LOCUS       NM_001400933            1198 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus centrin 2 (Cetn2), transcript variant 1, mRNA.
ACCESSION   NM_001400933 XM_006229519
VERSION     NM_001400933.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Mahuzier,A., Shihavuddin,A., Fournier,C., Lansade,P., Faucourt,M.,
            Menezes,N., Meunier,A., Garfa-Traore,M., Carlier,M.F.,
            Voituriez,R., Genovesio,A., Spassky,N. and Delgehyr,N.
  TITLE     Ependymal cilia beating induces an actin network to protect
            centrioles against shear stress
  JOURNAL   Nat Commun 9 (1), 2279 (2018)
   PUBMED   29891944
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Insolera,R., Shao,W., Airik,R., Hildebrandt,F. and Shi,S.H.
  TITLE     SDCCAG8 regulates pericentriolar material recruitment and neuronal
            migration in the developing cortex
  JOURNAL   Neuron 83 (4), 805-822 (2014)
   PUBMED   25088364
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Kobayashi,T., Kim,S., Lin,Y.C., Inoue,T. and Dynlacht,B.D.
  TITLE     The CP110-interacting proteins Talpid3 and Cep290 play overlapping
            and distinct roles in cilia assembly
  JOURNAL   J Cell Biol 204 (2), 215-229 (2014)
   PUBMED   24421332
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Umlauf,D., Bonnet,J., Waharte,F., Fournier,M., Stierle,M.,
            Fischer,B., Brino,L., Devys,D. and Tora,L.
  TITLE     The human TREX-2 complex is stably associated with the nuclear pore
            basket
  JOURNAL   J Cell Sci 126 (Pt 12), 2656-2667 (2013)
   PUBMED   23591820
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Compe,E. and Egly,J.M.
  TITLE     TFIIH: when transcription met DNA repair
  JOURNAL   Nat Rev Mol Cell Biol 13 (6), 343-354 (2012)
   PUBMED   22572993
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2012 Jul;13(7):476]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Gavet,O., Alvarez,C., Gaspar,P. and Bornens,M.
  TITLE     Centrin4p, a novel mammalian centrin specifically expressed in
            ciliated cells
  JOURNAL   Mol Biol Cell 14 (5), 1818-1834 (2003)
   PUBMED   12802058
REFERENCE   7  (bases 1 to 1198)
  AUTHORS   Salisbury,J.L., Suino,K.M., Busby,R. and Springett,M.
  TITLE     Centrin-2 is required for centriole duplication in mammalian cells
  JOURNAL   Curr Biol 12 (15), 1287-1292 (2002)
   PUBMED   12176356
REFERENCE   8  (bases 1 to 1198)
  AUTHORS   Araki,M., Masutani,C., Takemura,M., Uchida,A., Sugasawa,K.,
            Kondoh,J., Ohkuma,Y. and Hanaoka,F.
  TITLE     Centrosome protein centrin 2/caltractin 1 is part of the xeroderma
            pigmentosum group C complex that initiates global genome nucleotide
            excision repair
  JOURNAL   J Biol Chem 276 (22), 18665-18672 (2001)
   PUBMED   11279143
REFERENCE   9  (bases 1 to 1198)
  AUTHORS   Hart,P.E., Poynter,G.M., Whitehead,C.M., Orth,J.D., Glantz,J.N.,
            Busby,R.C., Barrett,S.L. and Salisbury,J.L.
  TITLE     Characterization of the X-linked murine centrin Cetn2 gene
  JOURNAL   Gene 264 (2), 205-213 (2001)
   PUBMED   11250075
REFERENCE   10 (bases 1 to 1198)
  AUTHORS   Wolfrum,U. and Salisbury,J.L.
  TITLE     Expression of centrin isoforms in the mammalian retina
  JOURNAL   Exp Cell Res 242 (1), 10-17 (1998)
   PUBMED   9665797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jan 28, 2022 this sequence version replaced XM_006229519.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM123447.1, FM114009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000021.1  155816919-155817101 c
            184-342             JAXUCZ010000021.1  155814974-155815132 c
            343-471             JAXUCZ010000021.1  155814564-155814692 c
            472-609             JAXUCZ010000021.1  155813160-155813297 c
            610-1198            JAXUCZ010000021.1  155812212-155812800 c
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1198
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /note="centrin 2"
                     /db_xref="GeneID:84593"
                     /db_xref="RGD:620247"
     exon            1..183
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..699
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Caltractin; centrin, EF-hand protein, 2"
                     /codon_start=1
                     /product="centrin-2 isoform 1"
                     /protein_id="NP_001387862.1"
                     /db_xref="GeneID:84593"
                     /db_xref="RGD:620247"
                     /translation="MELCSGRASNFKKTNMASSAQRKRMSPKPELTEEQKQEIREAFD
                     LFDADGTGTIDMKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFSDFLTVMTQK
                     MSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGD
                     GEVNEQEFLRIMKKTSLY"
     exon            184..342
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /inference="alignment:Splign:2.1.0"
     exon            343..471
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /inference="alignment:Splign:2.1.0"
     exon            472..609
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1198
                     /gene="Cetn2"
                     /gene_synonym="Calt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtacgctg ttgacttaac aaccggtggc agcgtctgtt gggtgatggt aagtgctgga
       61 ggttcggtgg actaccgcgg cgttcccggg cctttcctag gcctcggtgc aggcttgcaa
      121 ccttccttgc acggttcttg gcgttgatgc actagttctt ccatggagct gtgttccgga
      181 agggcctcta attttaagaa gacaaacatg gcatccagtg cccagagaaa aaggatgagc
      241 cctaagcctg aacttactga agaacagaaa caggaaatcc gggaagcttt tgatctcttt
      301 gatgctgatg gaactggaac tatagacatg aaggaactaa aggtggcaat gagggccctg
      361 ggctttgaac ccaagaaaga agaaatcaag aaaatgataa gtgaaatcga taaagaagga
      421 acaggaaaaa tgaacttcag tgactttttg acagtgatga ctcagaaaat gtctgagaaa
      481 gacaccaaag aagaaatcct gaaagctttc aagctgtttg atgatgatga gactggaaaa
      541 atatcgttca agaatcttaa gcgtgtggcc aaggagctgg gcgagaacct gacagatgag
      601 gagctccagg aaatgattga tgaagctgat cgagatggag atggtgaggt caatgagcaa
      661 gagttcctgc gcatcatgaa gaagaccagc ctctattaag atcagtgttc ctttttctac
      721 tgcaagcaca tgtgactaga tttagtgcct ggcattttgt gacatatggc tttggagagc
      781 ccccctcccc taacctctgg gataacttta gccatgacct tgaatctatt tttgactttt
      841 ggaagtgttc tttgatatta agttctttgt acatttacct gctgactaag tcagaagaag
      901 aacataaagt ggggaaaagg gtctgaaggt gtgactgtgg ccactccacc ttccatgact
      961 tcaccttact catgcatttc cacagagctg aaaacatgca ctggcttctt agttgtccat
     1021 gtatccatgt caccataagc tgtagtggtt cttaaaatgg ttttggtttt catttgacac
     1081 cacaatgcag ttttctcttt tataaaacct aatgagtgct tgctgtggca tttggatgtg
     1141 tgttaatgca tttgttttgt ctttaaaaaa ataaaacctt tcttaattta agctctca
//
