LOCUS       NM_133295               1938 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carboxylesterase 1D (Ces1d), mRNA.
ACCESSION   NM_133295 XM_346519
VERSION     NM_133295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Capece,D., D'Andrea,D., Begalli,F., Goracci,L., Tornatore,L.,
            Alexander,J.L., Di Veroli,A., Leow,S.C., Vaiyapuri,T.S.,
            Ellis,J.K., Verzella,D., Bennett,J., Savino,L., Ma,Y.,
            McKenzie,J.S., Doria,M.L., Mason,S.E., Chng,K.R., Keun,H.C.,
            Frost,G., Tergaonkar,V., Broniowska,K., Stunkel,W., Takats,Z.,
            Kinross,J.M., Cruciani,G. and Franzoso,G.
  TITLE     Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes
            aggressive colorectal carcinoma
  JOURNAL   J Clin Invest 131 (11) (2021)
   PUBMED   33878036
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Liu,D., Li,X., Li,X., Wang,H. and Dong,M.
  TITLE     Carboxylesterase 1 polymorphisms are associated with clinical
            outcomes in gastroenteric cancer patients treated with capecitabine
  JOURNAL   Cancer Chemother Pharmacol 87 (5), 681-687 (2021)
   PUBMED   33586000
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Hou,J.Y., Wang,Y.G., Ma,S.J., Yang,B.Y. and Li,Q.P.
  TITLE     Identification of a prognostic 5-Gene expression signature for
            gastric cancer
  JOURNAL   J Cancer Res Clin Oncol 143 (4), 619-629 (2017)
   PUBMED   28035468
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Quiroga,A.D., Ceballos,M.P., Parody,J.P., Comanzo,C.G.,
            Lorenzetti,F., Pisani,G.B., Ronco,M.T., Alvarez,M.L. and
            Carrillo,M.C.
  TITLE     Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early
            stages of liver cancer development in the rat
  JOURNAL   Biochim Biophys Acta 1862 (11), 2043-2053 (2016)
   PUBMED   27523631
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Wallace,T.J., Kodsi,E.M., Langston,T.B., Gergis,M.R. and
            Grogan,W.M.
  TITLE     Mutation of residues 423 (Met/Ile), 444 (Thr/Met), and 506
            (Asn/Ser) confer cholesteryl esterase activity on rat lung
            carboxylesterase. Ser-506 is required for activation by
            cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 276 (35), 33165-33174 (2001)
   PUBMED   11429416
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Ghosh,S.
  TITLE     Cholesteryl ester hydrolase in human monocyte/macrophage: cloning,
            sequencing, and expression of full-length cDNA
  JOURNAL   Physiol Genomics 2 (1), 1-8 (2000)
   PUBMED   11015575
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Ghosh,S., Mallonee,D.H., Hylemon,P.B. and Grogan,W.M.
  TITLE     Molecular cloning and expression of rat hepatic neutral cholesteryl
            ester hydrolase
  JOURNAL   Biochim Biophys Acta 1259 (3), 305-312 (1995)
   PUBMED   8541339
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Medda,S. and Proia,R.L.
  TITLE     The carboxylesterase family exhibits C-terminal sequence diversity
            reflecting the presence or absence of
            endoplasmic-reticulum-retention sequences
  JOURNAL   Eur J Biochem 206 (3), 801-806 (1992)
   PUBMED   1606962
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Robbi,M., Beaufay,H. and Octave,J.N.
  TITLE     Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase
            (ES-10), a carboxylesterase located in the lumen of the endoplasmic
            reticulum
  JOURNAL   Biochem J 269 (2), 451-458 (1990)
   PUBMED   2386485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061789.1, CO574231.1 and CF111142.1.
