LOCUS       NM_001008351            1887 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cilia and flagella associated protein 410
            (Cfap410), mRNA.
ACCESSION   NM_001008351 XM_228068
VERSION     NM_001008351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He
            F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG
            and Chen R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Suga A, Mizota A, Kato M, Kuniyoshi K, Yoshitake K, Sultan W,
            Yamazaki M, Shimomura Y, Ikeo K, Tsunoda K and Iwata T.
  TITLE     Identification of Novel Mutations in the LRR-Cap Domain of C21orf2
            in Japanese Patients With Retinitis Pigmentosa and Cone-Rod
            Dystrophy
  JOURNAL   Invest Ophthalmol Vis Sci 57 (10), 4255-4263 (2016)
   PUBMED   27548899
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T,
            Alswaid A, Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A,
            Rustad CF, Merckoll E, Westvik J, Stattin EL, Grigelioniene G, Kou
            I, Nakajima M, Ohashi H, Smithson S, Matsumoto N, Nishimura G and
            Ikegawa S.
  TITLE     Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations
  JOURNAL   PLoS One 11 (3), e0150555 (2016)
   PUBMED   26974433
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Khan AO, Eisenberger T, Nagel-Wolfrum K, Wolfrum U and Bolz HJ.
  TITLE     C21orf2 is mutated in recessive early-onset retinal dystrophy with
            macular staphyloma and encodes a protein that localises to the
            photoreceptor primary cilium
  JOURNAL   Br J Ophthalmol 99 (12), 1725-1731 (2015)
   PUBMED   26294103
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Fang X, Lin H, Wang X, Zuo Q, Qin J and Zhang P.
  TITLE     The NEK1 interactor, C21ORF2, is required for efficient DNA damage
            repair
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 47 (10), 834-841 (2015)
   PUBMED   26290490
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H,
            Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed
            ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry
            DA, Letteboer SJF, Roosing S, Adams M, Bell SM, Bond J, Higgins J,
            Morrison EE, Tomlinson DC, Slaats GG, van Dam TJP, Huang L, Kessler
            K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M,
            Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN,
            Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT,
            Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM,
            McKibbin M, Inglehearn CF, Stewart F, Omran H, Huynen MA,
            Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby
            CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum
            U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R and
            Johnson CA.
  CONSRTM   UK10K Consortium; University of Washington Center for Mendelian
            Genomics
  TITLE     An siRNA-based functional genomics screen for the identification of
            regulators of ciliogenesis and ciliopathy genes
  JOURNAL   Nat Cell Biol 17 (8), 1074-1087 (2015)
   PUBMED   26167768
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V,
            Suryavanshi N, Bechtel S, Wiemann S, Baum B and Ridley AJ.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF,
            Li L and Scales SJ.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   9  (bases 1 to 1887)
  AUTHORS   Krohn K, Ovod V, Vilja P, Heino M, Scott H, Kyriakou DS,
            Antonarakis S, Jacobs HT, Isola J and Peterson P.
  TITLE     Immunochemical characterization of a novel mitochondrially located
            protein encoded by a nuclear gene within the DFNB8/10 critical
            region on 21q22.3
  JOURNAL   Biochem Biophys Res Commun 238 (3), 806-810 (1997)
   PUBMED   9325172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085944.1.
