LOCUS       NM_001012056            2156 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carboxylesterase 5A (Ces5a), mRNA.
ACCESSION   NM_001012056 XM_226263
VERSION     NM_001012056.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Ru,Y.F., Xue,H.M., Ni,Z.M., Xia,D., Zhou,Y.C. and Zhang,Y.L.
  TITLE     An epididymis-specific carboxyl esterase CES5A is required for
            sperm capacitation and male fertility in the rat
  JOURNAL   Asian J Androl 17 (2), 292-297 (2015)
   PUBMED   25475668
  REMARK    GeneRIF: CES5A plays an important role in sperm maturation and male
            fertility in the rat.
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Zhang,L., Hu,Z., Zhu,C., Liu,Q., Zhou,Y. and Zhang,Y.
  TITLE     Identification and characterization of an epididymis-specific gene,
            Ces7
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (10), 809-815 (2009)
   PUBMED   19779645
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Zhang,L., Liu,Q., Zhou,Y. and Zhang,Y.
  TITLE     Baculo-expression and enzymatic characterization of CES7 esterase
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (9), 731-736 (2009)
   PUBMED   19727521
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     Mammalian carboxylesterase 5: comparative biochemistry and genomics
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 3 (3), 195-204
            (2008)
   PUBMED   19727319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Mar 5, 2021 this sequence version replaced NM_001012056.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF479659.1, SRR26643297.50962.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000019.1  11475318-11475531
            215-419             JAXUCZ010000019.1  11476407-11476611
            420-558             JAXUCZ010000019.1  11479960-11480098
            559-692             JAXUCZ010000019.1  11482140-11482273
            693-846             JAXUCZ010000019.1  11484360-11484513
            847-951             JAXUCZ010000019.1  11487110-11487214
            952-1056            JAXUCZ010000019.1  11489619-11489723
            1057-1197           JAXUCZ010000019.1  11491094-11491234
            1198-1266           JAXUCZ010000019.1  11493819-11493887
            1267-1414           JAXUCZ010000019.1  11494820-11494967
            1415-1564           JAXUCZ010000019.1  11501788-11501937
            1565-1637           JAXUCZ010000019.1  11504219-11504291
            1638-2156           JAXUCZ010000019.1  11504369-11504887
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p12"
     gene            1..2156
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /note="carboxylesterase 5A"
                     /db_xref="GeneID:307660"
                     /db_xref="RGD:1549717"
     exon            1..214
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1869
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /EC_number="3.1.1.1"
                     /note="cauxin; epididymis-specific gene 615 protein;
                     carboxylesterase-like urinary excreted protein homolog;
                     carboxylesterase 7; carboxylesterase 615"
                     /codon_start=1
                     /product="carboxylesterase 5A precursor"
                     /protein_id="NP_001012056.2"
                     /db_xref="GeneID:307660"
                     /db_xref="RGD:1549717"
                     /translation="MSGDWVHTGQALIWVLWIFAAIIRGSVTEEPHRYTRLGWVQGKQ
                     ATVLGRLEPVNVFLGIPFAAPPLGPLRFSNPQPPIPWHDLREATTYPNVCFQNLEWLF
                     IYQNLLKVHYPKLGVSEDCLYLNIYAPAYANDGSRLPVMMWIPGGGFETGSASIFDGS
                     ALAAYEDVLIVTIQYRLGIFGFFNTQNQHAPGNWAFQDQLAALQWVRENINYFGGNPD
                     SVTIFGGSAGAISISSLILSPLSAGLFHRAIMQSGVAIIPSLKNFDDELKHGLQVVAD
                     VCKCNVSDSKVLLKCLREKSSLELLSLGQKTKAFTRVVDGSFFPEEPMELLSQKTFKT
