LOCUS       NM_001044258            2065 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus carboxylesterase 2H (Ces2h), transcript variant
            1, mRNA.
ACCESSION   NM_001044258 XM_001071586 XM_574225
VERSION     NM_001044258.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Xie S, Borazjani A, Hatfield MJ, Edwards CC, Potter PM and Ross MK.
  TITLE     Inactivation of lipid glyceryl ester metabolism in human THP1
            monocytes/macrophages by activated organophosphorus insecticides:
            role of carboxylesterases 1 and 2
  JOURNAL   Chem Res Toxicol 23 (12), 1890-1904 (2010)
   PUBMED   21049984
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T,
            Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo
            MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R and
            Maltais LJ.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Takahashi S, Katoh M, Saitoh T, Nakajima M and Yokoi T.
  TITLE     Different inhibitory effects in rat and human carboxylesterases
  JOURNAL   Drug Metab Dispos 37 (5), 956-961 (2009)
   PUBMED   19225040
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Tully DB, Bao W, Goetz AK, Blystone CR, Ren H, Schmid JE, Strader
            LF, Wood CR, Best DS, Narotsky MG, Wolf DC, Rockett JC and Dix DJ.
  TITLE     Gene expression profiling in liver and testis of rats to
            characterize the toxicity of triazole fungicides
  JOURNAL   Toxicol Appl Pharmacol 215 (3), 260-273 (2006)
   PUBMED   16643972
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC088223.1 and BC107806.1.
            
            On Jun 17, 2010 this sequence version replaced NM_001044258.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BC088223.1         1-34
            35-2065             BC107806.1         5-2035
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2065
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /note="carboxylesterase 2H"
                     /db_xref="GeneID:498940"
                     /db_xref="RGD:1560889"
     exon            1..113
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1717
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carboxylesterase 2 (intestine, liver)"
                     /codon_start=1
                     /product="carboxylesterase 2 isoform 1 precursor"
                     /protein_id="NP_001037723.1"
                     /db_xref="GeneID:498940"
                     /db_xref="RGD:1560889"
                     /translation="MGLKQIHARLTTAACGLLLLLQVQGQDSLSPIRTTHTGQILGSL
                     IHMKGLDVGVHSFLGIPFAKPPIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMN
                     MQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSNLPVMVWIHGGALVIGMASLYDG
                     SMLAAMENVVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQVAALHWVQQNIAHFGGNP
                     DRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVANL
                     SGCEQVDSKALVNCLRGKSEEEIMSINKAFRIISGIVDGIFLPRHPKELLASADFHPI
                     PSIIGVNNDEYGWIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEY
                     MGDSEDPQFLQVQFKEMMEDFTFVIPALQVAHFQRSNAPVYFYEFQHRPSFFKDSKPP
                     HVKADHGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFARQGNPNSEGLPYWP
                     VFDHDEQYLQLDTQPAVGRALKAKRLQFWTKTLPEKIRELKDTEDRHTEL"
     exon            114..318
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..460
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..594
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..853
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..952
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1093
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1174
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1319
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1457
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1530
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2000
                     /gene="Ces2h"
                     /gene_synonym="Ces2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccctaca gaagttcaga cacacgcctg tgtaccaacc atgggactga aacaaattca
       61 cgctcggcta accaccgcgg cctgtgggct cctgcttctc ctccaggtcc agggccagga
      121 ctcactcagt cccatcagga ccacacacac aggccagata ctgggcagcc tcatccatat
      181 gaagggcctt gatgtgggtg tccacagctt cctgggaatt ccctttgcca agcctcctat
      241 agggccactg cgctttgctc cccctgaggc ccctgagcca tggagtggtg tgagagatgg
      301 gacctcacat ccggccatgt gtctgcagga catcactgca atgaatatgc aggcttttaa
      361 actgttgaag ctgaccttgc ctctcatccc tatgtctgaa gactgcctat accttaacat
      421 ttatacacca aatcatgccc acgagggttc caacctacct gtgatggtgt ggatccatgg
      481 aggtgcactg gttataggca tggcttcatt gtatgatggc tccatgctgg cagccatgga
      541 gaatgtagtg gtggtcacta tccaataccg cctaggtgtt ctgggtttct tcagcacagg
      601 agaccagcac gccaggggga actggggata cctggaccaa gtggccgccc tacactgggt
      661 ccagcagaac atcgcccact ttggaggcaa ccctgaccgg gtcaccattt ttggcgagtc
      721 agcaggtggc acaagtgtgt cttcacacgt tgtgtccccc atgtcccgtg ggctcttcca
      781 tggtgccatc atggagagtg gggtggccct gatgtcgagc ctcatctcag tatcttctga
      841 cgttgtctat agaacagtgg ccaacctttc tggatgtgag caggtggact ccaaggctct
      901 ggtgaactgt ctacgaggca agagcgagga agagattatg tctattaaca aggccttcag
      961 gatcatctct ggcatagtgg atggtatctt ccttcccaga catcccaagg agctgttggc
     1021 ctctgctgac tttcacccca ttcccagcat tattggtgtc aacaatgatg agtatggctg
     1081 gatcattccc tcgagcatga ccaccactga ctccaagaag aaaatggaca gacagatggt
     1141 gcaagctatc ctgcagaaga gggtagccca gatgatgtgg cctcctgaat ttagtgacct
     1201 gctgctagag gagtacatgg gggacagtga ggaccctcag tttctccaag tgcagttcaa
     1261 ggagatgatg gaagacttca cttttgtgat ccctgcactg caagtagcac attttcaacg
     1321 ttccaatgcc cctgtctact tctatgagtt ccaacatcgg cccagtttct tcaaggactc
     1381 caagccaccc catgtgaagg ctgaccatgg tgatgagatt ctctttatct tcagatcatt
     1441 ttggggaggc acccaagttg acctcactga ggaggaggag ctgctgagca ggaggatgat
     1501 gaagtactgg gccaactttg cacgacaggg gaatcccaac agtgagggtc taccctactg
     1561 gcctgtgttt gaccatgatg agcagtacct gcagctggac acccagcctg ctgtgggacg
     1621 agccctgaag gccaaaaggc tgcagttctg gaccaagact cttcctgaaa agatacggga
     1681 gttaaaagat actgaggaca gacatacaga gttgtagcac cctgcattgc attgtagttt
     1741 gtcatgagtg caggtgggcc tattctgaac tttctaaaca ccttaaaaag agacacgggg
     1801 ggctggagag atggctcaag ggttaaaagc actgactgct cttccagaga tcctgagttc
     1861 aaatcccagc caccacatgt tggctcataa ctatctataa tgagatctga tatcctcttc
     1921 tgatgtgtct gaagacagct acaatgtact tataaataat taaatcttat aaataaacaa
     1981 atctttttaa aaaagagaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaa
//