            
            On Apr 5, 2007 this sequence version replaced NM_133295.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061789.1, L81144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-968               BC061789.1         1-968
            969-1330            CO574231.1         291-652
            1331-1567           BC061789.1         1331-1567
            1568-1938           CF111142.1         1068-1438
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1938
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /note="carboxylesterase 1D"
                     /db_xref="GeneID:113902"
                     /db_xref="RGD:70896"
     exon            1..103
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1749
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /EC_number="3.1.1.1"
                     /EC_number="3.1.1.67"
                     /note="ES-HVEL; FAEE synthase; pI 6.1 esterase;
                     carboxyesterase ES-10; liver carboxylesterase 10; fatty
                     acid ethyl ester synthase; carboxylesterase 3"
                     /codon_start=1
                     /product="carboxylesterase 1D precursor"
                     /protein_id="NP_579829.3"
                     /db_xref="GeneID:113902"
                     /db_xref="RGD:70896"
                     /translation="MRLYPLVWLFLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFA
                     QPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFT
                     NRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGQVLSAH
                     ENVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALHWVQDNIANFGGNPGSVTIF
                     GESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLSGCKTT
                     TSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKTPEEI
                     LTEKSFNTVPYIVGINKQEFGWIIPTLMGYPLSEGKLDQKTAKSLLWKSYPTLKISEK
                     MIPVVAEKYFGGTDDPAKRKDLFQDLVADVMFGVPSVMVSRSHRDAGAPTFMYEFEYR
                     PSFVSAMRPKTVIGDHGDELFSVFGSPFLKDGASEEETNLSKMVMKYWANFARNGSPN
                     GGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVAFWSELRAKEAAEEPSHWKHVEL"
     exon            104..308
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            309..453
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            454..587
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..741
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            742..846
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            847..951
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..990
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1131
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1212
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1360
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1492
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1565
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1938
                     /gene="Ces1d"
                     /gene_synonym="Ces3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctaaagga acaaatagcc cacagatccg cagaaccctt gtccttccac aatgcgcctc
       61 taccctctgg tctggctttt tcttgctgcg tgcacagctt gggggtaccc atcctcacca
      121 cctgtggtga acactgttaa aggcaaagtc ctggggaagt atgtcaattt ggaaggattt
      181 gcacagcctg tggctgtttt cctgggaatc cccttcgcca agccccctct tggctccttg
      241 aggtttgctc caccacagcc tgcagagcct tggaactttg tgaagaatac tacctcctac
      301 ccacctatgt gctctcaaga tgctgttgga gggcaggttc tctcagagct tttcaccaac
      361 aggaaggaaa acattccttt acagttttct gaagactgcc tctacctgaa cgtttatact
      421 cccgctgact tgacaaagaa cagccggcta ccagtgatgg tgtggatcca tggaggtgga
      481 ctggtagtgg gtggagcatc cacctatgat ggacaggtcc tctctgccca tgaaaatgtg
      541 gtggtggtga ccattcagta tcgccttggc atctggggat tcttcagcac aggggatgaa
      601 cacagccagg gcaactgggg tcacttggac caggtggctg cactacactg ggtccaggac
      661 aacattgcca actttggggg taacccaggc tctgtgacca tctttggaga atctgcagga
      721 ggtttcagtg tctctgctct tgtgttatct cctctggcca agaacctctt ccacagggcc
      781 atttctgaga gtggtgtggt cctcacttct gctctgatta caacagatag caagcccatt
      841 gctaatctga ttgctactct ttctgggtgt aaaaccacca catcagctgt tatggttcat
      901 tgcctgcgcc agaagacaga ggatgaactc ctggagactt cattaaaatt gaatcttttc
      961 aaactggatt tacttggaaa cccaaaagag agctatccct tcctacctac tgtgattgac
     1021 ggagtggtgc tgccaaagac accagaagag atcctgactg agaagagttt caacacagtc
     1081 ccctacatag tgggcatcaa caagcaagag tttggctgga tcattccaac gcttatgggc
     1141 tatccactct ccgaaggcaa actggaccag aaaacagcca aatccctctt gtggaagtcc
     1201 tacccaacac tgaaaatctc tgagaaaatg attccagtgg ttgctgagaa gtacttcgga
     1261 gggacagatg accctgccaa aaggaaagac ctgttccagg acttggttgc agatgtgatg
     1321 tttggtgtcc catcagtaat ggtgtctcga agtcacagag atgctggagc ccccaccttc
     1381 atgtatgaat ttgagtatcg cccaagcttt gtatcagcca tgaggcccaa gacagtgatc
     1441 ggagaccatg gtgatgaact cttctcagta tttggatctc catttttaaa agatggtgcc
     1501 tcagaagagg agaccaatct cagcaaaatg gtgatgaaat actgggccaa ctttgctcgg
     1561 aatgggagcc ctaatggggg agggctgccc cattggccag aatatgacca gaaggaaggg
     1621 tacctgaaga ttggtgcctc aactcaggca gcccagaggc tgaaggacaa agaagtggct
     1681 ttttggtctg agctcagggc caaggaggca gcagaggaac catcccactg gaaacatgtt
     1741 gagctctgat caggagggtc agccatgttt gagaacctga agctaaaggg gaattattcc
     1801 acagaagatt ttgtaaagac ataacacttc ttgtctttga gactataaca tcacatggta
     1861 ttttgtacaa atgcattaaa gggaaaatac ttaaccttat tgcttcaact tgtaaaataa
     1921 aacattgttt agaaattc
//
