LOCUS       NM_017004               1872 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carboxylesterase 1C (Ces1c), mRNA.
ACCESSION   NM_017004 XM_341651
VERSION     NM_017004.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Furihata,T., Hosokawa,M., Fujii,A., Derbel,M., Satoh,T. and
            Chiba,K.
  TITLE     Dexamethasone-induced methylprednisolone hemisuccinate hydrolase:
            its identification as a member of the rat carboxylesterase 2 family
            and its unique existence in plasma
  JOURNAL   Biochem Pharmacol 69 (8), 1287-1297 (2005)
   PUBMED   15794950
  REMARK    GeneRIF: Es2 was induced by dexamethasone in liver microsomes and
            identified in plasma.
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Sun,G., Alexson,S.E. and Harrison,E.H.
  TITLE     Purification and characterization of a neutral, bile
            salt-independent retinyl ester hydrolase from rat liver microsomes.
            Relationship To rat carboxylesterase ES-2
  JOURNAL   J Biol Chem 272 (39), 24488-24493 (1997)
   PUBMED   9305911
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Alexson,S.E., Finlay,T.H., Hellman,U., Svensson,L.T., Diczfalusy,U.
            and Eggertsen,G.
  TITLE     Molecular cloning and identification of a rat serum
            carboxylesterase expressed in the liver
  JOURNAL   J Biol Chem 269 (25), 17118-17124 (1994)
   PUBMED   8006016
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Takagi,Y., Morohashi,K., Kawabata,S., Go,M. and Omura,T.
  TITLE     Molecular cloning and nucleotide sequence of cDNA of microsomal
            carboxyesterase E1 of rat liver
  JOURNAL   J Biochem 104 (5), 801-806 (1988)
   PUBMED   3235453
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Long,R.M., Satoh,H., Martin,B.M., Kimura,S., Gonzalez,F.J. and
            Pohl,L.R.
  TITLE     Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence
            for a multigene family
  JOURNAL   Biochem Biophys Res Commun 156 (2), 866-873 (1988)
   PUBMED   2973315
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Harano,T., Miyata,T., Lee,S., Aoyagi,H. and Omura,T.
  TITLE     Biosynthesis and localization of rat liver microsomal
            carboxyesterase E1
  JOURNAL   J Biochem 103 (1), 149-155 (1988)
   PUBMED   3360755
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088251.1.
            
            On Jan 13, 2005 this sequence version replaced XM_341651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088251.1, M20629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1872
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /note="carboxylesterase 1C"
                     /db_xref="GeneID:24346"
                     /db_xref="RGD:2571"
     exon            1..92
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1690
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /EC_number="3.1.1.1"
                     /note="esterase 2, member of carboxylesterase-cluster 1;
                     liver carboxylesterase 1; E1; REH; NREH; ES-THET;
                     esterase-2; carboxyesterase ES-1; retinyl ester hydrolase;
                     neutral retinyl ester hydrolase; Esterase 2 member of
                     carboxylesterase-cluster 1; esterase 1; microsomal
                     carboxyesterase E1-like"
                     /codon_start=1
                     /product="carboxylesterase 1C precursor"
                     /protein_id="NP_058700.1"
                     /db_xref="GeneID:24346"
                     /db_xref="RGD:2571"
                     /translation="MWLCVLVWASLAACPIWGHPSSPPVVDTTKGKVLGKYVSLEGFT
                     QPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYPPMCSQDGVVGKLLADMLS
                     TGKENIPLEFSEDCLYLNIYSPADLTKNSRLPVMVWIHGGGLIIGGASPYSGLALSAH
