LOCUS       NM_001115031            1746 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus cerberus 1, DAN family BMP antagonist (Cer1),
            mRNA.
ACCESSION   NM_001115031 XR_008686
VERSION     NM_001115031.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Chi L, Saarela U, Railo A, Prunskaite-Hyyrylainen R, Skovorodkin I,
            Anthony S, Katsu K, Liu Y, Shan J, Salgueiro AM, Belo JA, Davies J,
            Yokouchi Y and Vainio SJ.
  TITLE     A secreted BMP antagonist, Cer1, fine tunes the spatial
            organization of the ureteric bud tree during mouse kidney
            development
  JOURNAL   PLoS One 6 (11), e27676 (2011)
   PUBMED   22114682
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Tang PL, Cheung CL, Sham PC, McClurg P, Lee B, Chan SY, Smith DK,
            Tanner JA, Su AI, Cheah KS, Kung AW and Song YQ.
  TITLE     Genome-wide haplotype association mapping in mice identifies a
            genetic variant in CER1 associated with BMD and fracture in
            southern Chinese women
  JOURNAL   J Bone Miner Res 24 (6), 1013-1021 (2009)
   PUBMED   19113921
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez
            G, Kyba M, Lin S, Janknecht R, Lim DS and Choi K.
  TITLE     ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and
            vessel progenitor specification
  JOURNAL   Cell Stem Cell 2 (5), 497-507 (2008)
   PUBMED   18462699
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Liguori GL, Borges AC, D'Andrea D, Liguoro A, Goncalves L,
            Salgueiro AM, Persico MG and Belo JA.
  TITLE     Cripto-independent Nodal signaling promotes positioning of the A-P
            axis in the early mouse embryo
  JOURNAL   Dev Biol 315 (2), 280-289 (2008)
   PUBMED   18241853
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Simic P, Culej JB, Orlic I, Grgurevic L, Draca N, Spaventi R and
            Vukicevic S.
  TITLE     Systemically administered bone morphogenetic protein-6 restores
            bone in aged ovariectomized rats by increasing bone formation and
            suppressing bone resorption
  JOURNAL   J Biol Chem 281 (35), 25509-25521 (2006)
   PUBMED   16798745
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Yamamoto M, Saijoh Y, Perea-Gomez A, Shawlot W, Behringer RR, Ang
            SL, Hamada H and Meno C.
  TITLE     Nodal antagonists regulate formation of the anteroposterior axis of
            the mouse embryo
  JOURNAL   Nature 428 (6981), 387-392 (2004)
   PUBMED   15004567
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Belo,J.A., Bachiller,D., Agius,E., Kemp,C., Borges,A.C.,
            Marques,S., Piccolo,S. and De Robertis,E.M.
  TITLE     Cerberus-like is a secreted BMP and nodal antagonist not essential
            for mouse development
  JOURNAL   Genesis 26 (4), 265-270 (2000)
   PUBMED   10748465
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Hsu DR, Economides AN, Wang X, Eimon PM and Harland RM.
  TITLE     The Xenopus dorsalizing factor Gremlin identifies a novel family of
            secreted proteins that antagonize BMP activities
  JOURNAL   Mol Cell 1 (5), 673-683 (1998)
   PUBMED   9660951
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, Lah
            M, Wang CC, Nash A, Hilton D, Ang SL, Mohun T and Harvey RP.
  TITLE     Murine cerberus homologue mCer-1: a candidate anterior patterning
            molecule
  JOURNAL   Dev Biol 194 (2), 135-151 (1998)
   PUBMED   9501024
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M
            and De Robertis EM.
  TITLE     Cerberus-like is a secreted factor with neutralizing activity
            expressed in the anterior primitive endoderm of the mouse gastrula
  JOURNAL   Mech Dev 68 (1-2), 45-57 (1997)
   PUBMED   9431803
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158726.1.
