LOCUS       NM_001127561            2825 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ceramide synthase 3 (Cers3), mRNA.
ACCESSION   NM_001127561 XM_001059767 XM_574469
VERSION     NM_001127561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2825)
  AUTHORS   Radner,F.P., Marrakchi,S., Kirchmeier,P., Kim,G.J., Ribierre,F.,
            Kamoun,B., Abid,L., Leipoldt,M., Turki,H., Schempp,W., Heilig,R.,
            Lathrop,M. and Fischer,J.
  TITLE     Mutations in CERS3 cause autosomal recessive congenital ichthyosis
            in humans
  JOURNAL   PLoS Genet 9 (6), e1003536 (2013)
   PUBMED   23754960
  REMARK    Erratum:[PLoS Genet. 2013 Jun;9(6):
            doi/10.1371/annotation/df5af830-8e1d-495a-a206-f881ed85e7fe]
REFERENCE   2  (bases 1 to 2825)
  AUTHORS   Jennemann,R., Rabionet,M., Gorgas,K., Epstein,S., Dalpke,A.,
            Rothermel,U., Bayerle,A., van der Hoeven,F., Imgrund,S., Kirsch,J.,
            Nickel,W., Willecke,K., Riezman,H., Grone,H.J. and Sandhoff,R.
  TITLE     Loss of ceramide synthase 3 causes lethal skin barrier disruption
  JOURNAL   Hum Mol Genet 21 (3), 586-608 (2012)
   PUBMED   22038835
REFERENCE   3  (bases 1 to 2825)
  AUTHORS   Lahiri,S., Lee,H., Mesicek,J., Fuks,Z., Haimovitz-Friedman,A.,
            Kolesnick,R.N. and Futerman,A.H.
  TITLE     Kinetic characterization of mammalian ceramide synthases:
            determination of K(m) values towards sphinganine
  JOURNAL   FEBS Lett 581 (27), 5289-5294 (2007)
   PUBMED   17977534
REFERENCE   4  (bases 1 to 2825)
  AUTHORS   Mizutani,Y., Kihara,A. and Igarashi,Y.
  TITLE     LASS3 (longevity assurance homologue 3) is a mainly testis-specific
            (dihydro)ceramide synthase with relatively broad substrate
            specificity
  JOURNAL   Biochem J 398 (3), 531-538 (2006)
   PUBMED   16753040
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160913.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_001059767.1, XM_574469.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2825
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2825
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /note="ceramide synthase 3"
                     /db_xref="GeneID:499174"
                     /db_xref="RGD:1564356"
     exon            1..11
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            12..19
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            20..25
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            26..199
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1202
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /EC_number="2.3.1.24"
                     /note="LAG1 longevity assurance homolog 3; LAG1 homolog,
                     ceramide synthase 3"
                     /codon_start=1
                     /product="ceramide synthase 3"
                     /protein_id="NP_001121033.1"
                     /db_xref="GeneID:499174"
                     /db_xref="RGD:1564356"
                     /translation="MFYRFRKWFWSERFWLPPTIKWSDLEDHEGLVFVKASHLYITIP
                     YALLLLVVRYFFEKFVATPLANALGIQKAQHKIKPNAILENFFQHSTSQPSHNEVYGL
                     AKKCNLTERQVERWFRIRQKQNKPCRLQKFQESCWRFTFYFMMTVAGAVFLYDKPWAY
                     DLWEVWYDYPRQPLLPSQYWYYVLEMSFYWSLVFSLGSDIKRKDFLANVIHHLAAISL
                     MSFSWCANYIRSGTLVMFVHDISDIWLESAKMFSYAGWKQTCNTLFFIFAIVFFISRF
                     IIFPFWILYCTLILPLHYLEPFFSYIFLNLQLMILQGLHIYWGYLILKMLNRCIFTQN
                     IQDVRSDNEEEEDEEEEEEEEEEEEEEEENTKGKETEYLKNGLGTNRHLIPNGQHGR"
     exon            200..314
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            315..433
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            434..491
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            492..542
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            543..635
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            636..764
