LOCUS       NM_031565               2062 bp    mRNA    linear   ROD 29-APR-2012
DEFINITION  Rattus norvegicus carboxylesterase 1E (Ces1e), mRNA.
ACCESSION   NM_031565 XM_343651
VERSION     NM_031565.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm. Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 2062)
  AUTHORS   Takahashi,S., Katoh,M., Saitoh,T., Nakajima,M. and Yokoi,T.
  TITLE     Different inhibitory effects in rat and human carboxylesterases
  JOURNAL   Drug Metab. Dispos. 37 (5), 956-961 (2009)
   PUBMED   19225040
REFERENCE   3  (bases 1 to 2062)
  AUTHORS   Holmes,R.S., Glenn,J.P., VandeBerg,J.L. and Cox,L.A.
  TITLE     Baboon carboxylesterases 1 and 2: sequences, structures and
            phylogenetic relationships with human and other primate
            carboxylesterases
  JOURNAL   J. Med. Primatol. 38 (1), 27-38 (2009)
   PUBMED   19187434
REFERENCE   4  (bases 1 to 2062)
  AUTHORS   Taketani,M., Shii,M., Ohura,K., Ninomiya,S. and Imai,T.
  TITLE     Carboxylesterase in the liver and small intestine of experimental
            animals and human
  JOURNAL   Life Sci. 81 (11), 924-932 (2007)
   PUBMED   17764701
  REMARK    GeneRIF: comparative analysis of CES1 and CES2 in liver and small
            intestine of humans, monkeys, dogs, rabbits and rats
REFERENCE   5  (bases 1 to 2062)
  AUTHORS   Langston,T.B., Hylemon,P.B. and Grogan,W.M.
  TITLE     Over-expression of hepatic neutral cytosolic cholesteryl ester
            hydrolase in mice increases free cholesterol and reduces expression
            of HMG-CoAR, CYP27, and CYP7A1
  JOURNAL   Lipids 40 (1), 31-38 (2005)
   PUBMED   15825828
  REMARK    GeneRIF: results demonstrate elevation of FC and depletion of
            cholesteryl esters by over-expression of hncCEH, which were
            resistant to compensatory responses by other enzymes of cholesterol
            homeostasis
REFERENCE   6  (bases 1 to 2062)
  AUTHORS   Ghosh,S., Mallonee,D.H., Hylemon,P.B. and Grogan,W.M.
  TITLE     Molecular cloning and expression of rat hepatic neutral cholesteryl
            ester hydrolase
  JOURNAL   Biochim. Biophys. Acta 1259 (3), 305-312 (1995)
   PUBMED   8541339
REFERENCE   7  (bases 1 to 2062)
  AUTHORS   Yan,B., Yang,D., Brady,M. and Parkinson,A.
  TITLE     Rat kidney carboxylesterase. Cloning, sequencing, cellular
            localization, and relationship to rat liver hydrolase
  JOURNAL   J. Biol. Chem. 269 (47), 29688-29696 (1994)
   PUBMED   7961958
REFERENCE   8  (bases 1 to 2062)
  AUTHORS   Robbi,M. and Beaufay,H.
  TITLE     Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn)
  JOURNAL   Biochem. Biophys. Res. Commun. 203 (3), 1404-1411 (1994)
   PUBMED   7945287
REFERENCE   9  (bases 1 to 2062)
  AUTHORS   Medda,S. and Proia,R.L.
  TITLE     The carboxylesterase family exhibits C-terminal sequence diversity
            reflecting the presence or absence of
            endoplasmic-reticulum-retention sequences
  JOURNAL   Eur. J. Biochem. 206 (3), 801-806 (1992)
   PUBMED   1606962
REFERENCE   10 (bases 1 to 2062)
  AUTHORS   Robbi,M., Beaufay,H. and Octave,J.N.
  TITLE     Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase
            (ES-10), a carboxylesterase located in the lumen of the endoplasmic
            reticulum
  JOURNAL   Biochem. J. 269 (2), 451-458 (1990)
   PUBMED   2386485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM063764.1, EX493673.1, FM140223.1, FM062488.1, CB798951.1,
            AABR03115086.1 and AABR03115901.1.
            
            [WARNING] On Jun 29, 2023 this sequence was replaced by
            NM_031565.3.
            
            On Jun 17, 2010 this sequence version replaced NM_031565.1.
            
