LOCUS       NM_001108935            5336 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus ceramide transporter 1 (Cert1), mRNA.
ACCESSION   NM_001108935 XM_001068766 XM_345143
VERSION     NM_001108935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Wilson R, Geyer SH, Reissig L, Rose J, Szumska D, Hardman E, Prin
            F, McGuire C, Ramirez-Solis R, White J, Galli A, Tudor C, Tuck E,
            Mazzeo CI, Smith JC, Robertson E, Adams DJ, Mohun T and Weninger
            WJ.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5336)
  AUTHORS   Rao RP, Scheffer L, Srideshikan SM, Parthibane V,
            Kosakowska-Cholody T, Masood MA, Nagashima K, Gudla P, Lockett S,
            Acharya U and Acharya JK.
  TITLE     Ceramide transfer protein deficiency compromises organelle function
            and leads to senescence in primary cells
  JOURNAL   PLoS One 9 (3), e92142 (2014)
   PUBMED   24642596
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5336)
  AUTHORS   Vlassaks E, Mencarelli C, Nikiforou M, Strackx E, Ferraz MJ, Aerts
            JM, De Baets MH, Martinez-Martinez P and Gavilanes AW.
  TITLE     Fetal asphyxia induces acute and persisting changes in the ceramide
            metabolism in rat brain
  JOURNAL   J Lipid Res 54 (7), 1825-1833 (2013)
   PUBMED   23625371
REFERENCE   4  (bases 1 to 5336)
  AUTHORS   Mencarelli C, Hammels C, Van Den Broeck J, Losen M, Steinbusch H,
            Revert F, Saus J, Hopkins DA, De Baets MH, Steinbusch HW and
            Martinez-Martinez P.
  TITLE     The expression of the Goodpasture antigen-binding protein (ceramide
            transporter) in adult rat brain
  JOURNAL   J Chem Neuroanat 38 (2), 97-105 (2009)
   PUBMED   19555756
  REMARK    GeneRIF: Levels of GPBP were observed widely throughout the brain,
            suggesting that GPBP plays an important role in central nervous
            system neuron function.
REFERENCE   5  (bases 1 to 5336)
  AUTHORS   Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang
            H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U and
            Acharya JK.
  TITLE     Mitochondrial degeneration and not apoptosis is the primary cause
            of embryonic lethality in ceramide transfer protein mutant mice
  JOURNAL   J Cell Biol 184 (1), 143-158 (2009)
   PUBMED   19139267
REFERENCE   6  (bases 1 to 5336)
  AUTHORS   Saito S, Matsui H, Kawano M, Kumagai K, Tomishige N, Hanada K,
            Echigo S, Tamura S and Kobayashi T.
  TITLE     Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral
            membrane protein that dephosphorylates the ceramide transport
            protein CERT to enhance its association with organelle membranes
  JOURNAL   J Biol Chem 283 (10), 6584-6593 (2008)
   PUBMED   18165232
  REMARK    GeneRIF: CERT is a physiological substrate of PP2Cepsilon and that
            dephosphorylation of CERT by PP2Cepsilon may play an important role
            in the regulation of ceramide trafficking from the ER to the Golgi
            apparatus.
REFERENCE   7  (bases 1 to 5336)
  AUTHORS   Kudo N, Kumagai K, Tomishige N, Yamaji T, Wakatsuki S, Nishijima M,
            Hanada K and Kato R.
  TITLE     Structural basis for specific lipid recognition by CERT responsible
            for nonvesicular trafficking of ceramide
  JOURNAL   Proc Natl Acad Sci U S A 105 (2), 488-493 (2008)
   PUBMED   18184806
REFERENCE   8  (bases 1 to 5336)
  AUTHORS   Kawano M, Kumagai K, Nishijima M and Hanada K.
  TITLE     Efficient trafficking of ceramide from the endoplasmic reticulum to
            the Golgi apparatus requires a VAMP-associated protein-interacting
            FFAT motif of CERT
  JOURNAL   J Biol Chem 281 (40), 30279-30288 (2006)
   PUBMED   16895911
REFERENCE   9  (bases 1 to 5336)
  AUTHORS   Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M and
            Nishijima M.
