LOCUS       NM_133586               1891 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus carboxylesterase 2C (Ces2c), mRNA.
ACCESSION   NM_133586
VERSION     NM_133586.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Holmes,R.S., Glenn,J.P., VandeBerg,J.L. and Cox,L.A.
  TITLE     Baboon carboxylesterases 1 and 2: sequences, structures and
            phylogenetic relationships with human and other primate
            carboxylesterases
  JOURNAL   J Med Primatol 38 (1), 27-38 (2009)
   PUBMED   19187434
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Taketani,M., Shii,M., Ohura,K., Ninomiya,S. and Imai,T.
  TITLE     Carboxylesterase in the liver and small intestine of experimental
            animals and human
  JOURNAL   Life Sci 81 (11), 924-932 (2007)
   PUBMED   17764701
  REMARK    GeneRIF: comparative analysis of CES1 and CES2 in liver and small
            intestine of humans, monkeys, dogs, rabbits and rats
REFERENCE   4  (bases 1 to 1891)
  AUTHORS   Masaki,K., Hashimoto,M. and Imai,T.
  TITLE     Intestinal first-pass metabolism via carboxylesterase in rat
            jejunum and ileum
  JOURNAL   Drug Metab Dispos 35 (7), 1089-1095 (2007)
   PUBMED   17392394
  REMARK    GeneRIF: CES2 isoenzymes shown to be major intestinal esterases in
            first pass hydrolysis of ester containing drugs.
REFERENCE   5  (bases 1 to 1891)
  AUTHORS   Furihata,T., Hosokawa,M., Masuda,M., Satoh,T. and Chiba,K.
  TITLE     Hepatocyte nuclear factor-4alpha plays pivotal roles in the
            regulation of mouse carboxylesterase 2 gene transcription in mouse
            liver
  JOURNAL   Arch Biochem Biophys 447 (2), 107-117 (2006)
   PUBMED   16527247
REFERENCE   6  (bases 1 to 1891)
  AUTHORS   Furihata,T., Hosokawa,M., Fujii,A., Derbel,M., Satoh,T. and
            Chiba,K.
  TITLE     Dexamethasone-induced methylprednisolone hemisuccinate hydrolase:
            its identification as a member of the rat carboxylesterase 2 family
            and its unique existence in plasma
  JOURNAL   Biochem Pharmacol 69 (8), 1287-1297 (2005)
   PUBMED   15794950
REFERENCE   7  (bases 1 to 1891)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   8  (bases 1 to 1891)
  AUTHORS   Furihata,T., Hosokawa,M., Nakata,F., Satoh,T. and Chiba,K.
  TITLE     Purification, molecular cloning, and functional expression of
            inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging
            to the carboxylesterase multigene family
  JOURNAL   Arch Biochem Biophys 416 (1), 101-109 (2003)
   PUBMED   12859986
REFERENCE   9  (bases 1 to 1891)
  AUTHORS   Sanghani,S.P., Davis,W.I., Dumaual,N.G., Mahrenholz,A. and
            Bosron,W.F.
  TITLE     Identification of microsomal rat liver carboxylesterases and their
            activity with retinyl palmitate
  JOURNAL   Eur J Biochem 269 (18), 4387-4398 (2002)
   PUBMED   12230550
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_133586.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010635.1, AB191005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000001.1  270377201-270377292
            93-303              JAXUCZ010000001.1  270378192-270378402
            304-445             JAXUCZ010000001.1  270380037-270380178
            446-579             JAXUCZ010000001.1  270380801-270380934
            580-838             JAXUCZ010000001.1  270381011-270381269
            839-937             JAXUCZ010000001.1  270381975-270382073
            938-1078            JAXUCZ010000001.1  270382329-270382469
            1079-1159           JAXUCZ010000001.1  270382588-270382668
            1160-1304           JAXUCZ010000001.1  270382881-270383025
            1305-1442           JAXUCZ010000001.1  270383386-270383523
            1443-1515           JAXUCZ010000001.1  270383896-270383968
            1516-1891           JAXUCZ010000001.1  270384393-270384768
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1891
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /note="carboxylesterase 2C"
                     /db_xref="GeneID:171118"
                     /db_xref="RGD:621510"
     exon            1..92
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1702
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /EC_number="3.1.1.28"
                     /note="acylcarnitine hydrolase-like; carboxylesterase 2