                     ENVVVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQLAALRWVQDNIANFGGNPDSVTIF
                     GESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKNTQAVAQMIATLSGCNNT
                     SSAAMVQCLRQKTEAELLELTVKLDNTSMSTVIDGVVLPKTPEEILTEKSFNTVPYIV
                     GFNKQEFGWIIPTMMGNLLSEGRMNEKMASSLLRRFSPNLNISESVIPAIIEKYLRGT
                     DDPAKKKELLLDMFSDVFFGIPAVLMSRSLRDAGAPTYMYEFQYRPSFVSDQRPQTVQ
                     GDHGDEIFSVFGTPFLKEGASEEETNLSKLVMKFWANFARNGNPNGEGLPHWPEYDQK
                     EGYLQIGATTQQAQKLKGEEVAFWTELLAKNPPQTEHTEHT"
     exon            93..297
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..442
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..576
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..730
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..835
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..940
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1081
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1162
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1310
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1442
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1515
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1850
                     /gene="Ces1c"
                     /gene_synonym="Es1; Es2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagacacctc cctgtctcca agagctcttg ttcttccgcc atgtggctct gtgttctggt
       61 ctgggcttct cttgctgctt gcccaatttg gggacaccca tcctcaccac cagtggtgga
      121 caccacgaaa ggcaaagtcc tggggaagta tgtcagctta gaaggattta cacagcctgt
      181 ggccgtcttc ctgggagtcc cttttgccaa gcctcctctt ggatctctga ggtttgctcc
      241 accagagcct gcagagccct ggagcttcgt gaagaacacc accacctacc cgcctatgtg
      301 ctcccaagat ggagttgtgg gaaagttact cgcagatatg ttgagcaccg gaaaagagaa
      361 tatacctctc gagttttccg aagactgtct ctacctgaat atttacagtc ctgctgactt
      421 gacaaaaaac agccgattgc ctgtgatggt gtggatccat ggaggtggac taataatagg
      481 cggagcatca ccctatagtg gactagctct ctctgcccac gaaaacgtgg tggtggtaac
      541 cattcaatac cgcctgggta tttggggatt gtttagcacc ggtgatgaac acagccgggg
      601 gaactgggct cacttggacc agctggctgc actacgctgg gtccaggata acattgcaaa
      661 ctttggaggg aacccggatt cagtgaccat ctttggagag tcagcaggag gtgtcagtgt
      721 ctctgttctt gtcttatctc ctctggccaa gaacctcttc cacagagcca tttctgagag
      781 tggtgtggtc ctcactacaa acctggacaa gaagaatact caggctgtgg ctcaaatgat
      841 tgctactctt tctgggtgta ataacacctc atcagccgcc atggttcagt gcttgcgcca
      901 gaagacagag gctgagctct tggagcttac agtgaaactg gacaatacct ccatgtccac
      961 tgtgattgat ggagtggtac tgccaaagac accggaagag atcctgactg agaagagttt
     1021 caacacggtc ccctacatag tgggcttcaa caagcaagag tttggctgga tcattccaac
     1081 gatgatggga aatctactct ctgaaggcag aatgaatgag aaaatggcca gttccctctt
     1141 gaggaggttc agccctaacc ttaacatctc tgagagtgtg attccagcaa tcattgagaa
     1201 gtacttaaga ggaacagatg accctgccaa aaagaaggaa cttctcctgg acatgttttc
     1261 agatgtcttt ttcggtatcc cagctgtact catgtcccgt agcctcagag atgccggagc
     1321 gcccacctac atgtatgagt ttcagtatcg cccaagcttc gtgtctgacc agagacccca
     1381 gacagttcag ggagaccatg gtgatgaaat cttctctgta tttgggactc catttttaaa
     1441 agagggcgcc tcagaagagg agaccaatct tagcaagttg gtgatgaagt tctgggccaa
     1501 ctttgctcga aatgggaacc caaatggaga ggggctgcct cactggccag aatatgatca
     1561 gaaggaaggg tatttgcaga ttggtgccac cacccagcaa gcccagaaac tgaaaggaga
     1621 ggaagtggct ttctggactg agctcttggc taagaatcca cctcagacag aacacactga
     1681 acacacataa atgggtctct gccagcctca gtaccagagg agcaaagatg gggctattcc
     1741 acaaaggatg gctatttgcc aaagatgaat cttacagagg aaactgcaca attgtacagt
     1801 tggggtattt gtatctcaac tttgaaataa atttcctttt agaaatcaaa aaaaaaaaaa
     1861 aaaaaaaaaa aa
//