  TITLE     Molecular machinery for non-vesicular trafficking of ceramide
  JOURNAL   Nature 426 (6968), 803-809 (2003)
   PUBMED   14685229
REFERENCE   10 (bases 1 to 5336)
  AUTHORS   Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E,
            Vieites B, Granero F, Forteza J and Saus J.
  TITLE     Goodpasture antigen-binding protein, the kinase that phosphorylates
            the goodpasture antigen, is an alternatively spliced variant
            implicated in autoimmune pathogenesis
  JOURNAL   J Biol Chem 275 (51), 40392-40399 (2000)
   PUBMED   11007769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068766.1, XM_345143.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..5336
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /note="ceramide transporter 1"
                     /db_xref="GeneID:365652"
                     /db_xref="RGD:1309131"
     exon            1..520
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2299
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /EC_number="2.7.11.1"
                     /note="procollagen, type IV, alpha 3 (Goodpasture antigen)
                     binding protein; alpha 3 type IV collagen binding protein;
                     collagen, type IV, alpha 3 (Goodpasture antigen) binding
                     protein; collagen type IV alpha 3 binding protein"
                     /codon_start=1
                     /product="ceramide transfer protein"
                     /protein_id="NP_001102405.1"
                     /db_xref="GeneID:365652"
                     /db_xref="RGD:1309131"
                     /translation="MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRW
                     VVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDP
                     DHRQQWVDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREK
                     LAEMETFRDILCRQVDTLQKYFDVCADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLH
                     NTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREESWQKR
                     HDREVEKRRRVEEAYKNVTEELKKKPRFGGPDYEEGPNSLINEEEFFDAVEAALDRQD
                     KIEEQSQSEKVRLHWPPSLPSGDTFSSVGTHRFVQKPYSRSPSMSSIDLVSASDDVHR
                     FSSQVEEMVQNHMNYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV
                     KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLY
                     LSAIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINIALICQTLVSPPEGDQ
                     EISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
                     "
     exon            521..655
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            656..772
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            773..880
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1019
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1103
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1261
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1354
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1441
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1534
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1612
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1708
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1841
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1912
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2041
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2171
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2308