            Summary: enzyme that hydrolyzes long-chain fatty acids; necessary
            for cholesterol esterification; may be important for detoxification
            of certain drugs [RGD, Feb 2006].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               FM063764.1         1-582
            583-871             EX493673.1         375-663
            872-1304            FM140223.1         190-622
            1305-1455           FM062488.1         429-579
            1456-1716           CB798951.1         160-420
            1717-1718           AABR03115086.1     7184-7185
            1719-2062           AABR03115901.1     197-540
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/SsNHsd/Mcwi"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2062
                     /gene="Ces1e"
                     /gene_synonym="Ces1; Es22"
                     /note="carboxylesterase 1E"
                     /db_xref="GeneID:29225"
                     /db_xref="RGD:621508"
     CDS             205..1890
                     /gene="Ces1e"
                     /gene_synonym="Ces1; Es22"
                     /EC_number="3.1.1.1"
                     /note="liver carboxylesterase 3; ES-HTEL; pI 5.5 esterase;
                     carboxyesterase ES-3; esterase 22; carboxylesterase 1;
                     egasyn"
                     /codon_start=1
                     /product="carboxylesterase 1E precursor"
                     /protein_id="NP_113753.2"
                     /db_xref="GeneID:29225"
                     /db_xref="RGD:621508"
                     /translation="MCLYALILVFLAAFTAGGHPSSLPVVDTLQGKVLGKYVSLEGFT
                     QPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQIVNDLLT
                     NREENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALSTH
                     ENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIF
                     GESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPLAEKIAVVSGCKST
                     TSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPFVPTVLDGVVLPKMPEEI
                     LAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEE
                     AIPVAVEKYLRHTDDPDRNKDQLLELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYR
                     PSFSSKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANFARNGNPN
                     GQGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEVAFWSELLAMKPLHAGHTEL"
ORIGIN      
        1 ctctgggtgg ggatggctta gtgaactcct gaaaagcccc gtaggactct ttggaataga
       61 aggattgttc ttttctggta gcatacaatc gattgagagg aatttgctag taatctccag
      121 gagtgcggca ggatccagga tccgtgtggt ccccttgtca taggctggag atctcgctgt
      181 cccccaagcc tgtagccttc tatcatgtgc ctctatgctc tgatcctggt gtttcttgca
      241 gcattcacag cagggggaca cccatcgtca ctacccgtag tggacaccct gcaaggcaaa
      301 gtcctcggga agtacgtcag cttagaagga ttcacacagc ctgtggccgt cttcctggga
      361 gtcccctttg ccaagccccc tctcggatct ctgaggtttg ctccaccaca gcctgcagag
      421 ccctggagct tcgtaaagaa caccacctcc taccctccta tgtgctccca agaccccgtg
      481 gcagggcaaa tagtcaatga ccttctaact aaccgggaag agaacatttc tctccagttt
      541 tctgaagact gtctctacct aaatatttac acgcctgctg acttgacaaa acgtgataga
      601 ctgccggtga tggtgtggat ccatggaggt ggactagtgt taggtggggc atccacctat
      661 gatggactag ccctgtctac tcatgaaaat gtggtggtag tggtcattca ataccgtctg
      721 ggtatttggg gattcttcag cacaggggat gaacacagcc ggggcaactg gggtcacttg
      781 gaccaggtgg ctgcactgca ctgggtccag gacaacattg acaactttgg aggggaccca
      841 ggctctgtga ccatctttgg agagtcagca ggaggtgaaa gtgtctctgt tcttgtgttg
      901 tctcccttgg ccaagaatct ctttcacaag gccatttccg aaagtggcgt ggccctcact
      961 gcaggcctgg tcaagaagaa caccaggccc ttggctgaga aaattgctgt tgtatctggt
     1021 tgtaaaagca caacttcagc tgccatggtt cactgccttc gccagaagac agaggaagag
     1081 ctcttggaga ccacactaaa attgaatctt ttttcgctgg atttgcacgg agactccagg
     1141 cagagctatc cgtttgttcc cactgtgctt gatggagtgg tgctgccaaa gatgcctgag
     1201 gagatcctgg ctgagaagga cttcaacact gtgccctaca tcgtgggaat caacaagcaa
     1261 gagtttggct ggattctgcc aacaatgatg aactatccac cctctgatat gaaattggac
     1321 ccgatgacag ccacatcgct cttgaagaag tcttcttttc ttcttaacct tcctgaagaa
     1381 gcaattccag tggccgttga gaagtattta agacacacag atgacccaga cagaaataaa
     1441 gaccaacttc tggaattgat tggggatgtg atcttcggtg tcccatcagt gattgtctcc
     1501 cgtggacata gagatgctgg agcccgcaca tacatgtacg agtttcaata tcgcccaagc
     1561 ttctcatcaa aaatgaaacc aagtacggtg gtaggagatc atggagacga aatctactct
     1621 gtctttggtg ctccaatttt aagaggtggt acctcaaaag aggagatcaa tctcagcaag
     1681 atgatgatga aattctgggc aaactttgct aggaatggga atcccaatgg acagggcctg
     1741 ccccattggc cagagtatga ccaaaaggaa ggttatcttc agattggagc caccactcaa
     1801 caagcccaga agctaaaaga aaaagaagtg gctttctggt ctgagcttct ggctatgaag
     1861 ccactgcatg caggacacac tgagctatga acgggaggct ctgccagcct catcctcagg
     1921 gcagctcaca tggaagatgg ttttggccaa ggctttgagg agacttcaga actgtgtggt
     1981 gggagtgggc agaggccagg gagaggatat ttgcacatgt ggactcaaac tgaaaaataa
     2041 attttgtttt ataaatcaat aa
//