                     VPSIIGVNNQECGYILPMREAPEILFGSNESTALTLIHVLLHIPPQYMHIVAKDYFHG
                     KHSLTDIRDTLLDLFGDVFFVVPGLVTARNHRDAGGPVYFYEFQHRPNCFQNTRPAFV
                     KADHTDEIRFVFGGPFLEGDVVMFEEATEDEKLLSRKMMSYWANFARSGDPNGDDLPL
                     WPAYDQNESYLKLDVNISTGWRLKDRRVEFWTDTLPLITSASKALLSPTFPLILFSLL
                     PPSLLSIAS"
     exon            215..419
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            420..558
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            559..692
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            693..846
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            847..951
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1056
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1197
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1266
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1414
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1564
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1637
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2156
                     /gene="Ces5a"
                     /gene_synonym="Ces5; Ces7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattcttgat ttcttctgcg tcccatgtct tgcctttggg gtgcctgtct actcacaggc
       61 agcacattcc ggtccctgac agaagttctt tgaggccaga agcaaccgtg gatatccaga
      121 cagttcaggc acaccaacca gatgagtggg gactgggtgc atacaggcca ggccctaatc
      181 tgggtccttt ggatctttgc agccatcatc agggggtctg tgactgaaga gccacatagg
      241 tataccaggc tgggatgggt gcaggggaag caagccactg tgctgggaag acttgaacct
      301 gtgaacgtgt ttcttgggat cccctttgct gcaccccctc tcggacctct gcggttttcc
      361 aatccacagc ctccgatccc atggcacgat ttgcgagaag ccactaccta tcccaatgtg
      421 tgctttcaga acttagagtg gctcttcata tatcaaaacc tgctcaaagt acattaccct
      481 aaacttggag tgtcagagga ctgtctgtac ctcaacattt atgcaccagc ctacgccaat
      541 gatggctccc gtctcccggt catgatgtgg atacctggag gtggctttga gactggctcg
      601 gcctccatct tcgatgggtc tgccctggct gcctatgagg acgtgttgat tgtgaccatc
      661 cagtaccgcc taggaatatt tggattcttc aacacacaga accagcatgc ccctgggaac
      721 tgggccttcc aggatcagtt ggctgccttg caatgggtta gggagaacat caactacttc
      781 ggtggaaacc ctgactctgt gaccatcttt ggtggctcgg caggagccat aagcatttct
      841 agcctcattc tgtctccttt gagcgcgggg ttattccaca gagccatcat gcagagcgga
      901 gtggccatca tccccagcct gaagaatttt gatgatgaac tgaaacatgg tttgcaggtg
      961 gttgcagatg tctgtaagtg caacgtatca gactccaagg ttttgctgaa gtgcctgagg
     1021 gaaaagtctt ctctcgagtt gctgagcctt ggccagaaaa caaaggcatt cactcgagtg
     1081 gttgatggtt ctttctttcc tgaagaaccg atggaactgt tgtctcaaaa gacatttaaa
     1141 acagttcctt ctatcattgg agtcaataac caggagtgtg gctacatact gcccatgagg
     1201 gaagcgcctg agattctttt cggctccaat gagtctaccg ctctcaccct gatacatgtc
     1261 ttgctgcata ttccccccca gtatatgcac atcgtggcaa aagattactt ccacggcaag
     1321 cattctctga ctgacatccg agacacttta ctggatttgt ttggagatgt gttctttgtg
     1381 gttcctgggc tggtcacagc tcgaaatcac agagatgctg gtggacctgt ctatttttat
     1441 gagtttcagc accgacccaa ctgctttcag aacacaaggc cagctttcgt gaaggctgac
     1501 cacacggatg aaatccgctt tgtctttgga ggcccattcc tggagggtga cgtggtcatg
     1561 tttgaggaag ccactgagga tgagaagttg ctaagcagga agatgatgag ctactgggct
     1621 aactttgcca ggagtgggga tcctaacggg gatgacctgc ctctgtggcc agcctacgat
     1681 cagaatgaat cgtacctgaa gctggatgtg aacatcagca ctggatggag actgaaagat
     1741 cggagagtgg aattttggac agacaccctg cccctgatca cgtctgcttc caaagcgcta
     1801 ctcagtccca ctttcccctt aatcctcttt tcgctgctgc cgccgtctct tctctccatt
     1861 gcttcttaga agtcatgatt gtttgcttct gattttcttc taagtttctc cctcagccat
     1921 tatccccatt cccagctgag ctgctttcct ggagacttct gtgcgctaat ctgctttcac
     1981 tgatgtttta tgggcttagg gatcaacctc ataaaattct tttcaacatc aaaaaaattc
     2041 aatttgtctt ggaaggtaat gaaattttct caatgagtct ggaggagggc tggtccatta
     2101 cttgtcatat aatgaaccca ttactcatat aaaataaaat cagagtgcaa aatgta
//
