbin,J., Bowers,P.,
            Ferrero,G.B., Marino,B., Schier,A.F., Shen,M.M., Muenke,M. and
            Casey,B.
  TITLE     Loss-of-function mutations in the EGF-CFC gene CFC1 are associated
            with human left-right laterality defects
  JOURNAL   Nat Genet 26 (3), 365-369 (2000)
   PUBMED   11062482
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):501]
REFERENCE   9  (bases 1 to 1009)
  AUTHORS   Gaio,U., Schweickert,A., Fischer,A., Garratt,A.N., Muller,T.,
            Ozcelik,C., Lankes,W., Strehle,M., Britsch,S., Blum,M. and
            Birchmeier,C.
  TITLE     A role of the cryptic gene in the correct establishment of the
            left-right axis
  JOURNAL   Curr Biol 9 (22), 1339-1342 (1999)
   PUBMED   10574770
REFERENCE   10 (bases 1 to 1009)
  AUTHORS   Yan,Y.T., Gritsman,K., Ding,J., Burdine,R.D., Corrales,J.D.,
            Price,S.M., Talbot,W.S., Schier,A.F. and Shen,M.M.
  TITLE     Conserved requirement for EGF-CFC genes in vertebrate left-right
            axis formation
  JOURNAL   Genes Dev 13 (19), 2527-2537 (1999)
   PUBMED   10521397
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473965.2.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001109304.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576538.2, XM_001055310.1.
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..1009
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /note="cripto, FRL-1, cryptic family 1"
                     /db_xref="GeneID:501121"
                     /db_xref="RGD:1562188"
     exon            1..309
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..812
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /codon_start=1
                     /product="cryptic protein"
                     /protein_id="NP_001102774.1"
                     /db_xref="GeneID:501121"
                     /db_xref="RGD:1562188"
                     /translation="MELGYQREGDGAREISYLLSPKLPGTTLDGTLSSSSRKNDSQEG
                     AHPSEALSGSNTLEESAVPGSRCCHNGGTCVLGSFCVCPAHFTGRYCEHDQRHRDCGA
                     LGHGAWTLHSCRLCRCIFSALYCLPRQTFSHCDLKSFLSSGARGSRACSIPRLLLLVL
                     CLLLQVVCGW"
     exon            310..477
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /inference="alignment:Splign:2.1.0"
     exon            478..592
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /inference="alignment:Splign:2.1.0"
     exon            593..702
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1009
                     /gene="Cfc1"
                     /gene_synonym="RGD1562188"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggactgcg tggagtcagc actccaagcc tggtggctca gcagtcctga cctgaggggg
       61 ctccagcacc tggactccca gatcttcctt cagccccgcc atcttctggc ccaggcagag
      121 ggcagagaca tccccatctt gcaagcttgt gcattctgta acccgctata gtgactccaa
      181 gacctgaagc aaaggactcc tccagggcta gaacatttga gtttcaactt ccgtggccat
      241 cggtcctcaa gcacggatga gagggaactc ggcaacccag ggtgtcggtt tgaaaacgaa
      301 tggagctagg ctatcagaga gaaggagatg gtgccagaga aattagctat ctcctgtctc
      361 caaagctccc agggacgaca ctggatggaa ccctgagtag ttccagtaga aagaatgaca
      421 gccaggaggg agcgcacccg tcggaggccc tttctggttc caacactttg gaggagagtg
      481 cggtccctgg atcccgctgt tgccacaatg gaggcacctg cgttctgggc agtttctgcg
      541 tgtgccccgc gcacttcaca ggtcgctact gcgagcacga ccagagacac agagactgtg
      601 gcgcactggg gcacggagct tggaccctgc acagctgccg cctatgcagg tgcatcttct
      661 cagcccttta ctgcctccca cgccaaacat tcagccactg tgacctgaaa agcttcctct
      721 cttcaggcgc cagaggatca agggcatgca gcatcccgag actcctcctg ctggtgctct
      781 gcctcctcct gcaggttgtg tgtggctggt aagggctgag gctctgaact gccctgacag
      841 aatctcctcc tgagcctgca aggtgtcacc cttgactacc catggcacca cagcacgcct
      901 gcaggaaagc tgggtggtgg gtatctgctt cagtgttgaa tgctgtaaat gaccgaatgg
      961 ctgaaatatg ctggatcctc gtgctgtgca ataaagacgt tcaacagcg
//
