LOCUS       NM_001106176            2437 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus carboxylesterase 4A (Ces4a), mRNA.
ACCESSION   NM_001106176 XM_001075382 XM_226401
VERSION     NM_001106176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T,
            Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo
            MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R and
            Maltais LJ.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226401.4, XM_001075382.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2437
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /note="carboxylesterase 4A"
                     /db_xref="GeneID:291955"
                     /db_xref="RGD:1307418"
     exon            1..231
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1844
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /note="carboxylesterase 8 (putative)"
                     /codon_start=1
                     /product="carboxylesterase 4A precursor"
                     /protein_id="NP_001099646.1"
                     /db_xref="GeneID:291955"
                     /db_xref="RGD:1307418"
                     /translation="MAEAGWSMKWTLDLSLTLWLVVQTALGALHTKEPLLITKHGILQ
                     GKQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQ
                     ITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVMVWFPGGAFLVGSASTYE
                     GSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRWVQENIEAFGGD
                     PDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDPLKSAKKIAH
                     LAGCDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSHKDPKDIVWFLSPVVDGLVF
                     PEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYITKLLWSCSI
                     LLNITEEQIPLVAREYLSDAISHHDWKMFRNHLIDLVGDATFVYATLQAARYHRDAGS
                     PVYLYEFKHHAPGIIVKPRSDGADHGDELSYLFGSPFSKGSSRGEEKEFSLQMMKYWA
                     NFAHTGDPNDRELPYWPRFDKEEKYLQLDFDTRVGVKLREKQMTFWRRLRQPQKP"
     exon            232..433
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            434..575
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            576..709
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            710..863
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            864..968
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1073
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1112
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1253
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1334
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1491
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1620
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1693
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2437
                     /gene="Ces4a"
                     /gene_synonym="Ces8; RGD1307418"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctccaca gctggggaga agctggtcat aactcctcca gccccagctg ggaatgatgg
       61 gaatcgagaa gataaaggca gaactttctg gtgcttgcac acgtactcag agctcccttc
      121 tgaccccaga agcgtaggca tcaccgcagc ccatggcaga agctggctgg agcatgaagt
      181 ggactctgga cttgagcctc accctgtggc tggtagtcca gacagcctta ggtgctttgc
      241 acaccaagga acctctcctg atcaccaaac acgggatcct acaaggaaag caagtgcatg
      301 tgggagacac acccatccga gtcttcctgg gagtcccctt ctctcaacct cctgtgggca
      361 cacgcaggtt tgctcctcca gagcccccgc taccctggaa cggaatcaga gacgccacca
      421 cctacccacc ttcgtgcctt caggaatcct gggggcagat aacatccatg tacttaaaca
      481 cgcggaaaca gtacgagtgg ctgcatttca gcgaggactg cctttacctg aatgtatatg
      541 ccccagtact cgcacctggg gaccctctgc tgccggtgat ggtttggttc cctggaggtg
      601 ccttcctcgt cggttcggct tccacctatg aaggctcaga gttggcggcc cgtgggaaag
      661 tggtgctggt gtttcttcag tataggctgg gcatcctggg cttcttcagc acgggcaaca
      721 gccatgcccg cgggaactgg gggctactgg atcagatagc tgctctgcgg tgggtgcagg
      781 agaacatcga agcttttggt ggagacccgg acagtgtaac actatttggc cagtcggcag
      841 gagctatgag cgtctcagga ctgctgatgt cacctctagc ccagggctta ttccatcaag
      901 ccatttccca gagtggtact gcggtactga aaaccttcat cactcacgat ccactgaagt
      961 cagccaagaa aattgctcac ctggctggct gtgaccacaa cagtacgaag attatggtaa
     1021 aatgcctgaa ggctctaccg gcagagaagg tgatgcttgt ttccaagaag atgacattct
     1081 tccgtgctaa ctcccataaa gatccaaaag acatcgtgtg gttcctgagc ccagtggtgg
     1141 atggtttggt gttcccagaa gaccctgtgg tgctcctgac ccgtgggcag gttaaacctg
     1201 taccctacct tctaggtgtc aacagcgcgg agttcgagtg gtccttgcct tttctcatga
     1261 agctccagct aaatcagcgc ataatgaaca aaaactacat caccaaacta ctctggagtt
     1321 gcagcatttt gctgaatatc actgaggagc aaatcccact ggtggcaaga gagtacttga
     1381 gtgatgctat cagtcaccac gactggaaga tgttccgaaa ccacctgata gacctagtcg
     1441 gagatgccac ctttgtctat gccacactcc aagctgcgcg atatcaccga gatgctggct
     1501 cgcctgtcta tctgtatgaa ttcaagcacc atgctccagg catcattgtc aaacctcgaa
     1561 gtgatggagc agaccacgga gacgagcttt cctatctctt cgggagccct ttctccaaag
     1621 gctcatccag aggtgaggaa aaggaattca gcctccagat gatgaaatac tgggccaact
     1681 ttgctcacac tggggacccc aatgacagag agctgcccta ctggcctcgc tttgacaagg
     1741 aagaaaagta cctgcagttg gacttcgata caagagtggg tgtgaagctc agggagaaac
     1801 aaatgacttt ctggagacgg ctgcgccagc ctcaaaaacc ttagaagcac cggccatact
     1861 gagagtgacc aagcaagtgg aagctattct gcctcaagga gactggccct agatacatct
     1921 gaggacaaga gtcctcccca ctcaatctag gaccggtagg tgctcctgac tgccttcagg
     1981 ccatagctgg agcccttgtc catctttggg gcttagcacc accagtctag cctgatgtcc
     2041 catgacactt tatatctcac tgtttaaacc aggtcaggca gggcctttca tcgcactgtg
     2101 ctctacctgc tccctcctta gccccacccc catctcaagg caatctcttt tttctgtttt
     2161 ataagacctc ttatccttca tgatgtatct gcagccctct cttgtggaat gttctcacgg
     2221 gtgccacttc ctgtcattgt accctgcagt cattgatcat ctgctctgtt caacctgctt
     2281 gcttacactg gccttgaggc cccagacaat ccatttatga taaggagaaa agcttcgatg
     2341 gctcagaatc tgtattccct tctcacactc atctccccct tggtgctccc aaagcctgtt
     2401 cctagggatt gtgctcaata aaacaatgtg ttgattt
//
