LOCUS       NM_001190375            1896 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus carboxylesterase 1A (Ces1a), mRNA.
ACCESSION   NM_001190375 XM_001054575 XM_002725386
VERSION     NM_001190375.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Jin,Q., Li,Z., Zhang,M.J., Liu,W.C., Zou,L.W., Sui,H., Wang,D.D.,
            Tang,Q.F. and Ge,G.B.
  TITLE     Deciphering the species differences in CES1A-mediated hydrolytic
            metabolism by using a bioluminescence substrate
  JOURNAL   Chem Biol Interact 368, 110197 (2022)
   PUBMED   36174736
  REMARK    GeneRIF: Deciphering the species differences in CES1A-mediated
            hydrolytic metabolism by using a bioluminescence substrate.
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Jun 19, 2010 this sequence version replaced
            XM_002725386.1, XM_001054575.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.303086.1,
                                           SRR22582424.1807527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000019.1  30132678-30132729
            53-257              JAXUCZ010000019.1  30135617-30135821
            258-402             JAXUCZ010000019.1  30138383-30138527
            403-536             JAXUCZ010000019.1  30140574-30140707
            537-690             JAXUCZ010000019.1  30143511-30143664
            691-795             JAXUCZ010000019.1  30145605-30145709
            796-900             JAXUCZ010000019.1  30146916-30147020
            901-939             JAXUCZ010000019.1  30148539-30148577
            940-1080            JAXUCZ010000019.1  30152182-30152322
            1081-1161           JAXUCZ010000019.1  30154022-30154102
            1162-1309           JAXUCZ010000019.1  30154315-30154462
            1310-1441           JAXUCZ010000019.1  30157093-30157224
            1442-1514           JAXUCZ010000019.1  30158627-30158699
            1515-1896           JAXUCZ010000019.1  30158987-30159368
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1896
                     /gene="Ces1a"
                     /note="carboxylesterase 1A"
                     /db_xref="GeneID:679817"
                     /db_xref="RGD:1583671"
     CDS             1..1692
                     /gene="Ces1a"
                     /codon_start=1
                     /product="carboxylesterase 1-like precursor"
                     /protein_id="NP_001177304.1"
                     /db_xref="GeneID:679817"
                     /db_xref="RGD:1583671"
                     /translation="MWLFALALTSLNTYMAFGHPSSPPVVDTLQGKVLGKYISLEGFT
                     QPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNATSYPPMCSQITGVGPVLSEVFT
                     NQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGASTFDGLALSTH
                     EKVVVVVIQYRLGIWGFLSTGDEHSRGNWGHFDQVAALQWVQNNIVNFGGDPNSVTLF
                     GESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLFRENTRLAAEQVAIATGCAAT
                     TSADIVRCLREKTEEELLATTLKMKFFALDLHGDPRESYPFLTTVIDGVLLPKAPEEI
                     LSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSYPLTNISKE
                     LTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYHRDARATTYVYEFKYH
                     PSFVSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEEINLSTMMMKFWGNFARNGNPN
                     GEGLPHWPEYDEKESYLQIGTTIQQAQKLKYKEVAFWTGLRGMEVEEATEEDTQK"
     exon            1..52
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            53..257
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            258..402
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            403..536
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            537..690
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            691..795
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            796..900
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            901..939
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1080
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1161
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1309
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1441
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1514
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1896
                     /gene="Ces1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggctct ttgctctggc cctgacttct ctcaacactt acatggcttt tgggcaccca
       61 tcgtcaccac ccgtggtgga caccctgcaa ggcaaagtcc tgggaaagta catcagctta
      121 gaaggattca cacagcctgt ggctgtcttc ctgggagtcc cctttgccaa gccccctctt
      181 ggatctctga ggtttgctcc accacagcct gcagagtcct ggagcttcgt gaagaacgcc
      241 acctcctacc cacctatgtg ctcccaaatt acaggagtgg ggccagtgct ctctgaagtc
      301 ttcactaacc aactagaaaa tgttcctctt gaatattctg aagactgcct ttacctaaat
      361 atttattccc ctactgacct gacaagcaaa gacagactgc cggtgatggt gtgggtccac
      421 ggaggtggtt tactatctgg tggagcatca acttttgatg gactggccct gtccacccat
      481 gaaaaagtag tagtagtagt cattcagtat cgcctgggca tctggggatt cctcagcaca
      541 ggagatgaac acagccgagg aaactggggt cactttgacc aagtggctgc gttgcagtgg
      601 gtccagaaca acattgttaa ctttggaggg gacccaaact ctgtgaccct ctttggcgag
      661 tcagcaggag gggaaagcgt ctctgtcctt gttttgtctc cactgaccaa gaacctcttc
      721 cacagggcca tttctgagag tggtgtggcc ctcacgccat gtctcttcag ggagaataca
      781 aggctggcag ctgagcaagt tgccattgcc acagggtgtg cggccactac atcagccgat
      841 atagttcgct gtctacgtga gaagacagag gaggaactct tggctacaac cctgaagatg
      901 aaattctttg ctcttgattt gcatggagac cccagagaga gctacccttt cctgacaact
      961 gtgattgatg gggtactcct gccaaaggcg cctgaagaga ttctatctga gaagaacttc
     1021 aacactgtcc cctacatcgt gggcatcaac aagcaagagt ttggctggtt tattccaacg
     1081 atgatgggct atccactctc tgaaagcaaa ctggaccaga agacagccac atccctcctg
     1141 tggaagtcct acccacttac taacatctct aaggaactga ctccagtggc cactgagaag
     1201 tatttgggag gatcagactg ccctgacaaa aagaaagacc tctttttaga catgatggga
     1261 gatgtcttat ttgctgtgcc atctgtgatt gtggctcggt atcacagaga tgccagagcc
     1321 accacctacg tgtacgagtt taaatatcac ccaagcttcg tgtcggacat gagacccaag
     1381 acggtgatcg cagaccatgg agatgaagtt tactccgttt gggggacacc atttttaaaa
     1441 gagggcgcct ccgaggagga gatcaatctc agcaccatga tgatgaagtt ttggggcaat
     1501 tttgctcgga atgggaaccc aaatggggag ggactgccac actggccaga gtatgatgag
     1561 aaagagagtt accttcagat tgggaccacc atccagcaag ctcagaagct caaatacaaa
     1621 gaagtagctt tctggactgg cctccggggt atggaggtgg aggaagcaac cgaggaagac
     1681 actcagaaat gaagtcgaag gcagcacaac cctggaagcc attaacaacc tggtcaatgc
     1741 tgttccccag aaggtgtctg tagcccagag agctttctta tcacacaggc tgaagaactg
     1801 tgttggaagt gggcagaagc cagtgaagag aaatgtttgt aactgtggtt tcagtttgta
     1861 aaataaataa aataaaaatc ttcgagggga accaaa
//