            
            On Mar 2, 2008 this sequence version replaced XR_008686.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158726.1, EV775024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1746
                     /gene="Cer1"
                     /gene_synonym="RGD1563046"
                     /note="cerberus 1, DAN family BMP antagonist"
                     /db_xref="GeneID:500485"
                     /db_xref="RGD:1563046"
     exon            1..560
                     /gene="Cer1"
                     /gene_synonym="RGD1563046"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..857
                     /gene="Cer1"
                     /gene_synonym="RGD1563046"
                     /note="cerberus 1, cysteine knot superfamily, homolog"
                     /codon_start=1
                     /product="cerberus precursor"
                     /protein_id="NP_001108503.1"
                     /db_xref="GeneID:500485"
                     /db_xref="RGD:1563046"
                     /translation="MHLLFLQLIVLLPLGKAGLCVDDCQSQGSFSFALPERGRRDLHM
                     VNHEEAEDKPDLFVAVPHLMGTSSAREGQRQREKMLSRLGRFWKKPEAELYPTRDMES
                     DHVLSGIQALTQPADVRKLERSPLQEEAKKFWHRFMFRKGPASQGVILPIKSHEVHWE
                     TCRTVPFNQTIAHEDCQKVTVQNNLCFGKCGSIHFPGEGAHPHNFCSHCSPTKFTTTH
                     LRLNCTSPTPVVKMVIQVEECQCMVKTEHGEERRLLAGSQDSFISGLPA"
     exon            561..1706
                     /gene="Cer1"
                     /gene_synonym="RGD1563046"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttgggcc tggtgctctg taactctaat ctcagtttct gggatccagt accatgcatc
       61 tcctctttct tcagttgatt gtgctcttgc ctctggggaa ggcaggccta tgtgtagatg
      121 actgccagag tcagggctct ttttcctttg ccctcccaga aaggggtcgc agagacctcc
      181 acatggtcaa ccatgaggag gcagaagaca agccggatct gtttgtggct gtgccacatc
      241 tcatgggcac cagctcagct agggaaggcc agaggcagag agagaagatg ctgtctaggc
      301 ttggaagatt ctggaagaaa cctgaggcag aactttatcc cacaagggac atggaaagtg
      361 atcatgtcct atcggggatc caggccctca ctcagccagc agatgtgagg aaattggaga
      421 gatcacctct tcaggaggaa gccaagaaat tctggcatcg cttcatgttc agaaagggcc
      481 ccgcctccca gggggtcatc ctgcccatca aaagccatga agtacactgg gaaacctgca
      541 ggacagtgcc cttcaaccag accatcgccc acgaagactg tcaaaaagtc actgtccaga
      601 acaacctttg ctttgggaaa tgcggttcca ttcattttcc cggagaaggg gcacatcccc
      661 acaacttctg ctcccactgc tcacccacca aattcaccac cacgcacttg agactgaact
      721 gcaccagccc aacccccgtg gtcaagatgg tgatacaagt ggaagaatgt cagtgcatgg
      781 tgaagacgga acatggagag gagcgtcgcc tactggctgg ttcccaggat tccttcatct
      841 ctggactccc agcttaaaag acaaacccat gattacctca gaaaacaaaa ccagaatgag
      901 tgagggttgt ttaatctgga aaggtcaagt gggttatata aaactcaatg gaaatctctc
      961 tctctctctc tctctctctc tctctctctc tctctctcac acacacacac acacacacac
     1021 acacacacac acacacacac acacttgtgt ttagacaggg tcttgtgtat tccaggctgg
     1081 cctcaaactt gctatgtggc tggggatgct tttaaactcc tgatccactt cctgagtgct
     1141 gggattacag gcatgcacca taacacatag ctcccagagg cacttttaaa gagatttttg
     1201 catgcttcaa agttgccttt gagactcagg aaattttttt attctatgga atggatcttg
     1261 ccacagatgt gggagcagtg tgcttggtgg cccatgtttt ttgatttcct ttctgtactg
     1321 tctgcatgaa gtttttactg ttggttatct gactttgaag aaacaatagt gatgctactc
     1381 ttagcagttt acacgtggga ggggttcagg catgaggaac caagcctcct cctggaataa
     1441 gaggaaagga catgaacagt agtagagtca cttgaggaag ttactaagac actccataag
     1501 tctctaagta cattgcaagt cattttgaag caaaatggtc tatagacaaa atcttctact
     1561 cacatgcctt tgaatcttga agtaagttga atttctattt tgtgcttctt cctattgtat
     1621 gagtatgcat gacaaattca aacgtcaaca acaagttctg aatatgatct gaatgttgta
     1681 atacattaaa ttgtagcatg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaa
//