            
            On Dec 16, 2004 this sequence version replaced XM_228068.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085944.1, SRR8487226.47308.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1887
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /note="cilia and flagella associated protein 410"
                     /db_xref="GeneID:309681"
                     /db_xref="RGD:1309594"
     exon            1..125
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..798
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /codon_start=1
                     /product="cilia and flagella associated protein 410"
                     /protein_id="NP_001008352.1"
                     /db_xref="GeneID:309681"
                     /db_xref="RGD:1309594"
                     /translation="MKLTRKMVLSRAKASELHSVRKLNCWGSQLTDISICREMPSLEV
                     ITLSVNSVSTLEPVRGCRRLSELYLRRNRIPSLNELFYLKDLPHLRVLWLAENPCCGA
                     SPHLYRMTVLRNLPHLQKLDNQAVTEEELTRALMEGDEITAAPSREGAGNGCPKPPYN
                     LSSVGSATETSQRLLSYTEETEVQGQTASDQSPSFSPRDTMKNPKNRNILTAILLLLR
                     ELDTEGLETVQQTVGNRLQALHRLEPQEDME"
     exon            126..144
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     exon            145..191
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     exon            192..421
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     exon            422..593
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     exon            594..669
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1751
                     /gene="Cfap410"
                     /gene_synonym="RGD1309594"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagtgta cagctgaggg gcgccgggcc tgtggccctg cggccaccat gaagctgaca
       61 cgaaagatgg ttctgtcccg agccaaggct tcagagctgc acagcgtgcg gaagctcaac
      121 tgctggggca gccagctcac agatatttct atatgccggg agatgcccag cctggaggta
      181 atcacactca gtgtcaacag tgtctccacc ctggaacccg tgcgtggctg ccgacgcctg
      241 agcgagctgt acctgaggag gaaccgcatc cccagcctga acgagctctt ctacctgaag
      301 gacttgccac acctccgggt actatggttg gccgagaacc cgtgctgcgg cgccagccca
      361 cacctctacc gcatgaccgt gctgcgtaac ctgccccacc tgcagaagct ggacaaccaa
      421 gccgtgacgg aggaagaact gacccgcgca ctgatggagg gcgatgagat caccgccgcc
      481 cccagcagag aaggcgcagg caatggctgt cccaagcccc cgtacaacct cagctctgtc
      541 ggctctgcca ctgagaccag ccagcgcctg ctgagctaca cagaggagac agaagtccag
      601 ggccagactg cctcagacca atctccttcc ttctcaccaa gggacactat gaagaatccc
      661 aagaatagga acatcctgac cgccatattg ctgctgctgc gggagctgga cacggagggg
      721 ctagagaccg tccagcagac tgtgggcaac cggctacagg cactgcacag actggagccc
      781 caggaagaca tggagtgact tcacatgcgc caggatctgg accctgttac gtcctgagga
      841 aatacagctc tgcctggaaa gcctccctct gggttcccag tgcagatgca gtggctgccg
      901 gccaggccga cccctctcct gtgcttagag ctggcagaga tgctgcccac caacatggcc
      961 cctgggactt acctgctgag gcctcgatgc cctgggcacc gtctgaccct gcctcagggg
     1021 aggactgtac aagccatacc ctccaataaa gcactgtctg tctgggctgg aaggtctggg
     1081 gcaggaagca tctcagcggc gggcagggcc ttgaccccag ggttatgctg tttctcagcc
     1141 actaggggga gccctggtat ccctgtagca agcctccctg ggaactgcct ggaatatccc
     1201 acagggcact atgtcccagg tgtccttaga catagcctgg gagaatggat ttctttcagg
     1261 acaaggctgg gcaggacact gtcctgtttc tttcttcagg agagtgatgt cacctaggta
     1321 gagggactgt tggggacatc cagggtcgct catcattctg aggtgccaga taccatcaac
     1381 aaagctgtgt ttgttagagc aatttgggga ggccccgtag cttacccagg cagggccacc
     1441 ttagtgccac tctggggtga cctgccacaa ggaaggtacc agctctgctg agtctccaat
     1501 ccctgacccc caccaccagc cacaaggaag gtatcaaggt taacatatgt aaaacgacct
     1561 gaggaagggc caagggacag gtagagcagc gtgtgaagaa gcctgctgca aacagtagct
     1621 ggctgtgtag gtgacctgta agggtcttaa tgctgaaggg tcagggcagc tgggcccttg
     1681 gctcggctcc accactggcc cccttccaaa catgggaata ctttctctct taataaactg
     1741 tttctaccag taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