                     (intestine, liver); carboxylic ester hydrolase"
                     /codon_start=1
                     /product="acylcarnitine hydrolase precursor"
                     /protein_id="NP_598270.2"
                     /db_xref="GeneID:171118"
                     /db_xref="RGD:621510"
                     /translation="MARKQPHSWLNAVLFGLLLILIHVWGQDSPESSSIRTTHTGQVR
                     GKLDHVRDTKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHPAMCLQNID
                     MLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGSNLPVMVCIHGGALVIGMASM
                     CDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFG
                     GNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTV
                     AKLSGCEATDSETLVRCLRAKSGAEILVINKVFKMIPAVVDGEFLPRHPKELLASEDF
                     HPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPECGDLLM
                     EEYMGNTDDPQTLQIQYAEMMGDFLFVIPALQVAHFQRSHAPVYFYEFQHAPSYFKNV
                     RPPHVKADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMKYWANFARHGNPNSEGLP
                     YWPVLDHDEQYLQLDTQPAVDRALKARRLQFWTKTLPQKIQELNGAQKNHAEL"
     exon            93..303
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            304..445
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            446..579
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            580..838
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            839..937
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1078
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1159
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1304
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1442
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1515
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1891
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; Ces2; Ces2l; CESRL4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaactgagaa ctggccatgg cacggaaaca accacatagc tggctgaatg ctgtgctctt
       61 tgggctcctg cttattctta tccatgtgtg gggtcaggac tcaccagagt ccagctccat
      121 caggaccaca cacacgggcc aggtccgagg aaagcttgac cacgtgaggg acactaaagc
      181 tggtgtccac accttcctgg gaattccctt tgccaaggct cctgtaggac cgctgcgctt
      241 tgcacctcct gaggaccctg agccatggag tggtgtgaga gatgggacct cacatccggc
      301 catgtgtctg caaaatattg atatgctgga tgaagtaggc ctgacagata tgaaaatgat
      361 actgtcttcc attcctatgt ctgaggactg cctgtatctc aacatctata caccagccca
      421 tgcccatgag ggctctaacc tgcctgtgat ggtgtgcatc cacggaggtg cactggttat
      481 aggaatggct tccatgtgtg atggatctct attggcagtc aatgaggact tggtggttgt
      541 cgctatccag tatcgtctgg gtgtcctggg ctttttcagc actggagatg agcatgccag
      601 aggcaactgg ggatacctgg accaagtggc tgccctgcga tgggtccagc agaatatcgc
      661 ccattttgga ggcaacccta accgggtcac tatttttggc gtgtctgcag gtggcacaag
      721 tgtgtcttca catgttatat cccccatgtc tcaagggctc ttccatggtg ccatcatgga
      781 gagtggagtg gccctgctgc ctgaccttat ctctgaaacc tctgagacgg tctccactac
      841 agtggccaag ctctctggat gtgaggccac ggactcagag accctggtgc gctgcctgag
      901 agccaagagt ggagcagaga ttctggtcat taacaaggtc ttcaagatga ttcccgctgt
      961 ggtggatgga gagttcctac ccaggcatcc caaagagctg ttggcatctg aggattttca
     1021 ccctgtcccc agcatcattg gtgttaacac tgatgagtac tgttgcacca ttcctatggt
     1081 catgggcact gctcaaataa taaaggagtt atccagagag aacctgcagg ctgttctaaa
     1141 ggatacagca gcacaaatga tgcttcctcc tgagtgtggt gacctgctaa tggaagagta
     1201 catggggaac actgatgatc cccagaccct acaaatacag tacgctgaga tgatgggaga
     1261 cttcctgttt gtgatccctg cactccaagt tgcacacttt caacgttccc atgcccctgt
     1321 ctacttctat gagttccaac atgcacccag ctatttcaag aatgtcaggc caccccacgt
     1381 gaaggctgac catgctgatg aggttccttt tgtctttggg tccttcttct ggggcataaa
     1441 agttgacttc actgaggagg agaagctgct gagtaggcgg atgatgaagt actgggccaa
     1501 ttttgcaaga cacgggaacc ccaacagcga gggtctaccc tactggcctg tgttggacca
     1561 cgatgagcag tacctgcagt tggacaccca gcctgctgtg gaccgagccc tgaaggccag
     1621 aaggctgcag ttctggacca agactctgcc ccagaagatc caggagctaa atggagctca
     1681 gaaaaaccat gcagagctgt agtgtctggt gaaaggaaca gagtgtggga gtgagggcag
     1741 gtgggatcat tctgagtttc aaagtctaat tttctgttcc aacacgcaga atcctttcca
     1801 accccaatat tttccctttc tgacatgaat gagaagccct ccgtgtgtta ctctttattc
     1861 ttctgggcaa aatttaattg gactcaataa a
//