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..5336
                     /gene="Cert1"
                     /gene_synonym="Col4a3bp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaatagtg gacccggcag gaagatggcg gctgtagcgg aggtgtgagt ggatctgggt
       61 ctctgctgtt ggcttggctc ttcccgtctt cctccccctc ctccctccct gactgaggtt
      121 ggcatctagg gggccgagtt caggtggcgg cgccgggcgc agcgcagggg tcacggccac
      181 ggcggctgac ggctggaagg gcaggctttc ttcgccgctc gtcctccttc cctggtccgc
      241 tcggtgtcag gcgcggcggc ggcggcgcag cgggcgcgct tcgtccctct tcctgttccc
      301 tcactccccg gagcgggcac tcttggctgt gccatccccc gacccttcac cccagggact
      361 aggcgcctgc actggcgcag ctcgcggagc gggggccggt ctcctgctcg gctgtcgcgt
      421 ctccatgtcg gataaccaga gctggaactc gtcgggctcg gaggaggatc cggagacaga
      481 gtccgggccg cctgtggagc gctgcggagt cctcagcaag tggacaaact atattcatgg
      541 gtggcaggat cgttgggttg ttttgaaaaa taatactttg agttactaca aatctgaaga
      601 tgaaacagaa tatggctgta ggggatccat ctgtctaagc aaggctgtga tcacgcctca
      661 tgactttgat gaatgccggt ttgatattag tgtgaatgat agtgtttggt atcttcgtgc
      721 tcaggaccca gatcatagac agcagtgggt agacgccatt gagcagcaca agactgaatc
      781 aggatatgga tctgagtcca gcttgcgtag acatggctca atggtgtcac tggtgtctgg
      841 agcaagtggc tattctgcta cgtccacatc ttcattcaag aaaggccaca gtttacgtga
      901 gaagttggct gaaatggaaa cctttagaga catcctgtgt aggcaggttg atactctgca
      961 gaagtacttt gatgtctgtg ctgatgctgt ctccaaggat gaacttcaaa gggataaagt
     1021 ggtagaagac gatgaagatg acttccctac aactcgctct gatggagact tcttgcacaa
     1081 taccaatggt aataaggaaa aattatttcc acatgtaaca ccaaaaggaa ttaatggcat
     1141 agactttaag ggggaagcaa taacttttaa agcaactact gctggcatcc ttgctacact
     1201 gtctcattgt attgaactga tggtaaaacg cgaagaaagc tggcaaaaaa ggcatgatag
     1261 ggaagtggaa aagcggagac gagtagagga agcatacaag aatgtgacgg aggaacttaa
     1321 gaagaaacct cgcttcggag ggccagacta tgaagaaggt ccaaacagtc tgattaatga
     1381 ggaagagttc tttgatgctg ttgaagctgc tcttgacaga caagataaaa tagaggaaca
     1441 gtcacagagt gaaaaggtca ggttacactg gcctccgtca ttgccatctg gagatacctt
     1501 ttcttcagtt gggactcaca gattcgtaca aaagccctat agtcgctctc cctccatgtc
     1561 ttccattgat ctagtcagtg cctctgacga tgtccacaga ttcagctccc aggttgaaga
     1621 gatggtacag aaccacatga attattcatt acaggatgta ggtggtgatg caaattggca
     1681 gctggttgta gaagaaggag aaatgaaggt gtacagaaga gaagttgaag aaaatggaat
     1741 cgttctggat cctttgaaag ctactcatgc agttaaaggt gttacaggac acgaggtctg
     1801 caattacttt tggaatgttg atgttcgcaa tgactgggaa actactatag aaaactttca
     1861 tgtggtggaa acattagctg ataatgcaat catcatttat caaacgcaca agagagtgtg
     1921 gcccgcttct cagagagacg tgctgtatct ttctgctatt cggaagatcc cagccttgac
     1981 tgagaacgac cctgagactt ggatagtttg taatttctct gtggaccatg acagtgctcc
     2041 tctgaacaat cgatgtgtcc gtgccaaaat caatattgct ttgatttgtc aaactttggt
     2101 aagcccacca gagggagacc aggagataag cagagacaac attctgtgca agattacata
     2161 tgtagctaat gtgaacccag gaggatgggc gccagcctcg gtgttaagag cagtggcaaa
     2221 gcgagaatac cctaagtttc taaaacgatt tacttcttat gtccaagaaa aaactgcagg
     2281 aaaaccaatt ttgttttagt gttaacagtg actgaagcaa ggctgtgtga cattccatgt
     2341 tggagaaaga aggaaagaaa aatcctctaa actggaacgc aggatctaca gccttgtctg
     2401 gcccggaaga aacgttgcaa tagtaaagct gggtacccaa ctagccatct cctgctagat
     2461 ctcctcgctc ggcgtgtaac tataaataca tgagactcac atgtatatgg ctatattttt
     2521 atttgcttgc tcctaggagt gaaaaaaatt aactttgaat tacaactagg aattaaccga