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            765..871
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1025
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..2797
                     /gene="Cers3"
                     /gene_synonym="Lass3; RGD1564356"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcttctca agggactgga aagagaatgt tttacaggtt tagaaaatgg ttctggtcgg
       61 agagattctg gcttcctccg acaataaagt ggtcagacct ggaagatcat gaaggactgg
      121 tctttgtgaa agcgtcccac ttgtatatca caattccgta tgcccttctc ttactggtcg
      181 tcagatactt ctttgaaaag tttgttgcca cacctctagc caatgcactt ggcattcaaa
      241 aggcacagca taaaattaaa ccaaatgcca tcttagagaa ttttttccag cattccacaa
      301 gtcaaccgtc acataatgaa gtttacggac tggcaaagaa gtgtaacttg acagagcgcc
      361 aggttgaaag atggtttaga attcgccaga agcaaaacaa accttgcagg ttgcagaaat
      421 tccaagaatc ttgctggcga tttacattct atttcatgat gacggtggct ggagctgtgt
      481 ttctgtatga taaaccatgg gcatacgacc tctgggaggt ttggtatgat tatcccagac
      541 agcctttgct gccctcccag tactggtact acgttttgga gatgagtttt tattggtcac
      601 tggtgtttag cctgggctct gatatcaaga ggaaggattt cctcgctaat gtcatccacc
      661 acctggctgc tattagtctg atgagcttct cctggtgtgc taattacatt cgcagtggga
      721 ccctcgtgat gtttgttcat gatatatctg acatttggct agagtctgct aagatgtttt
      781 cctatgctgg atggaagcaa acctgtaata ccctgttctt catcttcgcc atcgtgttct
      841 tcattagccg attcattata tttccgttct ggattctgta ctgcaccctg atcctgcctt
      901 tgcactatct cgagcccttc ttctcctaca tcttcctcaa cctccagctc atgatccttc
      961 agggccttca catttactgg ggttacttaa tcctgaagat gctcaacaga tgcatattca
     1021 cacagaacat ccaggatgtg aggagtgaca acgaagagga agaagatgag gaggaggaag
     1081 aggaggaaga agaagaggaa gaagaggagg aggagaacac caaaggcaaa gagacagagt
     1141 atttgaagaa tggccttggg accaacaggc atctcattcc caatggtcag catggccgtt
     1201 agcttgaagc acagtgtgct gccaggacct tgggggcctg aactgctccc ctatccactg
     1261 ctgtggaccc acagagaccc cattttgcct tttattttat tttattttat tttattgaga
     1321 tggagtctcc tatgttgctc aaggtggccc ccaactcagt catcctgcct gtgataagtg
     1381 ttagaaggtg gatgccagtg gatggcccag cagcccaggc tgctggagtg ctcagagatt
     1441 tctccaggca gggtcagttc ttgttgtgtt tcccccatcc agaaccagct gagatgcttc
     1501 tctgcacagg gcctctgagg gcatctgctc tactacctca cagagttaga gtaaggatcg
     1561 ggcgagacga caggggtgcc agtgtctccc gcaggtgtta gtggtcttcg ctgcactaga
     1621 attccagctt tgacaaaaca cacaaccctg gctgagcgtg ctgtgagaaa ccccatctta
     1681 taaatggctc ttaatgtgta agatacctgg aggtgcaaaa gtccagaagt ctgtttctgt
     1741 ttgtaactat attgtttcca ggggtaattc tcagatgacc ccagagcctt cctggcaggg
     1801 tcctggggta gaaggaaggg agttttggtg tctagctgcc ctgtgctgtc accctgagcc
     1861 ccatcctcag gcttacagag atgccatggg ctatgagggt tgcttgggga ccactgagga
     1921 gagtaggatc caagagaggt tgctcactga gccatattac ccaggaagcc agccccgggg
     1981 tggcatacat gagagcttca tggtctgaag gaactcttga aagtggaaag aggaagccat
     2041 gttgtggtct cagggtccaa ctccttctga ctactgaaca gtaaggagcc cagcaggccg
     2101 tcaggcaccc taagtagcaa aagtcctgtg cacactaaat ggtctgagag tttcagtttt
     2161 taatttttaa aatagcgtgt ttttaaaacc ttcaggctaa taagaaaatg caagcaaaca
     2221 aacaaaaact cttcagaatt ctgttcccaa caaaatatct tgttaaagaa ttgtaggaaa
     2281 aacagggaaa aaagcaagtc ttaagttaat atttgttttt atgagcacag caccatgtgt
     2341 attatatctg taatgtgatc tcatatttaa aatgtctcta ctcactttag ggcatagtta
     2401 ttggtttatt gttcttactt tggtgaaagg tctcactaaa atacttttat gtgtccggtt
     2461 aacgaagtat ttccccttga tttactttgg ttttctttgt ctacagaacc ttttcttgct
     2521 tacagtgaag cattgtttat tgctataccc tccaacttct ttttctgact ttgactgtag
     2581 aaggtaaaac tgatatgctc tcaaattttg agctctcaaa cagctgaagc actgtcctgc
     2641 agaaaggaag aggcgtgctc tgcagcacca ttgggggctg tcgtggctag gaaaggtaac
     2701 cccctttccc gtagcaaaca agggttcagt gcaatgtgag gtgactttgt aaaattctaa
     2761 gccacattga cttacaataa aacaaaaaag aatcccaaaa aaaaaaaaaa aaaaaaaaaa
     2821 aaaaa
//
