LOCUS       NM_001103359            1935 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus carboxylesterase 1F (Ces1f), mRNA.
ACCESSION   NM_001103359
VERSION     NM_001103359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Parathath,S., Dogan,S., Joaquin,V.A., Ghosh,S., Guo,L.,
            Weibel,G.L., Rothblat,G.H., Harrison,E.H. and Fisher,E.A.
  TITLE     Rat carboxylesterase ES-4 enzyme functions as a major hepatic
            neutral cholesteryl ester hydrolase
  JOURNAL   J Biol Chem 286 (46), 39683-39692 (2011)
   PUBMED   21937439
  REMARK    GeneRIF: establish ES-4 as a bona fide endogenous nCEH that can
            account for the majority of cholesteryl ester hydrolysis in
            transformed rat hepatic cells and primary rat hepatocytes.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Sanghani,S.P., Davis,W.I., Dumaual,N.G., Mahrenholz,A. and
            Bosron,W.F.
  TITLE     Identification of microsomal rat liver carboxylesterases and their
            activity with retinyl palmitate
  JOURNAL   Eur J Biochem 269 (18), 4387-4398 (2002)
   PUBMED   12230550
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Robbi,M., Van Schaftingen,E. and Beaufay,H.
  TITLE     Cloning and sequencing of rat liver carboxylesterase ES-4
            (microsomal palmitoyl-CoA hydrolase)
  JOURNAL   Biochem J 313 (Pt 3) (Pt 3), 821-826 (1996)
   PUBMED   8611161
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Yan,B., Yang,D., Brady,M. and Parkinson,A.
  TITLE     Rat kidney carboxylesterase. Cloning, sequencing, cellular
            localization, and relationship to rat liver hydrolase
  JOURNAL   J Biol Chem 269 (47), 29688-29696 (1994)
   PUBMED   7961958
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FM041665.1 and
            BC128711.1.
            
            On May 9, 2012 this sequence version replaced NM_001103359.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               FM041665.1         1-535
            536-1935            BC128711.1         518-1917
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1935
                     /gene="Ces1f"
                     /note="carboxylesterase 1F"
                     /db_xref="GeneID:100125372"
                     /db_xref="RGD:1642419"
     exon            1..86
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1720
                     /gene="Ces1f"
                     /EC_number="3.1.1.1"
                     /note="liver carboxylesterase 4; carboxylesterase ES-4;
                     carboxyesterase ES-4; kidney microsomal carboxylesterase;
                     microsomal palmitoyl-CoA hydrolase; liver carboxylesterase
                     1F"
                     /codon_start=1
                     /product="liver carboxylesterase 1F precursor"
                     /protein_id="NP_001096829.2"
                     /db_xref="GeneID:100125372"
                     /db_xref="RGD:1642419"
                     /translation="MCLSFLFLVSLATCVVYGNPSSPPVVDTTKGKVLGKYVSLEGVT
                     QSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAKGQRMNDLLT
                     NRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLGGASTYDGRVLSAY
                     ENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIF
                     GESAGGFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCETT
                     TSAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTVVDNVVLPKDPKEI
                     LAEKNFNTVPYIVGINKQECGWLLPTMMGFVPADVELDKKMAITLLEKFASLYGIPED
                     IIPVAIEKYRKGSDDSIKIRDGILAFIGDVSFSIPSVMVSRDHRDAGAPTYMYEYQYY
                     PSFSSPQRPKHVVGDHADDLYSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPN
                     GRGLPHWPQYDQKEEYLQIGATTQQSQRLKAEEVAFWTQLLAKRQPQPHHNEL"
     exon            87..291
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            292..436
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            437..570
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            571..724
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            725..829
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            830..934
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            935..973
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1114
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1195
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1343
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1475
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1548
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1910
                     /gene="Ces1f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaactctact gactggagca cctgtccatg caagatgtgc ctcagcttcc tgttcctggt
       61 gtccctagca acctgtgtgg tttatggaaa cccctcttca ccacccgtgg tggacaccac
      121 gaaaggcaaa gtcctgggga agtacgtcag cttagaagga gtcacacagt ctgtagctgt
      181 cttcctggga gtcccttttg ccaagccccc tctgggatct ctgaggtttg ctccaccaca
      241 gcctgcagag ccctggagct tcgtgaagaa caccaccacc tatccaccta tgtgctctca
      301 agatgcagca aaagggcaga ggatgaatga tctcctaacc aacagaaagg agaaaatcca
      361 tctcgagttt tctgaagatt gtctctacct gaatatttac actcctgcag actttacaaa
      421 gaatagcagg ctgccagtga tggtgtggat ccatggaggt ggaatgacac tgggcggggc
      481 atcaacctat gatggccggg tcctctctgc ctatgaaaac gtggtggtag tggccattca
      541 gtatcgcctg ggcatctggg gattcttcag cacaggggat gaacacagca ggggaaactg
      601 gggtcatttg gaccaagtgg ctgcgctgca ctgggtccag gacaacattg ccaactttgg
      661 gggtgaccca ggctctgtga ccatctttgg agagtcagca ggaggtttca gtgtctctgt
      721 tcttgtgttg tccccactga ccaagaacct cttccacagg gccatttctg agagtggggt
      781 ggtcttcctt cctggattgt taaccaagga tgttagacca gccgctaagc aaattgctga
      841 tatggctgga tgtgaaacca ccacatctgc catcattgtt cactgcctgc gtcaaaagac
      901 agaagaggag ctcttagaga ttatgaagaa aatgaatctg attaaactca gttcacaaag
      961 ggataacaaa gagagctacc actttttgtc aactgtggtt gacaatgtag tgctgccgaa
     1021 ggacccaaaa gagatcctgg ctgagaagaa cttcaacacc gtgccctaca ttgtgggaat
     1081 caacaagcaa gaatgtggct ggcttctgcc aacaatgatg ggatttgtac cagctgatgt
     1141 agaattggac aagaagatgg ccattacgct cctggagaaa tttgcttccc tatatggtat
     1201 accagaggat attattccag ttgccattga gaagtacaga aaaggtagtg atgactccat
     1261 caagatcaga gatggaatcc ttgcctttat tggggatgtg tcattttcta tcccatcagt
     1321 gatggtgtcc cgtgaccaca gagatgctgg agctcccacc tacatgtatg agtatcaata
     1381 ctacccgagc ttctcatcac cccaaagacc caagcatgta gtaggagacc atgcagatga
     1441 tctctactct gtctttggtg ccccaatttt aagagatggt gcctcagaag aggagatcaa
     1501 gctcagcaag atggtgatga aattttgggc caactttgct cggaatggga accctaatgg
     1561 ccgagggcta cctcattggc cacagtatga ccagaaagaa gaatatctgc agattggtgc
     1621 caccacccag caatcgcaga gactgaaagc agaggaagtg gctttttgga cacagttact
     1681 ggctaagaga caacctcagc cacaccacaa cgagctgtga atgcaagtct ctgtcatctt
     1741 cagaacaagc aagccaagat atagttcttc cactaaagat gtatgtaaat ggaagatgga
     1801 tctggaggat cctgaagaat tttgtcaaag agacagggag aacccaggaa agagaaatat
     1861 ttgtacttat ggcaccaatt tagagaataa atgacatttt tacggtcaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaa
//