     2581 tgctttaatt ttgaggaact ttttcagaat tttttattta ccgtggtcca gcctaagacc
     2641 ctcagctgca tcaggttttg tgcataaaag aaaagcacaa aagttgaccg cacctgagat
     2701 gtgtgctctc tgtgcaccaa atattcagat gggcttcttt ttacaggcct atgtctgtgt
     2761 gtctgtctgg aagtttttga cttttttgct ttgtataatc atagagtcta ttgctgctgg
     2821 tttctacatg gactcatgtc gtgtgtctct tcataactga ggactgtcaa taacctgtga
     2881 ttttgccttt tctatagtct tactcccatg aagaacgttg gttctgatgg aggaagaatg
     2941 aaaagcttta tcccccagat atctttatat ttttattatg tattttagtt gtgtactatg
     3001 tgctaccaac ttttttcagt ttgttacaaa cacaatttgg taatttttaa attggttctg
     3061 cctgcctcca gtcagacaac tgtacatctc ttatggtata gagtacttta tatacagagg
     3121 tcaggataaa gtgggttcat attttccctg aaatttgtaa gagaatatat ggtattactt
     3181 gttaaaccaa atcagactgt ttgaatttga catttgattt aatatttcta gtattctgta
     3241 acaaatatgg gagtttttct agcttggatc actttaaatg atctatcgaa ggtatgtata
     3301 gaaatctgaa caatgctcaa ttttcctctt gatcataaat ttcagcagag cagtgaaatt
     3361 ccacactatt caaactgaaa tgctgtcttt agttgctatg agaagctaag gtaaaatacc
     3421 tgatttagtt gtagtcctct atgaaaaact ttgcagcatg gagttgaggc aaggaatgta
     3481 ctcacttcag ctgggatgac tgcccacttc aaactcttga ttgtgtttac aagcagatgt
     3541 atttatgtaa atcaggcatt ttgtaaatgc tttgctgact tgttcctctc cttagaaaca
     3601 caaaaatcag acccttttgt aaagcagaga gtcatgtcat gtaaaacatg acctgtatat
     3661 attccatcca tcgaaatgga gtctaaagat gaatgcaagg tgtgctaatt taatgatggg
     3721 attagtctga acacttagga tgcacaatcc tggaagtgaa gcacttgcat cagatagaat
     3781 gatatttatt actctgtaca gagaggaaag tacatataaa tcatagagct tacattacat
     3841 gcacgcagtt tcacgtccca taaatccttt atatttttaa tttaccttct ctaaatgatg
     3901 tgcatggaat ctgccttatt acagaaatgc tattcataat ttgactctgt ggaaaagtgc
     3961 ctatacggtg gtaaagctag gaaggcaagg aggactatcg caccagttta catcaccagt
     4021 tagcatttta tagtatgacg tttaaaaaga aaagtttata cctcaaatgt gtgttttatt
     4081 ttgcaatcag ctgtggggtt gggatgggag aacgggaggg ttgggaggga aagtttattt
     4141 gccataggca ctggtgggaa tcttagggaa aaaaacaaaa caaaaacaaa cagccaaaaa
     4201 aaaaacccaa aaaagcaaaa caaaactctc tacacccact ataaatgttc ctctgtttgc
     4261 atttgtggta actctgttga accaggcaaa taactctttc aaaactaaat tgaatagctt
     4321 tattttacaa acaggcgcaa agtttatgag gcagggtctg catctaatta tcaccagttg
     4381 catttgcacc aaatggggtg ataatctttt acaatttatt ctgtaaataa aatgttacac
     4441 taaaaatgtt tgtggtaaaa aaaagataag gaatgaccat tttaccgcta agtaattgac
     4501 tggtacttta ttggagctgt ccctgtctag tcagatttag aactgagttc agaaatactg
     4561 acagcagcca gagtcagagt caggaggagc actggccgcg ttagaatatt cagaccctca
     4621 agggttcctt ccattaggct gagtcctaca tactgaagat ttattatatt tcttctcacc
     4681 tgggtattta tcttggccca agtccccatc ccacaacccc ccaaaacaag cccctttact
     4741 caattctgct ggattatttc atgatgttag acacctgaaa aatactggtg ctgcggggat
     4801 ttgtccctgc gtgtgagtga atgccatggg agagcacagt gctcctctag agattgagga
     4861 ctccgtattt gaggtggaga aacttgattt ggtgttgcta taggaggagc agcaaaggca
     4921 ggagggaggt gtgtggaggc aaagaaagat aaaggagcca cggttctcat ctgttggttt
     4981 tcatgactac tttattaaaa cacctataca atagcagtgt cggtggctac agaatgtgag
     5041 ctgagctgag ctggttcgct ggtgagactg ctggttacct tgaagcttac ggtcgtttgt
     5101 cggctcagac gctgggccag tacttagtcc aggctgtaca gacagtgtat tggatcgttg
     5161 tccttggtca tctacagact caaaacataa tcattttcaa ataccttggg agtgtgtaga
     5221 gtgtaactat aatagcttta tgattctgat gatgtttttt aaaaatataa aagatggatc
     5281 ttccatgtta caatcacaaa attaaaacca gtatttaaaa gtggagaagt attaaa
//
